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Updated November 2019
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Protein Info
Short Name:
USP24
Full Name:
Ubiquitin carboxyl-terminal hydrolase 24
Alias:
Deubiquitinating enzyme 24; KIAA1057; UB24; Ubiquitin specific peptidase 24; Ubiquitin specific protease 24; Ubiquitin thiolesterase 24; Ubiquitin-specific processing protease 24; UBP24
Type:
EC 3.1.2.15; Protease
Mass (Da):
294365
Number AA:
2620
UniProt ID:
Q9UPU5
International Prot ID:
IPI00398505
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
M
G
F
S
D
P
A
T
I
R
K
A
L
R
L
Site 2
Y50
N
E
R
P
G
L
D
Y
G
G
Y
E
P
M
D
Site 3
Y53
P
G
L
D
Y
G
G
Y
E
P
M
D
S
G
G
Site 4
S58
G
G
Y
E
P
M
D
S
G
G
G
P
S
P
G
Site 5
S63
M
D
S
G
G
G
P
S
P
G
P
G
G
G
P
Site 6
S84
D
G
G
G
G
G
P
S
R
G
G
S
T
G
G
Site 7
S88
G
G
P
S
R
G
G
S
T
G
G
G
G
G
F
Site 8
Y101
G
F
D
P
P
P
A
Y
H
E
V
V
D
A
E
Site 9
T126
E
G
I
E
F
P
T
T
N
L
Y
E
L
E
S
Site 10
Y129
E
F
P
T
T
N
L
Y
E
L
E
S
R
V
L
Site 11
S133
T
N
L
Y
E
L
E
S
R
V
L
T
D
H
W
Site 12
T137
E
L
E
S
R
V
L
T
D
H
W
S
I
P
Y
Site 13
S141
R
V
L
T
D
H
W
S
I
P
Y
K
R
E
E
Site 14
Y144
T
D
H
W
S
I
P
Y
K
R
E
E
S
L
G
Site 15
S149
I
P
Y
K
R
E
E
S
L
G
K
C
L
L
A
Site 16
S166
Y
L
A
R
L
G
L
S
E
S
D
E
N
C
R
Site 17
S168
A
R
L
G
L
S
E
S
D
E
N
C
R
R
F
Site 18
S190
A
F
K
K
L
L
T
S
S
A
V
H
K
W
G
Site 19
S191
F
K
K
L
L
T
S
S
A
V
H
K
W
G
T
Site 20
T198
S
A
V
H
K
W
G
T
E
I
H
E
G
I
Y
Site 21
Y205
T
E
I
H
E
G
I
Y
N
M
L
M
L
L
I
Site 22
Y242
A
F
N
P
D
N
E
Y
H
F
K
N
R
M
K
Site 23
S268
E
G
N
M
F
A
V
S
P
V
S
T
F
Q
K
Site 24
S271
M
F
A
V
S
P
V
S
T
F
Q
K
E
P
H
Site 25
T272
F
A
V
S
P
V
S
T
F
Q
K
E
P
H
G
Site 26
S347
T
T
I
Q
D
V
R
S
V
E
E
K
D
L
K
Site 27
S401
M
L
K
S
P
H
F
S
A
K
M
N
S
L
K
Site 28
S417
V
T
K
L
I
E
D
S
T
L
S
K
S
V
K
Site 29
T418
T
K
L
I
E
D
S
T
L
S
K
S
V
K
N
Site 30
S420
L
I
E
D
S
T
L
S
K
S
V
K
N
A
I
Site 31
S422
E
D
S
T
L
S
K
S
V
K
N
A
I
D
T
Site 32
T429
S
V
K
N
A
I
D
T
D
R
L
L
D
W
L
Site 33
Y455
G
N
I
D
Q
A
Q
Y
C
D
R
I
K
G
I
Site 34
S483
T
K
I
W
K
I
Q
S
G
Q
S
S
T
V
I
Site 35
S487
K
I
Q
S
G
Q
S
S
T
V
I
E
N
I
H
Site 36
T488
I
Q
S
G
Q
S
S
T
V
I
E
N
I
H
T
Site 37
S519
L
F
V
L
I
Q
K
S
W
E
T
E
S
D
R
Site 38
S524
Q
K
S
W
E
T
E
S
D
R
V
R
Q
K
L
Site 39
S533
R
V
R
Q
K
L
L
S
L
I
G
R
I
G
R
Site 40
T546
G
R
E
A
R
F
E
T
T
S
G
K
V
L
D
Site 41
S548
E
A
R
F
E
T
T
S
G
K
V
L
D
V
L
Site 42
T578
Q
A
L
E
E
H
L
T
I
L
S
D
A
Y
A
Site 43
S581
E
E
H
L
T
I
L
S
D
A
Y
A
V
K
E
Site 44
Y594
K
E
A
I
K
R
S
Y
I
I
K
C
I
E
D
Site 45
S609
I
K
R
P
G
E
W
S
G
L
E
K
N
K
K
Site 46
S621
N
K
K
D
G
F
K
S
S
Q
L
N
N
P
Q
Site 47
S622
K
K
D
G
F
K
S
S
Q
L
N
N
P
Q
F
Site 48
S645
Q
L
H
E
I
T
R
S
F
I
K
Q
T
Y
Q
Site 49
S657
T
Y
Q
K
Q
D
K
S
I
I
Q
D
L
K
K
Site 50
S695
G
P
G
G
L
S
G
S
T
L
V
D
G
R
Y
Site 51
T696
P
G
G
L
S
G
S
T
L
V
D
G
R
Y
T
Site 52
Y702
S
T
L
V
D
G
R
Y
T
Y
R
E
Y
L
E
Site 53
T703
T
L
V
D
G
R
Y
T
Y
R
E
Y
L
E
A
Site 54
Y704
L
V
D
G
R
Y
T
Y
R
E
Y
L
E
A
H
Site 55
Y707
G
R
Y
T
Y
R
E
Y
L
E
A
H
L
K
F
Site 56
Y725
F
L
Q
E
A
T
L
Y
L
G
W
N
R
A
K
Site 57
S765
K
G
Q
H
D
L
E
S
D
V
Q
Q
Q
L
F
Site 58
Y782
K
I
L
K
L
E
S
Y
E
I
T
M
N
G
F
Site 59
T785
K
L
E
S
Y
E
I
T
M
N
G
F
N
L
F
Site 60
Y814
K
R
Q
G
A
Q
L
Y
V
E
K
L
E
L
I
Site 61
S833
I
W
K
I
A
M
E
S
P
D
E
E
I
A
N
Site 62
S862
N
P
R
L
K
K
D
S
V
S
L
H
K
K
F
Site 63
S864
R
L
K
K
D
S
V
S
L
H
K
K
F
I
A
Site 64
Y874
K
K
F
I
A
D
C
Y
T
R
L
E
A
A
S
Site 65
S881
Y
T
R
L
E
A
A
S
S
A
L
G
G
P
T
Site 66
T910
T
A
M
P
T
V
A
T
S
V
Q
S
P
Y
R
Site 67
S911
A
M
P
T
V
A
T
S
V
Q
S
P
Y
R
S
Site 68
S914
T
V
A
T
S
V
Q
S
P
Y
R
S
T
K
L
Site 69
S918
S
V
Q
S
P
Y
R
S
T
K
L
V
I
I
E
Site 70
T919
V
Q
S
P
Y
R
S
T
K
L
V
I
I
E
R
Site 71
T947
D
F
Y
S
V
P
R
T
I
L
P
H
G
A
S
Site 72
T961
S
F
H
G
H
L
L
T
L
N
V
T
Y
E
S
Site 73
T972
T
Y
E
S
T
K
D
T
F
T
V
E
A
H
S
Site 74
T974
E
S
T
K
D
T
F
T
V
E
A
H
S
N
E
Site 75
S979
T
F
T
V
E
A
H
S
N
E
T
I
G
S
V
Site 76
S985
H
S
N
E
T
I
G
S
V
R
W
K
I
A
K
Site 77
T1011
F
T
N
D
S
L
L
T
V
N
K
D
Q
K
L
Site 78
T1031
F
S
D
E
Q
I
L
T
V
K
T
S
G
S
G
Site 79
S1035
Q
I
L
T
V
K
T
S
G
S
G
T
P
S
G
Site 80
S1037
L
T
V
K
T
S
G
S
G
T
P
S
G
S
S
Site 81
T1039
V
K
T
S
G
S
G
T
P
S
G
S
S
A
D
Site 82
S1041
T
S
G
S
G
T
P
S
G
S
S
A
D
S
S
Site 83
S1043
G
S
G
T
P
S
G
S
S
A
D
S
S
T
S
Site 84
S1044
S
G
T
P
S
G
S
S
A
D
S
S
T
S
S
Site 85
S1047
P
S
G
S
S
A
D
S
S
T
S
S
S
S
S
Site 86
S1048
S
G
S
S
A
D
S
S
T
S
S
S
S
S
S
Site 87
T1049
G
S
S
A
D
S
S
T
S
S
S
S
S
S
S
Site 88
S1050
S
S
A
D
S
S
T
S
S
S
S
S
S
S
G
Site 89
S1051
S
A
D
S
S
T
S
S
S
S
S
S
S
G
V
Site 90
S1052
A
D
S
S
T
S
S
S
S
S
S
S
G
V
F
Site 91
S1053
D
S
S
T
S
S
S
S
S
S
S
G
V
F
S
Site 92
S1054
S
S
T
S
S
S
S
S
S
S
G
V
F
S
S
Site 93
S1055
S
T
S
S
S
S
S
S
S
G
V
F
S
S
S
Site 94
S1056
T
S
S
S
S
S
S
S
G
V
F
S
S
S
Y
Site 95
S1060
S
S
S
S
G
V
F
S
S
S
Y
A
M
E
Q
Site 96
S1062
S
S
G
V
F
S
S
S
Y
A
M
E
Q
E
K
Site 97
Y1063
S
G
V
F
S
S
S
Y
A
M
E
Q
E
K
S
Site 98
S1070
Y
A
M
E
Q
E
K
S
L
P
G
V
V
M
A
Site 99
T1098
N
L
E
E
P
R
I
T
L
R
V
R
K
L
L
Site 100
S1123
E
A
L
D
Q
L
D
S
L
G
R
K
K
T
L
Site 101
T1129
D
S
L
G
R
K
K
T
L
L
S
E
S
S
S
Site 102
S1132
G
R
K
K
T
L
L
S
E
S
S
S
Q
S
S
Site 103
S1134
K
K
T
L
L
S
E
S
S
S
Q
S
S
K
S
Site 104
S1135
K
T
L
L
S
E
S
S
S
Q
S
S
K
S
P
Site 105
S1136
T
L
L
S
E
S
S
S
Q
S
S
K
S
P
S
Site 106
S1138
L
S
E
S
S
S
Q
S
S
K
S
P
S
L
S
Site 107
S1139
S
E
S
S
S
Q
S
S
K
S
P
S
L
S
S
Site 108
S1141
S
S
S
Q
S
S
K
S
P
S
L
S
S
K
Q
Site 109
S1143
S
Q
S
S
K
S
P
S
L
S
S
K
Q
Q
H
Site 110
S1145
S
S
K
S
P
S
L
S
S
K
Q
Q
H
Q
P
Site 111
S1146
S
K
S
P
S
L
S
S
K
Q
Q
H
Q
P
S
Site 112
S1153
S
K
Q
Q
H
Q
P
S
A
S
S
I
L
E
S
Site 113
S1155
Q
Q
H
Q
P
S
A
S
S
I
L
E
S
L
F
Site 114
S1156
Q
H
Q
P
S
A
S
S
I
L
E
S
L
F
R
Site 115
S1170
R
S
F
A
P
G
M
S
T
F
R
V
L
Y
N
Site 116
S1183
Y
N
L
E
V
L
S
S
K
L
M
P
T
A
D
Site 117
S1196
A
D
D
D
M
A
R
S
C
A
K
S
F
C
E
Site 118
S1200
M
A
R
S
C
A
K
S
F
C
E
N
F
L
K
Site 119
S1222
V
N
V
M
Q
R
D
S
I
P
S
E
V
D
Y
Site 120
S1225
M
Q
R
D
S
I
P
S
E
V
D
Y
E
T
R
Site 121
Y1229
S
I
P
S
E
V
D
Y
E
T
R
Q
G
V
Y
Site 122
T1231
P
S
E
V
D
Y
E
T
R
Q
G
V
Y
S
I
Site 123
S1237
E
T
R
Q
G
V
Y
S
I
C
L
Q
L
A
R
Site 124
T1261
T
L
L
D
E
D
L
T
K
D
G
I
E
A
L
Site 125
S1269
K
D
G
I
E
A
L
S
S
R
P
F
R
N
V
Site 126
S1270
D
G
I
E
A
L
S
S
R
P
F
R
N
V
S
Site 127
S1277
S
R
P
F
R
N
V
S
R
Q
T
S
R
Q
M
Site 128
T1280
F
R
N
V
S
R
Q
T
S
R
Q
M
S
L
C
Site 129
S1281
R
N
V
S
R
Q
T
S
R
Q
M
S
L
C
G
Site 130
S1285
R
Q
T
S
R
Q
M
S
L
C
G
T
P
E
K
Site 131
T1289
R
Q
M
S
L
C
G
T
P
E
K
S
S
Y
R
Site 132
S1293
L
C
G
T
P
E
K
S
S
Y
R
Q
L
S
V
Site 133
S1294
C
G
T
P
E
K
S
S
Y
R
Q
L
S
V
S
Site 134
Y1295
G
T
P
E
K
S
S
Y
R
Q
L
S
V
S
D
Site 135
S1299
K
S
S
Y
R
Q
L
S
V
S
D
R
S
S
I
Site 136
S1301
S
Y
R
Q
L
S
V
S
D
R
S
S
I
R
V
Site 137
S1305
L
S
V
S
D
R
S
S
I
R
V
E
E
I
I
Site 138
S1351
G
R
L
D
L
V
G
S
S
Q
P
I
K
E
S
Site 139
S1352
R
L
D
L
V
G
S
S
Q
P
I
K
E
S
N
Site 140
S1358
S
S
Q
P
I
K
E
S
N
S
L
C
P
A
G
Site 141
S1360
Q
P
I
K
E
S
N
S
L
C
P
A
G
I
R
Site 142
S1371
A
G
I
R
N
R
L
S
S
S
G
S
N
C
S
Site 143
S1372
G
I
R
N
R
L
S
S
S
G
S
N
C
S
S
Site 144
S1373
I
R
N
R
L
S
S
S
G
S
N
C
S
S
G
Site 145
S1375
N
R
L
S
S
S
G
S
N
C
S
S
G
S
E
Site 146
S1378
S
S
S
G
S
N
C
S
S
G
S
E
G
E
P
Site 147
S1379
S
S
G
S
N
C
S
S
G
S
E
G
E
P
V
Site 148
S1398
G
I
C
V
R
Q
Q
S
V
S
T
K
D
S
L
Site 149
S1400
C
V
R
Q
Q
S
V
S
T
K
D
S
L
I
A
Site 150
S1404
Q
S
V
S
T
K
D
S
L
I
A
G
E
A
L
Site 151
Y1459
R
V
A
C
D
Q
L
Y
T
L
S
Q
T
D
T
Site 152
S1462
C
D
Q
L
Y
T
L
S
Q
T
D
T
S
A
H
Site 153
T1466
Y
T
L
S
Q
T
D
T
S
A
H
P
D
V
Q
Site 154
S1467
T
L
S
Q
T
D
T
S
A
H
P
D
V
Q
K
Site 155
S1492
T
A
Q
L
P
L
W
S
P
T
S
I
M
R
G
Site 156
S1495
L
P
L
W
S
P
T
S
I
M
R
G
V
N
Q
Site 157
S1506
G
V
N
Q
R
L
L
S
Q
C
M
E
Y
F
D
Site 158
T1523
C
Q
L
L
D
D
L
T
T
S
E
M
E
Q
L
Site 159
S1525
L
L
D
D
L
T
T
S
E
M
E
Q
L
R
I
Site 160
S1533
E
M
E
Q
L
R
I
S
P
A
T
M
L
E
D
Site 161
T1536
Q
L
R
I
S
P
A
T
M
L
E
D
E
I
T
Site 162
T1543
T
M
L
E
D
E
I
T
W
L
D
N
F
E
P
Site 163
T1553
D
N
F
E
P
N
R
T
A
E
C
E
T
S
E
Site 164
S1559
R
T
A
E
C
E
T
S
E
A
D
N
I
L
L
Site 165
S1590
E
K
E
M
L
G
S
S
L
I
K
P
L
L
D
Site 166
S1604
D
D
F
L
F
R
A
S
R
I
I
L
N
S
H
Site 167
S1610
A
S
R
I
I
L
N
S
H
S
P
A
G
S
A
Site 168
S1612
R
I
I
L
N
S
H
S
P
A
G
S
A
A
I
Site 169
S1616
N
S
H
S
P
A
G
S
A
A
I
S
Q
Q
D
Site 170
S1620
P
A
G
S
A
A
I
S
Q
Q
D
F
H
P
K
Site 171
S1629
Q
D
F
H
P
K
C
S
T
A
N
S
R
L
A
Site 172
S1633
P
K
C
S
T
A
N
S
R
L
A
A
Y
E
V
Site 173
S1661
I
I
I
K
E
L
L
S
M
H
H
Q
P
D
P
Site 174
Y1676
A
L
T
K
E
F
D
Y
L
P
P
V
D
S
R
Site 175
S1682
D
Y
L
P
P
V
D
S
R
S
S
S
G
F
V
Site 176
S1684
L
P
P
V
D
S
R
S
S
S
G
F
V
G
L
Site 177
S1685
P
P
V
D
S
R
S
S
S
G
F
V
G
L
R
Site 178
S1686
P
V
D
S
R
S
S
S
G
F
V
G
L
R
N
Site 179
Y1699
R
N
G
G
A
T
C
Y
M
N
A
V
F
Q
Q
Site 180
Y1708
N
A
V
F
Q
Q
L
Y
M
Q
P
G
L
P
E
Site 181
S1716
M
Q
P
G
L
P
E
S
L
L
S
V
D
D
D
Site 182
S1719
G
L
P
E
S
L
L
S
V
D
D
D
T
D
N
Site 183
T1724
L
L
S
V
D
D
D
T
D
N
P
D
D
S
V
Site 184
S1730
D
T
D
N
P
D
D
S
V
F
Y
Q
V
Q
S
Site 185
Y1733
N
P
D
D
S
V
F
Y
Q
V
Q
S
L
F
G
Site 186
Y1749
L
M
E
S
K
L
Q
Y
Y
V
P
E
N
F
W
Site 187
Y1750
M
E
S
K
L
Q
Y
Y
V
P
E
N
F
W
K
Site 188
Y1767
K
M
W
N
K
E
L
Y
V
R
E
Q
Q
D
A
Site 189
Y1775
V
R
E
Q
Q
D
A
Y
E
F
F
T
S
L
I
Site 190
S1780
D
A
Y
E
F
F
T
S
L
I
D
Q
M
D
E
Site 191
Y1788
L
I
D
Q
M
D
E
Y
L
K
K
M
G
R
D
Site 192
T1801
R
D
Q
I
F
K
N
T
F
Q
G
I
Y
S
D
Site 193
Y1819
C
K
D
C
P
H
R
Y
E
R
E
E
A
F
M
Site 194
S1841
S
C
Q
S
L
E
I
S
L
D
Q
F
V
R
G
Site 195
S1854
R
G
E
V
L
E
G
S
N
A
Y
Y
C
E
K
Site 196
Y1857
V
L
E
G
S
N
A
Y
Y
C
E
K
C
K
E
Site 197
Y1858
L
E
G
S
N
A
Y
Y
C
E
K
C
K
E
K
Site 198
T1868
K
C
K
E
K
R
I
T
V
K
R
T
C
I
K
Site 199
T1872
K
R
I
T
V
K
R
T
C
I
K
S
L
P
S
Site 200
Y1900
E
S
G
R
S
I
K
Y
D
E
Q
I
R
F
P
Site 201
Y1915
W
M
L
N
M
E
P
Y
T
V
S
G
M
A
R
Site 202
T1916
M
L
N
M
E
P
Y
T
V
S
G
M
A
R
Q
Site 203
S1925
S
G
M
A
R
Q
D
S
S
S
E
V
G
E
N
Site 204
S1926
G
M
A
R
Q
D
S
S
S
E
V
G
E
N
G
Site 205
S1927
M
A
R
Q
D
S
S
S
E
V
G
E
N
G
R
Site 206
S1935
E
V
G
E
N
G
R
S
V
D
Q
G
G
G
G
Site 207
S1943
V
D
Q
G
G
G
G
S
P
R
K
K
V
A
L
Site 208
T1951
P
R
K
K
V
A
L
T
E
N
Y
E
L
V
G
Site 209
S1973
A
H
A
G
H
Y
Y
S
F
I
K
D
R
R
G
Site 210
T2003
E
F
D
L
N
D
E
T
L
E
Y
E
C
F
G
Site 211
Y2006
L
N
D
E
T
L
E
Y
E
C
F
G
G
E
Y
Site 212
Y2018
G
E
Y
R
P
K
V
Y
D
Q
T
N
P
Y
T
Site 213
T2021
R
P
K
V
Y
D
Q
T
N
P
Y
T
D
V
R
Site 214
Y2024
V
Y
D
Q
T
N
P
Y
T
D
V
R
R
R
Y
Site 215
Y2035
R
R
R
Y
W
N
A
Y
M
L
F
Y
Q
R
V
Site 216
Y2039
W
N
A
Y
M
L
F
Y
Q
R
V
S
D
Q
N
Site 217
S2043
M
L
F
Y
Q
R
V
S
D
Q
N
S
P
V
L
Site 218
S2047
Q
R
V
S
D
Q
N
S
P
V
L
P
K
K
S
Site 219
S2054
S
P
V
L
P
K
K
S
R
V
S
V
V
R
Q
Site 220
S2057
L
P
K
K
S
R
V
S
V
V
R
Q
E
A
E
Site 221
S2067
R
Q
E
A
E
D
L
S
L
S
A
P
S
S
P
Site 222
S2069
E
A
E
D
L
S
L
S
A
P
S
S
P
E
I
Site 223
S2073
L
S
L
S
A
P
S
S
P
E
I
S
P
Q
S
Site 224
S2077
A
P
S
S
P
E
I
S
P
Q
S
S
P
R
P
Site 225
S2080
S
P
E
I
S
P
Q
S
S
P
R
P
H
R
P
Site 226
S2081
P
E
I
S
P
Q
S
S
P
R
P
H
R
P
N
Site 227
S2093
R
P
N
N
D
R
L
S
I
L
T
K
L
V
K
Site 228
T2096
N
D
R
L
S
I
L
T
K
L
V
K
K
G
E
Site 229
Y2117
E
K
M
P
A
R
I
Y
Q
M
V
R
D
E
N
Site 230
Y2134
F
M
K
N
R
D
V
Y
S
S
D
Y
F
S
F
Site 231
S2135
M
K
N
R
D
V
Y
S
S
D
Y
F
S
F
V
Site 232
S2136
K
N
R
D
V
Y
S
S
D
Y
F
S
F
V
L
Site 233
T2151
S
L
A
S
L
N
A
T
K
L
K
H
P
Y
Y
Site 234
Y2158
T
K
L
K
H
P
Y
Y
P
C
M
A
K
V
S
Site 235
Y2177
I
Q
F
L
F
Q
T
Y
L
R
T
K
K
K
L
Site 236
T2188
K
K
K
L
R
V
D
T
E
E
W
I
A
T
I
Site 237
T2194
D
T
E
E
W
I
A
T
I
E
A
L
L
S
K
Site 238
Y2212
A
C
Q
W
L
V
E
Y
F
I
S
S
E
G
R
Site 239
S2216
L
V
E
Y
F
I
S
S
E
G
R
E
L
I
K
Site 240
S2248
I
L
E
K
T
L
D
S
A
L
F
Y
Q
D
K
Site 241
Y2252
T
L
D
S
A
L
F
Y
Q
D
K
L
K
S
L
Site 242
S2258
F
Y
Q
D
K
L
K
S
L
H
Q
L
L
E
V
Site 243
S2330
N
N
Q
I
R
R
W
S
S
A
Q
A
R
E
F
Site 244
S2331
N
Q
I
R
R
W
S
S
A
Q
A
R
E
F
G
Site 245
S2354
L
V
L
H
S
D
V
S
S
Q
R
N
V
A
P
Site 246
S2355
V
L
H
S
D
V
S
S
Q
R
N
V
A
P
G
Site 247
S2371
F
K
Q
R
P
P
I
S
I
A
P
S
S
P
L
Site 248
T2452
P
P
H
E
L
K
N
T
F
Q
L
L
H
E
I
Site 249
Y2516
K
C
P
A
A
K
E
Y
F
K
E
N
S
H
H
Site 250
Y2539
Q
K
K
M
S
E
H
Y
W
T
P
Q
S
N
V
Site 251
T2541
K
M
S
E
H
Y
W
T
P
Q
S
N
V
S
N
Site 252
S2544
E
H
Y
W
T
P
Q
S
N
V
S
N
E
T
S
Site 253
S2547
W
T
P
Q
S
N
V
S
N
E
T
S
T
G
K
Site 254
S2551
S
N
V
S
N
E
T
S
T
G
K
T
F
Q
R
Site 255
T2555
N
E
T
S
T
G
K
T
F
Q
R
T
I
S
A
Site 256
T2559
T
G
K
T
F
Q
R
T
I
S
A
Q
D
T
L
Site 257
S2561
K
T
F
Q
R
T
I
S
A
Q
D
T
L
A
Y
Site 258
T2565
R
T
I
S
A
Q
D
T
L
A
Y
A
T
A
L
Site 259
T2570
Q
D
T
L
A
Y
A
T
A
L
L
N
E
K
E
Site 260
S2579
L
L
N
E
K
E
Q
S
G
S
S
N
G
S
E
Site 261
S2581
N
E
K
E
Q
S
G
S
S
N
G
S
E
S
S
Site 262
S2582
E
K
E
Q
S
G
S
S
N
G
S
E
S
S
P
Site 263
S2585
Q
S
G
S
S
N
G
S
E
S
S
P
A
N
E
Site 264
S2587
G
S
S
N
G
S
E
S
S
P
A
N
E
N
G
Site 265
S2588
S
S
N
G
S
E
S
S
P
A
N
E
N
G
D
Site 266
S2602
D
R
H
L
Q
Q
G
S
E
S
P
M
M
I
G
Site 267
S2604
H
L
Q
Q
G
S
E
S
P
M
M
I
G
E
L
Site 268
S2613
M
M
I
G
E
L
R
S
D
L
D
D
V
D
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation