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Updated November 2019
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Protein Info
Short Name:
UNC13A
Full Name:
Protein unc-13 homolog A
Alias:
KIAA1032; Munc13-1; UN13A; Unc-13 A; Unc-13 homolog A
Type:
Membrane protein, peripheral
Mass (Da):
192998
Number AA:
1703
UniProt ID:
Q9UPW8
International Prot ID:
IPI00164441
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0005737
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006887
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
G
A
Q
E
K
F
N
T
Y
V
T
L
K
V
Q
Site 2
Y23
A
Q
E
K
F
N
T
Y
V
T
L
K
V
Q
N
Site 3
S33
L
K
V
Q
N
V
K
S
T
T
I
A
V
R
G
Site 4
S41
T
T
I
A
V
R
G
S
Q
P
S
W
E
Q
D
Site 5
S44
A
V
R
G
S
Q
P
S
W
E
Q
D
F
M
F
Site 6
T61
N
R
L
D
L
G
L
T
V
E
V
W
N
K
G
Site 7
T84
T
V
W
I
P
L
R
T
I
R
Q
S
N
E
E
Site 8
S88
P
L
R
T
I
R
Q
S
N
E
E
G
P
G
E
Site 9
T98
E
G
P
G
E
W
L
T
L
D
S
Q
V
I
M
Site 10
S108
S
Q
V
I
M
A
D
S
E
I
C
G
T
K
D
Site 11
T113
A
D
S
E
I
C
G
T
K
D
P
T
F
H
R
Site 12
T117
I
C
G
T
K
D
P
T
F
H
R
I
L
L
D
Site 13
T125
F
H
R
I
L
L
D
T
R
F
E
L
P
L
D
Site 14
Y140
I
P
E
E
E
A
R
Y
W
A
K
K
L
E
Q
Site 15
Y157
A
M
R
D
Q
D
E
Y
S
F
Q
D
E
Q
D
Site 16
S158
M
R
D
Q
D
E
Y
S
F
Q
D
E
Q
D
K
Site 17
S192
Q
H
N
D
D
P
D
S
A
V
D
D
R
D
S
Site 18
S199
S
A
V
D
D
R
D
S
D
Y
R
S
E
T
S
Site 19
Y201
V
D
D
R
D
S
D
Y
R
S
E
T
S
N
S
Site 20
S203
D
R
D
S
D
Y
R
S
E
T
S
N
S
I
P
Site 21
T205
D
S
D
Y
R
S
E
T
S
N
S
I
P
P
P
Site 22
S206
S
D
Y
R
S
E
T
S
N
S
I
P
P
P
Y
Site 23
S208
Y
R
S
E
T
S
N
S
I
P
P
P
Y
Y
T
Site 24
Y213
S
N
S
I
P
P
P
Y
Y
T
T
S
Q
P
N
Site 25
Y214
N
S
I
P
P
P
Y
Y
T
T
S
Q
P
N
A
Site 26
T215
S
I
P
P
P
Y
Y
T
T
S
Q
P
N
A
S
Site 27
S217
P
P
P
Y
Y
T
T
S
Q
P
N
A
S
V
H
Site 28
S222
T
T
S
Q
P
N
A
S
V
H
Q
Y
S
V
R
Site 29
Y226
P
N
A
S
V
H
Q
Y
S
V
R
P
P
P
L
Site 30
S227
N
A
S
V
H
Q
Y
S
V
R
P
P
P
L
G
Site 31
S235
V
R
P
P
P
L
G
S
R
E
S
Y
S
D
S
Site 32
S238
P
P
L
G
S
R
E
S
Y
S
D
S
M
H
S
Site 33
Y239
P
L
G
S
R
E
S
Y
S
D
S
M
H
S
Y
Site 34
S240
L
G
S
R
E
S
Y
S
D
S
M
H
S
Y
E
Site 35
S242
S
R
E
S
Y
S
D
S
M
H
S
Y
E
E
F
Site 36
S245
S
Y
S
D
S
M
H
S
Y
E
E
F
S
E
P
Site 37
Y246
Y
S
D
S
M
H
S
Y
E
E
F
S
E
P
Q
Site 38
S250
M
H
S
Y
E
E
F
S
E
P
Q
A
L
S
P
Site 39
S256
F
S
E
P
Q
A
L
S
P
T
G
S
S
R
Y
Site 40
S260
Q
A
L
S
P
T
G
S
S
R
Y
A
S
S
G
Site 41
S261
A
L
S
P
T
G
S
S
R
Y
A
S
S
G
E
Site 42
Y263
S
P
T
G
S
S
R
Y
A
S
S
G
E
L
S
Site 43
S265
T
G
S
S
R
Y
A
S
S
G
E
L
S
Q
G
Site 44
S266
G
S
S
R
Y
A
S
S
G
E
L
S
Q
G
S
Site 45
S270
Y
A
S
S
G
E
L
S
Q
G
S
S
Q
L
S
Site 46
S273
S
G
E
L
S
Q
G
S
S
Q
L
S
E
D
F
Site 47
S274
G
E
L
S
Q
G
S
S
Q
L
S
E
D
F
D
Site 48
S277
S
Q
G
S
S
Q
L
S
E
D
F
D
P
D
E
Site 49
S286
D
F
D
P
D
E
H
S
L
Q
G
S
D
M
E
Site 50
S290
D
E
H
S
L
Q
G
S
D
M
E
D
E
R
D
Site 51
S300
E
D
E
R
D
R
D
S
Y
H
S
C
H
S
S
Site 52
Y301
D
E
R
D
R
D
S
Y
H
S
C
H
S
S
V
Site 53
S303
R
D
R
D
S
Y
H
S
C
H
S
S
V
S
Y
Site 54
S306
D
S
Y
H
S
C
H
S
S
V
S
Y
H
K
D
Site 55
S307
S
Y
H
S
C
H
S
S
V
S
Y
H
K
D
S
Site 56
S309
H
S
C
H
S
S
V
S
Y
H
K
D
S
P
R
Site 57
Y310
S
C
H
S
S
V
S
Y
H
K
D
S
P
R
W
Site 58
S314
S
V
S
Y
H
K
D
S
P
R
W
D
Q
D
E
Site 59
S376
P
K
D
F
K
R
I
S
L
P
P
A
A
P
G
Site 60
T407
K
V
A
P
K
P
A
T
P
D
K
V
P
A
A
Site 61
S428
E
P
P
K
D
E
E
S
F
R
P
R
E
D
E
Site 62
S443
E
G
Q
E
G
Q
D
S
M
S
R
A
K
A
N
Site 63
S445
Q
E
G
Q
D
S
M
S
R
A
K
A
N
W
L
Site 64
S472
A
R
G
E
G
E
M
S
K
S
L
W
F
K
G
Site 65
S474
G
E
G
E
M
S
K
S
L
W
F
K
G
G
P
Site 66
S490
G
G
L
I
I
I
D
S
M
P
D
I
R
K
R
Site 67
T519
Q
S
R
K
A
G
I
T
S
A
L
A
S
S
T
Site 68
S524
G
I
T
S
A
L
A
S
S
T
L
N
N
E
E
Site 69
Y537
E
E
L
K
N
H
V
Y
K
K
T
L
Q
A
L
Site 70
T563
F
E
V
W
T
A
T
T
P
T
Y
C
Y
E
C
Site 71
Y566
W
T
A
T
T
P
T
Y
C
Y
E
C
E
G
L
Site 72
Y568
A
T
T
P
T
Y
C
Y
E
C
E
G
L
L
W
Site 73
S611
L
Q
R
A
A
E
K
S
S
K
H
G
A
E
D
Site 74
T620
K
H
G
A
E
D
R
T
Q
N
I
I
M
V
L
Site 75
T671
K
Q
S
V
L
D
G
T
S
K
W
S
A
K
I
Site 76
S672
Q
S
V
L
D
G
T
S
K
W
S
A
K
I
S
Site 77
T694
G
L
Q
A
K
D
K
T
G
S
S
D
P
Y
V
Site 78
S696
Q
A
K
D
K
T
G
S
S
D
P
Y
V
T
V
Site 79
S697
A
K
D
K
T
G
S
S
D
P
Y
V
T
V
Q
Site 80
Y700
K
T
G
S
S
D
P
Y
V
T
V
Q
V
G
K
Site 81
T702
G
S
S
D
P
Y
V
T
V
Q
V
G
K
T
K
Site 82
T714
K
T
K
K
R
T
K
T
I
Y
G
N
L
N
P
Site 83
Y716
K
K
R
T
K
T
I
Y
G
N
L
N
P
V
W
Site 84
S734
F
H
F
E
C
H
N
S
S
D
R
I
K
V
R
Site 85
S735
H
F
E
C
H
N
S
S
D
R
I
K
V
R
V
Site 86
S751
D
E
D
D
D
I
K
S
R
V
K
Q
R
F
K
Site 87
S761
K
Q
R
F
K
R
E
S
D
D
F
L
G
Q
T
Site 88
Y783
S
G
E
M
D
V
W
Y
N
L
D
K
R
T
D
Site 89
S792
L
D
K
R
T
D
K
S
A
V
S
G
A
I
R
Site 90
S795
R
T
D
K
S
A
V
S
G
A
I
R
L
H
I
Site 91
S803
G
A
I
R
L
H
I
S
V
E
I
K
G
E
E
Site 92
Y815
G
E
E
K
V
A
P
Y
H
V
Q
Y
T
C
L
Site 93
Y819
V
A
P
Y
H
V
Q
Y
T
C
L
H
E
N
L
Site 94
Y869
V
D
E
F
A
M
R
Y
G
V
E
S
I
Y
Q
Site 95
Y875
R
Y
G
V
E
S
I
Y
Q
A
M
T
H
F
A
Site 96
S914
Y
Y
A
H
T
T
A
S
T
N
V
S
A
S
D
Site 97
S918
T
T
A
S
T
N
V
S
A
S
D
R
F
A
A
Site 98
S920
A
S
T
N
V
S
A
S
D
R
F
A
A
S
N
Site 99
S943
L
L
D
Q
L
H
N
S
L
R
I
D
L
S
M
Site 100
S949
N
S
L
R
I
D
L
S
M
Y
R
N
N
F
P
Site 101
Y951
L
R
I
D
L
S
M
Y
R
N
N
F
P
A
S
Site 102
S958
Y
R
N
N
F
P
A
S
S
P
E
R
L
Q
D
Site 103
S959
R
N
N
F
P
A
S
S
P
E
R
L
Q
D
L
Site 104
S968
E
R
L
Q
D
L
K
S
T
V
D
L
L
T
S
Site 105
T969
R
L
Q
D
L
K
S
T
V
D
L
L
T
S
I
Site 106
S988
M
K
V
Q
E
L
Q
S
P
P
R
A
S
Q
V
Site 107
S993
L
Q
S
P
P
R
A
S
Q
V
V
K
D
C
V
Site 108
Y1008
K
A
C
L
N
S
T
Y
E
Y
I
F
N
N
C
Site 109
Y1019
F
N
N
C
H
E
L
Y
S
R
E
Y
Q
T
D
Site 110
Y1023
H
E
L
Y
S
R
E
Y
Q
T
D
P
A
K
K
Site 111
S1041
P
P
E
E
Q
G
P
S
I
K
N
L
D
F
W
Site 112
T1067
E
E
D
K
N
S
Y
T
P
C
L
N
Q
F
P
Site 113
Y1097
L
F
A
Q
D
M
K
Y
A
M
E
E
H
D
K
Site 114
Y1113
R
L
C
K
S
A
D
Y
M
N
L
H
F
K
V
Site 115
Y1124
H
F
K
V
K
W
L
Y
N
E
Y
V
T
E
L
Site 116
Y1127
V
K
W
L
Y
N
E
Y
V
T
E
L
P
A
F
Site 117
Y1141
F
K
D
R
V
P
E
Y
P
A
W
F
E
P
F
Site 118
Y1217
D
P
Q
I
V
G
H
Y
M
R
R
F
A
K
T
Site 119
T1224
Y
M
R
R
F
A
K
T
I
S
N
V
L
L
Q
Site 120
S1242
I
I
S
K
D
F
A
S
Y
C
S
K
E
K
E
Site 121
S1245
K
D
F
A
S
Y
C
S
K
E
K
E
K
V
P
Site 122
S1283
K
E
L
D
A
E
A
S
D
I
L
K
E
L
Q
Site 123
S1307
L
S
R
V
F
A
T
S
F
Q
P
H
I
E
E
Site 124
S1324
K
Q
M
G
D
I
L
S
Q
V
K
G
T
G
N
Site 125
S1339
V
P
A
S
A
C
S
S
V
A
Q
D
A
D
N
Site 126
S1421
K
G
R
V
K
L
P
S
H
S
D
G
T
Q
M
Site 127
S1423
R
V
K
L
P
S
H
S
D
G
T
Q
M
I
F
Site 128
T1426
L
P
S
H
S
D
G
T
Q
M
I
F
N
A
A
Site 129
S1453
M
V
R
E
E
A
K
S
L
T
P
K
Q
C
A
Site 130
T1455
R
E
E
A
K
S
L
T
P
K
Q
C
A
V
V
Site 131
T1483
G
G
V
G
L
K
K
T
F
L
E
K
S
P
D
Site 132
S1488
K
K
T
F
L
E
K
S
P
D
L
Q
S
L
R
Site 133
S1493
E
K
S
P
D
L
Q
S
L
R
Y
A
L
S
L
Site 134
S1499
Q
S
L
R
Y
A
L
S
L
Y
T
Q
A
T
D
Site 135
S1517
K
T
F
V
Q
T
Q
S
A
Q
G
L
G
V
E
Site 136
T1548
G
T
G
E
H
K
V
T
V
K
V
V
A
A
N
Site 137
S1579
N
I
I
G
P
Q
L
S
D
K
K
R
K
F
A
Site 138
T1587
D
K
K
R
K
F
A
T
K
S
K
N
N
S
W
Site 139
S1589
K
R
K
F
A
T
K
S
K
N
N
S
W
A
P
Site 140
S1593
A
T
K
S
K
N
N
S
W
A
P
K
Y
N
E
Site 141
Y1598
N
N
S
W
A
P
K
Y
N
E
S
F
Q
F
T
Site 142
S1601
W
A
P
K
Y
N
E
S
F
Q
F
T
L
S
A
Site 143
T1605
Y
N
E
S
F
Q
F
T
L
S
A
D
A
G
P
Site 144
S1607
E
S
F
Q
F
T
L
S
A
D
A
G
P
E
C
Site 145
Y1624
L
Q
V
C
V
K
D
Y
C
F
A
R
E
D
R
Site 146
S1648
R
E
L
A
Q
R
G
S
A
A
C
W
L
P
L
Site 147
T1664
R
R
I
H
M
D
D
T
G
L
T
V
L
R
I
Site 148
T1667
H
M
D
D
T
G
L
T
V
L
R
I
L
S
Q
Site 149
S1673
L
T
V
L
R
I
L
S
Q
R
S
N
D
E
V
Site 150
S1689
K
E
F
V
K
L
K
S
D
T
R
S
A
E
E
Site 151
S1693
K
L
K
S
D
T
R
S
A
E
E
G
G
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation