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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMC3
Full Name:
Structural maintenance of chromosomes protein 3
Alias:
BAM; Bamacan; Bamacan proteoglycan; Basement membrane-associated chondroitin proteoglycan; BMH; Chondroitin sulfate proteoglycan 6; Chromosome-associated polypeptide; CSPG6; HCAP; SMC3L1; Structural maintenance of chromosome 3; Structural maintenance of chromosomes 3
Type:
DNA repair; Cell cycle regulation
Mass (Da):
141542
Number AA:
1217
UniProt ID:
Q9UQE7
International Prot ID:
IPI00219420
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005604
GO:0000785
GO:0008278
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0045502
GO:0003777
PhosphoSite+
KinaseNET
Biological Process:
GO:0009294
GO:0006281
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
I
I
Q
G
F
R
S
Y
R
D
Q
T
I
V
D
Site 2
T18
F
R
S
Y
R
D
Q
T
I
V
D
P
F
S
S
Site 3
S36
V
I
V
G
R
N
G
S
G
K
S
N
F
F
Y
Site 4
S39
G
R
N
G
S
G
K
S
N
F
F
Y
A
I
Q
Site 5
S54
F
V
L
S
D
E
F
S
H
L
R
P
E
Q
R
Site 6
S85
V
E
I
I
F
D
N
S
D
N
R
L
P
I
D
Site 7
S97
P
I
D
K
E
E
V
S
L
R
R
V
I
G
A
Site 8
Y109
I
G
A
K
K
D
Q
Y
F
L
D
K
K
M
V
Site 9
S127
D
V
M
N
L
L
E
S
A
G
F
S
R
S
N
Site 10
S131
L
L
E
S
A
G
F
S
R
S
N
P
Y
Y
I
Site 11
S133
E
S
A
G
F
S
R
S
N
P
Y
Y
I
V
K
Site 12
Y136
G
F
S
R
S
N
P
Y
Y
I
V
K
Q
G
K
Site 13
Y137
F
S
R
S
N
P
Y
Y
I
V
K
Q
G
K
I
Site 14
T149
G
K
I
N
Q
M
A
T
A
P
D
S
Q
R
L
Site 15
S153
Q
M
A
T
A
P
D
S
Q
R
L
K
L
L
R
Site 16
T165
L
L
R
E
V
A
G
T
R
V
Y
D
E
R
K
Site 17
Y168
E
V
A
G
T
R
V
Y
D
E
R
K
E
E
S
Site 18
S175
Y
D
E
R
K
E
E
S
I
S
L
M
K
E
T
Site 19
S177
E
R
K
E
E
S
I
S
L
M
K
E
T
E
G
Site 20
Y195
K
I
N
E
L
L
K
Y
I
E
E
R
L
H
T
Site 21
T202
Y
I
E
E
R
L
H
T
L
E
E
E
K
E
E
Site 22
Y213
E
K
E
E
L
A
Q
Y
Q
K
W
D
K
M
R
Site 23
Y225
K
M
R
R
A
L
E
Y
T
I
Y
N
Q
E
L
Site 24
T226
M
R
R
A
L
E
Y
T
I
Y
N
Q
E
L
N
Site 25
Y228
R
A
L
E
Y
T
I
Y
N
Q
E
L
N
E
T
Site 26
S243
R
A
K
L
D
E
L
S
A
K
R
E
T
S
G
Site 27
T248
E
L
S
A
K
R
E
T
S
G
E
K
S
R
Q
Site 28
S249
L
S
A
K
R
E
T
S
G
E
K
S
R
Q
L
Site 29
S253
R
E
T
S
G
E
K
S
R
Q
L
R
D
A
Q
Site 30
S282
R
E
L
K
T
K
I
S
A
M
K
E
E
K
E
Site 31
S292
K
E
E
K
E
Q
L
S
A
E
R
Q
E
Q
I
Site 32
T347
K
Q
K
E
L
A
E
T
E
P
K
F
N
S
V
Site 33
S353
E
T
E
P
K
F
N
S
V
K
E
K
E
E
R
Site 34
T369
I
A
R
L
A
Q
A
T
Q
E
R
T
D
L
Y
Site 35
Y376
T
Q
E
R
T
D
L
Y
A
K
Q
G
R
G
S
Site 36
S383
Y
A
K
Q
G
R
G
S
Q
F
T
S
K
E
E
Site 37
T386
Q
G
R
G
S
Q
F
T
S
K
E
E
R
D
K
Site 38
S387
G
R
G
S
Q
F
T
S
K
E
E
R
D
K
W
Site 39
S401
W
I
K
K
E
L
K
S
L
D
Q
A
I
N
D
Site 40
Y455
V
E
E
L
D
R
K
Y
Y
E
V
K
N
K
K
Site 41
Y456
E
E
L
D
R
K
Y
Y
E
V
K
N
K
K
D
Site 42
S467
N
K
K
D
E
L
Q
S
E
R
N
Y
L
W
R
Site 43
Y471
E
L
Q
S
E
R
N
Y
L
W
R
E
E
N
A
Site 44
Y560
T
A
G
N
R
L
F
Y
H
I
V
D
S
D
E
Site 45
T598
N
K
L
D
V
R
D
T
A
Y
P
E
T
N
D
Site 46
Y600
L
D
V
R
D
T
A
Y
P
E
T
N
D
A
I
Site 47
T603
R
D
T
A
Y
P
E
T
N
D
A
I
P
M
I
Site 48
Y615
P
M
I
S
K
L
R
Y
N
P
R
F
D
K
A
Site 49
S635
G
K
T
L
I
C
R
S
M
E
V
S
T
Q
L
Site 50
S659
T
L
E
G
D
Q
V
S
H
R
G
A
L
T
G
Site 51
Y668
R
G
A
L
T
G
G
Y
Y
D
T
R
K
S
R
Site 52
Y669
G
A
L
T
G
G
Y
Y
D
T
R
K
S
R
L
Site 53
T671
L
T
G
G
Y
Y
D
T
R
K
S
R
L
E
L
Site 54
S674
G
Y
Y
D
T
R
K
S
R
L
E
L
Q
K
D
Site 55
S731
Q
Q
R
K
F
K
A
S
R
D
S
I
L
S
E
Site 56
S734
K
F
K
A
S
R
D
S
I
L
S
E
M
K
M
Site 57
S737
A
S
R
D
S
I
L
S
E
M
K
M
L
K
E
Site 58
S749
L
K
E
K
R
Q
Q
S
E
K
T
F
M
P
K
Site 59
T752
K
R
Q
Q
S
E
K
T
F
M
P
K
Q
R
S
Site 60
S759
T
F
M
P
K
Q
R
S
L
Q
S
L
E
A
S
Site 61
S762
P
K
Q
R
S
L
Q
S
L
E
A
S
L
H
A
Site 62
S766
S
L
Q
S
L
E
A
S
L
H
A
M
E
S
T
Site 63
S772
A
S
L
H
A
M
E
S
T
R
E
S
L
K
A
Site 64
T773
S
L
H
A
M
E
S
T
R
E
S
L
K
A
E
Site 65
S776
A
M
E
S
T
R
E
S
L
K
A
E
L
G
T
Site 66
T783
S
L
K
A
E
L
G
T
D
L
L
S
Q
L
S
Site 67
S787
E
L
G
T
D
L
L
S
Q
L
S
L
E
D
Q
Site 68
S790
T
D
L
L
S
Q
L
S
L
E
D
Q
K
R
V
Site 69
T830
G
I
I
T
R
V
E
T
Y
L
N
E
N
L
R
Site 70
Y831
I
I
T
R
V
E
T
Y
L
N
E
N
L
R
K
Site 71
T853
E
L
N
E
L
R
E
T
E
G
G
T
V
L
T
Site 72
T876
I
N
K
R
V
K
D
T
M
A
R
S
E
D
L
Site 73
S886
R
S
E
D
L
D
N
S
I
D
K
T
E
A
G
Site 74
T890
L
D
N
S
I
D
K
T
E
A
G
I
K
E
L
Site 75
S948
K
K
I
R
E
L
G
S
L
P
Q
E
A
F
E
Site 76
Y957
P
Q
E
A
F
E
K
Y
Q
T
L
S
L
K
Q
Site 77
T959
E
A
F
E
K
Y
Q
T
L
S
L
K
Q
L
F
Site 78
T974
R
K
L
E
Q
C
N
T
E
L
K
K
Y
S
H
Site 79
Y979
C
N
T
E
L
K
K
Y
S
H
V
N
K
K
A
Site 80
Y1011
Q
E
E
L
D
R
G
Y
K
S
I
M
E
L
M
Site 81
S1013
E
L
D
R
G
Y
K
S
I
M
E
L
M
N
V
Site 82
Y1026
N
V
L
E
L
R
K
Y
E
A
I
Q
L
T
F
Site 83
T1032
K
Y
E
A
I
Q
L
T
F
K
Q
V
S
K
N
Site 84
S1041
K
Q
V
S
K
N
F
S
E
V
F
Q
K
L
V
Site 85
S1065
K
K
G
D
V
E
G
S
Q
S
Q
D
E
G
E
Site 86
S1067
G
D
V
E
G
S
Q
S
Q
D
E
G
E
G
S
Site 87
S1074
S
Q
D
E
G
E
G
S
G
E
S
E
R
G
S
Site 88
S1077
E
G
E
G
S
G
E
S
E
R
G
S
G
S
Q
Site 89
S1081
S
G
E
S
E
R
G
S
G
S
Q
S
S
V
P
Site 90
S1083
E
S
E
R
G
S
G
S
Q
S
S
V
P
S
V
Site 91
S1085
E
R
G
S
G
S
Q
S
S
V
P
S
V
D
Q
Site 92
S1086
R
G
S
G
S
Q
S
S
V
P
S
V
D
Q
F
Site 93
S1089
G
S
Q
S
S
V
P
S
V
D
Q
F
T
G
V
Site 94
S1101
T
G
V
G
I
R
V
S
F
T
G
K
Q
G
E
Site 95
S1116
M
R
E
M
Q
Q
L
S
G
G
Q
K
S
L
V
Site 96
Y1140
K
C
D
P
A
P
F
Y
L
F
D
E
I
D
Q
Site 97
S1158
A
Q
H
R
K
A
V
S
D
M
I
M
E
L
A
Site 98
T1174
H
A
Q
F
I
T
T
T
F
R
P
E
L
L
E
Site 99
S1182
F
R
P
E
L
L
E
S
A
D
K
F
Y
G
V
Site 100
Y1187
L
E
S
A
D
K
F
Y
G
V
K
F
R
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation