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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VPS4A
Full Name:
Vacuolar protein sorting-associated protein 4A
Alias:
HVPS4; SKD2; Vacuolar protein sorting-associating protein 4A; VPS4; VPS4-1
Type:
Vesicle protein
Mass (Da):
48898
Number AA:
437
UniProt ID:
Q9UN37
International Prot ID:
IPI00411356
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0030496
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042623
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0000910
GO:0016197
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y25
E
E
D
K
A
K
N
Y
E
E
A
L
R
L
Y
Site 2
Y32
Y
E
E
A
L
R
L
Y
Q
H
A
V
E
Y
F
Site 3
Y45
Y
F
L
H
A
I
K
Y
E
A
H
S
D
K
A
Site 4
S49
A
I
K
Y
E
A
H
S
D
K
A
K
E
S
I
Site 5
S55
H
S
D
K
A
K
E
S
I
R
A
K
C
V
Q
Site 6
Y63
I
R
A
K
C
V
Q
Y
L
D
R
A
E
K
L
Site 7
Y73
R
A
E
K
L
K
D
Y
L
R
S
K
E
K
H
Site 8
S95
N
Q
S
E
G
K
G
S
D
S
D
S
E
G
D
Site 9
S97
S
E
G
K
G
S
D
S
D
S
E
G
D
N
P
Site 10
S99
G
K
G
S
D
S
D
S
E
G
D
N
P
E
K
Site 11
T154
I
K
F
P
H
L
F
T
G
K
R
T
P
W
R
Site 12
T158
H
L
F
T
G
K
R
T
P
W
R
G
I
L
L
Site 13
T171
L
L
F
G
P
P
G
T
G
K
S
Y
L
A
K
Site 14
S174
G
P
P
G
T
G
K
S
Y
L
A
K
A
V
A
Site 15
Y175
P
P
G
T
G
K
S
Y
L
A
K
A
V
A
T
Site 16
S187
V
A
T
E
A
N
N
S
T
F
F
S
V
S
S
Site 17
T188
A
T
E
A
N
N
S
T
F
F
S
V
S
S
S
Site 18
S191
A
N
N
S
T
F
F
S
V
S
S
S
D
L
M
Site 19
S193
N
S
T
F
F
S
V
S
S
S
D
L
M
S
K
Site 20
S199
V
S
S
S
D
L
M
S
K
W
L
G
E
S
E
Site 21
S231
I
F
I
D
E
V
D
S
L
C
G
S
R
N
E
Site 22
S235
E
V
D
S
L
C
G
S
R
N
E
N
E
S
E
Site 23
S241
G
S
R
N
E
N
E
S
E
A
A
R
R
I
K
Site 24
T249
E
A
A
R
R
I
K
T
E
F
L
V
Q
M
Q
Site 25
T265
V
G
N
N
N
D
G
T
L
V
L
G
A
T
N
Site 26
S279
N
I
P
W
V
L
D
S
A
I
R
R
R
F
E
Site 27
Y290
R
R
F
E
K
R
I
Y
I
P
L
P
E
E
A
Site 28
S309
M
F
R
L
H
L
G
S
T
P
H
N
L
T
D
Site 29
T310
F
R
L
H
L
G
S
T
P
H
N
L
T
D
A
Site 30
T315
G
S
T
P
H
N
L
T
D
A
N
I
H
E
L
Site 31
T326
I
H
E
L
A
R
K
T
E
G
Y
S
G
A
D
Site 32
Y329
L
A
R
K
T
E
G
Y
S
G
A
D
I
S
I
Site 33
S362
F
K
K
V
C
G
P
S
R
T
N
P
S
M
M
Site 34
T364
K
V
C
G
P
S
R
T
N
P
S
M
M
I
D
Site 35
T375
M
M
I
D
D
L
L
T
P
C
S
P
G
D
P
Site 36
S378
D
D
L
L
T
P
C
S
P
G
D
P
G
A
M
Site 37
S410
C
M
S
D
M
L
R
S
L
A
T
T
R
P
T
Site 38
T413
D
M
L
R
S
L
A
T
T
R
P
T
V
N
A
Site 39
T414
M
L
R
S
L
A
T
T
R
P
T
V
N
A
D
Site 40
T417
S
L
A
T
T
R
P
T
V
N
A
D
D
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation