PhosphoNET

           
Protein Info 
   
Short Name:  PPIE
Full Name:  Peptidyl-prolyl cis-trans isomerase E
Alias:  Cyclophilin 33; Cyclophilin E; CYP33; CYP-33; MGC111222; MGC3736; Peptidylprolyl isomerase E; Peptidylprolyl isomerase E, isoform 1; PPIase E; Rotamase E
Type:  EC 5.2.1.8; Cyclophilin; Isomerase
Mass (Da):  33431
Number AA:  301
UniProt ID:  Q9UNP9
International Prot ID:  IPI00009316
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005681     Uniprot OncoNet
Molecular Function:  GO:0003723  GO:0016018  GO:0000166 PhosphoSite+ KinaseNET
Biological Process:  GO:0008380  GO:0006397  GO:0006457 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1Y41DIQIPLDYETEKHRG
Site 2T43QIPLDYETEKHRGFA
Site 3S70AIDNMNESELFGRTI
Site 4T76ESELFGRTIRVNLAK
Site 5S91PMRIKEGSSRPVWSD
Site 6S97GSSRPVWSDDDWLKK
Site 7S119ENKEEEGSEPPKAET
Site 8T126SEPPKAETQEGEPIA
Site 9S138PIAKKARSNPQVYMD
Site 10Y143ARSNPQVYMDIKIGN
Site 11T168RSDVVPMTAENFRCL
Site 12S187KGFGFKGSSFHRIIP
Site 13S188GFGFKGSSFHRIIPQ
Site 14S213HNGTGGKSIYGKKFD
Site 15Y215GTGGKSIYGKKFDDE
Site 16S235HTGPGLLSMANSGPN
Site 17S239GLLSMANSGPNTNGS
Site 18T243MANSGPNTNGSQFFL
Site 19S246SGPNTNGSQFFLTCD
Site 20S283RQIEAQGSKDGKPKQ
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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