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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNRF3
Full Name:
Zinc/RING finger protein 3 precursor
Alias:
BK747E2.3; FLJ22057; KIAA1133; RING finger protein 203; RNF203; zinc and ring finger 3; zinc/RING finger protein 3
Type:
Unknown function
Mass (Da):
100574
Number AA:
936
UniProt ID:
Q9ULT6
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
R
P
R
S
G
G
R
P
G
A
T
Site 2
T12
S
G
G
R
P
G
A
T
G
R
R
R
R
R
L
Site 3
S29
R
P
R
G
L
R
C
S
R
L
P
P
P
P
P
Site 4
Y182
P
L
K
R
P
V
V
Y
V
K
G
A
D
A
I
Site 5
S247
I
K
L
K
Q
R
R
S
Q
N
S
M
N
R
L
Site 6
S250
K
Q
R
R
S
Q
N
S
M
N
R
L
A
V
Q
Site 7
T264
Q
A
L
E
K
M
E
T
R
K
F
N
S
K
S
Site 8
S271
T
R
K
F
N
S
K
S
K
G
R
R
E
G
S
Site 9
S278
S
K
G
R
R
E
G
S
C
G
A
L
D
T
L
Site 10
T284
G
S
C
G
A
L
D
T
L
S
S
S
S
T
S
Site 11
S286
C
G
A
L
D
T
L
S
S
S
S
T
S
D
C
Site 12
S287
G
A
L
D
T
L
S
S
S
S
T
S
D
C
A
Site 13
Y300
C
A
I
C
L
E
K
Y
I
D
G
E
E
L
R
Site 14
T312
E
L
R
V
I
P
C
T
H
R
F
H
R
K
C
Site 15
T363
R
G
R
Q
Q
R
V
T
L
P
V
H
Y
P
G
Site 16
Y368
R
V
T
L
P
V
H
Y
P
G
R
V
H
R
T
Site 17
Y381
R
T
N
A
I
P
A
Y
P
T
R
T
S
M
D
Site 18
S386
P
A
Y
P
T
R
T
S
M
D
S
H
G
N
P
Site 19
S389
P
T
R
T
S
M
D
S
H
G
N
P
V
T
L
Site 20
T395
D
S
H
G
N
P
V
T
L
L
T
M
D
R
H
Site 21
T398
G
N
P
V
T
L
L
T
M
D
R
H
G
E
Q
Site 22
S406
M
D
R
H
G
E
Q
S
L
Y
S
P
Q
T
P
Site 23
Y408
R
H
G
E
Q
S
L
Y
S
P
Q
T
P
A
Y
Site 24
S409
H
G
E
Q
S
L
Y
S
P
Q
T
P
A
Y
I
Site 25
T412
Q
S
L
Y
S
P
Q
T
P
A
Y
I
R
S
Y
Site 26
Y415
Y
S
P
Q
T
P
A
Y
I
R
S
Y
P
P
L
Site 27
S418
Q
T
P
A
Y
I
R
S
Y
P
P
L
H
L
D
Site 28
Y419
T
P
A
Y
I
R
S
Y
P
P
L
H
L
D
H
Site 29
S427
P
P
L
H
L
D
H
S
L
A
A
H
R
C
G
Site 30
Y440
C
G
L
E
H
R
A
Y
S
P
A
H
P
F
R
Site 31
S441
G
L
E
H
R
A
Y
S
P
A
H
P
F
R
R
Site 32
S452
P
F
R
R
P
K
L
S
G
R
S
F
S
K
A
Site 33
S455
R
P
K
L
S
G
R
S
F
S
K
A
A
C
F
Site 34
S457
K
L
S
G
R
S
F
S
K
A
A
C
F
S
Q
Site 35
Y465
K
A
A
C
F
S
Q
Y
E
T
M
Y
Q
H
Y
Site 36
Y472
Y
E
T
M
Y
Q
H
Y
Y
F
Q
G
L
S
Y
Site 37
Y473
E
T
M
Y
Q
H
Y
Y
F
Q
G
L
S
Y
P
Site 38
Y479
Y
Y
F
Q
G
L
S
Y
P
E
Q
E
G
Q
S
Site 39
S486
Y
P
E
Q
E
G
Q
S
P
P
S
L
A
P
R
Site 40
S489
Q
E
G
Q
S
P
P
S
L
A
P
R
G
P
A
Site 41
S504
R
A
F
P
P
S
G
S
G
S
L
L
F
P
T
Site 42
S519
V
V
H
V
A
P
P
S
H
L
E
S
G
S
T
Site 43
S523
A
P
P
S
H
L
E
S
G
S
T
S
S
F
S
Site 44
S525
P
S
H
L
E
S
G
S
T
S
S
F
S
C
Y
Site 45
T526
S
H
L
E
S
G
S
T
S
S
F
S
C
Y
H
Site 46
S527
H
L
E
S
G
S
T
S
S
F
S
C
Y
H
G
Site 47
S528
L
E
S
G
S
T
S
S
F
S
C
Y
H
G
H
Site 48
S530
S
G
S
T
S
S
F
S
C
Y
H
G
H
R
S
Site 49
Y532
S
T
S
S
F
S
C
Y
H
G
H
R
S
V
C
Site 50
Y542
H
R
S
V
C
S
G
Y
L
A
D
C
P
G
S
Site 51
S549
Y
L
A
D
C
P
G
S
D
S
S
S
S
S
S
Site 52
S551
A
D
C
P
G
S
D
S
S
S
S
S
S
S
G
Site 53
S552
D
C
P
G
S
D
S
S
S
S
S
S
S
G
Q
Site 54
S553
C
P
G
S
D
S
S
S
S
S
S
S
G
Q
C
Site 55
S554
P
G
S
D
S
S
S
S
S
S
S
G
Q
C
H
Site 56
S555
G
S
D
S
S
S
S
S
S
S
G
Q
C
H
C
Site 57
S556
S
D
S
S
S
S
S
S
S
G
Q
C
H
C
S
Site 58
S557
D
S
S
S
S
S
S
S
G
Q
C
H
C
S
S
Site 59
S563
S
S
G
Q
C
H
C
S
S
S
D
S
V
V
D
Site 60
S565
G
Q
C
H
C
S
S
S
D
S
V
V
D
C
T
Site 61
S567
C
H
C
S
S
S
D
S
V
V
D
C
T
E
V
Site 62
T572
S
D
S
V
V
D
C
T
E
V
S
N
Q
G
V
Site 63
Y580
E
V
S
N
Q
G
V
Y
G
S
C
S
T
F
R
Site 64
S582
S
N
Q
G
V
Y
G
S
C
S
T
F
R
S
S
Site 65
S584
Q
G
V
Y
G
S
C
S
T
F
R
S
S
L
S
Site 66
T585
G
V
Y
G
S
C
S
T
F
R
S
S
L
S
S
Site 67
S588
G
S
C
S
T
F
R
S
S
L
S
S
D
Y
D
Site 68
S589
S
C
S
T
F
R
S
S
L
S
S
D
Y
D
P
Site 69
S591
S
T
F
R
S
S
L
S
S
D
Y
D
P
F
I
Site 70
S592
T
F
R
S
S
L
S
S
D
Y
D
P
F
I
Y
Site 71
Y594
R
S
S
L
S
S
D
Y
D
P
F
I
Y
R
S
Site 72
Y599
S
D
Y
D
P
F
I
Y
R
S
R
S
P
C
R
Site 73
S601
Y
D
P
F
I
Y
R
S
R
S
P
C
R
A
S
Site 74
S603
P
F
I
Y
R
S
R
S
P
C
R
A
S
E
A
Site 75
S608
S
R
S
P
C
R
A
S
E
A
G
G
S
G
S
Site 76
S613
R
A
S
E
A
G
G
S
G
S
S
G
R
G
P
Site 77
S615
S
E
A
G
G
S
G
S
S
G
R
G
P
A
L
Site 78
S616
E
A
G
G
S
G
S
S
G
R
G
P
A
L
C
Site 79
S627
P
A
L
C
F
E
G
S
P
P
P
E
E
L
P
Site 80
S638
E
E
L
P
A
V
H
S
H
G
A
G
R
G
E
Site 81
S652
E
P
W
P
G
P
A
S
P
S
G
D
Q
V
S
Site 82
S659
S
P
S
G
D
Q
V
S
T
C
S
L
E
M
N
Site 83
T660
P
S
G
D
Q
V
S
T
C
S
L
E
M
N
Y
Site 84
S662
G
D
Q
V
S
T
C
S
L
E
M
N
Y
S
S
Site 85
Y667
T
C
S
L
E
M
N
Y
S
S
N
S
S
L
E
Site 86
S668
C
S
L
E
M
N
Y
S
S
N
S
S
L
E
H
Site 87
S669
S
L
E
M
N
Y
S
S
N
S
S
L
E
H
R
Site 88
S672
M
N
Y
S
S
N
S
S
L
E
H
R
G
P
N
Site 89
S680
L
E
H
R
G
P
N
S
S
T
S
E
V
G
L
Site 90
S681
E
H
R
G
P
N
S
S
T
S
E
V
G
L
E
Site 91
S683
R
G
P
N
S
S
T
S
E
V
G
L
E
A
S
Site 92
S690
S
E
V
G
L
E
A
S
P
G
A
A
P
D
L
Site 93
T700
A
A
P
D
L
R
R
T
W
K
G
G
H
E
L
Site 94
S719
C
C
C
E
P
Q
P
S
P
A
G
P
S
A
G
Site 95
S743
G
P
H
L
Y
E
G
S
G
P
A
G
G
E
P
Site 96
S752
P
A
G
G
E
P
Q
S
G
S
S
Q
G
L
Y
Site 97
S754
G
G
E
P
Q
S
G
S
S
Q
G
L
Y
G
L
Site 98
Y759
S
G
S
S
Q
G
L
Y
G
L
H
P
D
H
L
Site 99
T769
H
P
D
H
L
P
R
T
D
G
V
K
Y
E
G
Site 100
Y774
P
R
T
D
G
V
K
Y
E
G
L
P
C
C
F
Site 101
Y782
E
G
L
P
C
C
F
Y
E
E
K
Q
V
A
R
Site 102
S795
A
R
G
G
G
G
G
S
G
C
Y
T
E
D
Y
Site 103
Y798
G
G
G
G
S
G
C
Y
T
E
D
Y
S
V
S
Site 104
T799
G
G
G
S
G
C
Y
T
E
D
Y
S
V
S
V
Site 105
Y802
S
G
C
Y
T
E
D
Y
S
V
S
V
Q
Y
T
Site 106
S805
Y
T
E
D
Y
S
V
S
V
Q
Y
T
L
T
E
Site 107
T809
Y
S
V
S
V
Q
Y
T
L
T
E
E
P
P
P
Site 108
T811
V
S
V
Q
Y
T
L
T
E
E
P
P
P
G
C
Site 109
Y819
E
E
P
P
P
G
C
Y
P
G
A
R
D
L
S
Site 110
S826
Y
P
G
A
R
D
L
S
Q
R
I
P
I
I
P
Site 111
S844
D
C
D
L
G
L
P
S
D
C
Q
G
T
H
S
Site 112
T849
L
P
S
D
C
Q
G
T
H
S
L
G
S
W
G
Site 113
S851
S
D
C
Q
G
T
H
S
L
G
S
W
G
G
T
Site 114
S854
Q
G
T
H
S
L
G
S
W
G
G
T
R
G
P
Site 115
T858
S
L
G
S
W
G
G
T
R
G
P
D
T
P
R
Site 116
T863
G
G
T
R
G
P
D
T
P
R
P
H
R
G
L
Site 117
T873
P
H
R
G
L
G
A
T
R
E
E
E
R
A
L
Site 118
S906
A
V
R
A
N
F
P
S
A
L
Q
D
T
Q
E
Site 119
T911
F
P
S
A
L
Q
D
T
Q
E
S
S
T
T
A
Site 120
T919
Q
E
S
S
T
T
A
T
E
A
A
G
P
R
S
Site 121
S926
T
E
A
A
G
P
R
S
H
S
A
D
S
S
S
Site 122
S928
A
A
G
P
R
S
H
S
A
D
S
S
S
P
G
Site 123
S931
P
R
S
H
S
A
D
S
S
S
P
G
A
_
_
Site 124
S932
R
S
H
S
A
D
S
S
S
P
G
A
_
_
_
Site 125
S933
S
H
S
A
D
S
S
S
P
G
A
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation