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Updated November 2019
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Protein Info
Short Name:
PLEKHH1
Full Name:
Alias:
Type:
Mass (Da):
151232
Number AA:
1364
UniProt ID:
Q9ULM0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
L
K
V
E
A
P
A
S
V
D
W
Q
K
R
C
Site 2
T20
D
W
Q
K
R
C
L
T
L
E
T
Q
L
F
R
Site 3
S33
F
R
F
R
L
Q
A
S
K
I
R
E
L
L
A
Site 4
T62
Q
R
A
E
N
A
E
T
Q
V
G
V
M
E
E
Site 5
S81
S
N
L
K
N
V
D
S
E
G
S
L
H
R
K
Site 6
S84
K
N
V
D
S
E
G
S
L
H
R
K
Y
Q
E
Site 7
Y89
E
G
S
L
H
R
K
Y
Q
E
L
L
K
A
I
Site 8
S104
K
G
K
D
E
L
I
S
Q
L
E
A
Q
L
E
Site 9
T123
M
R
A
E
E
A
K
T
V
Q
E
K
A
A
K
Site 10
S162
R
L
V
E
Q
V
G
S
L
Q
D
A
L
E
A
Site 11
Y183
R
K
L
L
V
P
P
Y
G
A
A
E
Q
D
S
Site 12
S190
Y
G
A
A
E
Q
D
S
V
P
S
E
P
G
I
Site 13
S204
I
Q
P
M
G
Q
D
S
G
S
Q
A
Q
G
L
Site 14
S206
P
M
G
Q
D
S
G
S
Q
A
Q
G
L
K
A
Site 15
S225
P
S
P
G
A
L
Q
S
K
D
S
V
S
E
A
Site 16
S228
G
A
L
Q
S
K
D
S
V
S
E
A
A
S
P
Site 17
S230
L
Q
S
K
D
S
V
S
E
A
A
S
P
L
E
Site 18
S234
D
S
V
S
E
A
A
S
P
L
E
D
S
S
S
Site 19
S239
A
A
S
P
L
E
D
S
S
S
S
T
V
H
S
Site 20
S240
A
S
P
L
E
D
S
S
S
S
T
V
H
S
G
Site 21
S241
S
P
L
E
D
S
S
S
S
T
V
H
S
G
E
Site 22
S242
P
L
E
D
S
S
S
S
T
V
H
S
G
E
T
Site 23
T243
L
E
D
S
S
S
S
T
V
H
S
G
E
T
V
Site 24
S246
S
S
S
S
T
V
H
S
G
E
T
V
E
A
K
Site 25
S263
Q
P
H
L
G
R
E
S
P
P
H
Q
P
C
M
Site 26
T274
Q
P
C
M
K
L
L
T
F
R
C
S
S
A
S
Site 27
S278
K
L
L
T
F
R
C
S
S
A
S
W
G
E
G
Site 28
S281
T
F
R
C
S
S
A
S
W
G
E
G
L
V
T
Site 29
T288
S
W
G
E
G
L
V
T
A
Q
R
G
M
L
P
Site 30
T299
G
M
L
P
G
T
K
T
S
A
R
E
G
G
P
Site 31
S300
M
L
P
G
T
K
T
S
A
R
E
G
G
P
G
Site 32
S308
A
R
E
G
G
P
G
S
S
L
T
L
P
K
V
Site 33
S309
R
E
G
G
P
G
S
S
L
T
L
P
K
V
R
Site 34
T311
G
G
P
G
S
S
L
T
L
P
K
V
R
A
P
Site 35
T320
P
K
V
R
A
P
G
T
P
R
D
S
I
Q
L
Site 36
S324
A
P
G
T
P
R
D
S
I
Q
L
A
K
R
H
Site 37
S333
Q
L
A
K
R
H
H
S
Q
P
Q
V
G
H
G
Site 38
S366
S
G
L
P
E
L
E
S
R
A
R
S
R
E
E
Site 39
S370
E
L
E
S
R
A
R
S
R
E
E
P
E
K
M
Site 40
S393
G
K
N
E
E
R
E
S
P
K
A
L
G
A
E
Site 41
T412
E
L
G
N
K
P
P
T
P
P
L
H
Q
F
S
Site 42
S419
T
P
P
L
H
Q
F
S
S
W
E
S
R
I
Y
Site 43
S420
P
P
L
H
Q
F
S
S
W
E
S
R
I
Y
A
Site 44
Y426
S
S
W
E
S
R
I
Y
A
V
A
T
S
G
M
Site 45
S436
A
T
S
G
M
R
L
S
D
M
S
P
R
S
N
Site 46
S439
G
M
R
L
S
D
M
S
P
R
S
N
T
A
C
Site 47
S442
L
S
D
M
S
P
R
S
N
T
A
C
C
A
S
Site 48
T444
D
M
S
P
R
S
N
T
A
C
C
A
S
S
P
Site 49
S456
S
S
P
P
A
L
V
S
P
G
S
F
S
G
L
Site 50
Y473
K
N
V
T
V
P
V
Y
T
A
L
K
G
R
A
Site 51
T481
T
A
L
K
G
R
A
T
Q
I
S
N
M
P
F
Site 52
S484
K
G
R
A
T
Q
I
S
N
M
P
F
M
D
E
Site 53
S492
N
M
P
F
M
D
E
S
S
G
S
D
D
D
C
Site 54
S493
M
P
F
M
D
E
S
S
G
S
D
D
D
C
S
Site 55
S495
F
M
D
E
S
S
G
S
D
D
D
C
S
S
Q
Site 56
S500
S
G
S
D
D
D
C
S
S
Q
A
S
F
R
I
Site 57
S501
G
S
D
D
D
C
S
S
Q
A
S
F
R
I
S
Site 58
S504
D
D
C
S
S
Q
A
S
F
R
I
S
V
P
S
Site 59
S508
S
Q
A
S
F
R
I
S
V
P
S
S
E
S
R
Site 60
S511
S
F
R
I
S
V
P
S
S
E
S
R
K
T
S
Site 61
S512
F
R
I
S
V
P
S
S
E
S
R
K
T
S
G
Site 62
S514
I
S
V
P
S
S
E
S
R
K
T
S
G
L
G
Site 63
T517
P
S
S
E
S
R
K
T
S
G
L
G
S
P
R
Site 64
S518
S
S
E
S
R
K
T
S
G
L
G
S
P
R
A
Site 65
S522
R
K
T
S
G
L
G
S
P
R
A
I
K
R
G
Site 66
S531
R
A
I
K
R
G
V
S
M
S
S
L
S
S
E
Site 67
S533
I
K
R
G
V
S
M
S
S
L
S
S
E
G
D
Site 68
S534
K
R
G
V
S
M
S
S
L
S
S
E
G
D
Y
Site 69
S537
V
S
M
S
S
L
S
S
E
G
D
Y
A
I
P
Site 70
Y541
S
L
S
S
E
G
D
Y
A
I
P
P
D
A
C
Site 71
S549
A
I
P
P
D
A
C
S
L
D
S
D
Y
S
E
Site 72
S552
P
D
A
C
S
L
D
S
D
Y
S
E
P
E
H
Site 73
Y554
A
C
S
L
D
S
D
Y
S
E
P
E
H
K
L
Site 74
S555
C
S
L
D
S
D
Y
S
E
P
E
H
K
L
Q
Site 75
T564
P
E
H
K
L
Q
R
T
S
S
Y
S
T
D
G
Site 76
S565
E
H
K
L
Q
R
T
S
S
Y
S
T
D
G
L
Site 77
S566
H
K
L
Q
R
T
S
S
Y
S
T
D
G
L
G
Site 78
Y567
K
L
Q
R
T
S
S
Y
S
T
D
G
L
G
L
Site 79
S568
L
Q
R
T
S
S
Y
S
T
D
G
L
G
L
G
Site 80
T569
Q
R
T
S
S
Y
S
T
D
G
L
G
L
G
G
Site 81
S578
G
L
G
L
G
G
E
S
L
E
K
S
G
Y
L
Site 82
S582
G
G
E
S
L
E
K
S
G
Y
L
L
K
M
G
Site 83
Y584
E
S
L
E
K
S
G
Y
L
L
K
M
G
S
Q
Site 84
S590
G
Y
L
L
K
M
G
S
Q
V
K
T
W
K
R
Site 85
Y609
L
R
Q
G
Q
I
M
Y
Y
K
S
P
S
D
V
Site 86
Y610
R
Q
G
Q
I
M
Y
Y
K
S
P
S
D
V
I
Site 87
S612
G
Q
I
M
Y
Y
K
S
P
S
D
V
I
R
K
Site 88
S628
Q
G
Q
V
D
L
N
S
R
C
Q
I
V
R
G
Site 89
S638
Q
I
V
R
G
E
G
S
Q
T
F
Q
L
I
S
Site 90
T640
V
R
G
E
G
S
Q
T
F
Q
L
I
S
E
K
Site 91
T649
Q
L
I
S
E
K
K
T
Y
Y
L
T
A
D
S
Site 92
Y650
L
I
S
E
K
K
T
Y
Y
L
T
A
D
S
P
Site 93
Y651
I
S
E
K
K
T
Y
Y
L
T
A
D
S
P
S
Site 94
T653
E
K
K
T
Y
Y
L
T
A
D
S
P
S
L
L
Site 95
S656
T
Y
Y
L
T
A
D
S
P
S
L
L
E
E
W
Site 96
T686
P
A
L
L
R
G
G
T
K
P
T
V
K
G
W
Site 97
T689
L
R
G
G
T
K
P
T
V
K
G
W
L
T
K
Site 98
T695
P
T
V
K
G
W
L
T
K
V
K
H
G
H
S
Site 99
Y715
A
L
V
G
K
I
F
Y
Y
Y
R
S
H
E
D
Site 100
Y716
L
V
G
K
I
F
Y
Y
Y
R
S
H
E
D
K
Site 101
Y717
V
G
K
I
F
Y
Y
Y
R
S
H
E
D
K
R
Site 102
S742
H
I
E
E
V
D
R
S
C
D
S
D
E
D
Y
Site 103
S745
E
V
D
R
S
C
D
S
D
E
D
Y
E
A
G
Site 104
Y749
S
C
D
S
D
E
D
Y
E
A
G
G
T
R
R
Site 105
T754
E
D
Y
E
A
G
G
T
R
R
L
L
S
S
H
Site 106
T774
H
P
T
E
H
S
P
T
Y
L
L
I
G
T
K
Site 107
Y775
P
T
E
H
S
P
T
Y
L
L
I
G
T
K
H
Site 108
S822
D
G
E
G
D
P
D
S
P
L
W
R
H
P
M
Site 109
Y838
C
Y
S
K
D
G
L
Y
A
S
L
T
T
L
P
Site 110
S840
S
K
D
G
L
Y
A
S
L
T
T
L
P
S
E
Site 111
T851
L
P
S
E
A
L
Q
T
E
A
L
K
L
F
K
Site 112
S951
Q
R
H
A
D
P
R
S
E
T
G
Q
Y
A
T
Site 113
T953
H
A
D
P
R
S
E
T
G
Q
Y
A
T
Y
C
Site 114
Y956
P
R
S
E
T
G
Q
Y
A
T
Y
C
Q
R
A
Site 115
Y959
E
T
G
Q
Y
A
T
Y
C
Q
R
A
V
E
R
Site 116
T967
C
Q
R
A
V
E
R
T
L
R
T
G
E
R
E
Site 117
S978
G
E
R
E
A
R
P
S
R
M
E
V
V
S
I
Site 118
S994
L
R
N
P
F
H
H
S
L
P
F
S
I
P
V
Site 119
T1018
V
G
F
D
G
S
S
T
V
D
E
F
L
Q
R
Site 120
S1036
E
I
G
M
R
K
P
S
H
S
G
F
A
L
F
Site 121
S1038
G
M
R
K
P
S
H
S
G
F
A
L
F
T
D
Site 122
T1044
H
S
G
F
A
L
F
T
D
D
P
S
G
R
D
Site 123
S1048
A
L
F
T
D
D
P
S
G
R
D
L
E
H
C
Site 124
S1081
K
E
L
H
P
G
K
S
E
G
G
T
R
V
V
Site 125
T1085
P
G
K
S
E
G
G
T
R
V
V
K
L
M
Y
Site 126
Y1092
T
R
V
V
K
L
M
Y
K
N
R
L
Y
F
R
Site 127
Y1097
L
M
Y
K
N
R
L
Y
F
R
S
Q
V
K
G
Site 128
S1100
K
N
R
L
Y
F
R
S
Q
V
K
G
E
T
D
Site 129
T1106
R
S
Q
V
K
G
E
T
D
R
E
R
L
L
L
Site 130
S1115
R
E
R
L
L
L
A
S
Q
T
S
R
E
I
V
Site 131
T1117
R
L
L
L
A
S
Q
T
S
R
E
I
V
A
G
Site 132
S1118
L
L
L
A
S
Q
T
S
R
E
I
V
A
G
R
Site 133
Y1145
A
L
M
A
Q
V
E
Y
G
D
L
E
K
P
A
Site 134
S1160
L
P
G
P
G
G
T
S
P
A
K
A
Q
H
L
Site 135
Y1180
D
R
F
H
P
R
R
Y
R
H
G
A
P
A
E
Site 136
T1197
R
H
L
A
D
M
L
T
T
K
W
A
T
L
Q
Site 137
Y1215
P
P
E
C
I
R
I
Y
L
T
V
A
R
K
W
Site 138
S1255
A
V
N
E
D
G
V
S
I
L
D
H
N
T
M
Site 139
T1267
N
T
M
Q
V
H
I
T
Y
P
Y
S
S
V
T
Site 140
Y1268
T
M
Q
V
H
I
T
Y
P
Y
S
S
V
T
T
Site 141
Y1270
Q
V
H
I
T
Y
P
Y
S
S
V
T
T
F
G
Site 142
T1275
Y
P
Y
S
S
V
T
T
F
G
G
C
R
D
D
Site 143
S1289
D
F
M
L
V
I
R
S
I
P
D
K
S
S
G
Site 144
S1294
I
R
S
I
P
D
K
S
S
G
K
S
H
I
E
Site 145
S1295
R
S
I
P
D
K
S
S
G
K
S
H
I
E
K
Site 146
S1298
P
D
K
S
S
G
K
S
H
I
E
K
L
I
F
Site 147
T1334
T
T
T
V
N
P
P
T
N
P
P
G
A
C
Q
Site 148
S1353
D
G
R
Q
F
F
S
S
V
S
C
A
T
K
G
Site 149
S1355
R
Q
F
F
S
S
V
S
C
A
T
K
G
P
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation