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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRIM33
Full Name:
Transcription intermediary factor 1-gamma
Alias:
EC 6.3.2.-; FLJ11429; KIAA1113; PTC7; Ret-fused gene 7; RET-fused gene 7 protein; RFG7; Rfg7 protein; TF1G; TIF1G; TIF1GAMMA; TIFGAMMA; Transcriptional intermediary factor 1 gamma; TRI33; Tripartite motif protein 33; Tripartite motif-containing 33; Tripartite motif-containing 33 (PTC7,TIF1G); Tripartite motif-containing 33 (PTC7;TIF1G)
Type:
Ligase; Protein kinase, atypical; EC 6.3.2.-; Transcription, coactivator/corepressor;
ATYPICAL
group; TIF1 family
Mass (Da):
122521
Number AA:
1127
UniProt ID:
Q9UPN9
International Prot ID:
IPI00010252
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0070412
GO:0070410
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0030514
GO:0016481
Phosida
TranscriptoNet
STRING
Kinexus Products
Transcription intermediary factor 1-gamma S1119 phosphosite-specific antibody AB-PK836#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK836#Transcription intermediary factor 1-gamma (R1116-R1122, human) pS1119 phosphopeptide - Powder PE-04AQB95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQB95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
K
G
G
G
E
A
E
S
G
G
G
G
S
G
S
Site 2
S19
S
G
G
G
G
S
G
S
A
P
V
T
A
G
A
Site 3
T39
Q
E
A
E
P
P
L
T
A
V
L
V
E
E
E
Site 4
S79
S
G
S
A
Q
A
A
S
S
P
A
A
S
V
G
Site 5
S80
G
S
A
Q
A
A
S
S
P
A
A
S
V
G
T
Site 6
S103
T
P
A
P
A
P
A
S
A
P
A
P
G
P
S
Site 7
S110
S
A
P
A
P
G
P
S
A
G
P
P
P
G
P
Site 8
S131
T
C
A
V
C
Q
Q
S
L
Q
S
R
R
E
A
Site 9
S134
V
C
Q
Q
S
L
Q
S
R
R
E
A
E
P
K
Site 10
S162
P
E
P
E
R
Q
L
S
V
P
I
P
G
G
S
Site 11
S169
S
V
P
I
P
G
G
S
N
G
D
I
Q
Q
V
Site 12
Y197
Q
I
D
L
V
D
N
Y
F
V
K
D
T
S
E
Site 13
T202
D
N
Y
F
V
K
D
T
S
E
A
P
S
S
S
Site 14
S203
N
Y
F
V
K
D
T
S
E
A
P
S
S
S
D
Site 15
S207
K
D
T
S
E
A
P
S
S
S
D
E
K
S
E
Site 16
S208
D
T
S
E
A
P
S
S
S
D
E
K
S
E
Q
Site 17
S209
T
S
E
A
P
S
S
S
D
E
K
S
E
Q
V
Site 18
S213
P
S
S
S
D
E
K
S
E
Q
V
C
T
S
C
Site 19
T218
E
K
S
E
Q
V
C
T
S
C
E
D
N
A
S
Site 20
S263
I
R
K
K
E
D
V
S
E
S
V
G
A
S
G
Site 21
S265
K
K
E
D
V
S
E
S
V
G
A
S
G
Q
R
Site 22
Y309
L
E
H
K
E
H
R
Y
Q
F
L
E
E
A
F
Site 23
Y336
K
L
L
E
K
K
N
Y
V
H
F
A
A
T
Q
Site 24
T354
R
I
K
E
V
N
E
T
N
K
R
V
E
Q
E
Site 25
S379
E
I
N
K
K
G
K
S
L
L
Q
Q
L
E
N
Site 26
T403
L
Q
Q
Q
N
D
I
T
G
L
S
R
Q
V
K
Site 27
T426
A
I
A
S
G
S
S
T
A
L
L
Y
S
K
R
Site 28
S480
L
G
N
L
V
I
E
S
K
P
A
P
G
Y
T
Site 29
Y486
E
S
K
P
A
P
G
Y
T
P
N
V
V
V
G
Site 30
T487
S
K
P
A
P
G
Y
T
P
N
V
V
V
G
Q
Site 31
T499
V
G
Q
V
P
P
G
T
N
H
I
S
K
T
P
Site 32
S503
P
P
G
T
N
H
I
S
K
T
P
G
Q
I
N
Site 33
T505
G
T
N
H
I
S
K
T
P
G
Q
I
N
L
A
Site 34
Y524
Q
H
M
Q
Q
Q
V
Y
A
Q
K
H
Q
Q
L
Site 35
S571
Q
Q
P
P
R
L
I
S
V
Q
T
M
Q
R
G
Site 36
S606
I
P
G
I
P
R
H
S
G
P
Q
Y
S
M
M
Site 37
Y610
P
R
H
S
G
P
Q
Y
S
M
M
Q
P
H
L
Site 38
S622
P
H
L
Q
R
Q
H
S
N
P
G
H
A
G
P
Site 39
T638
P
V
V
S
V
H
N
T
T
I
N
P
T
S
P
Site 40
S644
N
T
T
I
N
P
T
S
P
T
T
A
T
M
A
Site 41
T658
A
N
A
N
R
G
P
T
S
P
S
V
T
A
I
Site 42
S659
N
A
N
R
G
P
T
S
P
S
V
T
A
I
E
Site 43
S661
N
R
G
P
T
S
P
S
V
T
A
I
E
L
I
Site 44
S679
T
N
P
E
N
L
P
S
L
P
D
I
P
P
I
Site 45
S693
I
Q
L
E
D
A
G
S
S
S
L
D
N
L
L
Site 46
S695
L
E
D
A
G
S
S
S
L
D
N
L
L
S
R
Site 47
S701
S
S
L
D
N
L
L
S
R
Y
I
S
G
S
H
Site 48
Y703
L
D
N
L
L
S
R
Y
I
S
G
S
H
L
P
Site 49
S705
N
L
L
S
R
Y
I
S
G
S
H
L
P
P
Q
Site 50
S707
L
S
R
Y
I
S
G
S
H
L
P
P
Q
P
T
Site 51
T714
S
H
L
P
P
Q
P
T
S
T
M
N
P
S
P
Site 52
S715
H
L
P
P
Q
P
T
S
T
M
N
P
S
P
G
Site 53
T716
L
P
P
Q
P
T
S
T
M
N
P
S
P
G
P
Site 54
S720
P
T
S
T
M
N
P
S
P
G
P
S
A
L
S
Site 55
S724
M
N
P
S
P
G
P
S
A
L
S
P
G
S
S
Site 56
S727
S
P
G
P
S
A
L
S
P
G
S
S
G
L
S
Site 57
S730
P
S
A
L
S
P
G
S
S
G
L
S
N
S
H
Site 58
S731
S
A
L
S
P
G
S
S
G
L
S
N
S
H
T
Site 59
S734
S
P
G
S
S
G
L
S
N
S
H
T
P
V
R
Site 60
S736
G
S
S
G
L
S
N
S
H
T
P
V
R
P
P
Site 61
T738
S
G
L
S
N
S
H
T
P
V
R
P
P
S
T
Site 62
S744
H
T
P
V
R
P
P
S
T
S
S
T
G
S
R
Site 63
T745
T
P
V
R
P
P
S
T
S
S
T
G
S
R
G
Site 64
S746
P
V
R
P
P
S
T
S
S
T
G
S
R
G
S
Site 65
S747
V
R
P
P
S
T
S
S
T
G
S
R
G
S
C
Site 66
T748
R
P
P
S
T
S
S
T
G
S
R
G
S
C
G
Site 67
S750
P
S
T
S
S
T
G
S
R
G
S
C
G
S
S
Site 68
S753
S
S
T
G
S
R
G
S
C
G
S
S
G
R
T
Site 69
S756
G
S
R
G
S
C
G
S
S
G
R
T
A
E
K
Site 70
S757
S
R
G
S
C
G
S
S
G
R
T
A
E
K
T
Site 71
T760
S
C
G
S
S
G
R
T
A
E
K
T
S
L
S
Site 72
T764
S
G
R
T
A
E
K
T
S
L
S
F
K
S
D
Site 73
S765
G
R
T
A
E
K
T
S
L
S
F
K
S
D
Q
Site 74
S767
T
A
E
K
T
S
L
S
F
K
S
D
Q
V
K
Site 75
S770
K
T
S
L
S
F
K
S
D
Q
V
K
V
K
Q
Site 76
S787
G
T
E
D
E
I
C
S
F
S
G
G
V
K
Q
Site 77
T797
G
G
V
K
Q
E
K
T
E
D
G
R
R
S
A
Site 78
S803
K
T
E
D
G
R
R
S
A
C
M
L
S
S
P
Site 79
S808
R
R
S
A
C
M
L
S
S
P
E
S
S
L
T
Site 80
S809
R
S
A
C
M
L
S
S
P
E
S
S
L
T
P
Site 81
S812
C
M
L
S
S
P
E
S
S
L
T
P
P
L
S
Site 82
S813
M
L
S
S
P
E
S
S
L
T
P
P
L
S
T
Site 83
T815
S
S
P
E
S
S
L
T
P
P
L
S
T
N
L
Site 84
S819
S
S
L
T
P
P
L
S
T
N
L
H
L
E
S
Site 85
S826
S
T
N
L
H
L
E
S
E
L
D
A
L
A
S
Site 86
S833
S
E
L
D
A
L
A
S
L
E
N
H
V
K
T
Site 87
S848
E
P
A
D
M
N
E
S
C
K
Q
S
G
L
S
Site 88
S852
M
N
E
S
C
K
Q
S
G
L
S
S
L
V
N
Site 89
S856
C
K
Q
S
G
L
S
S
L
V
N
G
K
S
P
Site 90
S862
S
S
L
V
N
G
K
S
P
I
R
S
L
M
H
Site 91
S866
N
G
K
S
P
I
R
S
L
M
H
R
S
A
R
Site 92
S871
I
R
S
L
M
H
R
S
A
R
I
G
G
D
G
Site 93
Y941
I
G
K
P
E
V
E
Y
D
C
D
N
L
Q
H
Site 94
T954
Q
H
S
K
K
G
K
T
A
Q
G
L
S
P
V
Site 95
S959
G
K
T
A
Q
G
L
S
P
V
D
Q
R
K
C
Site 96
S989
F
Q
E
P
V
P
A
S
I
P
N
Y
Y
K
I
Site 97
Y993
V
P
A
S
I
P
N
Y
Y
K
I
I
K
K
P
Site 98
S1004
I
K
K
P
M
D
L
S
T
V
K
K
K
L
Q
Site 99
T1005
K
K
P
M
D
L
S
T
V
K
K
K
L
Q
K
Site 100
S1015
K
K
L
Q
K
K
H
S
Q
H
Y
Q
I
P
D
Site 101
Y1018
Q
K
K
H
S
Q
H
Y
Q
I
P
D
D
F
V
Site 102
Y1048
M
M
K
V
V
Q
V
Y
A
D
T
Q
E
I
N
Site 103
Y1072
A
G
K
A
V
A
L
Y
F
E
D
K
L
T
E
Site 104
T1078
L
Y
F
E
D
K
L
T
E
I
Y
S
D
R
T
Site 105
S1082
D
K
L
T
E
I
Y
S
D
R
T
F
A
P
L
Site 106
T1085
T
E
I
Y
S
D
R
T
F
A
P
L
P
E
F
Site 107
T1102
E
E
D
D
G
E
V
T
E
D
S
D
E
D
F
Site 108
S1105
D
G
E
V
T
E
D
S
D
E
D
F
I
Q
P
Site 109
S1119
P
R
R
K
R
L
K
S
D
E
R
P
V
H
I
Transcription intermediary factor 1-gamma S1119 phosphosite-specific antibody AB-PK836#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK836#Transcription intermediary factor 1-gamma (R1116-R1122, human) pS1119 phosphopeptide - Powder PE-04AQB95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQB95
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation