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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PADI4
Full Name:
Alias:
HL-60 PAD;Peptidylarginine deiminase IV;Protein-arginine deiminase type IV
Type:
Mass (Da):
74079
Number AA:
663
UniProt ID:
Q9UM07
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
Q
G
T
L
I
R
V
T
P
E
Q
P
T
H
A
Site 2
S31
L
T
Q
L
D
I
C
S
S
A
P
E
D
C
T
Site 3
S32
T
Q
L
D
I
C
S
S
A
P
E
D
C
T
S
Site 4
T38
S
S
A
P
E
D
C
T
S
F
S
I
N
A
S
Site 5
S39
S
A
P
E
D
C
T
S
F
S
I
N
A
S
P
Site 6
S41
P
E
D
C
T
S
F
S
I
N
A
S
P
G
V
Site 7
S55
V
V
V
D
I
A
H
S
P
P
A
K
K
K
S
Site 8
S62
S
P
P
A
K
K
K
S
T
G
S
S
T
W
P
Site 9
S66
K
K
K
S
T
G
S
S
T
W
P
L
D
P
G
Site 10
T67
K
K
S
T
G
S
S
T
W
P
L
D
P
G
V
Site 11
Y96
D
Q
K
V
Q
I
S
Y
Y
G
P
K
T
P
P
Site 12
Y97
Q
K
V
Q
I
S
Y
Y
G
P
K
T
P
P
V
Site 13
T101
I
S
Y
Y
G
P
K
T
P
P
V
K
A
L
L
Site 14
S161
C
D
R
D
N
L
E
S
S
A
M
D
C
E
D
Site 15
S162
D
R
D
N
L
E
S
S
A
M
D
C
E
D
D
Site 16
S174
E
D
D
E
V
L
D
S
E
D
L
Q
D
M
S
Site 17
S181
S
E
D
L
Q
D
M
S
L
M
T
L
S
T
K
Site 18
T184
L
Q
D
M
S
L
M
T
L
S
T
K
T
P
K
Site 19
S186
D
M
S
L
M
T
L
S
T
K
T
P
K
D
F
Site 20
T187
M
S
L
M
T
L
S
T
K
T
P
K
D
F
F
Site 21
T189
L
M
T
L
S
T
K
T
P
K
D
F
F
T
N
Site 22
T195
K
T
P
K
D
F
F
T
N
H
T
L
V
L
H
Site 23
T217
K
V
R
V
F
Q
A
T
R
G
K
L
S
S
K
Site 24
S226
G
K
L
S
S
K
C
S
V
V
L
G
P
K
W
Site 25
Y237
G
P
K
W
P
S
H
Y
L
M
V
P
G
G
K
Site 26
Y250
G
K
H
N
M
D
F
Y
V
E
A
L
A
F
P
Site 27
T299
R
V
A
P
W
I
M
T
P
N
T
Q
P
P
Q
Site 28
T302
P
W
I
M
T
P
N
T
Q
P
P
Q
E
V
Y
Site 29
S322
E
N
E
D
F
L
K
S
V
T
T
L
A
M
K
Site 30
T335
M
K
A
K
C
K
L
T
I
C
P
E
E
E
N
Site 31
T363
Y
I
Q
A
P
H
K
T
L
P
V
V
F
D
S
Site 32
S370
T
L
P
V
V
F
D
S
P
R
N
R
G
L
K
Site 33
Y391
V
M
G
P
D
F
G
Y
V
T
R
G
P
Q
T
Site 34
T393
G
P
D
F
G
Y
V
T
R
G
P
Q
T
G
G
Site 35
T398
Y
V
T
R
G
P
Q
T
G
G
I
S
G
L
D
Site 36
S402
G
P
Q
T
G
G
I
S
G
L
D
S
F
G
N
Site 37
S413
S
F
G
N
L
E
V
S
P
P
V
T
V
R
G
Site 38
T417
L
E
V
S
P
P
V
T
V
R
G
K
E
Y
P
Site 39
S433
G
R
I
L
F
G
D
S
C
Y
P
S
N
D
S
Site 40
Y435
I
L
F
G
D
S
C
Y
P
S
N
D
S
R
Q
Site 41
S440
S
C
Y
P
S
N
D
S
R
Q
M
H
Q
A
L
Site 42
S452
Q
A
L
Q
D
F
L
S
A
Q
Q
V
Q
A
P
Site 43
S464
Q
A
P
V
K
L
Y
S
D
W
L
S
V
G
H
Site 44
S468
K
L
Y
S
D
W
L
S
V
G
H
V
D
E
F
Site 45
S477
G
H
V
D
E
F
L
S
F
V
P
A
P
D
R
Site 46
Y498
L
A
S
P
R
S
C
Y
K
L
F
Q
E
Q
Q
Site 47
S531
Q
K
I
K
N
I
L
S
N
K
T
L
R
E
H
Site 48
T534
K
N
I
L
S
N
K
T
L
R
E
H
N
S
F
Site 49
S540
K
T
L
R
E
H
N
S
F
V
E
R
C
I
D
Site 50
S562
R
E
L
G
L
A
E
S
D
I
I
D
I
P
Q
Site 51
Y636
F
I
N
D
F
F
T
Y
H
I
R
H
G
E
V
Site 52
T647
H
G
E
V
H
C
G
T
N
V
R
R
K
P
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation