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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HPS5
Full Name:
Hermansky-Pudlak syndrome 5 protein
Alias:
AIBP63; Alpha-integrin-binding protein 63; KIAA1017; Ruby-eye protein 2 homolog
Type:
Mass (Da):
127449
Number AA:
1129
UniProt ID:
Q9UPZ3
International Prot ID:
IPI00010486
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
E
S
L
D
P
L
L
S
A
L
R
L
D
S
S
Site 2
S32
L
S
A
L
R
L
D
S
S
R
L
K
C
T
S
Site 3
S33
S
A
L
R
L
D
S
S
R
L
K
C
T
S
I
Site 4
S39
S
S
R
L
K
C
T
S
I
A
V
S
R
K
W
Site 5
S51
R
K
W
L
A
L
G
S
S
G
G
G
L
H
L
Site 6
S71
W
K
H
R
L
F
L
S
H
R
E
G
A
I
S
Site 7
S78
S
H
R
E
G
A
I
S
Q
V
A
C
C
L
H
Site 8
Y89
C
C
L
H
D
D
D
Y
V
A
V
A
T
S
Q
Site 9
Y116
R
G
K
P
E
Q
M
Y
V
S
S
E
H
K
G
Site 10
S118
K
P
E
Q
M
Y
V
S
S
E
H
K
G
R
R
Site 11
S119
P
E
Q
M
Y
V
S
S
E
H
K
G
R
R
V
Site 12
T127
E
H
K
G
R
R
V
T
A
L
C
W
D
T
A
Site 13
S197
L
I
S
S
L
T
R
S
F
L
C
D
T
E
R
Site 14
T202
T
R
S
F
L
C
D
T
E
R
E
K
F
W
K
Site 15
Y219
N
K
E
R
D
G
E
Y
G
A
C
F
F
P
G
Site 16
Y237
G
G
Q
Q
P
L
I
Y
C
A
R
P
G
S
R
Site 17
S256
N
F
D
G
E
V
I
S
T
H
Q
F
K
K
L
Site 18
T257
F
D
G
E
V
I
S
T
H
Q
F
K
K
L
L
Site 19
S265
H
Q
F
K
K
L
L
S
L
P
P
L
P
V
I
Site 20
T273
L
P
P
L
P
V
I
T
L
R
S
E
P
Q
Y
Site 21
S276
L
P
V
I
T
L
R
S
E
P
Q
Y
D
H
T
Site 22
Y280
T
L
R
S
E
P
Q
Y
D
H
T
A
G
S
S
Site 23
T283
S
E
P
Q
Y
D
H
T
A
G
S
S
Q
S
L
Site 24
S286
Q
Y
D
H
T
A
G
S
S
Q
S
L
S
F
P
Site 25
S287
Y
D
H
T
A
G
S
S
Q
S
L
S
F
P
K
Site 26
S289
H
T
A
G
S
S
Q
S
L
S
F
P
K
L
L
Site 27
T305
L
S
E
H
C
V
L
T
W
T
E
R
G
I
Y
Site 28
Y312
T
W
T
E
R
G
I
Y
I
F
I
P
Q
N
V
Site 29
S353
N
G
K
V
S
H
L
S
L
I
S
V
E
R
C
Site 30
S387
F
Q
N
S
V
I
A
S
R
A
R
K
T
L
T
Site 31
T392
I
A
S
R
A
R
K
T
L
T
A
D
K
L
E
Site 32
T394
S
R
A
R
K
T
L
T
A
D
K
L
E
H
L
Site 33
S403
D
K
L
E
H
L
K
S
Q
L
D
H
G
T
Y
Site 34
T409
K
S
Q
L
D
H
G
T
Y
N
D
L
I
S
Q
Site 35
Y410
S
Q
L
D
H
G
T
Y
N
D
L
I
S
Q
L
Site 36
S429
L
K
F
E
P
L
D
S
A
C
S
S
R
R
S
Site 37
S432
E
P
L
D
S
A
C
S
S
R
R
S
S
I
S
Site 38
S433
P
L
D
S
A
C
S
S
R
R
S
S
I
S
S
Site 39
S436
S
A
C
S
S
R
R
S
S
I
S
S
H
E
S
Site 40
S437
A
C
S
S
R
R
S
S
I
S
S
H
E
S
F
Site 41
S439
S
S
R
R
S
S
I
S
S
H
E
S
F
S
I
Site 42
S440
S
R
R
S
S
I
S
S
H
E
S
F
S
I
L
Site 43
S443
S
S
I
S
S
H
E
S
F
S
I
L
D
S
G
Site 44
S445
I
S
S
H
E
S
F
S
I
L
D
S
G
I
Y
Site 45
Y452
S
I
L
D
S
G
I
Y
R
I
I
S
S
R
R
Site 46
S456
S
G
I
Y
R
I
I
S
S
R
R
G
S
Q
S
Site 47
S457
G
I
Y
R
I
I
S
S
R
R
G
S
Q
S
D
Site 48
S461
I
I
S
S
R
R
G
S
Q
S
D
E
D
S
C
Site 49
S463
S
S
R
R
G
S
Q
S
D
E
D
S
C
S
L
Site 50
S467
G
S
Q
S
D
E
D
S
C
S
L
H
S
Q
T
Site 51
S469
Q
S
D
E
D
S
C
S
L
H
S
Q
T
L
S
Site 52
S472
E
D
S
C
S
L
H
S
Q
T
L
S
E
D
E
Site 53
T474
S
C
S
L
H
S
Q
T
L
S
E
D
E
R
F
Site 54
S476
S
L
H
S
Q
T
L
S
E
D
E
R
F
K
E
Site 55
S486
E
R
F
K
E
F
T
S
Q
Q
E
E
D
L
P
Site 56
T520
F
E
T
D
K
N
E
T
F
L
P
F
G
I
P
Site 57
S532
G
I
P
L
P
F
R
S
P
S
P
L
V
S
L
Site 58
S534
P
L
P
F
R
S
P
S
P
L
V
S
L
Q
A
Site 59
S538
R
S
P
S
P
L
V
S
L
Q
A
V
K
E
S
Site 60
S545
S
L
Q
A
V
K
E
S
V
S
S
F
V
R
K
Site 61
S548
A
V
K
E
S
V
S
S
F
V
R
K
T
T
E
Site 62
T553
V
S
S
F
V
R
K
T
T
E
K
I
G
T
L
Site 63
T554
S
S
F
V
R
K
T
T
E
K
I
G
T
L
H
Site 64
T559
K
T
T
E
K
I
G
T
L
H
T
S
P
D
L
Site 65
T562
E
K
I
G
T
L
H
T
S
P
D
L
K
V
R
Site 66
S563
K
I
G
T
L
H
T
S
P
D
L
K
V
R
P
Site 67
S578
E
L
R
G
D
E
Q
S
C
E
E
D
V
S
S
Site 68
S584
Q
S
C
E
E
D
V
S
S
D
T
C
P
K
E
Site 69
S585
S
C
E
E
D
V
S
S
D
T
C
P
K
E
E
Site 70
T594
T
C
P
K
E
E
D
T
E
E
E
K
E
V
T
Site 71
T601
T
E
E
E
K
E
V
T
S
P
P
P
E
E
D
Site 72
S602
E
E
E
K
E
V
T
S
P
P
P
E
E
D
R
Site 73
T650
W
L
S
H
L
E
K
T
F
A
M
K
D
F
S
Site 74
S660
M
K
D
F
S
G
V
S
D
T
D
N
S
S
M
Site 75
T662
D
F
S
G
V
S
D
T
D
N
S
S
M
K
L
Site 76
S665
G
V
S
D
T
D
N
S
S
M
K
L
N
Q
D
Site 77
S666
V
S
D
T
D
N
S
S
M
K
L
N
Q
D
V
Site 78
S679
D
V
L
L
V
N
E
S
K
K
G
I
L
D
E
Site 79
S695
N
E
K
E
K
R
D
S
L
G
N
E
E
S
V
Site 80
S701
D
S
L
G
N
E
E
S
V
D
K
T
A
C
E
Site 81
T705
N
E
E
S
V
D
K
T
A
C
E
C
V
R
S
Site 82
S712
T
A
C
E
C
V
R
S
P
R
E
S
L
D
D
Site 83
S716
C
V
R
S
P
R
E
S
L
D
D
L
F
Q
I
Site 84
S752
L
E
L
N
V
L
N
S
K
I
K
S
T
S
G
Site 85
S756
V
L
N
S
K
I
K
S
T
S
G
H
V
D
H
Site 86
T764
T
S
G
H
V
D
H
T
L
Q
Q
Y
S
P
E
Site 87
S769
D
H
T
L
Q
Q
Y
S
P
E
I
L
A
C
Q
Site 88
S793
N
L
K
R
A
K
E
S
I
K
L
S
Y
S
N
Site 89
S797
A
K
E
S
I
K
L
S
Y
S
N
S
P
S
V
Site 90
S799
E
S
I
K
L
S
Y
S
N
S
P
S
V
W
D
Site 91
S801
I
K
L
S
Y
S
N
S
P
S
V
W
D
T
F
Site 92
S803
L
S
Y
S
N
S
P
S
V
W
D
T
F
I
E
Site 93
T807
N
S
P
S
V
W
D
T
F
I
E
G
L
K
E
Site 94
S817
E
G
L
K
E
M
A
S
S
N
P
V
Y
M
E
Site 95
S818
G
L
K
E
M
A
S
S
N
P
V
Y
M
E
M
Site 96
Y822
M
A
S
S
N
P
V
Y
M
E
M
E
K
G
D
Site 97
Y851
D
S
P
L
L
V
V
Y
A
T
R
L
Y
E
K
Site 98
Y856
V
V
Y
A
T
R
L
Y
E
K
F
G
E
S
A
Site 99
S862
L
Y
E
K
F
G
E
S
A
L
R
S
L
I
K
Site 100
S896
E
F
L
A
Y
L
D
S
L
V
K
S
R
P
E
Site 101
S900
Y
L
D
S
L
V
K
S
R
P
E
D
Q
R
S
Site 102
S907
S
R
P
E
D
Q
R
S
S
F
L
E
S
L
L
Site 103
S908
R
P
E
D
Q
R
S
S
F
L
E
S
L
L
Q
Site 104
S912
Q
R
S
S
F
L
E
S
L
L
Q
P
E
S
L
Site 105
S918
E
S
L
L
Q
P
E
S
L
R
L
D
W
L
L
Site 106
S935
V
S
L
D
A
P
P
S
T
S
T
M
D
D
E
Site 107
Y944
S
T
M
D
D
E
G
Y
P
R
P
H
S
H
L
Site 108
S949
E
G
Y
P
R
P
H
S
H
L
L
S
W
G
Y
Site 109
S953
R
P
H
S
H
L
L
S
W
G
Y
S
Q
L
I
Site 110
T1004
E
R
R
R
E
A
F
T
N
I
V
Y
L
N
D
Site 111
T1025
D
N
G
W
I
P
E
T
V
E
E
W
K
L
L
Site 112
S1038
L
L
L
H
L
I
Q
S
K
S
T
R
P
A
P
Site 113
S1040
L
H
L
I
Q
S
K
S
T
R
P
A
P
Q
E
Site 114
S1048
T
R
P
A
P
Q
E
S
L
N
G
S
L
S
D
Site 115
S1052
P
Q
E
S
L
N
G
S
L
S
D
G
P
S
P
Site 116
S1054
E
S
L
N
G
S
L
S
D
G
P
S
P
I
N
Site 117
S1058
G
S
L
S
D
G
P
S
P
I
N
V
E
N
V
Site 118
S1080
M
G
P
D
R
A
W
S
L
L
Q
E
C
G
L
Site 119
S1115
R
Q
R
A
L
I
Q
S
M
L
E
K
C
D
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation