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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Dicer1
Full Name:
Endoribonuclease Dicer
Alias:
DICER; Dicer 1, double-stranded RNA-specific endoribonuclease; Dicer 1, ribonuclease type III; Helicase with RNase motif; Helicase-MOI; HERNA; K12H4.8-LIKE; KIAA0928
Type:
EC 3.1.26.-; RNA binding protein; EC 3.1.26.; Cell development/differentiation; RNA processing; Helicase; Ribonuclease
Mass (Da):
218682
Number AA:
1922
UniProt ID:
Q9UPY3
International Prot ID:
IPI00219036
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016442
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003725
PhosphoSite+
KinaseNET
Biological Process:
GO:0031054
GO:0030422
GO:0030423
Phosida
TranscriptoNet
STRING
Kinexus Products
Endoribonuclease Dicer pan-specific antibody AB-NN237-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN237-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y42
E
A
I
H
D
N
I
Y
T
P
R
K
Y
Q
V
Site 2
T43
A
I
H
D
N
I
Y
T
P
R
K
Y
Q
V
E
Site 3
Y47
N
I
Y
T
P
R
K
Y
Q
V
E
L
L
E
A
Site 4
S82
V
L
L
T
K
E
L
S
Y
Q
I
R
G
D
F
Site 5
T96
F
S
R
N
G
K
R
T
V
F
L
V
N
S
A
Site 6
T115
Q
Q
V
S
A
V
R
T
H
S
D
L
K
V
G
Site 7
S117
V
S
A
V
R
T
H
S
D
L
K
V
G
E
Y
Site 8
S132
S
N
L
E
V
N
A
S
W
T
K
E
R
W
N
Site 9
S232
K
L
E
K
I
L
K
S
N
A
E
T
A
T
D
Site 10
Y246
D
L
V
V
L
D
R
Y
T
S
Q
P
C
E
I
Site 11
T261
V
V
D
C
G
P
F
T
D
R
S
G
L
Y
E
Site 12
S264
C
G
P
F
T
D
R
S
G
L
Y
E
R
L
L
Site 13
Y267
F
T
D
R
S
G
L
Y
E
R
L
L
M
E
L
Site 14
S290
D
C
N
I
S
V
H
S
K
E
R
D
S
T
L
Site 15
S295
V
H
S
K
E
R
D
S
T
L
I
S
K
Q
I
Site 16
T296
H
S
K
E
R
D
S
T
L
I
S
K
Q
I
L
Site 17
S299
E
R
D
S
T
L
I
S
K
Q
I
L
S
D
C
Site 18
Y332
M
V
R
E
L
Q
K
Y
I
K
H
E
Q
E
E
Site 19
S364
A
L
C
E
E
H
F
S
P
A
S
L
D
L
K
Site 20
S367
E
E
H
F
S
P
A
S
L
D
L
K
F
V
T
Site 21
Y387
L
L
E
I
L
R
K
Y
K
P
Y
E
R
Q
Q
Site 22
Y390
I
L
R
K
Y
K
P
Y
E
R
Q
Q
F
E
S
Site 23
Y401
Q
F
E
S
V
E
W
Y
N
N
R
N
Q
D
N
Site 24
Y409
N
N
R
N
Q
D
N
Y
V
S
W
S
D
S
E
Site 25
S411
R
N
Q
D
N
Y
V
S
W
S
D
S
E
D
D
Site 26
S413
Q
D
N
Y
V
S
W
S
D
S
E
D
D
D
E
Site 27
S415
N
Y
V
S
W
S
D
S
E
D
D
D
E
D
E
Site 28
T432
E
E
K
E
K
P
E
T
N
F
P
S
P
F
T
Site 29
S436
K
P
E
T
N
F
P
S
P
F
T
N
I
L
C
Site 30
Y452
I
I
F
V
E
R
R
Y
T
A
V
V
L
N
R
Site 31
Y473
K
Q
D
P
E
L
A
Y
I
S
S
N
F
I
T
Site 32
S476
P
E
L
A
Y
I
S
S
N
F
I
T
G
H
G
Site 33
T480
Y
I
S
S
N
F
I
T
G
H
G
I
G
K
N
Site 34
T541
V
V
R
F
D
L
P
T
E
Y
R
S
Y
V
Q
Site 35
Y543
R
F
D
L
P
T
E
Y
R
S
Y
V
Q
S
K
Site 36
S545
D
L
P
T
E
Y
R
S
Y
V
Q
S
K
G
R
Site 37
Y546
L
P
T
E
Y
R
S
Y
V
Q
S
K
G
R
A
Site 38
S549
E
Y
R
S
Y
V
Q
S
K
G
R
A
R
A
P
Site 39
S558
G
R
A
R
A
P
I
S
N
Y
I
M
L
A
D
Site 40
T566
N
Y
I
M
L
A
D
T
D
K
I
K
S
F
E
Site 41
S571
A
D
T
D
K
I
K
S
F
E
E
D
L
K
T
Site 42
T578
S
F
E
E
D
L
K
T
Y
K
A
I
E
K
I
Site 43
S591
K
I
L
R
N
K
C
S
K
S
V
D
T
G
E
Site 44
S593
L
R
N
K
C
S
K
S
V
D
T
G
E
T
D
Site 45
Y614
D
D
D
V
F
P
P
Y
V
L
R
P
D
D
G
Site 46
T626
D
D
G
G
P
R
V
T
I
N
T
A
I
G
H
Site 47
T629
G
P
R
V
T
I
N
T
A
I
G
H
I
N
R
Site 48
Y637
A
I
G
H
I
N
R
Y
C
A
R
L
P
S
D
Site 49
S643
R
Y
C
A
R
L
P
S
D
P
F
T
H
L
A
Site 50
T647
R
L
P
S
D
P
F
T
H
L
A
P
K
C
R
Site 51
T662
T
R
E
L
P
D
G
T
F
Y
S
T
L
Y
L
Site 52
Y664
E
L
P
D
G
T
F
Y
S
T
L
Y
L
P
I
Site 53
Y668
G
T
F
Y
S
T
L
Y
L
P
I
N
S
P
L
Site 54
T719
L
M
P
V
G
K
E
T
V
K
Y
E
E
E
L
Site 55
Y722
V
G
K
E
T
V
K
Y
E
E
E
L
D
L
H
Site 56
S735
L
H
D
E
E
E
T
S
V
P
G
R
P
G
S
Site 57
S742
S
V
P
G
R
P
G
S
T
K
R
R
Q
C
Y
Site 58
T743
V
P
G
R
P
G
S
T
K
R
R
Q
C
Y
P
Site 59
Y749
S
T
K
R
R
Q
C
Y
P
K
A
I
P
E
C
Site 60
S760
I
P
E
C
L
R
D
S
Y
P
R
P
D
Q
P
Site 61
Y761
P
E
C
L
R
D
S
Y
P
R
P
D
Q
P
C
Site 62
Y793
N
F
R
R
R
K
L
Y
P
P
E
D
T
T
R
Site 63
T798
K
L
Y
P
P
E
D
T
T
R
C
F
G
I
L
Site 64
T799
L
Y
P
P
E
D
T
T
R
C
F
G
I
L
T
Site 65
Y819
Q
I
P
H
F
P
V
Y
T
R
S
G
E
V
T
Site 66
T820
I
P
H
F
P
V
Y
T
R
S
G
E
V
T
I
Site 67
S822
H
F
P
V
Y
T
R
S
G
E
V
T
I
S
I
Site 68
T826
Y
T
R
S
G
E
V
T
I
S
I
E
L
K
K
Site 69
S828
R
S
G
E
V
T
I
S
I
E
L
K
K
S
G
Site 70
T870
P
A
L
E
F
K
P
T
D
A
D
S
A
Y
C
Site 71
S888
L
N
V
V
N
D
S
S
T
L
D
I
D
F
K
Site 72
T889
N
V
V
N
D
S
S
T
L
D
I
D
F
K
F
Site 73
S903
F
M
E
D
I
E
K
S
E
A
R
I
G
I
P
Site 74
S911
E
A
R
I
G
I
P
S
T
K
Y
T
K
E
T
Site 75
Y914
I
G
I
P
S
T
K
Y
T
K
E
T
P
F
V
Site 76
T915
G
I
P
S
T
K
Y
T
K
E
T
P
F
V
F
Site 77
T918
S
T
K
Y
T
K
E
T
P
F
V
F
K
L
E
Site 78
Y936
D
A
V
I
I
P
R
Y
R
N
F
D
Q
P
H
Site 79
Y946
F
D
Q
P
H
R
F
Y
V
A
D
V
Y
T
D
Site 80
T955
A
D
V
Y
T
D
L
T
P
L
S
K
F
P
S
Site 81
S958
Y
T
D
L
T
P
L
S
K
F
P
S
P
E
Y
Site 82
S962
T
P
L
S
K
F
P
S
P
E
Y
E
T
F
A
Site 83
Y965
S
K
F
P
S
P
E
Y
E
T
F
A
E
Y
Y
Site 84
Y971
E
Y
E
T
F
A
E
Y
Y
K
T
K
Y
N
L
Site 85
T974
T
F
A
E
Y
Y
K
T
K
Y
N
L
D
L
T
Site 86
Y976
A
E
Y
Y
K
T
K
Y
N
L
D
L
T
N
L
Site 87
T981
T
K
Y
N
L
D
L
T
N
L
N
Q
P
L
L
Site 88
T993
P
L
L
D
V
D
H
T
S
S
R
L
N
L
L
Site 89
S994
L
L
D
V
D
H
T
S
S
R
L
N
L
L
T
Site 90
T1001
S
S
R
L
N
L
L
T
P
R
H
L
N
Q
K
Site 91
S1015
K
G
K
A
L
P
L
S
S
A
E
K
R
K
A
Site 92
S1016
G
K
A
L
P
L
S
S
A
E
K
R
K
A
K
Site 93
T1074
A
E
E
L
R
A
Q
T
A
S
D
A
G
V
G
Site 94
S1076
E
L
R
A
Q
T
A
S
D
A
G
V
G
V
R
Site 95
S1084
D
A
G
V
G
V
R
S
L
P
A
D
F
R
Y
Site 96
Y1091
S
L
P
A
D
F
R
Y
P
N
L
D
F
G
W
Site 97
S1101
L
D
F
G
W
K
K
S
I
D
S
K
S
F
I
Site 98
S1104
G
W
K
K
S
I
D
S
K
S
F
I
S
I
S
Site 99
S1106
K
K
S
I
D
S
K
S
F
I
S
I
S
N
S
Site 100
S1109
I
D
S
K
S
F
I
S
I
S
N
S
S
S
A
Site 101
S1111
S
K
S
F
I
S
I
S
N
S
S
S
A
E
N
Site 102
S1113
S
F
I
S
I
S
N
S
S
S
A
E
N
D
N
Site 103
S1115
I
S
I
S
N
S
S
S
A
E
N
D
N
Y
C
Site 104
Y1121
S
S
A
E
N
D
N
Y
C
K
H
S
T
I
V
Site 105
S1141
H
Q
G
A
N
R
T
S
S
L
E
N
H
D
Q
Site 106
S1142
Q
G
A
N
R
T
S
S
L
E
N
H
D
Q
M
Site 107
T1155
Q
M
S
V
N
C
R
T
L
L
S
E
S
P
G
Site 108
S1158
V
N
C
R
T
L
L
S
E
S
P
G
K
L
H
Site 109
S1160
C
R
T
L
L
S
E
S
P
G
K
L
H
V
E
Site 110
Y1204
C
Q
G
N
Q
L
N
Y
Y
K
Q
E
I
P
V
Site 111
Y1205
Q
G
N
Q
L
N
Y
Y
K
Q
E
I
P
V
Q
Site 112
T1215
E
I
P
V
Q
P
T
T
S
Y
S
I
Q
N
L
Site 113
S1216
I
P
V
Q
P
T
T
S
Y
S
I
Q
N
L
Y
Site 114
S1218
V
Q
P
T
T
S
Y
S
I
Q
N
L
Y
S
Y
Site 115
Y1223
S
Y
S
I
Q
N
L
Y
S
Y
E
N
Q
P
Q
Site 116
Y1225
S
I
Q
N
L
Y
S
Y
E
N
Q
P
Q
P
S
Site 117
S1232
Y
E
N
Q
P
Q
P
S
D
E
C
T
L
L
S
Site 118
T1236
P
Q
P
S
D
E
C
T
L
L
S
N
K
Y
L
Site 119
S1239
S
D
E
C
T
L
L
S
N
K
Y
L
D
G
N
Site 120
Y1242
C
T
L
L
S
N
K
Y
L
D
G
N
A
N
K
Site 121
S1250
L
D
G
N
A
N
K
S
T
S
D
G
S
P
V
Site 122
T1251
D
G
N
A
N
K
S
T
S
D
G
S
P
V
M
Site 123
S1255
N
K
S
T
S
D
G
S
P
V
M
A
V
M
P
Site 124
T1267
V
M
P
G
T
T
D
T
I
Q
V
L
K
G
R
Site 125
S1277
V
L
K
G
R
M
D
S
E
Q
S
P
S
I
G
Site 126
S1280
G
R
M
D
S
E
Q
S
P
S
I
G
Y
S
S
Site 127
S1282
M
D
S
E
Q
S
P
S
I
G
Y
S
S
R
T
Site 128
S1286
Q
S
P
S
I
G
Y
S
S
R
T
L
G
P
N
Site 129
S1287
S
P
S
I
G
Y
S
S
R
T
L
G
P
N
P
Site 130
T1289
S
I
G
Y
S
S
R
T
L
G
P
N
P
G
L
Site 131
Y1330
L
K
H
A
I
T
T
Y
L
F
C
T
Y
P
D
Site 132
Y1335
T
T
Y
L
F
C
T
Y
P
D
A
H
E
G
R
Site 133
S1344
D
A
H
E
G
R
L
S
Y
M
R
S
K
K
V
Site 134
Y1345
A
H
E
G
R
L
S
Y
M
R
S
K
K
V
S
Site 135
S1348
G
R
L
S
Y
M
R
S
K
K
V
S
N
C
N
Site 136
S1367
G
K
K
K
G
L
P
S
R
M
V
V
S
I
F
Site 137
Y1385
V
N
W
L
P
P
G
Y
V
V
N
Q
D
K
S
Site 138
Y1417
N
G
K
L
D
E
D
Y
E
E
E
D
E
E
E
Site 139
S1426
E
E
D
E
E
E
E
S
L
M
W
R
A
P
K
Site 140
Y1438
A
P
K
E
E
A
D
Y
E
D
D
F
L
E
Y
Site 141
Y1445
Y
E
D
D
F
L
E
Y
D
Q
E
H
I
R
F
Site 142
S1468
G
A
F
V
K
K
I
S
L
S
P
F
S
T
T
Site 143
S1470
F
V
K
K
I
S
L
S
P
F
S
T
T
D
S
Site 144
S1473
K
I
S
L
S
P
F
S
T
T
D
S
A
Y
E
Site 145
T1474
I
S
L
S
P
F
S
T
T
D
S
A
Y
E
W
Site 146
S1477
S
P
F
S
T
T
D
S
A
Y
E
W
K
M
P
Site 147
Y1479
F
S
T
T
D
S
A
Y
E
W
K
M
P
K
K
Site 148
S1487
E
W
K
M
P
K
K
S
S
L
G
S
M
P
F
Site 149
S1488
W
K
M
P
K
K
S
S
L
G
S
M
P
F
S
Site 150
S1491
P
K
K
S
S
L
G
S
M
P
F
S
S
D
F
Site 151
S1495
S
L
G
S
M
P
F
S
S
D
F
E
D
F
D
Site 152
S1496
L
G
S
M
P
F
S
S
D
F
E
D
F
D
Y
Site 153
Y1503
S
D
F
E
D
F
D
Y
S
S
W
D
A
M
C
Site 154
Y1511
S
S
W
D
A
M
C
Y
L
D
P
S
K
A
V
Site 155
S1515
A
M
C
Y
L
D
P
S
K
A
V
E
E
D
D
Site 156
T1539
E
E
N
C
G
V
D
T
G
K
Q
S
I
S
Y
Site 157
S1543
G
V
D
T
G
K
Q
S
I
S
Y
D
L
H
T
Site 158
S1545
D
T
G
K
Q
S
I
S
Y
D
L
H
T
E
Q
Site 159
Y1546
T
G
K
Q
S
I
S
Y
D
L
H
T
E
Q
C
Site 160
T1550
S
I
S
Y
D
L
H
T
E
Q
C
I
A
D
K
Site 161
T1597
V
L
P
V
I
K
R
T
D
R
E
K
A
L
C
Site 162
S1612
P
T
R
E
N
F
N
S
Q
Q
K
N
L
S
V
Site 163
S1618
N
S
Q
Q
K
N
L
S
V
S
C
A
A
A
S
Site 164
S1629
A
A
A
S
V
A
S
S
R
S
S
V
L
K
D
Site 165
S1632
S
V
A
S
S
R
S
S
V
L
K
D
S
E
Y
Site 166
S1637
R
S
S
V
L
K
D
S
E
Y
G
C
L
K
I
Site 167
Y1639
S
V
L
K
D
S
E
Y
G
C
L
K
I
P
P
Site 168
T1658
D
H
P
D
A
D
K
T
L
N
H
L
I
S
G
Site 169
Y1701
Y
N
T
I
T
D
C
Y
Q
R
L
E
F
L
G
Site 170
Y1721
Y
L
I
T
K
H
L
Y
E
D
P
R
Q
H
S
Site 171
S1728
Y
E
D
P
R
Q
H
S
P
G
V
L
T
D
L
Site 172
Y1752
F
A
S
L
A
V
K
Y
D
Y
H
K
Y
F
K
Site 173
Y1754
S
L
A
V
K
Y
D
Y
H
K
Y
F
K
A
V
Site 174
Y1757
V
K
Y
D
Y
H
K
Y
F
K
A
V
S
P
E
Site 175
S1787
N
E
M
Q
G
M
D
S
E
L
R
R
S
E
E
Site 176
S1792
M
D
S
E
L
R
R
S
E
E
D
E
E
K
E
Site 177
T1829
D
S
G
M
S
L
E
T
V
W
Q
V
Y
Y
P
Site 178
S1846
R
P
L
I
E
K
F
S
A
N
V
P
R
S
P
Site 179
S1852
F
S
A
N
V
P
R
S
P
V
R
E
L
L
E
Site 180
T1864
L
L
E
M
E
P
E
T
A
K
F
S
P
A
E
Site 181
S1868
E
P
E
T
A
K
F
S
P
A
E
R
T
Y
D
Site 182
Y1874
F
S
P
A
E
R
T
Y
D
G
K
V
R
V
T
Site 183
T1881
Y
D
G
K
V
R
V
T
V
E
V
V
G
K
G
Site 184
S1896
K
F
K
G
V
G
R
S
Y
R
I
A
K
S
A
Site 185
Y1897
F
K
G
V
G
R
S
Y
R
I
A
K
S
A
A
Site 186
S1902
R
S
Y
R
I
A
K
S
A
A
A
R
R
A
L
Site 187
S1911
A
A
R
R
A
L
R
S
L
K
A
N
Q
P
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation