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Updated November 2019
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Protein Info
Short Name:
HECTD1
Full Name:
E3 ubiquitin-protein ligase HECTD1
Alias:
E3 ligase for inhibin receptor; EULIR; HECD1; HECT domain containing 1; HECT domain-containing protein 1; KIAA1131
Type:
Ubiquitin ligase; Ubiquitin conjugating system; Ligase; EC 6.3.2.-
Mass (Da):
289595
Number AA:
2612
UniProt ID:
Q9ULT8
International Prot ID:
IPI00328911
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0046872
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0016567
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
A
D
V
D
P
D
T
L
L
E
W
L
Q
M
Site 2
T74
P
D
N
V
L
E
V
T
A
R
A
I
T
Y
Y
Site 3
S116
V
E
L
N
N
R
T
S
R
D
L
A
E
Q
C
Site 4
S154
V
L
T
F
I
R
D
S
G
H
L
V
H
K
D
Site 5
S182
G
K
M
E
P
Q
D
S
S
L
E
I
C
V
E
Site 6
S183
K
M
E
P
Q
D
S
S
L
E
I
C
V
E
S
Site 7
S193
I
C
V
E
S
L
S
S
L
L
K
H
E
D
H
Site 8
T218
A
S
L
A
D
R
F
T
R
R
G
V
D
P
A
Site 9
T233
P
L
A
K
H
G
L
T
E
E
L
L
S
R
M
Site 10
T246
R
M
A
A
A
G
G
T
V
S
G
P
S
S
A
Site 11
S251
G
G
T
V
S
G
P
S
S
A
C
K
P
G
R
Site 12
S252
G
T
V
S
G
P
S
S
A
C
K
P
G
R
S
Site 13
S259
S
A
C
K
P
G
R
S
T
T
G
A
P
S
T
Site 14
T260
A
C
K
P
G
R
S
T
T
G
A
P
S
T
T
Site 15
T261
C
K
P
G
R
S
T
T
G
A
P
S
T
T
A
Site 16
S265
R
S
T
T
G
A
P
S
T
T
A
D
S
K
L
Site 17
T266
S
T
T
G
A
P
S
T
T
A
D
S
K
L
S
Site 18
S270
A
P
S
T
T
A
D
S
K
L
S
N
Q
V
S
Site 19
S273
T
T
A
D
S
K
L
S
N
Q
V
S
T
I
V
Site 20
T294
C
R
G
S
P
V
V
T
H
D
L
L
R
S
E
Site 21
S300
V
T
H
D
L
L
R
S
E
L
P
D
S
I
E
Site 22
S305
L
R
S
E
L
P
D
S
I
E
S
A
L
Q
G
Site 23
S341
G
R
K
A
L
P
K
S
S
A
G
S
T
G
R
Site 24
S345
L
P
K
S
S
A
G
S
T
G
R
I
P
G
L
Site 25
T346
P
K
S
S
A
G
S
T
G
R
I
P
G
L
R
Site 26
S357
P
G
L
R
R
L
D
S
S
G
E
R
S
H
R
Site 27
S358
G
L
R
R
L
D
S
S
G
E
R
S
H
R
Q
Site 28
S362
L
D
S
S
G
E
R
S
H
R
Q
L
I
D
C
Site 29
S429
V
N
R
G
Q
R
S
S
S
L
H
Y
A
A
C
Site 30
S430
N
R
G
Q
R
S
S
S
L
H
Y
A
A
C
F
Site 31
Y433
Q
R
S
S
S
L
H
Y
A
A
C
F
G
R
P
Site 32
T445
G
R
P
Q
V
A
K
T
L
L
R
H
G
A
N
Site 33
T462
L
R
D
E
D
G
K
T
P
L
D
K
A
R
E
Site 34
S473
K
A
R
E
R
G
H
S
E
V
V
A
I
L
Q
Site 35
T535
F
A
Q
T
F
Q
Q
T
M
L
P
S
I
R
K
Site 36
S539
F
Q
Q
T
M
L
P
S
I
R
K
A
S
L
A
Site 37
S566
L
L
Q
E
V
C
D
S
D
V
G
H
N
L
P
Site 38
Y611
V
D
K
G
G
D
I
Y
K
H
Q
L
A
R
L
Site 39
S631
V
S
T
L
A
G
P
S
S
D
D
E
N
E
E
Site 40
S632
S
T
L
A
G
P
S
S
D
D
E
N
E
E
E
Site 41
Y676
I
R
G
R
D
C
L
Y
I
W
S
D
A
A
A
Site 42
S687
D
A
A
A
L
E
L
S
N
G
S
N
G
W
F
Site 43
T704
I
L
D
G
K
L
A
T
M
Y
S
S
G
S
P
Site 44
Y706
D
G
K
L
A
T
M
Y
S
S
G
S
P
E
G
Site 45
S707
G
K
L
A
T
M
Y
S
S
G
S
P
E
G
G
Site 46
S708
K
L
A
T
M
Y
S
S
G
S
P
E
G
G
S
Site 47
S710
A
T
M
Y
S
S
G
S
P
E
G
G
S
D
S
Site 48
S715
S
G
S
P
E
G
G
S
D
S
S
E
S
R
S
Site 49
S717
S
P
E
G
G
S
D
S
S
E
S
R
S
E
F
Site 50
S718
P
E
G
G
S
D
S
S
E
S
R
S
E
F
L
Site 51
S720
G
G
S
D
S
S
E
S
R
S
E
F
L
E
K
Site 52
S722
S
D
S
S
E
S
R
S
E
F
L
E
K
L
Q
Site 53
S738
A
R
G
Q
V
K
P
S
T
S
S
Q
P
I
L
Site 54
T739
R
G
Q
V
K
P
S
T
S
S
Q
P
I
L
S
Site 55
S740
G
Q
V
K
P
S
T
S
S
Q
P
I
L
S
A
Site 56
S741
Q
V
K
P
S
T
S
S
Q
P
I
L
S
A
P
Site 57
S746
T
S
S
Q
P
I
L
S
A
P
G
P
T
K
L
Site 58
T754
A
P
G
P
T
K
L
T
V
G
N
W
S
L
T
Site 59
T761
T
V
G
N
W
S
L
T
C
L
K
E
G
E
I
Site 60
S792
L
P
G
F
V
F
E
S
N
R
G
T
K
H
S
Site 61
T796
V
F
E
S
N
R
G
T
K
H
S
F
T
A
E
Site 62
S799
S
N
R
G
T
K
H
S
F
T
A
E
T
S
L
Site 63
T801
R
G
T
K
H
S
F
T
A
E
T
S
L
G
S
Site 64
S805
H
S
F
T
A
E
T
S
L
G
S
E
F
V
T
Site 65
S808
T
A
E
T
S
L
G
S
E
F
V
T
G
W
T
Site 66
T812
S
L
G
S
E
F
V
T
G
W
T
G
K
R
G
Site 67
S824
K
R
G
R
K
L
K
S
K
L
E
K
T
K
Q
Site 68
T835
K
T
K
Q
K
V
R
T
M
A
R
D
L
Y
D
Site 69
Y841
R
T
M
A
R
D
L
Y
D
D
H
F
K
A
V
Site 70
T864
V
T
L
R
N
I
A
T
Q
L
E
S
S
W
E
Site 71
T905
V
L
L
K
D
E
N
T
I
S
P
Y
E
M
C
Site 72
S907
L
K
D
E
N
T
I
S
P
Y
E
M
C
S
S
Site 73
Y909
D
E
N
T
I
S
P
Y
E
M
C
S
S
G
L
Site 74
T933
N
V
S
I
F
R
A
T
K
Q
K
Q
N
E
V
Site 75
S960
T
E
N
E
D
D
E
S
R
P
A
V
A
L
I
Site 76
Y985
E
R
L
P
L
H
L
Y
D
T
P
G
S
T
Y
Site 77
T987
L
P
L
H
L
Y
D
T
P
G
S
T
Y
N
L
Site 78
T1018
E
T
A
L
I
D
R
T
G
R
M
L
K
M
E
Site 79
T1029
L
K
M
E
P
L
A
T
V
E
S
L
E
Q
Y
Site 80
S1032
E
P
L
A
T
V
E
S
L
E
Q
Y
L
L
K
Site 81
Y1046
K
M
V
A
K
Q
W
Y
D
F
D
R
S
S
F
Site 82
Y1080
F
D
E
N
G
I
I
Y
W
I
G
T
N
A
K
Site 83
Y1090
G
T
N
A
K
T
A
Y
E
W
V
N
P
A
A
Site 84
Y1113
S
E
G
R
N
L
P
Y
G
R
L
E
D
I
L
Site 85
S1121
G
R
L
E
D
I
L
S
R
D
N
S
A
L
N
Site 86
S1125
D
I
L
S
R
D
N
S
A
L
N
C
H
S
N
Site 87
Y1160
T
L
R
H
A
R
G
Y
G
R
S
A
L
R
N
Site 88
Y1183
G
Q
N
W
T
S
L
Y
T
H
V
D
D
C
S
Site 89
S1190
Y
T
H
V
D
D
C
S
L
N
E
P
G
S
T
Site 90
S1196
C
S
L
N
E
P
G
S
T
A
T
W
P
L
D
Site 91
T1197
S
L
N
E
P
G
S
T
A
T
W
P
L
D
P
Site 92
T1228
G
K
N
A
S
G
Q
T
H
Y
L
S
L
S
G
Site 93
Y1230
N
A
S
G
Q
T
H
Y
L
S
L
S
G
F
E
Site 94
S1232
S
G
Q
T
H
Y
L
S
L
S
G
F
E
L
Y
Site 95
S1234
Q
T
H
Y
L
S
L
S
G
F
E
L
Y
G
T
Site 96
T1241
S
G
F
E
L
Y
G
T
V
N
G
V
C
E
D
Site 97
S1270
R
Q
R
R
L
V
R
S
Q
V
L
K
Y
M
V
Site 98
S1296
K
W
R
D
Q
D
G
S
P
Q
G
E
G
T
V
Site 99
T1302
G
S
P
Q
G
E
G
T
V
T
G
E
L
H
N
Site 100
T1304
P
Q
G
E
G
T
V
T
G
E
L
H
N
G
W
Site 101
S1321
V
T
W
D
A
G
G
S
N
S
Y
R
M
G
A
Site 102
S1323
W
D
A
G
G
S
N
S
Y
R
M
G
A
E
G
Site 103
Y1340
D
L
K
L
A
P
G
Y
D
P
D
T
V
A
S
Site 104
T1344
A
P
G
Y
D
P
D
T
V
A
S
P
K
P
V
Site 105
S1347
Y
D
P
D
T
V
A
S
P
K
P
V
S
S
T
Site 106
S1352
V
A
S
P
K
P
V
S
S
T
V
S
G
T
T
Site 107
S1353
A
S
P
K
P
V
S
S
T
V
S
G
T
T
Q
Site 108
T1354
S
P
K
P
V
S
S
T
V
S
G
T
T
Q
S
Site 109
S1356
K
P
V
S
S
T
V
S
G
T
T
Q
S
W
S
Site 110
T1358
V
S
S
T
V
S
G
T
T
Q
S
W
S
S
L
Site 111
T1359
S
S
T
V
S
G
T
T
Q
S
W
S
S
L
V
Site 112
S1361
T
V
S
G
T
T
Q
S
W
S
S
L
V
K
N
Site 113
S1363
S
G
T
T
Q
S
W
S
S
L
V
K
N
N
C
Site 114
S1364
G
T
T
Q
S
W
S
S
L
V
K
N
N
C
P
Site 115
T1374
K
N
N
C
P
D
K
T
S
A
A
A
G
S
S
Site 116
S1375
N
N
C
P
D
K
T
S
A
A
A
G
S
S
S
Site 117
S1380
K
T
S
A
A
A
G
S
S
S
R
K
G
S
S
Site 118
S1381
T
S
A
A
A
G
S
S
S
R
K
G
S
S
S
Site 119
S1382
S
A
A
A
G
S
S
S
R
K
G
S
S
S
S
Site 120
S1386
G
S
S
S
R
K
G
S
S
S
S
V
C
S
V
Site 121
S1387
S
S
S
R
K
G
S
S
S
S
V
C
S
V
A
Site 122
S1388
S
S
R
K
G
S
S
S
S
V
C
S
V
A
S
Site 123
S1389
S
R
K
G
S
S
S
S
V
C
S
V
A
S
S
Site 124
S1392
G
S
S
S
S
V
C
S
V
A
S
S
S
D
I
Site 125
S1395
S
S
V
C
S
V
A
S
S
S
D
I
S
L
G
Site 126
S1396
S
V
C
S
V
A
S
S
S
D
I
S
L
G
S
Site 127
S1400
V
A
S
S
S
D
I
S
L
G
S
T
K
T
E
Site 128
T1404
S
D
I
S
L
G
S
T
K
T
E
R
R
S
E
Site 129
T1406
I
S
L
G
S
T
K
T
E
R
R
S
E
I
V
Site 130
S1410
S
T
K
T
E
R
R
S
E
I
V
M
E
H
S
Site 131
T1440
S
A
E
N
V
P
Q
T
E
V
G
S
S
S
S
Site 132
S1444
V
P
Q
T
E
V
G
S
S
S
S
A
S
T
S
Site 133
S1445
P
Q
T
E
V
G
S
S
S
S
A
S
T
S
T
Site 134
S1446
Q
T
E
V
G
S
S
S
S
A
S
T
S
T
L
Site 135
S1447
T
E
V
G
S
S
S
S
A
S
T
S
T
L
T
Site 136
S1449
V
G
S
S
S
S
A
S
T
S
T
L
T
A
E
Site 137
S1451
S
S
S
S
A
S
T
S
T
L
T
A
E
T
G
Site 138
T1454
S
A
S
T
S
T
L
T
A
E
T
G
S
E
N
Site 139
S1470
E
R
K
L
G
P
D
S
S
V
R
T
P
G
E
Site 140
S1471
R
K
L
G
P
D
S
S
V
R
T
P
G
E
S
Site 141
T1474
G
P
D
S
S
V
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P
G
E
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S
A
I
Site 142
S1478
S
V
R
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G
E
S
S
A
I
S
M
G
I
Site 143
S1479
V
R
T
P
G
E
S
S
A
I
S
M
G
I
V
Site 144
S1487
A
I
S
M
G
I
V
S
V
S
S
P
D
V
S
Site 145
S1489
S
M
G
I
V
S
V
S
S
P
D
V
S
S
V
Site 146
S1490
M
G
I
V
S
V
S
S
P
D
V
S
S
V
S
Site 147
S1494
S
V
S
S
P
D
V
S
S
V
S
E
L
T
N
Site 148
S1495
V
S
S
P
D
V
S
S
V
S
E
L
T
N
K
Site 149
S1497
S
P
D
V
S
S
V
S
E
L
T
N
K
E
A
Site 150
S1506
L
T
N
K
E
A
A
S
Q
R
P
L
S
S
S
Site 151
S1511
A
A
S
Q
R
P
L
S
S
S
A
S
N
R
L
Site 152
S1512
A
S
Q
R
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L
S
S
S
A
S
N
R
L
S
Site 153
S1513
S
Q
R
P
L
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S
S
A
S
N
R
L
S
V
Site 154
S1515
R
P
L
S
S
S
A
S
N
R
L
S
V
S
S
Site 155
S1533
A
G
A
P
M
S
S
S
A
S
V
P
N
L
S
Site 156
S1535
A
P
M
S
S
S
A
S
V
P
N
L
S
S
R
Site 157
S1540
S
A
S
V
P
N
L
S
S
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E
T
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S
L
Site 158
S1541
A
S
V
P
N
L
S
S
R
E
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L
E
Site 159
T1544
P
N
L
S
S
R
E
T
S
S
L
E
S
F
V
Site 160
S1545
N
L
S
S
R
E
T
S
S
L
E
S
F
V
R
Site 161
S1546
L
S
S
R
E
T
S
S
L
E
S
F
V
R
R
Site 162
S1549
R
E
T
S
S
L
E
S
F
V
R
R
V
A
N
Site 163
S1569
A
T
N
N
M
N
L
S
R
S
S
S
D
N
N
Site 164
S1571
N
N
M
N
L
S
R
S
S
S
D
N
N
T
N
Site 165
S1572
N
M
N
L
S
R
S
S
S
D
N
N
T
N
T
Site 166
S1573
M
N
L
S
R
S
S
S
D
N
N
T
N
T
L
Site 167
T1577
R
S
S
S
D
N
N
T
N
T
L
G
R
N
V
Site 168
T1579
S
S
D
N
N
T
N
T
L
G
R
N
V
M
S
Site 169
S1590
N
V
M
S
T
A
T
S
P
L
M
G
A
Q
S
Site 170
S1597
S
P
L
M
G
A
Q
S
F
P
N
L
T
T
P
Site 171
T1602
A
Q
S
F
P
N
L
T
T
P
G
T
T
S
T
Site 172
T1603
Q
S
F
P
N
L
T
T
P
G
T
T
S
T
V
Site 173
T1606
P
N
L
T
T
P
G
T
T
S
T
V
T
M
S
Site 174
S1608
L
T
T
P
G
T
T
S
T
V
T
M
S
T
S
Site 175
T1609
T
T
P
G
T
T
S
T
V
T
M
S
T
S
S
Site 176
T1611
P
G
T
T
S
T
V
T
M
S
T
S
S
V
T
Site 177
S1613
T
T
S
T
V
T
M
S
T
S
S
V
T
S
S
Site 178
T1614
T
S
T
V
T
M
S
T
S
S
V
T
S
S
S
Site 179
S1615
S
T
V
T
M
S
T
S
S
V
T
S
S
S
N
Site 180
S1616
T
V
T
M
S
T
S
S
V
T
S
S
S
N
V
Site 181
S1619
M
S
T
S
S
V
T
S
S
S
N
V
A
T
A
Site 182
S1620
S
T
S
S
V
T
S
S
S
N
V
A
T
A
T
Site 183
T1639
V
G
Q
S
L
S
N
T
L
T
T
S
L
T
S
Site 184
T1641
Q
S
L
S
N
T
L
T
T
S
L
T
S
T
S
Site 185
T1642
S
L
S
N
T
L
T
T
S
L
T
S
T
S
S
Site 186
S1643
L
S
N
T
L
T
T
S
L
T
S
T
S
S
E
Site 187
T1645
N
T
L
T
T
S
L
T
S
T
S
S
E
S
D
Site 188
S1646
T
L
T
T
S
L
T
S
T
S
S
E
S
D
T
Site 189
T1647
L
T
T
S
L
T
S
T
S
S
E
S
D
T
G
Site 190
S1649
T
S
L
T
S
T
S
S
E
S
D
T
G
Q
E
Site 191
T1653
S
T
S
S
E
S
D
T
G
Q
E
A
E
Y
S
Site 192
S1660
T
G
Q
E
A
E
Y
S
L
Y
D
F
L
D
S
Site 193
Y1662
Q
E
A
E
Y
S
L
Y
D
F
L
D
S
C
R
Site 194
T1672
L
D
S
C
R
A
S
T
L
L
A
E
L
D
D
Site 195
Y1703
D
N
Q
E
D
Q
E
Y
E
E
V
M
I
L
R
Site 196
S1713
V
M
I
L
R
R
P
S
L
Q
R
R
A
G
S
Site 197
S1720
S
L
Q
R
R
A
G
S
R
S
D
V
T
H
H
Site 198
S1722
Q
R
R
A
G
S
R
S
D
V
T
H
H
A
V
Site 199
T1725
A
G
S
R
S
D
V
T
H
H
A
V
T
S
Q
Site 200
S1731
V
T
H
H
A
V
T
S
Q
L
P
Q
V
P
A
Site 201
Y1753
G
E
Q
E
E
E
E
Y
E
T
K
G
G
R
R
Site 202
T1762
T
K
G
G
R
R
R
T
W
D
D
D
Y
V
L
Site 203
Y1767
R
R
T
W
D
D
D
Y
V
L
K
R
Q
F
S
Site 204
S1774
Y
V
L
K
R
Q
F
S
A
L
V
P
A
F
D
Site 205
T1802
L
E
I
P
P
P
G
T
P
H
S
E
L
L
E
Site 206
S1805
P
P
P
G
T
P
H
S
E
L
L
E
E
V
E
Site 207
S1816
E
E
V
E
C
T
P
S
P
R
L
A
L
T
L
Site 208
T1839
R
E
V
E
L
P
L
T
N
F
R
S
T
I
F
Site 209
T1844
P
L
T
N
F
R
S
T
I
F
Y
Y
V
Q
K
Site 210
Y1847
N
F
R
S
T
I
F
Y
Y
V
Q
K
L
L
Q
Site 211
S1856
V
Q
K
L
L
Q
L
S
C
N
G
N
V
K
S
Site 212
T1873
L
R
R
I
W
E
P
T
Y
T
I
M
Y
R
E
Site 213
Y1874
R
R
I
W
E
P
T
Y
T
I
M
Y
R
E
M
Site 214
S1884
M
Y
R
E
M
K
D
S
D
K
E
K
E
N
G
Site 215
Y1904
S
I
E
H
V
E
Q
Y
L
G
T
D
E
L
P
Site 216
T1917
L
P
K
N
D
L
I
T
Y
L
Q
K
N
A
D
Site 217
T1934
F
L
R
H
W
K
L
T
G
T
N
K
S
I
R
Site 218
S1939
K
L
T
G
T
N
K
S
I
R
K
N
R
N
C
Site 219
S1947
I
R
K
N
R
N
C
S
Q
L
I
A
A
Y
K
Site 220
S1963
F
C
E
H
G
T
K
S
G
L
N
Q
G
A
I
Site 221
S1971
G
L
N
Q
G
A
I
S
T
L
Q
S
S
D
I
Site 222
T1982
S
S
D
I
L
N
L
T
K
E
Q
P
Q
A
K
Site 223
Y2017
Y
I
V
A
S
D
P
Y
S
R
I
S
Q
E
D
Site 224
S2018
I
V
A
S
D
P
Y
S
R
I
S
Q
E
D
G
Site 225
S2021
S
D
P
Y
S
R
I
S
Q
E
D
G
D
E
Q
Site 226
T2032
G
D
E
Q
P
Q
F
T
F
P
P
D
E
F
T
Site 227
T2044
E
F
T
S
K
K
I
T
T
K
I
L
Q
Q
I
Site 228
Y2085
P
F
E
T
R
Q
L
Y
F
T
C
T
A
F
G
Site 229
T2087
E
T
R
Q
L
Y
F
T
C
T
A
F
G
A
S
Site 230
T2089
R
Q
L
Y
F
T
C
T
A
F
G
A
S
R
A
Site 231
T2107
L
Q
N
R
R
E
A
T
V
E
R
T
R
T
T
Site 232
T2113
A
T
V
E
R
T
R
T
T
S
S
V
R
R
D
Site 233
T2114
T
V
E
R
T
R
T
T
S
S
V
R
R
D
D
Site 234
S2115
V
E
R
T
R
T
T
S
S
V
R
R
D
D
P
Site 235
S2116
E
R
T
R
T
T
S
S
V
R
R
D
D
P
G
Site 236
S2142
V
K
V
P
R
G
E
S
L
M
E
W
A
E
N
Site 237
S2159
Q
I
H
A
D
R
K
S
V
L
E
V
E
F
L
Site 238
S2206
D
N
F
P
D
D
E
S
R
H
V
D
L
G
G
Site 239
Y2220
G
G
L
K
P
P
G
Y
Y
V
Q
R
S
C
G
Site 240
Y2221
G
L
K
P
P
G
Y
Y
V
Q
R
S
C
G
L
Site 241
S2225
P
G
Y
Y
V
Q
R
S
C
G
L
F
T
A
P
Site 242
S2237
T
A
P
F
P
Q
D
S
D
E
L
E
R
I
T
Site 243
T2244
S
D
E
L
E
R
I
T
K
L
F
H
F
L
G
Site 244
Y2290
S
N
M
S
K
L
I
Y
E
S
R
G
D
R
D
Site 245
T2301
G
D
R
D
L
H
C
T
E
S
Q
S
E
A
S
Site 246
S2303
R
D
L
H
C
T
E
S
Q
S
E
A
S
T
E
Site 247
S2305
L
H
C
T
E
S
Q
S
E
A
S
T
E
E
G
Site 248
T2309
E
S
Q
S
E
A
S
T
E
E
G
H
D
S
L
Site 249
S2315
S
T
E
E
G
H
D
S
L
S
V
G
S
F
E
Site 250
S2317
E
E
G
H
D
S
L
S
V
G
S
F
E
E
D
Site 251
S2320
H
D
S
L
S
V
G
S
F
E
E
D
S
K
S
Site 252
S2325
V
G
S
F
E
E
D
S
K
S
E
F
I
L
D
Site 253
S2327
S
F
E
E
D
S
K
S
E
F
I
L
D
P
P
Site 254
S2377
I
K
R
R
Q
I
L
S
N
K
G
L
S
E
D
Site 255
S2382
I
L
S
N
K
G
L
S
E
D
E
K
N
T
K
Site 256
S2399
E
L
V
L
K
N
P
S
G
S
G
P
P
L
S
Site 257
S2401
V
L
K
N
P
S
G
S
G
P
P
L
S
I
E
Site 258
S2406
S
G
S
G
P
P
L
S
I
E
D
L
G
L
N
Site 259
T2426
S
S
R
I
Y
G
F
T
A
V
D
L
K
P
S
Site 260
T2440
S
G
E
D
E
M
I
T
M
D
N
A
E
E
Y
Site 261
Y2447
T
M
D
N
A
E
E
Y
V
D
L
M
F
D
F
Site 262
S2481
V
F
P
M
E
K
L
S
S
F
S
H
E
E
V
Site 263
S2482
F
P
M
E
K
L
S
S
F
S
H
E
E
V
Q
Site 264
S2497
M
I
L
C
G
N
Q
S
P
S
W
A
A
E
D
Site 265
Y2508
A
A
E
D
I
I
N
Y
T
E
P
K
L
G
Y
Site 266
Y2515
Y
T
E
P
K
L
G
Y
T
R
D
S
P
G
F
Site 267
S2519
K
L
G
Y
T
R
D
S
P
G
F
L
R
F
V
Site 268
S2534
R
V
L
C
G
M
S
S
D
E
R
K
A
F
L
Site 269
T2544
R
K
A
F
L
Q
F
T
T
G
C
S
T
L
P
Site 270
T2563
A
N
L
H
P
R
L
T
V
V
R
K
V
D
A
Site 271
T2571
V
V
R
K
V
D
A
T
D
A
S
Y
P
S
V
Site 272
S2574
K
V
D
A
T
D
A
S
Y
P
S
V
N
T
C
Site 273
Y2584
S
V
N
T
C
V
H
Y
L
K
L
P
E
Y
S
Site 274
Y2590
H
Y
L
K
L
P
E
Y
S
S
E
E
I
M
R
Site 275
S2592
L
K
L
P
E
Y
S
S
E
E
I
M
R
E
R
Site 276
T2604
R
E
R
L
L
A
A
T
M
E
K
G
F
H
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation