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Updated November 2019
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Protein Info
Short Name:
TNN
Full Name:
Alias:
Type:
Mass (Da):
144034
Number AA:
1299
UniProt ID:
Q9UQP3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T41
S
N
K
E
Q
Q
V
T
V
S
H
T
Y
K
I
Site 2
S43
K
E
Q
Q
V
T
V
S
H
T
Y
K
I
D
V
Site 3
S66
D
A
D
P
Q
P
L
S
D
D
G
A
S
L
L
Site 4
T94
R
H
N
I
R
L
Q
T
P
Q
K
D
C
E
L
Site 5
S104
K
D
C
E
L
A
G
S
V
Q
D
L
L
A
R
Site 6
S127
V
E
M
K
E
Q
C
S
A
Q
R
C
C
Q
G
Site 7
T136
Q
R
C
C
Q
G
V
T
D
L
S
R
H
C
S
Site 8
S139
C
Q
G
V
T
D
L
S
R
H
C
S
G
H
G
Site 9
S143
T
D
L
S
R
H
C
S
G
H
G
T
F
S
L
Site 10
T147
R
H
C
S
G
H
G
T
F
S
L
E
T
C
S
Site 11
Y192
R
C
L
C
H
E
P
Y
V
G
A
D
C
G
Y
Site 12
S229
D
F
M
S
E
D
C
S
E
K
R
C
P
G
D
Site 13
S277
L
L
K
N
T
E
D
S
L
L
V
S
W
E
P
Site 14
S281
T
E
D
S
L
L
V
S
W
E
P
S
S
Q
V
Site 15
S285
L
L
V
S
W
E
P
S
S
Q
V
D
H
Y
L
Site 16
S286
L
V
S
W
E
P
S
S
Q
V
D
H
Y
L
L
Site 17
Y291
P
S
S
Q
V
D
H
Y
L
L
S
Y
Y
P
L
Site 18
S294
Q
V
D
H
Y
L
L
S
Y
Y
P
L
G
K
E
Site 19
Y295
V
D
H
Y
L
L
S
Y
Y
P
L
G
K
E
L
Site 20
Y296
D
H
Y
L
L
S
Y
Y
P
L
G
K
E
L
S
Site 21
S303
Y
P
L
G
K
E
L
S
G
K
Q
I
Q
V
P
Site 22
S315
Q
V
P
K
E
Q
H
S
Y
E
I
L
G
L
L
Site 23
Y316
V
P
K
E
Q
H
S
Y
E
I
L
G
L
L
P
Site 24
T330
P
G
T
K
Y
I
V
T
L
R
N
V
K
N
E
Site 25
S341
V
K
N
E
V
S
S
S
P
Q
H
L
L
A
T
Site 26
S366
V
T
D
E
T
E
N
S
L
D
V
E
W
E
N
Site 27
T376
V
E
W
E
N
P
S
T
E
V
D
Y
Y
K
L
Site 28
Y380
N
P
S
T
E
V
D
Y
Y
K
L
R
Y
G
P
Site 29
Y381
P
S
T
E
V
D
Y
Y
K
L
R
Y
G
P
M
Site 30
Y385
V
D
Y
Y
K
L
R
Y
G
P
M
T
G
Q
E
Site 31
T389
K
L
R
Y
G
P
M
T
G
Q
E
V
A
E
V
Site 32
T397
G
Q
E
V
A
E
V
T
V
P
K
S
S
D
P
Site 33
S401
A
E
V
T
V
P
K
S
S
D
P
K
S
R
Y
Site 34
S402
E
V
T
V
P
K
S
S
D
P
K
S
R
Y
D
Site 35
S406
P
K
S
S
D
P
K
S
R
Y
D
I
T
G
L
Site 36
Y408
S
S
D
P
K
S
R
Y
D
I
T
G
L
H
P
Site 37
T411
P
K
S
R
Y
D
I
T
G
L
H
P
G
T
E
Site 38
Y419
G
L
H
P
G
T
E
Y
K
I
T
V
V
P
M
Site 39
T422
P
G
T
E
Y
K
I
T
V
V
P
M
R
G
E
Site 40
T441
P
I
L
L
N
G
R
T
E
I
D
S
P
T
N
Site 41
S445
N
G
R
T
E
I
D
S
P
T
N
V
V
T
D
Site 42
T447
R
T
E
I
D
S
P
T
N
V
V
T
D
R
V
Site 43
T451
D
S
P
T
N
V
V
T
D
R
V
T
E
D
T
Site 44
T455
N
V
V
T
D
R
V
T
E
D
T
A
T
V
S
Site 45
T458
T
D
R
V
T
E
D
T
A
T
V
S
W
D
P
Site 46
T460
R
V
T
E
D
T
A
T
V
S
W
D
P
V
Q
Site 47
S462
T
E
D
T
A
T
V
S
W
D
P
V
Q
A
V
Site 48
T478
D
K
Y
V
V
R
Y
T
S
A
D
G
D
T
K
Site 49
S479
K
Y
V
V
R
Y
T
S
A
D
G
D
T
K
E
Site 50
T484
Y
T
S
A
D
G
D
T
K
E
M
A
V
H
K
Site 51
T496
V
H
K
D
E
S
S
T
V
L
T
G
L
K
P
Site 52
T499
D
E
S
S
T
V
L
T
G
L
K
P
G
E
A
Site 53
Y510
P
G
E
A
Y
K
V
Y
V
W
A
E
R
G
N
Site 54
S520
A
E
R
G
N
Q
G
S
K
K
A
D
T
N
A
Site 55
T525
Q
G
S
K
K
A
D
T
N
A
L
T
E
I
D
Site 56
T529
K
A
D
T
N
A
L
T
E
I
D
S
P
A
N
Site 57
S533
N
A
L
T
E
I
D
S
P
A
N
L
V
T
D
Site 58
T539
D
S
P
A
N
L
V
T
D
R
V
T
E
N
T
Site 59
T543
N
L
V
T
D
R
V
T
E
N
T
A
T
I
S
Site 60
T546
T
D
R
V
T
E
N
T
A
T
I
S
W
D
P
Site 61
T548
R
V
T
E
N
T
A
T
I
S
W
D
P
V
Q
Site 62
S550
T
E
N
T
A
T
I
S
W
D
P
V
Q
A
T
Site 63
Y561
V
Q
A
T
I
D
K
Y
V
V
R
Y
T
S
A
Site 64
Y565
I
D
K
Y
V
V
R
Y
T
S
A
D
D
Q
E
Site 65
T566
D
K
Y
V
V
R
Y
T
S
A
D
D
Q
E
T
Site 66
S567
K
Y
V
V
R
Y
T
S
A
D
D
Q
E
T
R
Site 67
S584
L
V
G
K
E
Q
S
S
T
V
L
T
G
L
R
Site 68
T585
V
G
K
E
Q
S
S
T
V
L
T
G
L
R
P
Site 69
T588
E
Q
S
S
T
V
L
T
G
L
R
P
G
V
E
Site 70
Y596
G
L
R
P
G
V
E
Y
T
V
H
V
W
A
Q
Site 71
T597
L
R
P
G
V
E
Y
T
V
H
V
W
A
Q
K
Site 72
S609
A
Q
K
G
D
R
E
S
K
K
A
D
T
N
A
Site 73
T614
R
E
S
K
K
A
D
T
N
A
P
T
D
I
D
Site 74
T618
K
A
D
T
N
A
P
T
D
I
D
S
P
K
N
Site 75
S622
N
A
P
T
D
I
D
S
P
K
N
L
V
T
D
Site 76
T628
D
S
P
K
N
L
V
T
D
R
V
T
E
N
M
Site 77
T632
N
L
V
T
D
R
V
T
E
N
M
A
T
V
S
Site 78
T637
R
V
T
E
N
M
A
T
V
S
W
D
P
V
Q
Site 79
S639
T
E
N
M
A
T
V
S
W
D
P
V
Q
A
A
Site 80
Y654
I
D
K
Y
V
V
R
Y
T
S
A
G
G
E
T
Site 81
T655
D
K
Y
V
V
R
Y
T
S
A
G
G
E
T
R
Site 82
S656
K
Y
V
V
R
Y
T
S
A
G
G
E
T
R
E
Site 83
S672
P
V
G
K
E
Q
S
S
T
V
L
T
G
L
R
Site 84
T676
E
Q
S
S
T
V
L
T
G
L
R
P
G
M
E
Site 85
Y684
G
L
R
P
G
M
E
Y
M
V
H
V
W
A
Q
Site 86
T706
K
A
D
T
K
A
Q
T
D
I
D
S
P
Q
N
Site 87
S710
K
A
Q
T
D
I
D
S
P
Q
N
L
V
T
D
Site 88
T716
D
S
P
Q
N
L
V
T
D
R
V
T
E
N
M
Site 89
T725
R
V
T
E
N
M
A
T
V
S
W
D
P
V
R
Site 90
S727
T
E
N
M
A
T
V
S
W
D
P
V
R
A
T
Site 91
T734
S
W
D
P
V
R
A
T
I
D
R
Y
V
V
R
Site 92
Y738
V
R
A
T
I
D
R
Y
V
V
R
Y
T
S
A
Site 93
Y742
I
D
R
Y
V
V
R
Y
T
S
A
K
D
G
E
Site 94
T743
D
R
Y
V
V
R
Y
T
S
A
K
D
G
E
T
Site 95
S744
R
Y
V
V
R
Y
T
S
A
K
D
G
E
T
R
Site 96
T814
W
V
T
E
N
T
A
T
V
S
W
D
P
V
Q
Site 97
S816
T
E
N
T
A
T
V
S
W
D
P
V
Q
A
T
Site 98
Y827
V
Q
A
T
I
D
R
Y
V
V
H
Y
T
S
A
Site 99
Y831
I
D
R
Y
V
V
H
Y
T
S
A
N
G
E
T
Site 100
Y861
G
L
R
P
G
M
E
Y
T
V
H
V
W
A
Q
Site 101
S904
T
E
N
M
A
T
V
S
W
D
P
V
Q
A
T
Site 102
Y915
V
Q
A
T
I
D
K
Y
M
V
R
Y
T
S
A
Site 103
T920
D
K
Y
M
V
R
Y
T
S
A
D
G
E
T
R
Site 104
S921
K
Y
M
V
R
Y
T
S
A
D
G
E
T
R
E
Site 105
S937
P
V
G
K
E
H
S
S
T
V
L
T
G
L
R
Site 106
T938
V
G
K
E
H
S
S
T
V
L
T
G
L
R
P
Site 107
T941
E
H
S
S
T
V
L
T
G
L
R
P
G
M
E
Site 108
S982
P
P
R
N
L
R
P
S
A
V
T
Q
S
G
G
Site 109
T985
N
L
R
P
S
A
V
T
Q
S
G
G
I
L
T
Site 110
T992
T
Q
S
G
G
I
L
T
W
T
P
P
S
A
Q
Site 111
T994
S
G
G
I
L
T
W
T
P
P
S
A
Q
I
H
Site 112
T1013
T
Y
Q
F
P
D
G
T
V
K
E
M
Q
L
G
Site 113
S1050
A
F
K
G
G
R
R
S
R
N
V
S
T
T
L
Site 114
S1054
G
R
R
S
R
N
V
S
T
T
L
S
T
V
G
Site 115
T1056
R
S
R
N
V
S
T
T
L
S
T
V
G
A
R
Site 116
S1058
R
N
V
S
T
T
L
S
T
V
G
A
R
F
P
Site 117
S1068
G
A
R
F
P
H
P
S
D
C
S
Q
V
Q
Q
Site 118
S1071
F
P
H
P
S
D
C
S
Q
V
Q
Q
N
S
N
Site 119
S1077
C
S
Q
V
Q
Q
N
S
N
A
A
S
G
L
Y
Site 120
S1081
Q
Q
N
S
N
A
A
S
G
L
Y
T
I
Y
L
Site 121
Y1084
S
N
A
A
S
G
L
Y
T
I
Y
L
H
G
D
Site 122
Y1087
A
S
G
L
Y
T
I
Y
L
H
G
D
A
S
R
Site 123
Y1099
A
S
R
P
L
Q
V
Y
C
D
M
E
T
D
G
Site 124
T1117
I
V
F
Q
R
R
N
T
G
Q
L
D
F
F
K
Site 125
S1128
D
F
F
K
R
W
R
S
Y
V
E
G
F
G
D
Site 126
Y1129
F
F
K
R
W
R
S
Y
V
E
G
F
G
D
P
Site 127
T1154
L
H
N
L
T
T
G
T
P
A
R
Y
E
V
R
Site 128
Y1158
T
T
G
T
P
A
R
Y
E
V
R
V
D
L
Q
Site 129
T1166
E
V
R
V
D
L
Q
T
A
N
E
S
A
Y
A
Site 130
Y1187
V
A
S
S
K
E
R
Y
K
L
T
V
G
K
Y
Site 131
T1190
S
K
E
R
Y
K
L
T
V
G
K
Y
R
G
T
Site 132
Y1194
Y
K
L
T
V
G
K
Y
R
G
T
A
G
D
A
Site 133
T1197
T
V
G
K
Y
R
G
T
A
G
D
A
L
T
Y
Site 134
Y1204
T
A
G
D
A
L
T
Y
H
N
G
W
K
F
T
Site 135
S1252
R
Y
G
E
T
K
H
S
E
G
V
N
W
E
P
Site 136
S1266
P
W
K
G
H
E
F
S
I
P
Y
V
E
L
K
Site 137
Y1269
G
H
E
F
S
I
P
Y
V
E
L
K
I
R
P
Site 138
S1280
K
I
R
P
H
G
Y
S
R
E
P
V
L
G
R
Site 139
T1291
V
L
G
R
K
K
R
T
L
R
G
R
L
R
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation