KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ADAMTS8
Full Name:
Alias:
METH-2;METH-8
Type:
Mass (Da):
96672
Number AA:
890
UniProt ID:
Q9UP79
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
P
A
A
G
G
Q
A
S
E
L
V
V
P
T
R
Site 2
S74
L
R
L
A
P
D
D
S
F
L
A
P
E
F
K
Site 3
S88
K
I
E
R
L
G
G
S
G
R
A
T
G
G
E
Site 4
T92
L
G
G
S
G
R
A
T
G
G
E
R
G
L
R
Site 5
S104
G
L
R
G
C
F
F
S
G
T
V
N
G
E
P
Site 6
T106
R
G
C
F
F
S
G
T
V
N
G
E
P
E
S
Site 7
T135
L
L
D
G
E
E
F
T
I
Q
P
Q
G
A
G
Site 8
S144
Q
P
Q
G
A
G
G
S
L
A
Q
P
H
R
L
Site 9
S187
R
G
D
H
Q
E
D
S
E
E
E
S
Q
E
E
Site 10
S191
Q
E
D
S
E
E
E
S
Q
E
E
E
A
E
G
Site 11
S200
E
E
E
A
E
G
A
S
E
P
P
P
P
L
G
Site 12
S217
S
R
T
K
R
F
V
S
E
A
R
F
V
E
T
Site 13
Y255
M
S
V
A
A
R
I
Y
K
H
P
S
I
K
N
Site 14
S259
A
R
I
Y
K
H
P
S
I
K
N
S
I
N
L
Site 15
S263
K
H
P
S
I
K
N
S
I
N
L
M
V
V
K
Site 16
S284
E
K
W
G
P
E
V
S
D
N
G
G
L
T
L
Site 17
S305
Q
R
R
F
N
Q
P
S
D
R
H
P
E
H
Y
Site 18
Y312
S
D
R
H
P
E
H
Y
D
T
A
I
L
L
T
Site 19
T314
R
H
P
E
H
Y
D
T
A
I
L
L
T
R
Q
Site 20
S347
T
I
C
D
P
N
K
S
C
S
V
I
E
D
E
Site 21
S349
C
D
P
N
K
S
C
S
V
I
E
D
E
G
L
Site 22
T361
E
G
L
Q
A
A
H
T
L
A
H
E
L
G
H
Site 23
S371
H
E
L
G
H
V
L
S
M
P
H
D
D
S
K
Site 24
S377
L
S
M
P
H
D
D
S
K
P
C
T
R
L
F
Site 25
T381
H
D
D
S
K
P
C
T
R
L
F
G
P
M
G
Site 26
Y447
L
P
G
R
M
A
L
Y
Q
L
D
Q
Q
C
R
Site 27
T489
G
A
E
P
L
C
H
T
K
N
G
S
L
P
W
Site 28
S493
L
C
H
T
K
N
G
S
L
P
W
A
D
G
T
Site 29
T500
S
L
P
W
A
D
G
T
P
C
G
P
G
H
L
Site 30
S509
C
G
P
G
H
L
C
S
E
G
S
C
L
P
E
Site 31
S512
G
H
L
C
S
E
G
S
C
L
P
E
E
E
V
Site 32
Y573
C
L
G
R
R
A
K
Y
Q
S
C
H
T
E
E
Site 33
S575
G
R
R
A
K
Y
Q
S
C
H
T
E
E
C
P
Site 34
S587
E
C
P
P
D
G
K
S
F
R
E
Q
Q
C
E
Site 35
Y596
R
E
Q
Q
C
E
K
Y
N
A
Y
N
Y
T
D
Site 36
Y601
E
K
Y
N
A
Y
N
Y
T
D
M
D
G
N
L
Site 37
Y615
L
L
Q
W
V
P
K
Y
A
G
V
S
P
R
D
Site 38
S619
V
P
K
Y
A
G
V
S
P
R
D
R
C
K
L
Site 39
S634
F
C
R
A
R
G
R
S
E
F
K
V
F
E
A
Site 40
S673
G
C
D
H
V
V
D
S
P
R
K
L
D
K
C
Site 41
S689
V
C
G
G
K
G
N
S
C
R
K
V
S
G
S
Site 42
S694
G
N
S
C
R
K
V
S
G
S
L
T
P
T
N
Site 43
S696
S
C
R
K
V
S
G
S
L
T
P
T
N
Y
G
Site 44
T698
R
K
V
S
G
S
L
T
P
T
N
Y
G
Y
N
Site 45
T700
V
S
G
S
L
T
P
T
N
Y
G
Y
N
D
I
Site 46
Y704
L
T
P
T
N
Y
G
Y
N
D
I
V
T
I
P
Site 47
T709
Y
G
Y
N
D
I
V
T
I
P
A
G
A
T
N
Site 48
S723
N
I
D
V
K
Q
R
S
H
P
G
V
Q
N
D
Site 49
Y733
G
V
Q
N
D
G
N
Y
L
A
L
K
T
A
D
Site 50
Y743
L
K
T
A
D
G
Q
Y
L
L
N
G
N
L
A
Site 51
T773
K
Y
S
G
S
I
A
T
L
E
R
L
Q
S
F
Site 52
S779
A
T
L
E
R
L
Q
S
F
R
P
L
P
E
P
Site 53
Y805
V
F
P
P
K
V
K
Y
T
F
F
V
P
N
D
Site 54
T806
F
P
P
K
V
K
Y
T
F
F
V
P
N
D
V
Site 55
S816
V
P
N
D
V
D
F
S
M
Q
S
S
K
E
R
Site 56
S820
V
D
F
S
M
Q
S
S
K
E
R
A
T
T
N
Site 57
T825
Q
S
S
K
E
R
A
T
T
N
I
I
Q
P
L
Site 58
T826
S
S
K
E
R
A
T
T
N
I
I
Q
P
L
L
Site 59
T857
G
A
G
W
Q
R
R
T
V
E
C
R
D
P
S
Site 60
S864
T
V
E
C
R
D
P
S
G
Q
A
S
A
T
C
Site 61
S868
R
D
P
S
G
Q
A
S
A
T
C
N
K
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation