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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CTNND2
Full Name:
Catenin delta-2
Alias:
Catenin, delta 2; CTND2; Delta-catenin; GT24; Neural plakophilin-related ARM-repeat protein; Neurojungin; NPRAP
Type:
Cytoskeletal protein, actin binding
Mass (Da):
132656
Number AA:
1225
UniProt ID:
Q9UQB3
International Prot ID:
IPI00220032
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005912
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
GO:0007158
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
M
P
V
P
D
Q
P
S
S
A
S
E
K
T
S
Site 2
S23
P
V
P
D
Q
P
S
S
A
S
E
K
T
S
S
Site 3
S25
P
D
Q
P
S
S
A
S
E
K
T
S
S
L
S
Site 4
T28
P
S
S
A
S
E
K
T
S
S
L
S
P
G
L
Site 5
S29
S
S
A
S
E
K
T
S
S
L
S
P
G
L
N
Site 6
S30
S
A
S
E
K
T
S
S
L
S
P
G
L
N
T
Site 7
S32
S
E
K
T
S
S
L
S
P
G
L
N
T
S
N
Site 8
S38
L
S
P
G
L
N
T
S
N
G
D
G
S
E
T
Site 9
S43
N
T
S
N
G
D
G
S
E
T
E
T
T
S
A
Site 10
T45
S
N
G
D
G
S
E
T
E
T
T
S
A
I
L
Site 11
T47
G
D
G
S
E
T
E
T
T
S
A
I
L
A
S
Site 12
T48
D
G
S
E
T
E
T
T
S
A
I
L
A
S
V
Site 13
S54
T
T
S
A
I
L
A
S
V
K
E
Q
E
L
Q
Site 14
T66
E
L
Q
F
E
R
L
T
R
E
L
E
A
E
R
Site 15
S78
A
E
R
Q
I
V
A
S
Q
L
E
R
C
K
L
Site 16
S87
L
E
R
C
K
L
G
S
E
T
G
S
M
S
S
Site 17
T89
R
C
K
L
G
S
E
T
G
S
M
S
S
M
S
Site 18
S91
K
L
G
S
E
T
G
S
M
S
S
M
S
S
A
Site 19
S93
G
S
E
T
G
S
M
S
S
M
S
S
A
E
E
Site 20
S94
S
E
T
G
S
M
S
S
M
S
S
A
E
E
Q
Site 21
S96
T
G
S
M
S
S
M
S
S
A
E
E
Q
F
Q
Site 22
S97
G
S
M
S
S
M
S
S
A
E
E
Q
F
Q
W
Site 23
T118
K
D
I
E
D
E
L
T
T
G
L
E
L
V
D
Site 24
S126
T
G
L
E
L
V
D
S
C
I
R
S
L
Q
E
Site 25
S134
C
I
R
S
L
Q
E
S
G
I
L
D
P
Q
D
Site 26
Y142
G
I
L
D
P
Q
D
Y
S
T
G
E
R
P
S
Site 27
S143
I
L
D
P
Q
D
Y
S
T
G
E
R
P
S
L
Site 28
T144
L
D
P
Q
D
Y
S
T
G
E
R
P
S
L
L
Site 29
S149
Y
S
T
G
E
R
P
S
L
L
S
Q
S
A
L
Site 30
S152
G
E
R
P
S
L
L
S
Q
S
A
L
Q
L
N
Site 31
S154
R
P
S
L
L
S
Q
S
A
L
Q
L
N
S
K
Site 32
S165
L
N
S
K
P
E
G
S
F
Q
Y
P
A
S
Y
Site 33
Y168
K
P
E
G
S
F
Q
Y
P
A
S
Y
H
S
N
Site 34
S171
G
S
F
Q
Y
P
A
S
Y
H
S
N
Q
T
L
Site 35
T184
T
L
A
L
G
E
T
T
P
S
Q
L
P
A
R
Site 36
S186
A
L
G
E
T
T
P
S
Q
L
P
A
R
G
T
Site 37
T193
S
Q
L
P
A
R
G
T
Q
A
R
A
T
G
Q
Site 38
T198
R
G
T
Q
A
R
A
T
G
Q
S
F
S
Q
G
Site 39
S201
Q
A
R
A
T
G
Q
S
F
S
Q
G
T
T
S
Site 40
S203
R
A
T
G
Q
S
F
S
Q
G
T
T
S
R
A
Site 41
T206
G
Q
S
F
S
Q
G
T
T
S
R
A
G
H
L
Site 42
T207
Q
S
F
S
Q
G
T
T
S
R
A
G
H
L
A
Site 43
S208
S
F
S
Q
G
T
T
S
R
A
G
H
L
A
G
Site 44
S233
P
R
E
P
F
A
P
S
L
G
S
A
F
H
L
Site 45
Y254
A
A
A
A
A
L
Y
Y
S
S
S
T
L
P
A
Site 46
S256
A
A
A
L
Y
Y
S
S
S
T
L
P
A
P
P
Site 47
S257
A
A
L
Y
Y
S
S
S
T
L
P
A
P
P
R
Site 48
T258
A
L
Y
Y
S
S
S
T
L
P
A
P
P
R
G
Site 49
S267
P
A
P
P
R
G
G
S
P
L
A
A
P
Q
G
Site 50
S276
L
A
A
P
Q
G
G
S
P
T
K
L
Q
R
G
Site 51
S285
T
K
L
Q
R
G
G
S
A
P
E
G
A
T
Y
Site 52
Y292
S
A
P
E
G
A
T
Y
A
A
P
R
G
S
S
Site 53
S298
T
Y
A
A
P
R
G
S
S
P
K
Q
S
P
S
Site 54
S299
Y
A
A
P
R
G
S
S
P
K
Q
S
P
S
R
Site 55
S303
R
G
S
S
P
K
Q
S
P
S
R
L
A
K
S
Site 56
S305
S
S
P
K
Q
S
P
S
R
L
A
K
S
Y
S
Site 57
S310
S
P
S
R
L
A
K
S
Y
S
T
S
S
P
I
Site 58
Y311
P
S
R
L
A
K
S
Y
S
T
S
S
P
I
N
Site 59
S312
S
R
L
A
K
S
Y
S
T
S
S
P
I
N
I
Site 60
S315
A
K
S
Y
S
T
S
S
P
I
N
I
V
V
S
Site 61
S323
P
I
N
I
V
V
S
S
A
G
L
S
P
I
R
Site 62
T332
G
L
S
P
I
R
V
T
S
P
P
T
V
Q
S
Site 63
S333
L
S
P
I
R
V
T
S
P
P
T
V
Q
S
T
Site 64
T336
I
R
V
T
S
P
P
T
V
Q
S
T
I
S
S
Site 65
S339
T
S
P
P
T
V
Q
S
T
I
S
S
S
P
I
Site 66
T340
S
P
P
T
V
Q
S
T
I
S
S
S
P
I
H
Site 67
S342
P
T
V
Q
S
T
I
S
S
S
P
I
H
Q
L
Site 68
S343
T
V
Q
S
T
I
S
S
S
P
I
H
Q
L
S
Site 69
S344
V
Q
S
T
I
S
S
S
P
I
H
Q
L
S
S
Site 70
S350
S
S
P
I
H
Q
L
S
S
T
I
G
T
Y
A
Site 71
S351
S
P
I
H
Q
L
S
S
T
I
G
T
Y
A
T
Site 72
T355
Q
L
S
S
T
I
G
T
Y
A
T
L
S
P
T
Site 73
Y356
L
S
S
T
I
G
T
Y
A
T
L
S
P
T
K
Site 74
T358
S
T
I
G
T
Y
A
T
L
S
P
T
K
R
L
Site 75
S360
I
G
T
Y
A
T
L
S
P
T
K
R
L
V
H
Site 76
S369
T
K
R
L
V
H
A
S
E
Q
Y
S
K
H
S
Site 77
S373
V
H
A
S
E
Q
Y
S
K
H
S
Q
E
L
Y
Site 78
Y380
S
K
H
S
Q
E
L
Y
A
T
A
T
L
Q
R
Site 79
T382
H
S
Q
E
L
Y
A
T
A
T
L
Q
R
P
G
Site 80
T384
Q
E
L
Y
A
T
A
T
L
Q
R
P
G
S
L
Site 81
S390
A
T
L
Q
R
P
G
S
L
A
A
G
S
R
A
Site 82
S395
P
G
S
L
A
A
G
S
R
A
S
Y
S
S
Q
Site 83
S398
L
A
A
G
S
R
A
S
Y
S
S
Q
H
G
H
Site 84
Y399
A
A
G
S
R
A
S
Y
S
S
Q
H
G
H
L
Site 85
S400
A
G
S
R
A
S
Y
S
S
Q
H
G
H
L
G
Site 86
S401
G
S
R
A
S
Y
S
S
Q
H
G
H
L
G
P
Site 87
S415
P
E
L
R
A
L
Q
S
P
E
H
H
I
D
P
Site 88
Y424
E
H
H
I
D
P
I
Y
E
D
R
V
Y
Q
K
Site 89
Y429
P
I
Y
E
D
R
V
Y
Q
K
P
P
M
R
S
Site 90
S436
Y
Q
K
P
P
M
R
S
L
S
Q
S
Q
G
D
Site 91
S438
K
P
P
M
R
S
L
S
Q
S
Q
G
D
P
L
Site 92
S440
P
M
R
S
L
S
Q
S
Q
G
D
P
L
P
P
Site 93
T452
L
P
P
A
H
T
G
T
Y
R
T
S
T
A
P
Site 94
T455
A
H
T
G
T
Y
R
T
S
T
A
P
S
S
P
Site 95
S456
H
T
G
T
Y
R
T
S
T
A
P
S
S
P
G
Site 96
T457
T
G
T
Y
R
T
S
T
A
P
S
S
P
G
V
Site 97
S460
Y
R
T
S
T
A
P
S
S
P
G
V
D
S
V
Site 98
S461
R
T
S
T
A
P
S
S
P
G
V
D
S
V
P
Site 99
S466
P
S
S
P
G
V
D
S
V
P
L
Q
R
T
G
Site 100
T472
D
S
V
P
L
Q
R
T
G
S
Q
H
G
P
Q
Site 101
S474
V
P
L
Q
R
T
G
S
Q
H
G
P
Q
N
A
Site 102
T485
P
Q
N
A
A
A
A
T
F
Q
R
A
S
Y
A
Site 103
S490
A
A
T
F
Q
R
A
S
Y
A
A
G
P
A
S
Site 104
Y491
A
T
F
Q
R
A
S
Y
A
A
G
P
A
S
N
Site 105
S497
S
Y
A
A
G
P
A
S
N
Y
A
D
P
Y
R
Site 106
Y499
A
A
G
P
A
S
N
Y
A
D
P
Y
R
Q
L
Site 107
Y503
A
S
N
Y
A
D
P
Y
R
Q
L
Q
Y
C
P
Site 108
Y508
D
P
Y
R
Q
L
Q
Y
C
P
S
V
E
S
P
Site 109
S511
R
Q
L
Q
Y
C
P
S
V
E
S
P
Y
S
K
Site 110
S514
Q
Y
C
P
S
V
E
S
P
Y
S
K
S
G
P
Site 111
Y516
C
P
S
V
E
S
P
Y
S
K
S
G
P
A
L
Site 112
S517
P
S
V
E
S
P
Y
S
K
S
G
P
A
L
P
Site 113
S519
V
E
S
P
Y
S
K
S
G
P
A
L
P
P
E
Site 114
T528
P
A
L
P
P
E
G
T
L
A
R
S
P
S
I
Site 115
S532
P
E
G
T
L
A
R
S
P
S
I
D
S
I
Q
Site 116
S534
G
T
L
A
R
S
P
S
I
D
S
I
Q
K
D
Site 117
S537
A
R
S
P
S
I
D
S
I
Q
K
D
P
R
E
Site 118
Y573
V
Q
S
N
A
A
A
Y
L
Q
H
L
C
F
G
Site 119
T606
D
L
L
D
H
R
M
T
E
V
H
R
S
A
C
Site 120
S611
R
M
T
E
V
H
R
S
A
C
G
A
L
R
N
Site 121
Y621
G
A
L
R
N
L
V
Y
G
K
A
N
D
D
N
Site 122
T648
L
V
R
L
L
R
K
T
T
D
L
E
I
R
E
Site 123
T649
V
R
L
L
R
K
T
T
D
L
E
I
R
E
L
Site 124
S691
N
A
V
I
I
P
H
S
G
W
E
N
S
P
L
Site 125
S696
P
H
S
G
W
E
N
S
P
L
Q
D
D
R
K
Site 126
S709
R
K
I
Q
L
H
S
S
Q
V
L
R
N
A
T
Site 127
T716
S
Q
V
L
R
N
A
T
G
C
L
R
N
V
S
Site 128
S723
T
G
C
L
R
N
V
S
S
A
G
E
E
A
R
Site 129
S724
G
C
L
R
N
V
S
S
A
G
E
E
A
R
R
Site 130
S753
V
I
Q
S
A
L
G
S
S
E
I
D
S
K
T
Site 131
S754
I
Q
S
A
L
G
S
S
E
I
D
S
K
T
V
Site 132
S758
L
G
S
S
E
I
D
S
K
T
V
E
N
C
V
Site 133
T760
S
S
E
I
D
S
K
T
V
E
N
C
V
C
I
Site 134
S772
V
C
I
L
R
N
L
S
Y
R
L
A
A
E
T
Site 135
T779
S
Y
R
L
A
A
E
T
S
Q
G
Q
H
M
G
Site 136
S780
Y
R
L
A
A
E
T
S
Q
G
Q
H
M
G
T
Site 137
S805
A
N
G
K
D
A
E
S
S
G
C
W
G
K
K
Site 138
S806
N
G
K
D
A
E
S
S
G
C
W
G
K
K
K
Site 139
S818
K
K
K
K
K
K
K
S
Q
D
Q
W
D
G
V
Site 140
S855
K
P
Y
L
T
L
L
S
E
C
S
N
P
D
T
Site 141
S858
L
T
L
L
S
E
C
S
N
P
D
T
L
E
G
Site 142
T862
S
E
C
S
N
P
D
T
L
E
G
A
A
G
A
Site 143
Y883
G
S
W
K
W
S
V
Y
I
R
A
A
V
R
K
Site 144
Y932
N
K
E
L
I
G
K
Y
A
M
R
D
L
V
H
Site 145
S947
R
L
P
G
G
N
N
S
N
N
T
A
S
K
A
Site 146
S952
N
N
S
N
N
T
A
S
K
A
M
S
D
D
T
Site 147
S956
N
T
A
S
K
A
M
S
D
D
T
V
T
A
V
Site 148
S996
K
L
V
G
I
S
K
S
K
G
D
K
H
S
P
Site 149
S1002
K
S
K
G
D
K
H
S
P
K
V
V
K
A
A
Site 150
Y1019
V
L
N
S
M
W
Q
Y
R
D
L
R
S
L
Y
Site 151
S1024
W
Q
Y
R
D
L
R
S
L
Y
K
K
D
G
W
Site 152
Y1026
Y
R
D
L
R
S
L
Y
K
K
D
G
W
S
Q
Site 153
Y1034
K
K
D
G
W
S
Q
Y
H
F
V
A
S
S
S
Site 154
Y1051
E
R
D
R
Q
R
P
Y
S
S
S
R
T
P
S
Site 155
S1052
R
D
R
Q
R
P
Y
S
S
S
R
T
P
S
I
Site 156
S1053
D
R
Q
R
P
Y
S
S
S
R
T
P
S
I
S
Site 157
S1054
R
Q
R
P
Y
S
S
S
R
T
P
S
I
S
P
Site 158
T1056
R
P
Y
S
S
S
R
T
P
S
I
S
P
V
R
Site 159
S1058
Y
S
S
S
R
T
P
S
I
S
P
V
R
V
S
Site 160
S1060
S
S
R
T
P
S
I
S
P
V
R
V
S
P
N
Site 161
S1065
S
I
S
P
V
R
V
S
P
N
N
R
S
A
S
Site 162
S1070
R
V
S
P
N
N
R
S
A
S
A
P
A
S
P
Site 163
S1072
S
P
N
N
R
S
A
S
A
P
A
S
P
R
E
Site 164
S1076
R
S
A
S
A
P
A
S
P
R
E
M
I
S
L
Site 165
S1082
A
S
P
R
E
M
I
S
L
K
E
R
K
T
D
Site 166
T1088
I
S
L
K
E
R
K
T
D
Y
E
C
T
G
S
Site 167
Y1090
L
K
E
R
K
T
D
Y
E
C
T
G
S
N
A
Site 168
Y1099
C
T
G
S
N
A
T
Y
H
G
A
K
G
E
H
Site 169
T1114
T
S
R
K
D
A
M
T
A
Q
N
T
G
I
S
Site 170
T1122
A
Q
N
T
G
I
S
T
L
Y
R
N
S
Y
G
Site 171
Y1124
N
T
G
I
S
T
L
Y
R
N
S
Y
G
A
P
Site 172
S1127
I
S
T
L
Y
R
N
S
Y
G
A
P
A
E
D
Site 173
Y1128
S
T
L
Y
R
N
S
Y
G
A
P
A
E
D
I
Site 174
Y1154
Q
E
P
S
R
K
D
Y
E
T
Y
Q
P
F
Q
Site 175
T1156
P
S
R
K
D
Y
E
T
Y
Q
P
F
Q
N
S
Site 176
Y1157
S
R
K
D
Y
E
T
Y
Q
P
F
Q
N
S
T
Site 177
S1163
T
Y
Q
P
F
Q
N
S
T
R
N
Y
D
E
S
Site 178
Y1167
F
Q
N
S
T
R
N
Y
D
E
S
F
F
E
D
Site 179
S1170
S
T
R
N
Y
D
E
S
F
F
E
D
Q
V
H
Site 180
S1183
V
H
H
R
P
P
A
S
E
Y
T
M
H
L
G
Site 181
Y1185
H
R
P
P
A
S
E
Y
T
M
H
L
G
L
K
Site 182
S1193
T
M
H
L
G
L
K
S
T
G
N
Y
V
D
F
Site 183
Y1197
G
L
K
S
T
G
N
Y
V
D
F
Y
S
A
A
Site 184
Y1201
T
G
N
Y
V
D
F
Y
S
A
A
R
P
Y
S
Site 185
S1202
G
N
Y
V
D
F
Y
S
A
A
R
P
Y
S
E
Site 186
Y1207
F
Y
S
A
A
R
P
Y
S
E
L
N
Y
E
T
Site 187
S1208
Y
S
A
A
R
P
Y
S
E
L
N
Y
E
T
S
Site 188
Y1212
R
P
Y
S
E
L
N
Y
E
T
S
H
Y
P
A
Site 189
S1215
S
E
L
N
Y
E
T
S
H
Y
P
A
S
P
D
Site 190
Y1217
L
N
Y
E
T
S
H
Y
P
A
S
P
D
S
W
Site 191
S1220
E
T
S
H
Y
P
A
S
P
D
S
W
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation