PhosphoNET

           
Protein Info 
   
Short Name:  WBP7
Full Name:  ISOFORM 1 OF WW DOMAIN-BINDING PROTEIN 7.
Alias:  HRX2; KIAA0304; Mixed lineage leukemia gene homolog 2 protein; MLL4; Myeloid/lymphoid or mixed-lineage leukemia protein 4; Trithorax homolog 2; TRX2; WW domain binding protein 7; WW domain-binding protein 7
Type:  DNA binding protein; Methyltransferase; Transcription factor; EC 2.1.1.43
Mass (Da):  293515
Number AA:  2715
UniProt ID:  Q9UMN6
International Prot ID:  IPI00218823
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0035097     Uniprot OncoNet
Molecular Function:  GO:0042800  GO:0005515  GO:0003700 PhosphoSite+ KinaseNET
Biological Process:  GO:0048096  GO:0006350   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S15GSCPGPGSARGRFPG
Site 2T54LRRGGGATGPGGAEP
Site 3S104RGRGWGPSRGCVPEE
Site 4S113GCVPEEESSDGESDE
Site 5S114CVPEEESSDGESDEE
Site 6S118EESSDGESDEEEFQG
Site 7S128EEFQGFHSDEDVAPS
Site 8S136DEDVAPSSLRSALRS
Site 9S139VAPSSLRSALRSQRG
Site 10S143SLRSALRSQRGRAPR
Site 11T158GRGRKHKTTPLPPPR
Site 12T159 RGRKHKTTPLPPPRL
Site 13T172RLADVAPTPPKTPAR
Site 14T176VAPTPPKTPARKRGE
Site 15T186RKRGEEGTERMVQAL
Site 16S208QAPQAPRSRACEPST
Site 17S214RSRACEPSTPRRSRG
Site 18T215SRACEPSTPRRSRGR
Site 19S219EPSTPRRSRGRPPGR
Site 20T278GPGPGPGTPRRGGQS
Site 21S285TPRRGGQSSRGGRGG
Site 22S286PRRGGQSSRGGRGGR
Site 23S320KVKMGQLSLGLESGQ
Site 24S346VPQRRVGSGQGGSPC
Site 25S351VGSGQGGSPCWKKQE
Site 26T407KLPPPPLTPPAPSPP
Site 27S412PLTPPAPSPPPPLPP
Site 28S421PPPLPPPSTSPPPPL
Site 29T422PPLPPPSTSPPPPLC
Site 30S423PLPPPSTSPPPPLCP
Site 31S437PPPPPPVSPPPLPSP
Site 32S443VSPPPLPSPPPPPAQ
Site 33S456AQEEQEESPPPVVPA
Site 34T464PPPVVPATCSRKRGR
Site 35T475KRGRPPLTPSQRAER
Site 36S477GRPPLTPSQRAEREA
Site 37S493RAGPEGTSPPTPTPS
Site 38T496PEGTSPPTPTPSTAT
Site 39T498GTSPPTPTPSTATGG
Site 40S500SPPTPTPSTATGGPP
Site 41T501PPTPTPSTATGGPPE
Site 42S510TGGPPEDSPTVAPKS
Site 43T512GPPEDSPTVAPKSTT
Site 44S517SPTVAPKSTTFLKNI
Site 45S537PVVSARSSRVIKTPR
Site 46T542RSSRVIKTPRRFMDE
Site 47S560KPPKVEVSPVLRPPI
Site 48T568PVLRPPITTSPPVPQ
Site 49T569VLRPPITTSPPVPQE
Site 50S570LRPPITTSPPVPQEP
Site 51S582QEPAPVPSPPRAPTP
Site 52T588PSPPRAPTPPSTPVP
Site 53S591PRAPTPPSTPVPLPE
Site 54T592RAPTPPSTPVPLPEK
Site 55S602PLPEKRRSILREPTF
Site 56T608RSILREPTFRWTSLT
Site 57T612REPTFRWTSLTRELP
Site 58S613EPTFRWTSLTRELPP
Site 59T615TFRWTSLTRELPPPP
Site 60S632PPPPPAPSPPPAPAT
Site 61T639SPPPAPATSSRRPLL
Site 62S640PPPAPATSSRRPLLL
Site 63S641PPAPATSSRRPLLLR
Site 64T653LLRAPQFTPSEAHLK
Site 65S655RAPQFTPSEAHLKIY
Site 66Y662SEAHLKIYESVLTPP
Site 67T667KIYESVLTPPPLGAP
Site 68S687EPPPADDSPAEPEPR
Site 69T699EPRAVGRTNHLSLPR
Site 70S703VGRTNHLSLPRFAPV
Site 71S720TPVKAEVSPHGAPAL
Site 72S728PHGAPALSNGPQTQA
Site 73T733ALSNGPQTQAQLLQP
Site 74S765PQLQPPPSPQQMPPL
Site 75S782ARIAGVGSLPLSGVE
Site 76S786GVGSLPLSGVEEKMF
Site 77S794GVEEKMFSLLKRAKV
Site 78S817QQQKVAASMPLSPGG
Site 79S821VAASMPLSPGGQMEE
Site 80S837AGAVKQISDRGPVRS
Site 81S844SDRGPVRSEDESVEA
Site 82S848PVRSEDESVEAKRER
Site 83S857EAKRERPSGPESPVQ
Site 84S861ERPSGPESPVQGPRI
Site 85S894PEDVPRLSALPLRDR
Site 86T906RDRQDLATEDTSSAS
Site 87T909QDLATEDTSSASETE
Site 88S911LATEDTSSASETESV
Site 89S913TEDTSSASETESVPS
Site 90T915DTSSASETESVPSRS
Site 91S917SSASETESVPSRSRR
Site 92S920SETESVPSRSRRGKV
Site 93S922TESVPSRSRRGKVEA
Site 94S936AAGPGGESEPTGSGG
Site 95T939PGGESEPTGSGGTLA
Site 96S941GESEPTGSGGTLAHT
Site 97T948SGGTLAHTPRRSLPS
Site 98S952LAHTPRRSLPSHHGK
Site 99S955TPRRSLPSHHGKKMR
Site 100T1026KGRTIVKTLLPWDSD
Site 101S1032KTLLPWDSDESPEAS
Site 102S1035LPWDSDESPEASPGP
Site 103S1039SDESPEASPGPPGPR
Site 104S1069PGPEEQDSLLQRKSA
Site 105S1075DSLLQRKSARRCVKQ
Site 106S1085RCVKQRPSYDIFEDS
Site 107Y1086CVKQRPSYDIFEDSD
Site 108S1092SYDIFEDSDDSEPGG
Site 109S1095IFEDSDDSEPGGPPA
Site 110T1107PPAPRRRTPRENELP
Site 111S1122LPEPEEQSRPRKPTL
Site 112T1128QSRPRKPTLQPVLQL
Site 113S1153LAPGPFASFPNGWTG
Site 114S1164GWTGKQKSPDGVHRV
Site 115S1262CGRKGRGSKHLLECE
Site 116Y1275CERCRHAYHPACLGP
Site 117S1283HPACLGPSYPTRATR
Site 118Y1284PACLGPSYPTRATRK
Site 119T1289PSYPTRATRKRRHWI
Site 120S1305SACVRCKSCGATPGK
Site 121T1309RCKSCGATPGKNWDV
Site 122Y1322DVEWSGDYSLCPRCT
Site 123Y1332CPRCTQLYEKGNYCP
Site 124Y1337QLYEKGNYCPICTRC
Site 125Y1350RCYEDNDYESKMMQC
Site 126S1372HAKCEGLSDEDYEIL
Site 127Y1376EGLSDEDYEILSGLP
Site 128S1406PRWREALSGALQGGL
Site 129S1453PCGLQAVSQRFEDGH
Site 130Y1461QRFEDGHYKSVHSFM
Site 131S1479VGILMRHSEEGETPD
Site 132T1484RHSEEGETPDRRAGG
Site 133Y1515FDAHDPKYWRRSTRL
Site 134S1519DPKYWRRSTRLPNGV
Site 135T1520PKYWRRSTRLPNGVL
Site 136S1535PNAVLPPSLDHVYAQ
Site 137Y1540PPSLDHVYAQWRQQE
Site 138T1550WRQQEPETPESGQPP
Site 139S1553QEPETPESGQPPGDP
Site 140S1561GQPPGDPSAAFQGKD
Site 141S1573GKDPAAFSHLEDPRQ
Site 142S1592LKYGDADSKEAGRLL
Site 143Y1600KEAGRLLYIGQNEWT
Site 144S1625VFEENDGSLKNVHAA
Site 145Y1707FDVLRRVYVDFEGIN
Site 146S1744IDSLGTLSDLSDCEG
Site 147Y1758GRLFPIGYQCSRLYW
Site 148Y1764GYQCSRLYWSTVDAR
Site 149T1767CSRLYWSTVDARRRC
Site 150Y1776DARRRCWYRCRILEY
Site 151Y1783YRCRILEYRPWGPRE
Site 152T1803EAAEENQTIVHSPAP
Site 153S1807ENQTIVHSPAPSSEP
Site 154S1811IVHSPAPSSEPPGGE
Site 155S1812VHSPAPSSEPPGGED
Site 156T1824GEDPPLDTDVLVPGA
Site 157S1836PGAPERHSPIQNLDP
Site 158S1849DPPLRPDSGSAPPPA
Site 159S1851PLRPDSGSAPPPAPR
Site 160S1859APPPAPRSFSGARIK
Site 161S1861PPAPRSFSGARIKVP
Site 162Y1870ARIKVPNYSPSRRPL
Site 163S1871RIKVPNYSPSRRPLG
Site 164S1873KVPNYSPSRRPLGGV
Site 165S1881RRPLGGVSFGPLPSP
Site 166S1887VSFGPLPSPGSPSSL
Site 167S1890GPLPSPGSPSSLTHH
Site 168S1892LPSPGSPSSLTHHIP
Site 169S1893PSPGSPSSLTHHIPT
Site 170T1895PGSPSSLTHHIPTVG
Site 171S1913FPAPPRRSRRPSPLA
Site 172S1917PRRSRRPSPLAPRPP
Site 173S1926LAPRPPPSRWASPPL
Site 174S1930PPPSRWASPPLKTSP
Site 175T1935WASPPLKTSPQLRVP
Site 176S1936ASPPLKTSPQLRVPP
Site 177S1966APPGPAPSPPPPEDL
Site 178S2015VAAGAMGSSHGGPGD
Site 179S2016AAGAMGSSHGGPGDS
Site 180S2023SHGGPGDSSEEESSP
Site 181S2024HGGPGDSSEEESSPT
Site 182S2028GDSSEEESSPTSRYI
Site 183S2029DSSEEESSPTSRYIH
Site 184T2031SEEESSPTSRYIHFP
Site 185S2032EEESSPTSRYIHFPV
Site 186S2050SAPGLAPSATPGAPR
Site 187T2052PGLAPSATPGAPRIE
Site 188T2068LDGVDDGTDSEAEAV
Site 189S2070GVDDGTDSEAEAVQQ
Site 190T2083QQPRGQGTPPSGPGV
Site 191S2086RGQGTPPSGPGVVRA
Site 192S2111RPPEDLPSEIVDFVL
Site 193S2135GAGPREESLPPAPPL
Site 194S2146APPLANGSQPSQGLT
Site 195T2153SQPSQGLTASPADPT
Site 196S2155PSQGLTASPADPTRT
Site 197T2162SPADPTRTFAWLPGA
Site 198T2223KQPPLPPTISPTAPT
Site 199S2225PPLPPTISPTAPTSW
Site 200S2231ISPTAPTSWTLPPGP
Site 201T2233PTAPTSWTLPPGPLL
Site 202T2261PPPPPPLTLVLSSGP
Site 203S2270VLSSGPASPPRQAIR
Site 204S2282AIRVKRVSTFSGRSP
Site 205T2283IRVKRVSTFSGRSPP
Site 206S2285VKRVSTFSGRSPPAP
Site 207S2288VSTFSGRSPPAPPPY
Site 208Y2295SPPAPPPYKAPRLDE
Site 209T2310DGEASEDTPQVPGLG
Site 210S2318PQVPGLGSGGFSRVR
Site 211S2322GLGSGGFSRVRMKTP
Site 212T2328FSRVRMKTPTVRGVL
Site 213T2330RVRMKTPTVRGVLDL
Site 214S2348GEPAGEESPGPLQER
Site 215S2356PGPLQERSPLLPLPE
Site 216S2380PPDLLLESQWHHYSG
Site 217S2386ESQWHHYSGEASSSE
Site 218S2390HHYSGEASSSEEEPP
Site 219S2392YSGEASSSEEEPPSP
Site 220S2398SSEEEPPSPDDKENQ
Site 221S2419PHLRFEISSEDGFSV
Site 222S2420HLRFEISSEDGFSVE
Site 223S2425ISSEDGFSVEAESLE
Site 224S2430GFSVEAESLEGAWRT
Site 225S2455HARLRHLSFSGMSGA
Site 226S2457RLRHLSFSGMSGARL
Site 227Y2515GAARAEVYLRKCTFD
Site 228S2529DMFNFLASQHRVLPE
Site 229S2551EDEVQLRSTRRATSL
Site 230T2552DEVQLRSTRRATSLE
Site 231T2556LRSTRRATSLELPMA
Site 232S2557RSTRRATSLELPMAM
Site 233T2572RFRHLKKTSKEAVGV
Site 234S2573FRHLKKTSKEAVGVY
Site 235Y2580SKEAVGVYRSAIHGR
Site 236S2582EAVGVYRSAIHGRGL
Site 237Y2604AGEMVIEYSGIVIRS
Site 238S2605GEMVIEYSGIVIRSV
Site 239Y2621TDKREKFYDGKGIGC
Site 240Y2629DGKGIGCYMFRMDDF
Site 241T2687ILRGEELTYDYKFPI
Site 242Y2688LRGEELTYDYKFPIE
Site 243Y2690GEELTYDYKFPIEDA
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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