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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLCL2
Full Name:
Inactive phospholipase C-like protein 2
Alias:
KIAA1092; Phospholipase C epsilon 2; Phospholipase C-L2; Phospholipase C-like 2; PLCE2; PLC-L(2); PLC-L2
Type:
Enzyme, phospholipid phospholipase (inactive)
Mass (Da):
125866
Number AA:
1127
UniProt ID:
Q9UPR0
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004435
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0006629
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
A
A
G
G
A
L
P
T
S
P
G
P
A
L
G
Site 2
S17
A
G
G
A
L
P
T
S
P
G
P
A
L
G
A
Site 3
Y49
L
G
H
G
R
A
R
Y
D
S
G
G
V
S
N
Site 4
S51
H
G
R
A
R
Y
D
S
G
G
V
S
N
G
D
Site 5
S55
R
Y
D
S
G
G
V
S
N
G
D
C
S
L
G
Site 6
S60
G
V
S
N
G
D
C
S
L
G
V
S
G
D
E
Site 7
S64
G
D
C
S
L
G
V
S
G
D
E
A
R
A
S
Site 8
S71
S
G
D
E
A
R
A
S
P
T
R
G
P
R
G
Site 9
T91
T
P
S
A
V
V
C
T
L
P
R
E
S
K
P
Site 10
S96
V
C
T
L
P
R
E
S
K
P
G
G
L
P
R
Site 11
S105
P
G
G
L
P
R
R
S
S
I
I
K
D
G
T
Site 12
S106
G
G
L
P
R
R
S
S
I
I
K
D
G
T
K
Site 13
T112
S
S
I
I
K
D
G
T
K
Q
K
R
E
R
K
Site 14
T121
Q
K
R
E
R
K
K
T
V
S
F
S
S
M
P
Site 15
S123
R
E
R
K
K
T
V
S
F
S
S
M
P
T
E
Site 16
S125
R
K
K
T
V
S
F
S
S
M
P
T
E
K
K
Site 17
S126
K
K
T
V
S
F
S
S
M
P
T
E
K
K
I
Site 18
T129
V
S
F
S
S
M
P
T
E
K
K
I
S
S
A
Site 19
S134
M
P
T
E
K
K
I
S
S
A
S
D
C
I
N
Site 20
S135
P
T
E
K
K
I
S
S
A
S
D
C
I
N
S
Site 21
S137
E
K
K
I
S
S
A
S
D
C
I
N
S
M
V
Site 22
S142
S
A
S
D
C
I
N
S
M
V
E
G
S
E
L
Site 23
S154
S
E
L
K
K
V
R
S
N
S
R
I
Y
H
R
Site 24
S156
L
K
K
V
R
S
N
S
R
I
Y
H
R
Y
F
Site 25
Y159
V
R
S
N
S
R
I
Y
H
R
Y
F
L
L
D
Site 26
Y162
N
S
R
I
Y
H
R
Y
F
L
L
D
A
D
M
Site 27
S171
L
L
D
A
D
M
Q
S
L
R
W
E
P
S
K
Site 28
S177
Q
S
L
R
W
E
P
S
K
K
D
S
E
K
A
Site 29
S181
W
E
P
S
K
K
D
S
E
K
A
K
I
D
I
Site 30
S190
K
A
K
I
D
I
K
S
I
K
E
V
R
T
G
Site 31
T200
E
V
R
T
G
K
N
T
D
I
F
R
S
N
G
Site 32
S205
K
N
T
D
I
F
R
S
N
G
I
S
D
Q
I
Site 33
S209
I
F
R
S
N
G
I
S
D
Q
I
S
E
D
C
Site 34
S213
N
G
I
S
D
Q
I
S
E
D
C
A
F
S
V
Site 35
S228
I
Y
G
E
N
Y
E
S
L
D
L
V
A
N
S
Site 36
Y248
I
W
V
T
G
L
R
Y
L
I
S
Y
G
K
H
Site 37
S251
T
G
L
R
Y
L
I
S
Y
G
K
H
T
L
D
Site 38
Y252
G
L
R
Y
L
I
S
Y
G
K
H
T
L
D
M
Site 39
S262
H
T
L
D
M
L
E
S
S
Q
D
N
M
R
T
Site 40
S263
T
L
D
M
L
E
S
S
Q
D
N
M
R
T
S
Site 41
S273
N
M
R
T
S
W
V
S
Q
M
F
S
E
I
D
Site 42
S277
S
W
V
S
Q
M
F
S
E
I
D
V
D
N
L
Site 43
S318
K
F
K
E
L
H
K
S
K
D
K
A
G
T
E
Site 44
T360
S
N
K
E
F
L
D
T
K
D
L
M
M
F
L
Site 45
Y388
S
L
E
I
I
H
K
Y
E
P
S
K
E
G
Q
Site 46
Y408
S
I
D
G
F
T
N
Y
L
M
S
P
D
C
Y
Site 47
Y415
Y
L
M
S
P
D
C
Y
I
F
D
P
E
H
K
Site 48
S433
Q
D
M
K
Q
P
L
S
H
Y
F
I
N
S
S
Site 49
Y435
M
K
Q
P
L
S
H
Y
F
I
N
S
S
H
N
Site 50
T443
F
I
N
S
S
H
N
T
Y
L
I
E
D
Q
F
Site 51
Y444
I
N
S
S
H
N
T
Y
L
I
E
D
Q
F
R
Site 52
S454
E
D
Q
F
R
G
P
S
D
I
T
G
Y
I
R
Site 53
Y459
G
P
S
D
I
T
G
Y
I
R
A
L
K
M
G
Site 54
Y485
P
D
N
E
P
V
I
Y
T
G
H
T
M
T
S
Site 55
Y544
K
L
L
G
D
K
L
Y
T
T
S
P
N
V
E
Site 56
T545
L
L
G
D
K
L
Y
T
T
S
P
N
V
E
E
Site 57
S547
G
D
K
L
Y
T
T
S
P
N
V
E
E
S
Y
Site 58
S553
T
S
P
N
V
E
E
S
Y
L
P
S
P
D
V
Site 59
Y554
S
P
N
V
E
E
S
Y
L
P
S
P
D
V
L
Site 60
S557
V
E
E
S
Y
L
P
S
P
D
V
L
K
G
K
Site 61
S573
L
I
K
A
K
K
L
S
S
N
C
S
G
V
E
Site 62
S574
I
K
A
K
K
L
S
S
N
C
S
G
V
E
G
Site 63
S577
K
K
L
S
S
N
C
S
G
V
E
G
D
V
T
Site 64
T584
S
G
V
E
G
D
V
T
D
E
D
E
G
A
E
Site 65
S593
E
D
E
G
A
E
M
S
Q
R
M
G
K
E
N
Site 66
S627
E
L
V
S
I
C
K
S
V
Q
F
K
E
F
Q
Site 67
Y642
V
S
F
Q
V
Q
K
Y
W
E
V
C
S
F
N
Site 68
S654
S
F
N
E
V
L
A
S
K
Y
A
N
E
N
P
Site 69
Y656
N
E
V
L
A
S
K
Y
A
N
E
N
P
G
D
Site 70
Y667
N
P
G
D
F
V
N
Y
N
K
R
F
L
A
R
Site 71
S684
P
S
P
M
R
I
D
S
S
N
M
N
P
Q
D
Site 72
S685
S
P
M
R
I
D
S
S
N
M
N
P
Q
D
F
Site 73
Y726
R
Q
N
G
N
C
G
Y
V
L
R
P
A
I
M
Site 74
S738
A
I
M
R
E
E
V
S
F
F
S
A
N
T
K
Site 75
S741
R
E
E
V
S
F
F
S
A
N
T
K
D
S
V
Site 76
S747
F
S
A
N
T
K
D
S
V
P
G
V
S
P
Q
Site 77
S752
K
D
S
V
P
G
V
S
P
Q
L
L
H
I
K
Site 78
Y782
K
G
D
V
V
D
P
Y
V
Y
V
E
I
H
G
Site 79
T801
C
A
E
Q
R
T
K
T
V
H
Q
N
G
D
A
Site 80
S814
D
A
P
I
F
D
E
S
F
E
F
Q
I
N
L
Site 81
T881
L
F
V
H
V
A
I
T
N
R
R
G
G
G
K
Site 82
S895
K
P
H
K
R
G
L
S
V
R
K
G
K
K
S
Site 83
S902
S
V
R
K
G
K
K
S
R
E
Y
A
S
L
R
Site 84
Y905
K
G
K
K
S
R
E
Y
A
S
L
R
T
L
W
Site 85
S907
K
K
S
R
E
Y
A
S
L
R
T
L
W
I
K
Site 86
T915
L
R
T
L
W
I
K
T
V
D
E
V
F
K
N
Site 87
T931
Q
P
P
I
R
D
A
T
D
L
R
E
N
M
Q
Site 88
Y984
V
L
N
L
S
E
Q
Y
P
T
M
E
L
Q
G
Site 89
T986
N
L
S
E
Q
Y
P
T
M
E
L
Q
G
I
V
Site 90
Y1004
L
K
K
I
V
T
T
Y
D
M
M
I
Q
S
L
Site 91
Y1022
I
E
N
A
D
A
V
Y
E
K
I
V
H
C
Q
Site 92
S1041
E
F
H
E
H
L
H
S
I
G
T
K
E
G
L
Site 93
Y1076
G
Q
A
D
L
L
K
Y
A
K
N
E
T
L
E
Site 94
T1102
C
G
L
N
K
P
G
T
E
N
A
D
V
Q
K
Site 95
S1113
D
V
Q
K
P
R
R
S
L
E
V
I
P
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation