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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LNK
Full Name:
SH2B adapter protein 3
Alias:
Lymphocyte adapter protein; SH2B3
Type:
Cytoplasm, Nucleus protein
Mass (Da):
63225
Number AA:
575
UniProt ID:
Q9UQQ2
International Prot ID:
IPI00010821
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
SH2B adapter protein 3 (R143-A157, human) peptide - Powder PE-01AFG90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AFG90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
N
G
P
A
L
Q
P
S
S
P
S
S
A
P
S
Site 2
S10
G
P
A
L
Q
P
S
S
P
S
S
A
P
S
A
Site 3
S12
A
L
Q
P
S
S
P
S
S
A
P
S
A
S
P
Site 4
S13
L
Q
P
S
S
P
S
S
A
P
S
A
S
P
A
Site 5
S16
S
S
P
S
S
A
P
S
A
S
P
A
A
A
P
Site 6
S18
P
S
S
A
P
S
A
S
P
A
A
A
P
R
G
Site 7
S27
A
A
A
P
R
G
W
S
E
F
C
E
L
H
A
Site 8
Y45
A
R
E
L
A
R
Q
Y
W
L
F
A
R
E
H
Site 9
Y74
F
T
D
L
F
Q
R
Y
F
C
R
E
V
R
D
Site 10
Y89
G
R
A
P
G
R
D
Y
R
D
T
G
R
G
P
Site 11
T92
P
G
R
D
Y
R
D
T
G
R
G
P
P
A
K
Site 12
S103
P
P
A
K
A
E
A
S
P
E
P
G
P
G
P
Site 13
S120
P
G
L
P
K
A
R
S
S
E
E
L
A
P
P
Site 14
S121
G
L
P
K
A
R
S
S
E
E
L
A
P
P
R
Site 15
S134
P
R
P
P
G
P
C
S
F
Q
H
F
R
R
S
Site 16
S141
S
F
Q
H
F
R
R
S
L
R
H
I
F
R
R
Site 17
S150
R
H
I
F
R
R
R
S
A
G
E
L
P
A
A
Site 18
T159
G
E
L
P
A
A
H
T
A
A
A
P
G
T
P
Site 19
T165
H
T
A
A
A
P
G
T
P
G
E
A
A
E
T
Site 20
T172
T
P
G
E
A
A
E
T
P
A
R
P
G
L
A
Site 21
S186
A
K
K
F
L
P
W
S
L
A
R
E
P
P
P
Site 22
S204
K
E
A
V
L
R
Y
S
L
A
D
E
A
S
M
Site 23
S210
Y
S
L
A
D
E
A
S
M
D
S
G
A
R
W
Site 24
S213
A
D
E
A
S
M
D
S
G
A
R
W
Q
R
G
Site 25
S245
E
L
F
D
P
P
K
S
S
R
P
K
L
Q
A
Site 26
S246
L
F
D
P
P
K
S
S
R
P
K
L
Q
A
A
Site 27
S255
P
K
L
Q
A
A
C
S
S
I
Q
E
V
R
W
Site 28
Y273
L
E
M
P
D
N
L
Y
T
F
V
L
K
V
K
Site 29
T274
E
M
P
D
N
L
Y
T
F
V
L
K
V
K
D
Site 30
S297
G
D
E
Q
Q
L
N
S
W
M
A
E
L
S
E
Site 31
S303
N
S
W
M
A
E
L
S
E
C
T
G
R
G
L
Site 32
S312
C
T
G
R
G
L
E
S
T
E
A
E
M
H
I
Site 33
T313
T
G
R
G
L
E
S
T
E
A
E
M
H
I
P
Site 34
S326
I
P
S
A
L
E
P
S
T
S
S
S
P
R
G
Site 35
T327
P
S
A
L
E
P
S
T
S
S
S
P
R
G
S
Site 36
S328
S
A
L
E
P
S
T
S
S
S
P
R
G
S
T
Site 37
S330
L
E
P
S
T
S
S
S
P
R
G
S
T
D
S
Site 38
S334
T
S
S
S
P
R
G
S
T
D
S
L
N
Q
G
Site 39
T335
S
S
S
P
R
G
S
T
D
S
L
N
Q
G
A
Site 40
S337
S
P
R
G
S
T
D
S
L
N
Q
G
A
S
P
Site 41
S343
D
S
L
N
Q
G
A
S
P
G
G
L
L
D
P
Site 42
S370
P
W
F
H
G
P
I
S
R
V
K
A
A
Q
L
Site 43
S394
G
V
F
L
V
R
Q
S
E
T
R
R
G
E
Y
Site 44
Y401
S
E
T
R
R
G
E
Y
V
L
T
F
N
F
Q
Site 45
T404
R
R
G
E
Y
V
L
T
F
N
F
Q
G
I
A
Site 46
S417
I
A
K
H
L
R
L
S
L
T
E
R
G
Q
C
Site 47
T419
K
H
L
R
L
S
L
T
E
R
G
Q
C
R
V
Site 48
S444
M
L
H
H
F
Q
R
S
P
I
P
L
E
C
G
Site 49
S480
N
T
V
L
F
P
F
S
L
P
H
W
D
S
E
Site 50
S486
F
S
L
P
H
W
D
S
E
S
L
P
H
W
G
Site 51
S488
L
P
H
W
D
S
E
S
L
P
H
W
G
S
E
Site 52
S494
E
S
L
P
H
W
G
S
E
L
G
L
P
H
L
Site 53
S502
E
L
G
L
P
H
L
S
S
S
G
C
P
R
G
Site 54
S504
G
L
P
H
L
S
S
S
G
C
P
R
G
L
S
Site 55
S511
S
G
C
P
R
G
L
S
P
E
G
L
P
G
R
Site 56
S520
E
G
L
P
G
R
S
S
P
P
E
Q
I
F
H
Site 57
S531
Q
I
F
H
L
V
P
S
P
E
E
L
A
N
S
Site 58
S538
S
P
E
E
L
A
N
S
L
Q
H
L
E
H
E
Site 59
S553
P
V
N
R
A
R
D
S
D
Y
E
M
D
S
S
Site 60
Y555
N
R
A
R
D
S
D
Y
E
M
D
S
S
S
R
Site 61
S559
D
S
D
Y
E
M
D
S
S
S
R
S
H
L
R
Site 62
S560
S
D
Y
E
M
D
S
S
S
R
S
H
L
R
A
Site 63
S561
D
Y
E
M
D
S
S
S
R
S
H
L
R
A
I
Site 64
S563
E
M
D
S
S
S
R
S
H
L
R
A
I
D
N
Site 65
Y572
L
R
A
I
D
N
Q
Y
T
P
L
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation