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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CENTG2
Full Name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
Alias:
AGAP1; AGAP-1; ArfGAP with GTPase domain, ankyrin repeat and PH domain 1; ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1; CENG2; Centaurin-gamma 2; Centaurin-gamma-2; GGAP1; GTP-binding and GTPase-activating protein 1; KIAA1099
Type:
Intracellular, Cytoplasm protein
Mass (Da):
94470
Number AA:
857
UniProt ID:
Q9UPQ3
International Prot ID:
IPI00456242
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0008060
GO:0005525
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
GO:0032312
GO:0007264
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
A
E
I
Q
R
F
E
S
V
H
P
N
I
Y
S
Site 2
S29
S
V
H
P
N
I
Y
S
I
Y
E
L
L
E
R
Site 3
S60
I
E
D
A
F
V
N
S
Q
E
W
T
L
S
R
Site 4
T64
F
V
N
S
Q
E
W
T
L
S
R
S
V
P
E
Site 5
S66
N
S
Q
E
W
T
L
S
R
S
V
P
E
L
K
Site 6
S68
Q
E
W
T
L
S
R
S
V
P
E
L
K
V
G
Site 7
S85
G
N
L
A
S
G
K
S
A
L
V
H
R
Y
L
Site 8
Y91
K
S
A
L
V
H
R
Y
L
T
G
T
Y
V
Q
Site 9
T93
A
L
V
H
R
Y
L
T
G
T
Y
V
Q
E
E
Site 10
T95
V
H
R
Y
L
T
G
T
Y
V
Q
E
E
S
P
Site 11
Y96
H
R
Y
L
T
G
T
Y
V
Q
E
E
S
P
E
Site 12
S101
G
T
Y
V
Q
E
E
S
P
E
G
G
R
F
K
Site 13
T154
E
D
E
I
S
F
Q
T
V
Y
H
Y
Y
S
R
Site 14
Y156
E
I
S
F
Q
T
V
Y
H
Y
Y
S
R
M
A
Site 15
Y158
S
F
Q
T
V
Y
H
Y
Y
S
R
M
A
N
Y
Site 16
Y159
F
Q
T
V
Y
H
Y
Y
S
R
M
A
N
Y
R
Site 17
T168
R
M
A
N
Y
R
N
T
S
E
I
P
L
V
L
Site 18
S183
V
G
T
Q
D
A
I
S
S
A
N
P
R
V
I
Site 19
S199
D
A
R
A
R
K
L
S
N
D
L
K
R
C
T
Site 20
Y207
N
D
L
K
R
C
T
Y
Y
E
T
C
A
T
Y
Site 21
Y208
D
L
K
R
C
T
Y
Y
E
T
C
A
T
Y
G
Site 22
T213
T
Y
Y
E
T
C
A
T
Y
G
L
N
V
E
R
Site 23
S239
T
R
K
K
Q
Q
L
S
I
G
P
C
K
S
L
Site 24
S245
L
S
I
G
P
C
K
S
L
P
N
S
P
S
H
Site 25
S249
P
C
K
S
L
P
N
S
P
S
H
S
S
V
C
Site 26
S251
K
S
L
P
N
S
P
S
H
S
S
V
C
S
A
Site 27
S253
L
P
N
S
P
S
H
S
S
V
C
S
A
Q
V
Site 28
S254
P
N
S
P
S
H
S
S
V
C
S
A
Q
V
S
Site 29
S257
P
S
H
S
S
V
C
S
A
Q
V
S
A
V
H
Site 30
S266
Q
V
S
A
V
H
I
S
Q
T
S
N
G
G
G
Site 31
T268
S
A
V
H
I
S
Q
T
S
N
G
G
G
S
L
Site 32
S269
A
V
H
I
S
Q
T
S
N
G
G
G
S
L
S
Site 33
S274
Q
T
S
N
G
G
G
S
L
S
D
Y
S
S
S
Site 34
S276
S
N
G
G
G
S
L
S
D
Y
S
S
S
V
P
Site 35
Y278
G
G
G
S
L
S
D
Y
S
S
S
V
P
S
T
Site 36
S279
G
G
S
L
S
D
Y
S
S
S
V
P
S
T
P
Site 37
S280
G
S
L
S
D
Y
S
S
S
V
P
S
T
P
S
Site 38
S281
S
L
S
D
Y
S
S
S
V
P
S
T
P
S
T
Site 39
S284
D
Y
S
S
S
V
P
S
T
P
S
T
S
Q
K
Site 40
T285
Y
S
S
S
V
P
S
T
P
S
T
S
Q
K
E
Site 41
S287
S
S
V
P
S
T
P
S
T
S
Q
K
E
L
R
Site 42
T288
S
V
P
S
T
P
S
T
S
Q
K
E
L
R
I
Site 43
S289
V
P
S
T
P
S
T
S
Q
K
E
L
R
I
D
Site 44
T303
D
V
P
P
T
A
N
T
P
T
P
V
R
K
Q
Site 45
T305
P
P
T
A
N
T
P
T
P
V
R
K
Q
S
K
Site 46
S311
P
T
P
V
R
K
Q
S
K
R
R
S
N
L
F
Site 47
S315
R
K
Q
S
K
R
R
S
N
L
F
T
S
R
K
Site 48
T319
K
R
R
S
N
L
F
T
S
R
K
G
S
D
P
Site 49
S320
R
R
S
N
L
F
T
S
R
K
G
S
D
P
D
Site 50
S324
L
F
T
S
R
K
G
S
D
P
D
K
E
K
K
Site 51
S335
K
E
K
K
G
L
E
S
R
A
D
S
I
G
S
Site 52
S339
G
L
E
S
R
A
D
S
I
G
S
G
R
A
I
Site 53
S342
S
R
A
D
S
I
G
S
G
R
A
I
P
I
K
Site 54
S360
L
L
K
R
S
G
K
S
L
N
K
E
W
K
K
Site 55
Y369
N
K
E
W
K
K
K
Y
V
T
L
C
D
N
G
Site 56
T371
E
W
K
K
K
Y
V
T
L
C
D
N
G
V
L
Site 57
T379
L
C
D
N
G
V
L
T
Y
H
P
S
L
H
D
Site 58
Y380
C
D
N
G
V
L
T
Y
H
P
S
L
H
D
Y
Site 59
Y387
Y
H
P
S
L
H
D
Y
M
Q
N
V
H
G
K
Site 60
T402
E
I
D
L
L
R
T
T
V
K
V
P
G
K
R
Site 61
T414
G
K
R
P
P
R
A
T
S
A
C
A
P
I
S
Site 62
S415
K
R
P
P
R
A
T
S
A
C
A
P
I
S
S
Site 63
S421
T
S
A
C
A
P
I
S
S
P
K
T
N
G
L
Site 64
S422
S
A
C
A
P
I
S
S
P
K
T
N
G
L
S
Site 65
T425
A
P
I
S
S
P
K
T
N
G
L
S
K
D
M
Site 66
S429
S
P
K
T
N
G
L
S
K
D
M
S
S
L
H
Site 67
S433
N
G
L
S
K
D
M
S
S
L
H
I
S
P
N
Site 68
S434
G
L
S
K
D
M
S
S
L
H
I
S
P
N
S
Site 69
S438
D
M
S
S
L
H
I
S
P
N
S
G
N
V
T
Site 70
S441
S
L
H
I
S
P
N
S
G
N
V
T
S
A
S
Site 71
T445
S
P
N
S
G
N
V
T
S
A
S
G
S
Q
M
Site 72
S446
P
N
S
G
N
V
T
S
A
S
G
S
Q
M
A
Site 73
S448
S
G
N
V
T
S
A
S
G
S
Q
M
A
S
G
Site 74
S450
N
V
T
S
A
S
G
S
Q
M
A
S
G
I
S
Site 75
S457
S
Q
M
A
S
G
I
S
L
V
S
F
N
S
R
Site 76
S460
A
S
G
I
S
L
V
S
F
N
S
R
P
D
G
Site 77
S463
I
S
L
V
S
F
N
S
R
P
D
G
M
H
Q
Site 78
S472
P
D
G
M
H
Q
R
S
Y
S
V
S
S
A
D
Site 79
Y473
D
G
M
H
Q
R
S
Y
S
V
S
S
A
D
Q
Site 80
S474
G
M
H
Q
R
S
Y
S
V
S
S
A
D
Q
W
Site 81
S476
H
Q
R
S
Y
S
V
S
S
A
D
Q
W
S
E
Site 82
S494
I
A
N
S
A
I
S
S
D
T
G
L
G
D
S
Site 83
S501
S
D
T
G
L
G
D
S
V
C
S
S
P
S
I
Site 84
S504
G
L
G
D
S
V
C
S
S
P
S
I
S
S
T
Site 85
S505
L
G
D
S
V
C
S
S
P
S
I
S
S
T
T
Site 86
S507
D
S
V
C
S
S
P
S
I
S
S
T
T
S
P
Site 87
S509
V
C
S
S
P
S
I
S
S
T
T
S
P
K
L
Site 88
T511
S
S
P
S
I
S
S
T
T
S
P
K
L
D
P
Site 89
S513
P
S
I
S
S
T
T
S
P
K
L
D
P
P
P
Site 90
S521
P
K
L
D
P
P
P
S
P
H
A
N
R
K
K
Site 91
S534
K
K
H
R
R
K
K
S
T
S
N
F
K
A
D
Site 92
T535
K
H
R
R
K
K
S
T
S
N
F
K
A
D
G
Site 93
S536
H
R
R
K
K
S
T
S
N
F
K
A
D
G
L
Site 94
S544
N
F
K
A
D
G
L
S
G
T
A
E
E
Q
E
Site 95
Y573
W
H
F
E
A
T
T
Y
E
E
R
D
A
W
V
Site 96
S590
I
E
S
Q
I
L
A
S
L
Q
S
C
E
S
S
Site 97
S593
Q
I
L
A
S
L
Q
S
C
E
S
S
K
N
K
Site 98
S596
A
S
L
Q
S
C
E
S
S
K
N
K
S
R
L
Site 99
S597
S
L
Q
S
C
E
S
S
K
N
K
S
R
L
T
Site 100
S601
C
E
S
S
K
N
K
S
R
L
T
S
Q
S
E
Site 101
T604
S
K
N
K
S
R
L
T
S
Q
S
E
A
M
A
Site 102
S605
K
N
K
S
R
L
T
S
Q
S
E
A
M
A
L
Site 103
S607
K
S
R
L
T
S
Q
S
E
A
M
A
L
Q
S
Site 104
S614
S
E
A
M
A
L
Q
S
I
R
N
M
R
G
N
Site 105
S659
R
N
L
G
T
H
L
S
R
V
R
S
L
D
L
Site 106
S663
T
H
L
S
R
V
R
S
L
D
L
D
D
W
P
Site 107
S687
I
G
N
E
L
A
N
S
V
W
E
E
S
S
Q
Site 108
S693
N
S
V
W
E
E
S
S
Q
G
R
T
K
P
S
Site 109
T697
E
E
S
S
Q
G
R
T
K
P
S
V
D
S
T
Site 110
S700
S
Q
G
R
T
K
P
S
V
D
S
T
R
E
E
Site 111
S703
R
T
K
P
S
V
D
S
T
R
E
E
K
E
R
Site 112
T704
T
K
P
S
V
D
S
T
R
E
E
K
E
R
W
Site 113
Y716
E
R
W
I
R
A
K
Y
E
Q
K
L
F
L
A
Site 114
T740
G
Q
H
L
L
R
A
T
A
D
E
D
L
R
T
Site 115
T763
S
R
D
E
V
N
E
T
C
G
E
G
D
G
R
Site 116
T771
C
G
E
G
D
G
R
T
A
L
H
L
A
C
R
Site 117
Y808
H
G
N
T
A
L
A
Y
A
R
Q
A
S
S
Q
Site 118
S813
L
A
Y
A
R
Q
A
S
S
Q
E
C
I
D
V
Site 119
S814
A
Y
A
R
Q
A
S
S
Q
E
C
I
D
V
L
Site 120
T836
E
R
F
V
L
M
A
T
P
N
L
S
R
R
N
Site 121
S840
L
M
A
T
P
N
L
S
R
R
N
N
N
R
N
Site 122
S849
R
N
N
N
R
N
N
S
S
G
R
V
P
T
I
Site 123
S850
N
N
N
R
N
N
S
S
G
R
V
P
T
I
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation