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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SHROOM4
Full Name:
Protein Shroom4
Alias:
KIAA1202; second homolog of apical protein; SHAP; SHRM4; shroom family 4; shroom family member 4; shroom4
Type:
Actin binding protein
Mass (Da):
165500
Number AA:
UniProt ID:
Q9ULL8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016324
GO:0009925
GO:0009898
Uniprot
OncoNet
Molecular Function:
GO:0051015
PhosphoSite+
KinaseNET
Biological Process:
GO:0007015
GO:0007420
GO:0050890
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
N
R
P
G
S
F
Q
Y
V
P
V
Q
Site 2
Y10
N
R
P
G
S
F
Q
Y
V
P
V
Q
L
Q
G
Site 3
T24
G
G
A
P
W
G
F
T
L
K
G
G
L
E
H
Site 4
T36
L
E
H
C
E
P
L
T
V
S
K
I
E
D
G
Site 5
S38
H
C
E
P
L
T
V
S
K
I
E
D
G
G
K
Site 6
S49
D
G
G
K
A
A
L
S
Q
K
M
R
T
G
D
Site 7
T64
E
L
V
N
I
N
G
T
P
L
Y
G
S
R
Q
Site 8
Y67
N
I
N
G
T
P
L
Y
G
S
R
Q
E
A
L
Site 9
S69
N
G
T
P
L
Y
G
S
R
Q
E
A
L
I
L
Site 10
S80
A
L
I
L
I
K
G
S
F
R
I
L
K
L
I
Site 11
S96
R
R
R
N
A
P
V
S
R
P
H
S
W
H
V
Site 12
S100
A
P
V
S
R
P
H
S
W
H
V
A
K
L
L
Site 13
T116
G
C
P
E
A
A
T
T
M
H
F
P
S
E
A
Site 14
S121
A
T
T
M
H
F
P
S
E
A
F
S
L
S
W
Site 15
S125
H
F
P
S
E
A
F
S
L
S
W
H
S
G
C
Site 16
S127
P
S
E
A
F
S
L
S
W
H
S
G
C
N
T
Site 17
S130
A
F
S
L
S
W
H
S
G
C
N
T
S
D
V
Site 18
S149
C
P
L
S
R
H
C
S
T
E
K
S
S
S
I
Site 19
T150
P
L
S
R
H
C
S
T
E
K
S
S
S
I
G
Site 20
S153
R
H
C
S
T
E
K
S
S
S
I
G
S
M
E
Site 21
S155
C
S
T
E
K
S
S
S
I
G
S
M
E
S
L
Site 22
S158
E
K
S
S
S
I
G
S
M
E
S
L
E
Q
P
Site 23
S161
S
S
I
G
S
M
E
S
L
E
Q
P
G
Q
A
Site 24
Y170
E
Q
P
G
Q
A
T
Y
E
S
H
L
L
P
I
Site 25
Y182
L
P
I
D
Q
N
M
Y
P
N
Q
R
D
S
A
Site 26
S188
M
Y
P
N
Q
R
D
S
A
Y
S
S
F
S
A
Site 27
Y190
P
N
Q
R
D
S
A
Y
S
S
F
S
A
S
S
Site 28
S191
N
Q
R
D
S
A
Y
S
S
F
S
A
S
S
N
Site 29
S192
Q
R
D
S
A
Y
S
S
F
S
A
S
S
N
A
Site 30
S194
D
S
A
Y
S
S
F
S
A
S
S
N
A
S
D
Site 31
S196
A
Y
S
S
F
S
A
S
S
N
A
S
D
C
A
Site 32
S197
Y
S
S
F
S
A
S
S
N
A
S
D
C
A
L
Site 33
S200
F
S
A
S
S
N
A
S
D
C
A
L
S
L
R
Site 34
S205
N
A
S
D
C
A
L
S
L
R
P
E
E
P
A
Site 35
S213
L
R
P
E
E
P
A
S
T
D
C
I
M
Q
G
Site 36
T214
R
P
E
E
P
A
S
T
D
C
I
M
Q
G
P
Site 37
T224
I
M
Q
G
P
G
P
T
K
A
P
S
G
R
P
Site 38
S228
P
G
P
T
K
A
P
S
G
R
P
N
V
A
E
Site 39
T243
T
S
G
G
S
R
R
T
N
G
G
H
L
T
P
Site 40
T249
R
T
N
G
G
H
L
T
P
S
S
Q
M
S
S
Site 41
S251
N
G
G
H
L
T
P
S
S
Q
M
S
S
R
P
Site 42
S252
G
G
H
L
T
P
S
S
Q
M
S
S
R
P
Q
Site 43
S255
L
T
P
S
S
Q
M
S
S
R
P
Q
E
G
Y
Site 44
S256
T
P
S
S
Q
M
S
S
R
P
Q
E
G
Y
Q
Site 45
Y262
S
S
R
P
Q
E
G
Y
Q
S
G
P
A
K
A
Site 46
S264
R
P
Q
E
G
Y
Q
S
G
P
A
K
A
V
R
Site 47
S282
Q
P
P
V
R
R
D
S
L
Q
A
S
R
A
Q
Site 48
S286
R
R
D
S
L
Q
A
S
R
A
Q
L
L
N
G
Site 49
S299
N
G
E
Q
R
R
A
S
E
P
V
V
P
L
P
Site 50
S312
L
P
Q
K
E
K
L
S
L
E
P
V
L
P
A
Site 51
T335
L
S
G
H
D
Q
V
T
S
E
G
H
Q
N
C
Site 52
S336
S
G
H
D
Q
V
T
S
E
G
H
Q
N
C
E
Site 53
S345
G
H
Q
N
C
E
F
S
Q
P
P
E
S
S
Q
Site 54
S350
E
F
S
Q
P
P
E
S
S
Q
Q
G
S
E
H
Site 55
S351
F
S
Q
P
P
E
S
S
Q
Q
G
S
E
H
L
Site 56
S355
P
E
S
S
Q
Q
G
S
E
H
L
L
M
Q
A
Site 57
S363
E
H
L
L
M
Q
A
S
T
K
A
V
G
S
P
Site 58
S369
A
S
T
K
A
V
G
S
P
K
A
C
D
R
A
Site 59
S377
P
K
A
C
D
R
A
S
S
V
D
S
N
P
L
Site 60
S378
K
A
C
D
R
A
S
S
V
D
S
N
P
L
N
Site 61
S381
D
R
A
S
S
V
D
S
N
P
L
N
E
A
S
Site 62
S395
S
A
E
L
A
K
A
S
F
G
R
P
P
H
L
Site 63
S411
G
P
T
G
H
R
H
S
A
P
E
Q
L
L
A
Site 64
T428
L
Q
H
V
H
L
D
T
R
G
S
K
G
M
E
Site 65
S431
V
H
L
D
T
R
G
S
K
G
M
E
L
P
P
Site 66
T446
V
Q
D
G
H
Q
W
T
L
S
P
L
H
S
S
Site 67
S448
D
G
H
Q
W
T
L
S
P
L
H
S
S
H
K
Site 68
S452
W
T
L
S
P
L
H
S
S
H
K
G
K
K
S
Site 69
S453
T
L
S
P
L
H
S
S
H
K
G
K
K
S
P
Site 70
S459
S
S
H
K
G
K
K
S
P
C
P
P
T
G
G
Site 71
S471
T
G
G
T
H
D
Q
S
S
K
E
R
K
T
R
Site 72
S472
G
G
T
H
D
Q
S
S
K
E
R
K
T
R
Q
Site 73
T477
Q
S
S
K
E
R
K
T
R
Q
V
D
D
R
S
Site 74
S484
T
R
Q
V
D
D
R
S
L
V
L
G
H
Q
S
Site 75
S491
S
L
V
L
G
H
Q
S
Q
S
S
P
P
H
G
Site 76
S493
V
L
G
H
Q
S
Q
S
S
P
P
H
G
E
A
Site 77
S494
L
G
H
Q
S
Q
S
S
P
P
H
G
E
A
D
Site 78
S505
G
E
A
D
G
H
P
S
E
K
G
F
L
D
P
Site 79
T515
G
F
L
D
P
N
R
T
S
R
A
A
S
E
L
Site 80
S516
F
L
D
P
N
R
T
S
R
A
A
S
E
L
A
Site 81
S520
N
R
T
S
R
A
A
S
E
L
A
N
Q
Q
P
Site 82
S528
E
L
A
N
Q
Q
P
S
A
S
G
S
L
V
Q
Site 83
S532
Q
Q
P
S
A
S
G
S
L
V
Q
Q
A
T
D
Site 84
T538
G
S
L
V
Q
Q
A
T
D
C
S
S
T
T
K
Site 85
S542
Q
Q
A
T
D
C
S
S
T
T
K
A
A
S
G
Site 86
S558
E
A
G
E
E
G
D
S
E
P
K
E
C
S
R
Site 87
S571
S
R
M
G
G
R
R
S
G
G
T
R
G
R
S
Site 88
T574
G
G
R
R
S
G
G
T
R
G
R
S
I
Q
N
Site 89
S578
S
G
G
T
R
G
R
S
I
Q
N
R
R
K
S
Site 90
S585
S
I
Q
N
R
R
K
S
E
R
F
A
T
N
L
Site 91
T590
R
K
S
E
R
F
A
T
N
L
R
N
E
I
Q
Site 92
S606
R
K
A
Q
L
Q
K
S
K
G
P
L
S
Q
L
Site 93
S611
Q
K
S
K
G
P
L
S
Q
L
C
D
T
K
E
Site 94
T616
P
L
S
Q
L
C
D
T
K
E
P
V
E
E
T
Site 95
S629
E
T
Q
E
P
P
E
S
P
P
L
T
A
S
N
Site 96
T633
P
P
E
S
P
P
L
T
A
S
N
T
S
L
L
Site 97
S635
E
S
P
P
L
T
A
S
N
T
S
L
L
S
S
Site 98
T637
P
P
L
T
A
S
N
T
S
L
L
S
S
C
K
Site 99
S638
P
L
T
A
S
N
T
S
L
L
S
S
C
K
K
Site 100
S641
A
S
N
T
S
L
L
S
S
C
K
K
P
P
S
Site 101
S642
S
N
T
S
L
L
S
S
C
K
K
P
P
S
P
Site 102
S648
S
S
C
K
K
P
P
S
P
R
D
K
L
F
N
Site 103
S657
R
D
K
L
F
N
K
S
M
M
L
R
A
R
S
Site 104
S664
S
M
M
L
R
A
R
S
S
E
C
L
S
Q
A
Site 105
S665
M
M
L
R
A
R
S
S
E
C
L
S
Q
A
P
Site 106
S669
A
R
S
S
E
C
L
S
Q
A
P
E
S
H
E
Site 107
S674
C
L
S
Q
A
P
E
S
H
E
S
R
T
G
L
Site 108
S677
Q
A
P
E
S
H
E
S
R
T
G
L
E
G
R
Site 109
S686
T
G
L
E
G
R
I
S
P
G
Q
R
P
G
Q
Site 110
S694
P
G
Q
R
P
G
Q
S
S
L
G
L
N
T
W
Site 111
S695
G
Q
R
P
G
Q
S
S
L
G
L
N
T
W
W
Site 112
S708
W
W
K
A
P
D
P
S
S
S
D
P
E
K
A
Site 113
S709
W
K
A
P
D
P
S
S
S
D
P
E
K
A
H
Site 114
S710
K
A
P
D
P
S
S
S
D
P
E
K
A
H
A
Site 115
S729
R
G
G
H
W
R
W
S
P
E
H
N
S
Q
P
Site 116
S734
R
W
S
P
E
H
N
S
Q
P
L
V
A
A
A
Site 117
S757
D
N
K
E
L
K
A
S
T
A
Q
A
G
E
D
Site 118
S780
R
R
K
F
F
E
E
S
S
K
S
L
S
T
S
Site 119
S781
R
K
F
F
E
E
S
S
K
S
L
S
T
S
H
Site 120
S783
F
F
E
E
S
S
K
S
L
S
T
S
H
L
P
Site 121
S785
E
E
S
S
K
S
L
S
T
S
H
L
P
G
L
Site 122
S787
S
S
K
S
L
S
T
S
H
L
P
G
L
T
T
Site 123
T794
S
H
L
P
G
L
T
T
H
S
N
K
T
F
T
Site 124
S796
L
P
G
L
T
T
H
S
N
K
T
F
T
Q
R
Site 125
T799
L
T
T
H
S
N
K
T
F
T
Q
R
P
K
P
Site 126
T801
T
H
S
N
K
T
F
T
Q
R
P
K
P
I
D
Site 127
S815
D
Q
N
F
Q
P
M
S
S
S
C
R
E
L
R
Site 128
S816
Q
N
F
Q
P
M
S
S
S
C
R
E
L
R
R
Site 129
S817
N
F
Q
P
M
S
S
S
C
R
E
L
R
R
H
Site 130
S829
R
R
H
P
M
D
Q
S
Y
H
S
A
D
Q
P
Site 131
Y830
R
H
P
M
D
Q
S
Y
H
S
A
D
Q
P
Y
Site 132
Y837
Y
H
S
A
D
Q
P
Y
H
A
T
D
Q
S
Y
Site 133
S843
P
Y
H
A
T
D
Q
S
Y
H
S
M
S
P
L
Site 134
Y844
Y
H
A
T
D
Q
S
Y
H
S
M
S
P
L
Q
Site 135
S846
A
T
D
Q
S
Y
H
S
M
S
P
L
Q
S
E
Site 136
S848
D
Q
S
Y
H
S
M
S
P
L
Q
S
E
T
P
Site 137
S852
H
S
M
S
P
L
Q
S
E
T
P
T
Y
S
E
Site 138
T854
M
S
P
L
Q
S
E
T
P
T
Y
S
E
C
F
Site 139
T856
P
L
Q
S
E
T
P
T
Y
S
E
C
F
A
S
Site 140
Y857
L
Q
S
E
T
P
T
Y
S
E
C
F
A
S
K
Site 141
S858
Q
S
E
T
P
T
Y
S
E
C
F
A
S
K
G
Site 142
S863
T
Y
S
E
C
F
A
S
K
G
L
E
N
S
M
Site 143
S869
A
S
K
G
L
E
N
S
M
C
C
K
P
L
H
Site 144
Y882
L
H
C
G
D
F
D
Y
H
R
T
C
S
Y
S
Site 145
Y888
D
Y
H
R
T
C
S
Y
S
C
S
V
Q
G
A
Site 146
S950
H
S
A
L
E
D
S
S
L
A
P
G
N
T
W
Site 147
T963
T
W
K
P
R
K
L
T
V
Q
E
F
P
G
D
Site 148
T976
G
D
K
W
N
P
I
T
G
N
R
K
T
S
Q
Site 149
T981
P
I
T
G
N
R
K
T
S
Q
S
G
R
E
M
Site 150
S982
I
T
G
N
R
K
T
S
Q
S
G
R
E
M
A
Site 151
S984
G
N
R
K
T
S
Q
S
G
R
E
M
A
H
S
Site 152
S991
S
G
R
E
M
A
H
S
K
T
S
F
S
W
A
Site 153
S994
E
M
A
H
S
K
T
S
F
S
W
A
T
P
F
Site 154
S996
A
H
S
K
T
S
F
S
W
A
T
P
F
H
P
Site 155
T999
K
T
S
F
S
W
A
T
P
F
H
P
C
L
E
Site 156
S1013
E
N
P
A
L
D
L
S
S
Y
R
A
I
S
S
Site 157
S1014
N
P
A
L
D
L
S
S
Y
R
A
I
S
S
L
Site 158
Y1015
P
A
L
D
L
S
S
Y
R
A
I
S
S
L
D
Site 159
S1019
L
S
S
Y
R
A
I
S
S
L
D
L
L
G
D
Site 160
S1020
S
S
Y
R
A
I
S
S
L
D
L
L
G
D
F
Site 161
S1034
F
K
H
A
L
K
K
S
E
E
T
S
V
Y
E
Site 162
S1038
L
K
K
S
E
E
T
S
V
Y
E
E
G
S
S
Site 163
Y1040
K
S
E
E
T
S
V
Y
E
E
G
S
S
L
A
Site 164
S1045
S
V
Y
E
E
G
S
S
L
A
S
M
P
H
P
Site 165
S1048
E
E
G
S
S
L
A
S
M
P
H
P
L
R
S
Site 166
S1055
S
M
P
H
P
L
R
S
R
A
F
S
E
S
H
Site 167
S1059
P
L
R
S
R
A
F
S
E
S
H
I
S
L
A
Site 168
S1061
R
S
R
A
F
S
E
S
H
I
S
L
A
P
Q
Site 169
S1064
A
F
S
E
S
H
I
S
L
A
P
Q
S
T
R
Site 170
S1069
H
I
S
L
A
P
Q
S
T
R
A
W
G
Q
H
Site 171
S1082
Q
H
R
R
E
L
F
S
K
G
D
E
T
Q
S
Site 172
T1087
L
F
S
K
G
D
E
T
Q
S
D
L
L
G
A
Site 173
S1089
S
K
G
D
E
T
Q
S
D
L
L
G
A
R
K
Site 174
Y1112
P
P
P
N
W
E
K
Y
R
L
F
R
A
A
Q
Site 175
Y1168
E
E
E
L
P
P
Q
Y
F
S
S
E
T
S
G
Site 176
S1170
E
L
P
P
Q
Y
F
S
S
E
T
S
G
S
C
Site 177
S1171
L
P
P
Q
Y
F
S
S
E
T
S
G
S
C
A
Site 178
S1174
Q
Y
F
S
S
E
T
S
G
S
C
A
L
N
P
Site 179
S1176
F
S
S
E
T
S
G
S
C
A
L
N
P
E
E
Site 180
S1192
L
E
Q
P
Q
P
L
S
F
G
H
L
E
G
S
Site 181
S1199
S
F
G
H
L
E
G
S
R
Q
G
S
Q
S
V
Site 182
S1203
L
E
G
S
R
Q
G
S
Q
S
V
P
A
E
Q
Site 183
S1205
G
S
R
Q
G
S
Q
S
V
P
A
E
Q
E
S
Site 184
S1212
S
V
P
A
E
Q
E
S
F
A
L
H
S
S
D
Site 185
S1218
E
S
F
A
L
H
S
S
D
F
L
P
P
I
R
Site 186
S1230
P
I
R
G
H
L
G
S
Q
P
E
Q
A
Q
P
Site 187
Y1240
E
Q
A
Q
P
P
C
Y
Y
G
I
G
G
L
W
Site 188
Y1241
Q
A
Q
P
P
C
Y
Y
G
I
G
G
L
W
R
Site 189
S1250
I
G
G
L
W
R
T
S
G
Q
E
A
T
E
S
Site 190
S1257
S
G
Q
E
A
T
E
S
A
K
Q
E
F
Q
H
Site 191
S1266
K
Q
E
F
Q
H
F
S
P
P
S
G
A
P
G
Site 192
S1269
F
Q
H
F
S
P
P
S
G
A
P
G
I
P
T
Site 193
T1276
S
G
A
P
G
I
P
T
S
Y
S
A
Y
Y
N
Site 194
S1277
G
A
P
G
I
P
T
S
Y
S
A
Y
Y
N
I
Site 195
S1279
P
G
I
P
T
S
Y
S
A
Y
Y
N
I
S
V
Site 196
Y1281
I
P
T
S
Y
S
A
Y
Y
N
I
S
V
A
K
Site 197
S1325
K
K
I
Q
L
I
E
S
I
S
R
K
L
S
V
Site 198
S1331
E
S
I
S
R
K
L
S
V
L
R
E
A
Q
R
Site 199
Y1370
K
S
N
E
F
E
K
Y
H
L
F
V
G
D
L
Site 200
S1400
R
V
E
N
A
L
N
S
I
D
S
E
A
N
Q
Site 201
Y1447
V
F
G
M
V
S
R
Y
L
P
Q
D
Q
L
Q
Site 202
Y1456
P
Q
D
Q
L
Q
D
Y
Q
H
F
V
K
M
K
Site 203
S1464
Q
H
F
V
K
M
K
S
A
L
I
I
E
Q
R
Site 204
S1490
Q
L
K
C
L
R
E
S
L
L
L
G
P
S
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation