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Updated November 2019
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Protein Info
Short Name:
LIMCH1
Full Name:
LIM and calponin homology domains-containing protein 1
Alias:
DKFZp451D112; DKFZP686A01247; LIM and calponin homology domains 1; LIM and calponiny domains 1; LIMCH1A; LMO7B
Type:
Unknown function
Mass (Da):
121837
Number AA:
1083
UniProt ID:
Q9UPQ0
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0031032
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
P
P
P
E
P
A
F
S
E
A
Q
K
W
I
E
Site 2
T35
Q
K
W
I
E
Q
V
T
G
R
S
F
G
D
K
Site 3
S38
I
E
Q
V
T
G
R
S
F
G
D
K
D
F
R
Site 4
T46
F
G
D
K
D
F
R
T
G
L
E
N
G
I
L
Site 5
T74
K
K
I
N
R
L
P
T
P
I
A
G
L
D
N
Site 6
S97
K
E
L
G
L
K
E
S
Q
L
F
D
P
S
D
Site 7
S103
E
S
Q
L
F
D
P
S
D
L
Q
D
T
S
N
Site 8
T108
D
P
S
D
L
Q
D
T
S
N
R
V
T
V
K
Site 9
S109
P
S
D
L
Q
D
T
S
N
R
V
T
V
K
S
Site 10
T113
Q
D
T
S
N
R
V
T
V
K
S
L
D
Y
S
Site 11
S116
S
N
R
V
T
V
K
S
L
D
Y
S
R
K
L
Site 12
Y119
V
T
V
K
S
L
D
Y
S
R
K
L
K
N
V
Site 13
S120
T
V
K
S
L
D
Y
S
R
K
L
K
N
V
L
Site 14
S142
K
A
A
N
S
C
T
S
Y
S
G
T
T
L
N
Site 15
Y143
A
A
N
S
C
T
S
Y
S
G
T
T
L
N
L
Site 16
T146
S
C
T
S
Y
S
G
T
T
L
N
L
K
E
F
Site 17
T164
L
A
Q
M
R
K
D
T
D
D
I
E
S
P
K
Site 18
S169
K
D
T
D
D
I
E
S
P
K
R
S
I
R
D
Site 19
S173
D
I
E
S
P
K
R
S
I
R
D
S
G
Y
I
Site 20
S177
P
K
R
S
I
R
D
S
G
Y
I
D
C
W
D
Site 21
Y179
R
S
I
R
D
S
G
Y
I
D
C
W
D
S
E
Site 22
S185
G
Y
I
D
C
W
D
S
E
R
S
D
S
L
S
Site 23
S188
D
C
W
D
S
E
R
S
D
S
L
S
P
P
R
Site 24
S190
W
D
S
E
R
S
D
S
L
S
P
P
R
H
G
Site 25
S192
S
E
R
S
D
S
L
S
P
P
R
H
G
R
D
Site 26
S201
P
R
H
G
R
D
D
S
F
D
S
L
D
S
F
Site 27
S204
G
R
D
D
S
F
D
S
L
D
S
F
G
S
R
Site 28
S207
D
S
F
D
S
L
D
S
F
G
S
R
S
R
Q
Site 29
S210
D
S
L
D
S
F
G
S
R
S
R
Q
T
P
S
Site 30
S212
L
D
S
F
G
S
R
S
R
Q
T
P
S
P
D
Site 31
T215
F
G
S
R
S
R
Q
T
P
S
P
D
V
V
L
Site 32
S217
S
R
S
R
Q
T
P
S
P
D
V
V
L
R
G
Site 33
S225
P
D
V
V
L
R
G
S
S
D
G
R
G
S
D
Site 34
S226
D
V
V
L
R
G
S
S
D
G
R
G
S
D
S
Site 35
S231
G
S
S
D
G
R
G
S
D
S
E
S
D
L
P
Site 36
S233
S
D
G
R
G
S
D
S
E
S
D
L
P
H
R
Site 37
S235
G
R
G
S
D
S
E
S
D
L
P
H
R
K
L
Site 38
S251
D
V
K
K
D
D
M
S
A
R
R
T
S
H
G
Site 39
T255
D
D
M
S
A
R
R
T
S
H
G
E
P
K
S
Site 40
S256
D
M
S
A
R
R
T
S
H
G
E
P
K
S
A
Site 41
S262
T
S
H
G
E
P
K
S
A
V
P
F
N
Q
Y
Site 42
Y269
S
A
V
P
F
N
Q
Y
L
P
N
K
S
N
Q
Site 43
S274
N
Q
Y
L
P
N
K
S
N
Q
T
A
Y
V
P
Site 44
T277
L
P
N
K
S
N
Q
T
A
Y
V
P
A
P
L
Site 45
Y279
N
K
S
N
Q
T
A
Y
V
P
A
P
L
R
K
Site 46
Y294
K
K
A
E
R
E
E
Y
R
K
S
W
S
T
A
Site 47
S297
E
R
E
E
Y
R
K
S
W
S
T
A
T
S
P
Site 48
S299
E
E
Y
R
K
S
W
S
T
A
T
S
P
L
G
Site 49
T300
E
Y
R
K
S
W
S
T
A
T
S
P
L
G
G
Site 50
T302
R
K
S
W
S
T
A
T
S
P
L
G
G
E
R
Site 51
S303
K
S
W
S
T
A
T
S
P
L
G
G
E
R
P
Site 52
Y313
G
G
E
R
P
F
R
Y
G
P
R
T
P
V
S
Site 53
T317
P
F
R
Y
G
P
R
T
P
V
S
D
D
A
E
Site 54
S320
Y
G
P
R
T
P
V
S
D
D
A
E
S
T
S
Site 55
S327
S
D
D
A
E
S
T
S
M
F
D
M
R
C
E
Site 56
S343
E
A
A
V
Q
P
H
S
R
A
R
Q
E
Q
L
Site 57
S373
D
D
L
A
R
W
K
S
R
R
R
S
V
S
Q
Site 58
S377
R
W
K
S
R
R
R
S
V
S
Q
D
L
I
K
Site 59
S379
K
S
R
R
R
S
V
S
Q
D
L
I
K
K
E
Site 60
S403
L
A
G
E
D
G
T
S
E
R
R
K
S
I
K
Site 61
S408
G
T
S
E
R
R
K
S
I
K
T
Y
R
E
I
Site 62
T411
E
R
R
K
S
I
K
T
Y
R
E
I
V
Q
E
Site 63
Y412
R
R
K
S
I
K
T
Y
R
E
I
V
Q
E
K
Site 64
S435
E
A
Y
K
N
A
R
S
Q
E
E
A
E
G
I
Site 65
Y446
A
E
G
I
L
Q
Q
Y
I
E
R
F
T
I
S
Site 66
T451
Q
Q
Y
I
E
R
F
T
I
S
E
A
V
L
E
Site 67
S471
K
I
L
E
R
S
H
S
T
E
P
N
L
S
S
Site 68
S477
H
S
T
E
P
N
L
S
S
F
L
N
D
P
N
Site 69
S478
S
T
E
P
N
L
S
S
F
L
N
D
P
N
P
Site 70
Y488
N
D
P
N
P
M
K
Y
L
R
Q
Q
S
L
P
Site 71
S493
M
K
Y
L
R
Q
Q
S
L
P
P
P
K
F
T
Site 72
T502
P
P
P
K
F
T
A
T
V
E
T
T
I
A
R
Site 73
S511
E
T
T
I
A
R
A
S
V
L
D
T
S
M
S
Site 74
T515
A
R
A
S
V
L
D
T
S
M
S
A
G
S
G
Site 75
S516
R
A
S
V
L
D
T
S
M
S
A
G
S
G
S
Site 76
S518
S
V
L
D
T
S
M
S
A
G
S
G
S
P
S
Site 77
S521
D
T
S
M
S
A
G
S
G
S
P
S
K
T
V
Site 78
S523
S
M
S
A
G
S
G
S
P
S
K
T
V
T
P
Site 79
S525
S
A
G
S
G
S
P
S
K
T
V
T
P
K
A
Site 80
T527
G
S
G
S
P
S
K
T
V
T
P
K
A
V
P
Site 81
T529
G
S
P
S
K
T
V
T
P
K
A
V
P
M
L
Site 82
T537
P
K
A
V
P
M
L
T
P
K
P
Y
S
Q
P
Site 83
Y541
P
M
L
T
P
K
P
Y
S
Q
P
K
N
S
Q
Site 84
S542
M
L
T
P
K
P
Y
S
Q
P
K
N
S
Q
D
Site 85
S547
P
Y
S
Q
P
K
N
S
Q
D
V
L
K
T
F
Site 86
T553
N
S
Q
D
V
L
K
T
F
K
V
D
G
K
V
Site 87
S561
F
K
V
D
G
K
V
S
V
N
G
E
T
V
H
Site 88
T566
K
V
S
V
N
G
E
T
V
H
R
E
E
E
K
Site 89
T579
E
K
E
R
E
C
P
T
V
A
P
A
H
S
L
Site 90
S585
P
T
V
A
P
A
H
S
L
T
K
S
Q
M
F
Site 91
S589
P
A
H
S
L
T
K
S
Q
M
F
E
G
V
A
Site 92
S601
G
V
A
R
V
H
G
S
P
L
E
L
K
Q
D
Site 93
S611
E
L
K
Q
D
N
G
S
I
E
I
N
I
K
K
Site 94
S621
I
N
I
K
K
P
N
S
V
P
Q
E
L
A
A
Site 95
T629
V
P
Q
E
L
A
A
T
T
E
K
T
E
P
N
Site 96
T633
L
A
A
T
T
E
K
T
E
P
N
S
Q
E
D
Site 97
S637
T
E
K
T
E
P
N
S
Q
E
D
K
N
D
G
Site 98
S647
D
K
N
D
G
G
K
S
R
K
G
N
I
E
L
Site 99
S657
G
N
I
E
L
A
S
S
E
P
Q
H
F
T
T
Site 100
T665
E
P
Q
H
F
T
T
T
V
T
R
C
S
P
T
Site 101
S670
T
T
T
V
T
R
C
S
P
T
V
A
F
V
E
Site 102
T672
T
V
T
R
C
S
P
T
V
A
F
V
E
F
P
Site 103
S681
A
F
V
E
F
P
S
S
P
Q
L
K
N
D
V
Site 104
S689
P
Q
L
K
N
D
V
S
E
E
K
D
Q
K
K
Site 105
S702
K
K
P
E
N
E
M
S
G
K
V
E
L
V
L
Site 106
S710
G
K
V
E
L
V
L
S
Q
K
V
V
K
P
K
Site 107
S718
Q
K
V
V
K
P
K
S
P
E
P
E
A
T
L
Site 108
T724
K
S
P
E
P
E
A
T
L
T
F
P
F
L
D
Site 109
T726
P
E
P
E
A
T
L
T
F
P
F
L
D
K
M
Site 110
S746
L
H
L
P
N
L
N
S
Q
V
D
S
P
S
S
Site 111
S750
N
L
N
S
Q
V
D
S
P
S
S
E
K
S
P
Site 112
S752
N
S
Q
V
D
S
P
S
S
E
K
S
P
V
T
Site 113
S753
S
Q
V
D
S
P
S
S
E
K
S
P
V
T
T
Site 114
S756
D
S
P
S
S
E
K
S
P
V
T
T
P
Q
F
Site 115
T759
S
S
E
K
S
P
V
T
T
P
Q
F
K
F
W
Site 116
T760
S
E
K
S
P
V
T
T
P
Q
F
K
F
W
A
Site 117
Y817
V
E
E
E
E
R
R
Y
Y
E
E
E
R
K
I
Site 118
Y818
E
E
E
E
R
R
Y
Y
E
E
E
R
K
I
I
Site 119
T833
E
D
T
V
V
P
F
T
V
S
S
S
S
A
D
Site 120
S837
V
P
F
T
V
S
S
S
S
A
D
Q
L
S
T
Site 121
S838
P
F
T
V
S
S
S
S
A
D
Q
L
S
T
S
Site 122
S843
S
S
S
A
D
Q
L
S
T
S
S
S
M
T
E
Site 123
S845
S
A
D
Q
L
S
T
S
S
S
M
T
E
G
S
Site 124
S846
A
D
Q
L
S
T
S
S
S
M
T
E
G
S
G
Site 125
S847
D
Q
L
S
T
S
S
S
M
T
E
G
S
G
T
Site 126
T849
L
S
T
S
S
S
M
T
E
G
S
G
T
M
N
Site 127
T854
S
M
T
E
G
S
G
T
M
N
K
I
D
L
G
Site 128
S875
Q
D
R
R
W
K
K
S
F
Q
G
D
D
S
D
Site 129
S881
K
S
F
Q
G
D
D
S
D
L
L
L
K
T
R
Site 130
S890
L
L
L
K
T
R
E
S
D
R
L
E
E
K
G
Site 131
S898
D
R
L
E
E
K
G
S
L
T
E
G
A
L
A
Site 132
S907
T
E
G
A
L
A
H
S
G
N
P
V
S
K
G
Site 133
S912
A
H
S
G
N
P
V
S
K
G
V
H
E
D
H
Site 134
T923
H
E
D
H
Q
L
D
T
E
A
G
A
P
H
C
Site 135
S941
P
Q
L
A
Q
D
P
S
Q
N
Q
Q
T
S
N
Site 136
T946
D
P
S
Q
N
Q
Q
T
S
N
P
T
H
S
S
Site 137
S947
P
S
Q
N
Q
Q
T
S
N
P
T
H
S
S
E
Site 138
S953
T
S
N
P
T
H
S
S
E
D
V
K
P
K
T
Site 139
T960
S
E
D
V
K
P
K
T
L
P
L
D
K
S
I
Site 140
S966
K
T
L
P
L
D
K
S
I
N
H
Q
I
E
S
Site 141
S973
S
I
N
H
Q
I
E
S
P
S
E
R
R
K
K
Site 142
S975
N
H
Q
I
E
S
P
S
E
R
R
K
K
S
P
Site 143
S981
P
S
E
R
R
K
K
S
P
R
E
H
F
Q
A
Site 144
S992
H
F
Q
A
G
P
F
S
P
C
S
P
T
P
P
Site 145
S995
A
G
P
F
S
P
C
S
P
T
P
P
G
Q
S
Site 146
T997
P
F
S
P
C
S
P
T
P
P
G
Q
S
P
N
Site 147
S1002
S
P
T
P
P
G
Q
S
P
N
R
S
I
S
G
Site 148
S1006
P
G
Q
S
P
N
R
S
I
S
G
K
K
L
C
Site 149
S1008
Q
S
P
N
R
S
I
S
G
K
K
L
C
S
S
Site 150
S1015
S
G
K
K
L
C
S
S
C
G
L
P
L
G
K
Site 151
S1054
G
Q
L
G
D
A
V
S
G
T
D
V
R
I
R
Site 152
T1056
L
G
D
A
V
S
G
T
D
V
R
I
R
N
G
Site 153
Y1071
L
L
N
C
N
D
C
Y
M
R
S
R
S
A
G
Site 154
S1076
D
C
Y
M
R
S
R
S
A
G
Q
P
T
T
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation