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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTF2
Full Name:
Transcription termination factor 2
Alias:
F2; Factor 2; HuF2; Lodestar homolog; Lodestar protein; RNA polymerase II termination factor; Transcription release factor 2; Transcription termination factor, RNA polymerase II
Type:
EC 3.6.1.-; Transcription regulation; DNA binding protein; Helicase
Mass (Da):
129588
Number AA:
1162
UniProt ID:
Q9UNY4
International Prot ID:
IPI00290812
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005681
GO:0008023
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006397
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
G
T
F
C
F
L
K
T
G
V
R
D
G
P
N
Site 2
S28
D
G
P
N
K
G
K
S
F
Y
V
C
R
A
D
Site 3
Y30
P
N
K
G
K
S
F
Y
V
C
R
A
D
T
C
Site 4
S48
R
A
T
D
I
P
V
S
H
C
L
L
H
E
D
Site 5
S99
I
P
W
Q
D
P
D
S
K
E
H
S
V
S
N
Site 6
S103
D
P
D
S
K
E
H
S
V
S
N
K
S
Q
H
Site 7
S105
D
S
K
E
H
S
V
S
N
K
S
Q
H
A
S
Site 8
S108
E
H
S
V
S
N
K
S
Q
H
A
S
E
T
F
Site 9
S112
S
N
K
S
Q
H
A
S
E
T
F
H
H
S
S
Site 10
S118
A
S
E
T
F
H
H
S
S
N
W
L
R
N
P
Site 11
S179
E
M
M
E
K
D
L
S
S
G
L
V
P
K
K
Site 12
S217
G
T
H
K
R
D
F
S
E
I
K
S
Q
Q
C
Site 13
S221
R
D
F
S
E
I
K
S
Q
Q
C
Q
G
N
E
Site 14
T230
Q
C
Q
G
N
E
L
T
R
P
S
A
S
S
Q
Site 15
S233
G
N
E
L
T
R
P
S
A
S
S
Q
E
K
S
Site 16
S235
E
L
T
R
P
S
A
S
S
Q
E
K
S
S
G
Site 17
S236
L
T
R
P
S
A
S
S
Q
E
K
S
S
G
K
Site 18
S240
S
A
S
S
Q
E
K
S
S
G
K
S
Q
D
V
Site 19
S244
Q
E
K
S
S
G
K
S
Q
D
V
Q
R
E
S
Site 20
S251
S
Q
D
V
Q
R
E
S
E
P
L
R
E
K
V
Site 21
S268
L
L
P
Q
N
V
H
S
H
N
S
I
S
K
P
Site 22
S273
V
H
S
H
N
S
I
S
K
P
Q
K
G
G
P
Site 23
Y285
G
G
P
L
N
K
E
Y
T
N
W
E
A
K
E
Site 24
T286
G
P
L
N
K
E
Y
T
N
W
E
A
K
E
T
Site 25
T293
T
N
W
E
A
K
E
T
K
A
K
D
G
P
S
Site 26
T304
D
G
P
S
I
Q
A
T
Q
K
S
L
P
Q
G
Site 27
S307
S
I
Q
A
T
Q
K
S
L
P
Q
G
H
F
Q
Site 28
T319
H
F
Q
E
R
P
E
T
H
S
V
P
A
P
G
Site 29
S321
Q
E
R
P
E
T
H
S
V
P
A
P
G
G
P
Site 30
S340
A
P
A
A
P
G
L
S
L
G
E
G
R
E
A
Site 31
T349
G
E
G
R
E
A
A
T
S
S
D
D
E
E
E
Site 32
S350
E
G
R
E
A
A
T
S
S
D
D
E
E
E
D
Site 33
S351
G
R
E
A
A
T
S
S
D
D
E
E
E
D
D
Site 34
S363
E
D
D
V
V
F
V
S
S
K
P
G
S
P
L
Site 35
S368
F
V
S
S
K
P
G
S
P
L
L
F
D
S
T
Site 36
S374
G
S
P
L
L
F
D
S
T
L
D
L
E
T
K
Site 37
T375
S
P
L
L
F
D
S
T
L
D
L
E
T
K
E
Site 38
T380
D
S
T
L
D
L
E
T
K
E
N
L
Q
F
P
Site 39
S390
N
L
Q
F
P
D
R
S
V
Q
R
K
V
S
P
Site 40
S396
R
S
V
Q
R
K
V
S
P
A
S
G
V
S
K
Site 41
S399
Q
R
K
V
S
P
A
S
G
V
S
K
K
V
E
Site 42
S402
V
S
P
A
S
G
V
S
K
K
V
E
P
S
D
Site 43
S408
V
S
K
K
V
E
P
S
D
P
V
A
R
R
V
Site 44
Y416
D
P
V
A
R
R
V
Y
L
T
T
Q
L
K
Q
Site 45
T418
V
A
R
R
V
Y
L
T
T
Q
L
K
Q
K
K
Site 46
T419
A
R
R
V
Y
L
T
T
Q
L
K
Q
K
K
S
Site 47
S426
T
Q
L
K
Q
K
K
S
T
L
A
S
V
N
I
Site 48
S430
Q
K
K
S
T
L
A
S
V
N
I
Q
A
L
P
Site 49
S455
Q
E
L
E
E
V
L
S
G
L
T
L
S
P
E
Site 50
T458
E
E
V
L
S
G
L
T
L
S
P
E
Q
G
T
Site 51
S460
V
L
S
G
L
T
L
S
P
E
Q
G
T
N
E
Site 52
T465
T
L
S
P
E
Q
G
T
N
E
K
S
N
S
Q
Site 53
S469
E
Q
G
T
N
E
K
S
N
S
Q
V
P
Q
Q
Site 54
S471
G
T
N
E
K
S
N
S
Q
V
P
Q
Q
S
H
Site 55
S477
N
S
Q
V
P
Q
Q
S
H
F
T
K
T
T
T
Site 56
T482
Q
Q
S
H
F
T
K
T
T
T
G
P
P
H
L
Site 57
T484
S
H
F
T
K
T
T
T
G
P
P
H
L
V
P
Site 58
T500
Q
P
L
P
R
R
G
T
Q
P
V
G
S
L
E
Site 59
S505
R
G
T
Q
P
V
G
S
L
E
L
K
S
A
C
Site 60
T515
L
K
S
A
C
Q
V
T
A
G
G
S
S
Q
C
Site 61
S520
Q
V
T
A
G
G
S
S
Q
C
Y
R
G
H
T
Site 62
Y523
A
G
G
S
S
Q
C
Y
R
G
H
T
N
Q
D
Site 63
S549
A
I
G
Q
L
H
R
S
L
E
S
C
P
G
E
Site 64
S586
A
W
L
L
W
R
E
S
Q
K
P
Q
G
G
I
Site 65
S625
K
K
E
E
K
E
K
S
T
A
L
T
W
L
S
Site 66
T629
K
E
K
S
T
A
L
T
W
L
S
K
D
D
S
Site 67
S632
S
T
A
L
T
W
L
S
K
D
D
S
C
D
F
Site 68
S636
T
W
L
S
K
D
D
S
C
D
F
T
S
H
G
Site 69
T640
K
D
D
S
C
D
F
T
S
H
G
T
L
I
I
Site 70
T644
C
D
F
T
S
H
G
T
L
I
I
C
P
A
S
Site 71
S666
E
V
E
K
R
V
N
S
N
K
L
R
V
Y
L
Site 72
Y672
N
S
N
K
L
R
V
Y
L
Y
H
G
P
N
R
Site 73
Y674
N
K
L
R
V
Y
L
Y
H
G
P
N
R
D
S
Site 74
S681
Y
H
G
P
N
R
D
S
R
A
R
V
L
S
T
Site 75
Y777
Q
N
N
L
L
D
M
Y
S
L
L
K
F
L
R
Site 76
S796
D
E
F
N
L
W
R
S
Q
V
D
N
G
S
K
Site 77
S802
R
S
Q
V
D
N
G
S
K
K
G
G
E
R
L
Site 78
S810
K
K
G
G
E
R
L
S
I
L
T
K
S
L
L
Site 79
T813
G
E
R
L
S
I
L
T
K
S
L
L
L
R
R
Site 80
S815
R
L
S
I
L
T
K
S
L
L
L
R
R
T
K
Site 81
T821
K
S
L
L
L
R
R
T
K
D
Q
L
D
S
T
Site 82
S827
R
T
K
D
Q
L
D
S
T
G
R
P
L
V
I
Site 83
T828
T
K
D
Q
L
D
S
T
G
R
P
L
V
I
L
Site 84
S848
Q
L
H
H
L
K
L
S
E
D
E
E
T
V
Y
Site 85
T853
K
L
S
E
D
E
E
T
V
Y
N
V
F
F
A
Site 86
Y855
S
E
D
E
E
T
V
Y
N
V
F
F
A
R
S
Site 87
S862
Y
N
V
F
F
A
R
S
R
S
A
L
Q
S
Y
Site 88
S864
V
F
F
A
R
S
R
S
A
L
Q
S
Y
L
K
Site 89
S868
R
S
R
S
A
L
Q
S
Y
L
K
R
H
E
S
Site 90
Y869
S
R
S
A
L
Q
S
Y
L
K
R
H
E
S
R
Site 91
S875
S
Y
L
K
R
H
E
S
R
G
N
Q
S
G
R
Site 92
S880
H
E
S
R
G
N
Q
S
G
R
S
P
N
N
P
Site 93
S883
R
G
N
Q
S
G
R
S
P
N
N
P
F
S
R
Site 94
S889
R
S
P
N
N
P
F
S
R
V
A
L
E
F
G
Site 95
S903
G
S
E
E
P
R
H
S
E
A
A
D
S
P
R
Site 96
S908
R
H
S
E
A
A
D
S
P
R
S
S
T
V
H
Site 97
S911
E
A
A
D
S
P
R
S
S
T
V
H
I
L
S
Site 98
S912
A
A
D
S
P
R
S
S
T
V
H
I
L
S
Q
Site 99
T913
A
D
S
P
R
S
S
T
V
H
I
L
S
Q
L
Site 100
S918
S
S
T
V
H
I
L
S
Q
L
L
R
L
R
Q
Site 101
S950
K
G
E
G
L
V
L
S
L
E
E
Q
L
S
A
Site 102
S961
Q
L
S
A
L
T
L
S
E
L
R
D
S
E
P
Site 103
S966
T
L
S
E
L
R
D
S
E
P
S
S
T
V
S
Site 104
S969
E
L
R
D
S
E
P
S
S
T
V
S
L
N
G
Site 105
S970
L
R
D
S
E
P
S
S
T
V
S
L
N
G
T
Site 106
T971
R
D
S
E
P
S
S
T
V
S
L
N
G
T
F
Site 107
S973
S
E
P
S
S
T
V
S
L
N
G
T
F
F
K
Site 108
S990
L
F
E
G
M
R
E
S
T
K
I
S
S
L
L
Site 109
T991
F
E
G
M
R
E
S
T
K
I
S
S
L
L
A
Site 110
S994
M
R
E
S
T
K
I
S
S
L
L
A
E
L
E
Site 111
S995
R
E
S
T
K
I
S
S
L
L
A
E
L
E
A
Site 112
S1007
L
E
A
I
Q
R
N
S
A
S
Q
K
S
V
I
Site 113
S1009
A
I
Q
R
N
S
A
S
Q
K
S
V
I
V
S
Site 114
S1012
R
N
S
A
S
Q
K
S
V
I
V
S
Q
W
T
Site 115
S1016
S
Q
K
S
V
I
V
S
Q
W
T
N
M
L
K
Site 116
Y1036
L
K
K
H
G
L
T
Y
A
T
I
D
G
S
V
Site 117
T1038
K
H
G
L
T
Y
A
T
I
D
G
S
V
N
P
Site 118
S1042
T
Y
A
T
I
D
G
S
V
N
P
K
Q
R
M
Site 119
Y1103
D
Q
A
C
D
R
I
Y
R
V
G
Q
Q
K
D
Site 120
T1121
H
R
F
V
C
E
G
T
V
E
E
K
I
L
Q
Site 121
S1142
D
L
A
K
Q
V
L
S
G
S
G
E
S
V
T
Site 122
S1144
A
K
Q
V
L
S
G
S
G
E
S
V
T
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation