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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SORCS3
Full Name:
VPS10 domain-containing receptor SorCS3 precursor
Alias:
KIAA1059; SORC3; SORCS; sortilin-related VPS10 domain containing receptor 3; VPS10 domain receptor protein SORCS 3
Type:
Mass (Da):
135750
Number AA:
UniProt ID:
Q9UPU3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0008188
PhosphoSite+
KinaseNET
Biological Process:
GO:0007218
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
E
A
A
R
T
E
R
P
A
G
R
P
Site 2
T40
A
E
I
T
W
D
A
T
G
G
P
G
R
P
A
Site 3
S51
G
R
P
A
A
P
A
S
R
P
P
A
L
S
P
Site 4
S57
A
S
R
P
P
A
L
S
P
L
S
P
R
A
V
Site 5
S60
P
P
A
L
S
P
L
S
P
R
A
V
A
S
Q
Site 6
S66
L
S
P
R
A
V
A
S
Q
W
P
E
E
L
A
Site 7
S74
Q
W
P
E
E
L
A
S
A
R
R
A
A
V
L
Site 8
S109
Q
V
E
A
G
G
T
S
P
A
G
E
R
R
G
Site 9
S131
K
L
G
G
A
R
R
S
R
R
A
Q
P
P
I
Site 10
T139
R
R
A
Q
P
P
I
T
Q
E
R
G
D
A
W
Site 11
T148
E
R
G
D
A
W
A
T
A
P
A
D
G
S
R
Site 12
S154
A
T
A
P
A
D
G
S
R
G
S
R
P
L
A
Site 13
S157
P
A
D
G
S
R
G
S
R
P
L
A
K
G
S
Site 14
S164
S
R
P
L
A
K
G
S
R
E
E
V
K
A
P
Site 15
S185
A
E
D
L
R
L
P
S
T
S
F
A
L
T
G
Site 16
T186
E
D
L
R
L
P
S
T
S
F
A
L
T
G
D
Site 17
S187
D
L
R
L
P
S
T
S
F
A
L
T
G
D
S
Site 18
T191
P
S
T
S
F
A
L
T
G
D
S
A
H
N
Q
Site 19
S194
S
F
A
L
T
G
D
S
A
H
N
Q
A
M
V
Site 20
S209
H
W
S
G
H
N
S
S
V
I
L
I
L
T
K
Site 21
S224
L
Y
D
F
N
L
G
S
V
T
E
S
S
L
W
Site 22
T226
D
F
N
L
G
S
V
T
E
S
S
L
W
R
S
Site 23
S228
N
L
G
S
V
T
E
S
S
L
W
R
S
T
D
Site 24
S229
L
G
S
V
T
E
S
S
L
W
R
S
T
D
Y
Site 25
S233
T
E
S
S
L
W
R
S
T
D
Y
G
T
T
Y
Site 26
T234
E
S
S
L
W
R
S
T
D
Y
G
T
T
Y
E
Site 27
Y236
S
L
W
R
S
T
D
Y
G
T
T
Y
E
K
L
Site 28
T239
R
S
T
D
Y
G
T
T
Y
E
K
L
N
D
K
Site 29
Y240
S
T
D
Y
G
T
T
Y
E
K
L
N
D
K
V
Site 30
T251
N
D
K
V
G
L
K
T
V
L
S
Y
L
Y
V
Site 31
Y255
G
L
K
T
V
L
S
Y
L
Y
V
N
P
T
N
Site 32
Y257
K
T
V
L
S
Y
L
Y
V
N
P
T
N
K
R
Site 33
T261
S
Y
L
Y
V
N
P
T
N
K
R
K
I
M
L
Site 34
S270
K
R
K
I
M
L
L
S
D
P
E
M
E
S
S
Site 35
S276
L
S
D
P
E
M
E
S
S
I
L
I
S
S
D
Site 36
S277
S
D
P
E
M
E
S
S
I
L
I
S
S
D
E
Site 37
S281
M
E
S
S
I
L
I
S
S
D
E
G
A
T
Y
Site 38
S282
E
S
S
I
L
I
S
S
D
E
G
A
T
Y
Q
Site 39
Y288
S
S
D
E
G
A
T
Y
Q
K
Y
R
L
T
F
Site 40
Y291
E
G
A
T
Y
Q
K
Y
R
L
T
F
Y
I
Q
Site 41
T294
T
Y
Q
K
Y
R
L
T
F
Y
I
Q
S
L
L
Site 42
Y296
Q
K
Y
R
L
T
F
Y
I
Q
S
L
L
F
H
Site 43
S314
E
D
W
V
L
A
Y
S
L
D
Q
K
L
Y
S
Site 44
Y320
Y
S
L
D
Q
K
L
Y
S
S
M
D
F
G
R
Site 45
S321
S
L
D
Q
K
L
Y
S
S
M
D
F
G
R
R
Site 46
S322
L
D
Q
K
L
Y
S
S
M
D
F
G
R
R
W
Site 47
Y342
R
I
T
P
N
R
F
Y
W
S
V
A
G
L
D
Site 48
S344
T
P
N
R
F
Y
W
S
V
A
G
L
D
K
E
Site 49
Y365
E
V
R
T
T
D
G
Y
A
H
Y
L
T
C
R
Site 50
Y368
T
T
D
G
Y
A
H
Y
L
T
C
R
I
Q
E
Site 51
T379
R
I
Q
E
C
A
E
T
T
R
S
G
P
F
A
Site 52
T380
I
Q
E
C
A
E
T
T
R
S
G
P
F
A
R
Site 53
S382
E
C
A
E
T
T
R
S
G
P
F
A
R
S
I
Site 54
S393
A
R
S
I
D
I
S
S
L
V
V
Q
D
E
Y
Site 55
T406
E
Y
I
F
I
Q
V
T
T
S
G
R
A
S
Y
Site 56
S412
V
T
T
S
G
R
A
S
Y
Y
V
S
Y
R
R
Site 57
Y413
T
T
S
G
R
A
S
Y
Y
V
S
Y
R
R
E
Site 58
Y414
T
S
G
R
A
S
Y
Y
V
S
Y
R
R
E
A
Site 59
S416
G
R
A
S
Y
Y
V
S
Y
R
R
E
A
F
A
Site 60
Y430
A
Q
I
K
L
P
K
Y
S
L
P
K
D
M
H
Site 61
S431
Q
I
K
L
P
K
Y
S
L
P
K
D
M
H
I
Site 62
Y459
E
W
N
Q
N
D
T
Y
N
L
Y
I
S
D
T
Site 63
Y462
Q
N
D
T
Y
N
L
Y
I
S
D
T
R
G
I
Site 64
Y470
I
S
D
T
R
G
I
Y
F
T
L
A
M
E
N
Site 65
T472
D
T
R
G
I
Y
F
T
L
A
M
E
N
I
K
Site 66
S480
L
A
M
E
N
I
K
S
S
R
G
L
M
G
N
Site 67
S481
A
M
E
N
I
K
S
S
R
G
L
M
G
N
I
Site 68
S555
L
H
L
H
L
Q
L
S
E
N
P
Y
S
S
G
Site 69
Y559
L
Q
L
S
E
N
P
Y
S
S
G
R
I
S
S
Site 70
S560
Q
L
S
E
N
P
Y
S
S
G
R
I
S
S
K
Site 71
S561
L
S
E
N
P
Y
S
S
G
R
I
S
S
K
E
Site 72
S565
P
Y
S
S
G
R
I
S
S
K
E
T
A
P
G
Site 73
S566
Y
S
S
G
R
I
S
S
K
E
T
A
P
G
L
Site 74
S594
T
D
I
G
V
F
I
S
S
D
G
G
N
T
W
Site 75
S595
D
I
G
V
F
I
S
S
D
G
G
N
T
W
R
Site 76
Y646
E
G
H
S
W
D
K
Y
G
F
T
S
V
P
L
Site 77
T649
S
W
D
K
Y
G
F
T
S
V
P
L
F
V
D
Site 78
Y688
W
Q
L
V
K
V
D
Y
K
S
I
F
S
R
H
Site 79
Y701
R
H
C
T
K
E
D
Y
Q
T
W
H
L
L
N
Site 80
S737
C
A
L
G
R
D
H
S
G
S
V
V
S
E
P
Site 81
S739
L
G
R
D
H
S
G
S
V
V
S
E
P
C
V
Site 82
Y758
D
F
E
C
D
Y
G
Y
E
R
H
G
E
S
Q
Site 83
Y772
Q
C
V
P
A
F
W
Y
N
P
A
S
P
S
K
Site 84
S776
A
F
W
Y
N
P
A
S
P
S
K
D
C
S
L
Site 85
S778
W
Y
N
P
A
S
P
S
K
D
C
S
L
G
Q
Site 86
S782
A
S
P
S
K
D
C
S
L
G
Q
S
Y
L
N
Site 87
S786
K
D
C
S
L
G
Q
S
Y
L
N
S
T
G
Y
Site 88
Y787
D
C
S
L
G
Q
S
Y
L
N
S
T
G
Y
R
Site 89
S790
L
G
Q
S
Y
L
N
S
T
G
Y
R
R
I
V
Site 90
Y793
S
Y
L
N
S
T
G
Y
R
R
I
V
S
N
N
Site 91
S798
T
G
Y
R
R
I
V
S
N
N
C
T
D
G
L
Site 92
T802
R
I
V
S
N
N
C
T
D
G
L
R
E
K
Y
Site 93
Y809
T
D
G
L
R
E
K
Y
T
A
K
A
Q
M
C
Site 94
T810
D
G
L
R
E
K
Y
T
A
K
A
Q
M
C
P
Site 95
T842
A
E
Q
G
H
N
A
T
F
I
I
L
M
E
E
Site 96
S873
A
V
S
Y
A
N
F
S
P
I
E
D
G
I
K
Site 97
Y883
E
D
G
I
K
H
V
Y
K
S
A
G
I
F
Q
Site 98
Y894
G
I
F
Q
V
T
A
Y
A
E
N
N
L
G
S
Site 99
S934
R
N
K
E
V
N
I
S
A
V
V
W
P
S
Q
Site 100
Y947
S
Q
L
G
T
L
T
Y
F
W
W
F
G
N
S
Site 101
T960
N
S
T
K
P
L
I
T
L
D
S
S
I
S
F
Site 102
Y999
K
E
I
A
V
H
E
Y
F
Q
S
Q
L
L
S
Site 103
S1002
A
V
H
E
Y
F
Q
S
Q
L
L
S
F
S
P
Site 104
S1006
Y
F
Q
S
Q
L
L
S
F
S
P
N
L
D
Y
Site 105
S1008
Q
S
Q
L
L
S
F
S
P
N
L
D
Y
H
N
Site 106
Y1013
S
F
S
P
N
L
D
Y
H
N
P
D
I
P
E
Site 107
T1067
I
L
P
P
K
N
L
T
E
R
R
K
G
N
E
Site 108
S1118
T
L
A
P
L
V
D
S
S
A
G
H
S
S
S
Site 109
S1119
L
A
P
L
V
D
S
S
A
G
H
S
S
S
A
Site 110
Y1156
K
I
P
W
I
N
I
Y
A
Q
V
Q
H
D
K
Site 111
S1170
K
E
Q
E
M
I
G
S
V
S
Q
S
E
N
A
Site 112
S1172
Q
E
M
I
G
S
V
S
Q
S
E
N
A
P
K
Site 113
S1174
M
I
G
S
V
S
Q
S
E
N
A
P
K
I
T
Site 114
T1181
S
E
N
A
P
K
I
T
L
S
D
F
T
E
P
Site 115
S1183
N
A
P
K
I
T
L
S
D
F
T
E
P
E
E
Site 116
T1186
K
I
T
L
S
D
F
T
E
P
E
E
L
L
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation