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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEU3
Full Name:
Sialidase-3
Alias:
Ganglioside sialidase; Membrane sialidase; N-acetyl-alpha-neuraminidase 3; NEUR3; Sialidase 3
Type:
Lipid Metabolism - sphingolipid; Hydrolase; Glycan Metabolism - other glycan degradation; EC 3.2.1.18
Mass (Da):
48252
Number AA:
428
UniProt ID:
Q9UQ49
International Prot ID:
IPI00220736
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0004308
PhosphoSite+
KinaseNET
Biological Process:
GO:0005975
GO:0006689
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
E
V
T
T
C
S
F
N
S
P
L
F
R
Site 2
S11
V
T
T
C
S
F
N
S
P
L
F
R
Q
E
D
Site 3
T23
Q
E
D
D
R
G
I
T
Y
R
I
P
A
L
L
Site 4
Y24
E
D
D
R
G
I
T
Y
R
I
P
A
L
L
Y
Site 5
Y31
Y
R
I
P
A
L
L
Y
I
P
P
T
H
T
F
Site 6
T35
A
L
L
Y
I
P
P
T
H
T
F
L
A
F
A
Site 7
S46
L
A
F
A
E
K
R
S
T
R
R
D
E
D
A
Site 8
T47
A
F
A
E
K
R
S
T
R
R
D
E
D
A
L
Site 9
S119
T
E
R
Q
Q
I
V
S
G
R
N
A
A
R
L
Site 10
S139
Q
D
A
G
C
S
W
S
E
V
R
D
L
T
E
Site 11
T145
W
S
E
V
R
D
L
T
E
E
V
I
G
S
E
Site 12
T158
S
E
L
K
H
W
A
T
F
A
V
G
P
G
H
Site 13
S200
P
C
K
T
R
P
H
S
L
M
I
Y
S
D
D
Site 14
Y204
R
P
H
S
L
M
I
Y
S
D
D
L
G
V
T
Site 15
Y241
R
A
G
H
P
V
L
Y
C
S
A
R
T
P
N
Site 16
S243
G
H
P
V
L
Y
C
S
A
R
T
P
N
R
C
Site 17
T246
V
L
Y
C
S
A
R
T
P
N
R
C
R
A
E
Site 18
S256
R
C
R
A
E
A
L
S
T
D
H
G
E
G
F
Site 19
T257
C
R
A
E
A
L
S
T
D
H
G
E
G
F
Q
Site 20
S282
P
P
H
G
C
Q
G
S
V
V
S
F
R
P
L
Site 21
S298
I
P
H
R
C
Q
D
S
S
S
K
D
A
P
T
Site 22
S299
P
H
R
C
Q
D
S
S
S
K
D
A
P
T
I
Site 23
S300
H
R
C
Q
D
S
S
S
K
D
A
P
T
I
Q
Site 24
T305
S
S
S
K
D
A
P
T
I
Q
Q
S
S
P
G
Site 25
S309
D
A
P
T
I
Q
Q
S
S
P
G
S
S
L
R
Site 26
S310
A
P
T
I
Q
Q
S
S
P
G
S
S
L
R
L
Site 27
S313
I
Q
Q
S
S
P
G
S
S
L
R
L
E
E
E
Site 28
S314
Q
Q
S
S
P
G
S
S
L
R
L
E
E
E
A
Site 29
T323
R
L
E
E
E
A
G
T
P
S
E
S
W
L
L
Site 30
S325
E
E
E
A
G
T
P
S
E
S
W
L
L
Y
S
Site 31
S327
E
A
G
T
P
S
E
S
W
L
L
Y
S
H
P
Site 32
Y331
P
S
E
S
W
L
L
Y
S
H
P
T
S
R
K
Site 33
S332
S
E
S
W
L
L
Y
S
H
P
T
S
R
K
Q
Site 34
S336
L
L
Y
S
H
P
T
S
R
K
Q
R
V
D
L
Site 35
Y346
Q
R
V
D
L
G
I
Y
L
N
Q
T
P
L
E
Site 36
T403
Q
I
A
F
R
L
F
T
H
R
E
I
L
S
H
Site 37
T416
S
H
L
Q
G
D
C
T
S
P
G
R
N
P
S
Site 38
S417
H
L
Q
G
D
C
T
S
P
G
R
N
P
S
Q
Site 39
S423
T
S
P
G
R
N
P
S
Q
F
K
S
N
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation