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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHG1
Full Name:
Pleckstrin homology domain-containing family G member 1
Alias:
KIAA1209; PKHG1; pleckstrin homology domain containing family G member 1; pleckstrin homology domain containing, family G (with RhoGef domain) member 1; pleckstriny domain containing, family G (with RhoGef domain) member 1
Type:
Unknown function
Mass (Da):
155439
Number AA:
1385
UniProt ID:
Q9ULL1
International Prot ID:
IPI00008173
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
L
S
D
S
D
R
P
V
S
F
G
Site 2
S11
S
D
S
D
R
P
V
S
F
G
S
T
S
S
S
Site 3
S14
D
R
P
V
S
F
G
S
T
S
S
S
A
S
S
Site 4
T15
R
P
V
S
F
G
S
T
S
S
S
A
S
S
R
Site 5
S16
P
V
S
F
G
S
T
S
S
S
A
S
S
R
D
Site 6
S17
V
S
F
G
S
T
S
S
S
A
S
S
R
D
S
Site 7
S18
S
F
G
S
T
S
S
S
A
S
S
R
D
S
H
Site 8
S20
G
S
T
S
S
S
A
S
S
R
D
S
H
G
S
Site 9
S21
S
T
S
S
S
A
S
S
R
D
S
H
G
S
F
Site 10
S24
S
S
A
S
S
R
D
S
H
G
S
F
G
S
R
Site 11
S27
S
S
R
D
S
H
G
S
F
G
S
R
M
T
L
Site 12
T33
G
S
F
G
S
R
M
T
L
V
S
N
S
H
M
Site 13
S63
L
I
P
A
R
P
F
S
S
S
E
L
Q
R
D
Site 14
S65
P
A
R
P
F
S
S
S
E
L
Q
R
D
N
P
Site 15
T74
L
Q
R
D
N
P
A
T
G
Q
Q
N
A
D
E
Site 16
S83
Q
Q
N
A
D
E
G
S
E
R
P
P
R
A
Q
Site 17
S95
R
A
Q
W
R
V
D
S
N
G
A
P
K
T
I
Site 18
T101
D
S
N
G
A
P
K
T
I
A
D
S
A
T
S
Site 19
S105
A
P
K
T
I
A
D
S
A
T
S
P
K
L
L
Site 20
Y113
A
T
S
P
K
L
L
Y
V
D
R
V
V
Q
E
Site 21
T124
V
V
Q
E
I
L
E
T
E
R
T
Y
V
Q
D
Site 22
T127
E
I
L
E
T
E
R
T
Y
V
Q
D
L
K
S
Site 23
Y128
I
L
E
T
E
R
T
Y
V
Q
D
L
K
S
I
Site 24
S134
T
Y
V
Q
D
L
K
S
I
V
E
D
Y
L
D
Site 25
Y139
L
K
S
I
V
E
D
Y
L
D
C
I
R
D
Q
Site 26
T147
L
D
C
I
R
D
Q
T
K
L
P
L
G
T
E
Site 27
T153
Q
T
K
L
P
L
G
T
E
E
R
S
A
L
F
Site 28
Y167
F
G
N
I
Q
D
I
Y
H
F
N
S
E
L
L
Site 29
Y201
K
S
E
E
F
H
I
Y
T
Q
Y
C
T
N
Y
Site 30
Y208
Y
T
Q
Y
C
T
N
Y
P
R
S
V
A
V
L
Site 31
T216
P
R
S
V
A
V
L
T
E
C
M
R
N
K
I
Site 32
T234
F
F
R
E
R
Q
E
T
L
K
H
S
L
P
L
Site 33
S238
R
Q
E
T
L
K
H
S
L
P
L
G
S
Y
L
Site 34
S243
K
H
S
L
P
L
G
S
Y
L
L
K
P
V
Q
Site 35
Y244
H
S
L
P
L
G
S
Y
L
L
K
P
V
Q
R
Site 36
T270
E
N
H
L
D
K
D
T
E
G
Y
D
V
V
L
Site 37
S308
V
R
L
Q
E
I
Q
S
L
L
T
N
W
K
G
Site 38
T319
N
W
K
G
P
D
L
T
S
Y
G
E
L
V
L
Site 39
Y321
K
G
P
D
L
T
S
Y
G
E
L
V
L
E
G
Site 40
T329
G
E
L
V
L
E
G
T
F
R
I
Q
R
A
K
Site 41
T357
I
T
K
K
R
D
D
T
F
T
Y
K
A
H
I
Site 42
T359
K
K
R
D
D
T
F
T
Y
K
A
H
I
L
C
Site 43
Y360
K
R
D
D
T
F
T
Y
K
A
H
I
L
C
G
Site 44
S381
V
I
P
K
E
P
L
S
F
S
V
F
H
Y
K
Site 45
S383
P
K
E
P
L
S
F
S
V
F
H
Y
K
N
P
Site 46
Y387
L
S
F
S
V
F
H
Y
K
N
P
K
L
Q
H
Site 47
T395
K
N
P
K
L
Q
H
T
V
Q
A
K
S
Q
Q
Site 48
S400
Q
H
T
V
Q
A
K
S
Q
Q
D
K
R
L
W
Site 49
Y444
I
H
H
P
G
F
C
Y
S
P
E
G
G
T
K
Site 50
S445
H
H
P
G
F
C
Y
S
P
E
G
G
T
K
A
Site 51
S456
G
T
K
A
L
F
G
S
K
E
G
S
A
P
Y
Site 52
S460
L
F
G
S
K
E
G
S
A
P
Y
R
L
R
R
Site 53
S469
P
Y
R
L
R
R
K
S
E
P
S
S
R
S
H
Site 54
S472
L
R
R
K
S
E
P
S
S
R
S
H
K
V
L
Site 55
S473
R
R
K
S
E
P
S
S
R
S
H
K
V
L
K
Site 56
S475
K
S
E
P
S
S
R
S
H
K
V
L
K
T
S
Site 57
S497
K
V
S
R
E
E
G
S
P
Q
L
S
S
A
R
Site 58
S501
E
E
G
S
P
Q
L
S
S
A
R
P
S
P
A
Site 59
S502
E
G
S
P
Q
L
S
S
A
R
P
S
P
A
Q
Site 60
S506
Q
L
S
S
A
R
P
S
P
A
Q
R
N
S
Q
Site 61
S512
P
S
P
A
Q
R
N
S
Q
P
S
S
S
T
M
Site 62
S515
A
Q
R
N
S
Q
P
S
S
S
T
M
I
S
V
Site 63
S516
Q
R
N
S
Q
P
S
S
S
T
M
I
S
V
L
Site 64
S517
R
N
S
Q
P
S
S
S
T
M
I
S
V
L
R
Site 65
S545
I
R
Q
A
L
F
P
S
R
R
S
P
Q
E
N
Site 66
S548
A
L
F
P
S
R
R
S
P
Q
E
N
E
D
D
Site 67
Y559
N
E
D
D
E
D
D
Y
Q
M
F
V
P
S
F
Site 68
S565
D
Y
Q
M
F
V
P
S
F
S
S
S
D
L
N
Site 69
S567
Q
M
F
V
P
S
F
S
S
S
D
L
N
S
T
Site 70
S569
F
V
P
S
F
S
S
S
D
L
N
S
T
R
L
Site 71
S573
F
S
S
S
D
L
N
S
T
R
L
C
E
D
S
Site 72
S580
S
T
R
L
C
E
D
S
T
S
S
R
P
C
S
Site 73
T581
T
R
L
C
E
D
S
T
S
S
R
P
C
S
W
Site 74
S582
R
L
C
E
D
S
T
S
S
R
P
C
S
W
H
Site 75
S587
S
T
S
S
R
P
C
S
W
H
M
G
Q
M
E
Site 76
S595
W
H
M
G
Q
M
E
S
T
E
T
S
S
S
G
Site 77
T596
H
M
G
Q
M
E
S
T
E
T
S
S
S
G
H
Site 78
T598
G
Q
M
E
S
T
E
T
S
S
S
G
H
R
I
Site 79
S599
Q
M
E
S
T
E
T
S
S
S
G
H
R
I
V
Site 80
S601
E
S
T
E
T
S
S
S
G
H
R
I
V
R
R
Site 81
S610
H
R
I
V
R
R
A
S
S
A
G
E
S
N
T
Site 82
S611
R
I
V
R
R
A
S
S
A
G
E
S
N
T
C
Site 83
S615
R
A
S
S
A
G
E
S
N
T
C
P
P
E
I
Site 84
T617
S
S
A
G
E
S
N
T
C
P
P
E
I
G
T
Site 85
S625
C
P
P
E
I
G
T
S
D
R
T
R
E
L
Q
Site 86
S634
R
T
R
E
L
Q
N
S
P
K
T
E
G
Q
E
Site 87
T644
T
E
G
Q
E
E
M
T
P
F
G
S
S
I
E
Site 88
Y661
I
D
D
I
D
H
V
Y
D
N
I
S
Y
E
D
Site 89
S681
A
K
R
E
E
A
E
S
T
P
S
K
S
A
R
Site 90
T682
K
R
E
E
A
E
S
T
P
S
K
S
A
R
D
Site 91
S684
E
E
A
E
S
T
P
S
K
S
A
R
D
S
V
Site 92
S686
A
E
S
T
P
S
K
S
A
R
D
S
V
R
P
Site 93
S690
P
S
K
S
A
R
D
S
V
R
P
K
S
T
P
Site 94
S695
R
D
S
V
R
P
K
S
T
P
E
L
A
F
T
Site 95
T696
D
S
V
R
P
K
S
T
P
E
L
A
F
T
K
Site 96
T702
S
T
P
E
L
A
F
T
K
R
Q
A
G
H
S
Site 97
S709
T
K
R
Q
A
G
H
S
K
G
S
L
Y
A
Q
Site 98
S712
Q
A
G
H
S
K
G
S
L
Y
A
Q
T
D
G
Site 99
Y714
G
H
S
K
G
S
L
Y
A
Q
T
D
G
T
L
Site 100
T717
K
G
S
L
Y
A
Q
T
D
G
T
L
S
G
G
Site 101
T720
L
Y
A
Q
T
D
G
T
L
S
G
G
E
A
S
Site 102
S722
A
Q
T
D
G
T
L
S
G
G
E
A
S
S
Q
Site 103
S727
T
L
S
G
G
E
A
S
S
Q
S
T
H
E
L
Site 104
S728
L
S
G
G
E
A
S
S
Q
S
T
H
E
L
Q
Site 105
S730
G
G
E
A
S
S
Q
S
T
H
E
L
Q
A
V
Site 106
Y742
Q
A
V
E
E
N
I
Y
D
T
I
G
L
P
D
Site 107
S752
I
G
L
P
D
P
P
S
L
G
F
K
C
S
S
Site 108
S758
P
S
L
G
F
K
C
S
S
L
K
R
A
K
R
Site 109
S759
S
L
G
F
K
C
S
S
L
K
R
A
K
R
S
Site 110
T767
L
K
R
A
K
R
S
T
F
L
G
L
E
A
D
Site 111
S786
D
S
L
R
P
F
V
S
Q
D
S
L
Q
L
S
Site 112
S789
R
P
F
V
S
Q
D
S
L
Q
L
S
E
D
E
Site 113
S793
S
Q
D
S
L
Q
L
S
E
D
E
A
P
Y
H
Site 114
T803
E
A
P
Y
H
Q
A
T
P
D
H
G
Y
L
S
Site 115
Y808
Q
A
T
P
D
H
G
Y
L
S
L
L
Y
D
S
Site 116
S810
T
P
D
H
G
Y
L
S
L
L
Y
D
S
P
S
Site 117
Y813
H
G
Y
L
S
L
L
Y
D
S
P
S
G
N
L
Site 118
S815
Y
L
S
L
L
Y
D
S
P
S
G
N
L
S
M
Site 119
S817
S
L
L
Y
D
S
P
S
G
N
L
S
M
P
H
Site 120
S821
D
S
P
S
G
N
L
S
M
P
H
K
P
V
S
Site 121
S828
S
M
P
H
K
P
V
S
D
K
L
S
E
E
V
Site 122
S832
K
P
V
S
D
K
L
S
E
E
V
D
E
I
W
Site 123
S864
L
L
A
A
F
P
V
S
K
D
D
V
P
D
R
Site 124
S876
P
D
R
L
H
A
E
S
T
P
E
L
S
R
D
Site 125
T877
D
R
L
H
A
E
S
T
P
E
L
S
R
D
V
Site 126
S881
A
E
S
T
P
E
L
S
R
D
V
G
R
S
V
Site 127
S887
L
S
R
D
V
G
R
S
V
S
T
L
S
L
P
Site 128
S889
R
D
V
G
R
S
V
S
T
L
S
L
P
E
S
Site 129
S892
G
R
S
V
S
T
L
S
L
P
E
S
Q
A
L
Site 130
T901
P
E
S
Q
A
L
L
T
P
V
K
S
R
A
G
Site 131
S905
A
L
L
T
P
V
K
S
R
A
G
R
A
S
R
Site 132
S911
K
S
R
A
G
R
A
S
R
A
N
C
P
F
E
Site 133
S923
P
F
E
E
D
L
I
S
K
E
G
S
F
M
S
Site 134
S927
D
L
I
S
K
E
G
S
F
M
S
L
N
R
L
Site 135
S930
S
K
E
G
S
F
M
S
L
N
R
L
S
L
A
Site 136
S938
L
N
R
L
S
L
A
S
E
M
P
L
M
D
N
Site 137
Y947
M
P
L
M
D
N
P
Y
D
L
A
N
S
G
L
Site 138
T969
P
D
L
G
M
E
A
T
D
K
T
K
S
R
V
Site 139
T972
G
M
E
A
T
D
K
T
K
S
R
V
F
M
M
Site 140
S974
E
A
T
D
K
T
K
S
R
V
F
M
M
A
R
Site 141
Y983
V
F
M
M
A
R
Q
Y
S
Q
K
I
K
K
A
Site 142
S998
N
Q
L
L
K
V
K
S
L
E
L
E
Q
P
P
Site 143
S1007
E
L
E
Q
P
P
A
S
Q
H
Q
K
S
M
H
Site 144
S1012
P
A
S
Q
H
Q
K
S
M
H
K
D
L
A
A
Site 145
S1039
G
A
R
I
A
E
Y
S
Q
L
Y
D
Q
I
V
Site 146
Y1042
I
A
E
Y
S
Q
L
Y
D
Q
I
V
F
R
E
Site 147
S1050
D
Q
I
V
F
R
E
S
P
L
K
I
Q
K
D
Site 148
S1061
I
Q
K
D
G
W
A
S
P
Q
E
S
S
L
L
Site 149
S1065
G
W
A
S
P
Q
E
S
S
L
L
R
S
V
S
Site 150
S1066
W
A
S
P
Q
E
S
S
L
L
R
S
V
S
P
Site 151
S1070
Q
E
S
S
L
L
R
S
V
S
P
S
Q
V
H
Site 152
S1072
S
S
L
L
R
S
V
S
P
S
Q
V
H
H
G
Site 153
S1074
L
L
R
S
V
S
P
S
Q
V
H
H
G
S
G
Site 154
S1080
P
S
Q
V
H
H
G
S
G
D
W
L
L
H
S
Site 155
S1087
S
G
D
W
L
L
H
S
T
Y
S
N
G
E
L
Site 156
Y1089
D
W
L
L
H
S
T
Y
S
N
G
E
L
A
D
Site 157
S1090
W
L
L
H
S
T
Y
S
N
G
E
L
A
D
F
Site 158
S1107
P
P
E
Q
D
L
R
S
R
Y
P
T
F
E
I
Site 159
Y1109
E
Q
D
L
R
S
R
Y
P
T
F
E
I
N
T
Site 160
T1111
D
L
R
S
R
Y
P
T
F
E
I
N
T
K
S
Site 161
S1118
T
F
E
I
N
T
K
S
T
P
R
Q
L
S
A
Site 162
T1119
F
E
I
N
T
K
S
T
P
R
Q
L
S
A
A
Site 163
S1124
K
S
T
P
R
Q
L
S
A
A
C
S
V
P
S
Site 164
S1128
R
Q
L
S
A
A
C
S
V
P
S
L
Q
T
S
Site 165
S1135
S
V
P
S
L
Q
T
S
D
P
L
P
G
S
V
Site 166
S1141
T
S
D
P
L
P
G
S
V
Q
R
C
S
V
V
Site 167
S1146
P
G
S
V
Q
R
C
S
V
V
V
S
Q
P
N
Site 168
S1150
Q
R
C
S
V
V
V
S
Q
P
N
K
E
N
W
Site 169
Y1163
N
W
C
Q
D
H
L
Y
N
S
L
G
R
K
G
Site 170
S1165
C
Q
D
H
L
Y
N
S
L
G
R
K
G
I
S
Site 171
S1172
S
L
G
R
K
G
I
S
A
K
S
Q
P
Y
H
Site 172
S1175
R
K
G
I
S
A
K
S
Q
P
Y
H
R
S
Q
Site 173
Y1178
I
S
A
K
S
Q
P
Y
H
R
S
Q
S
S
S
Site 174
S1181
K
S
Q
P
Y
H
R
S
Q
S
S
S
S
V
L
Site 175
S1183
Q
P
Y
H
R
S
Q
S
S
S
S
V
L
I
N
Site 176
S1184
P
Y
H
R
S
Q
S
S
S
S
V
L
I
N
K
Site 177
S1185
Y
H
R
S
Q
S
S
S
S
V
L
I
N
K
S
Site 178
S1186
H
R
S
Q
S
S
S
S
V
L
I
N
K
S
M
Site 179
S1192
S
S
V
L
I
N
K
S
M
D
S
I
N
Y
P
Site 180
S1195
L
I
N
K
S
M
D
S
I
N
Y
P
S
D
V
Site 181
Y1198
K
S
M
D
S
I
N
Y
P
S
D
V
G
K
Q
Site 182
S1209
V
G
K
Q
Q
L
L
S
L
H
R
S
S
R
C
Site 183
S1213
Q
L
L
S
L
H
R
S
S
R
C
E
S
H
Q
Site 184
S1214
L
L
S
L
H
R
S
S
R
C
E
S
H
Q
D
Site 185
S1218
H
R
S
S
R
C
E
S
H
Q
D
L
L
P
D
Site 186
S1229
L
L
P
D
I
A
D
S
H
Q
Q
G
T
E
K
Site 187
S1238
Q
Q
G
T
E
K
L
S
D
L
T
L
Q
D
S
Site 188
T1241
T
E
K
L
S
D
L
T
L
Q
D
S
Q
K
V
Site 189
S1245
S
D
L
T
L
Q
D
S
Q
K
V
V
V
V
N
Site 190
T1263
P
L
N
A
Q
I
A
T
Q
N
Y
F
S
N
F
Site 191
Y1266
A
Q
I
A
T
Q
N
Y
F
S
N
F
K
E
T
Site 192
Y1280
T
D
G
D
E
D
D
Y
V
E
I
K
S
E
E
Site 193
S1285
D
D
Y
V
E
I
K
S
E
E
D
E
S
E
L
Site 194
S1290
I
K
S
E
E
D
E
S
E
L
E
L
S
H
N
Site 195
S1295
D
E
S
E
L
E
L
S
H
N
R
R
R
K
S
Site 196
S1302
S
H
N
R
R
R
K
S
D
S
K
F
V
D
A
Site 197
S1304
N
R
R
R
K
S
D
S
K
F
V
D
A
D
F
Site 198
S1312
K
F
V
D
A
D
F
S
D
N
V
C
S
G
N
Site 199
S1317
D
F
S
D
N
V
C
S
G
N
T
L
H
S
L
Site 200
S1323
C
S
G
N
T
L
H
S
L
N
S
P
R
T
P
Site 201
S1326
N
T
L
H
S
L
N
S
P
R
T
P
K
K
P
Site 202
T1329
H
S
L
N
S
P
R
T
P
K
K
P
V
N
S
Site 203
S1336
T
P
K
K
P
V
N
S
K
L
G
L
S
P
Y
Site 204
S1341
V
N
S
K
L
G
L
S
P
Y
L
T
P
Y
N
Site 205
Y1343
S
K
L
G
L
S
P
Y
L
T
P
Y
N
D
S
Site 206
T1345
L
G
L
S
P
Y
L
T
P
Y
N
D
S
D
K
Site 207
Y1347
L
S
P
Y
L
T
P
Y
N
D
S
D
K
L
N
Site 208
Y1356
D
S
D
K
L
N
D
Y
L
W
R
G
P
S
P
Site 209
S1362
D
Y
L
W
R
G
P
S
P
N
Q
Q
N
I
V
Site 210
S1371
N
Q
Q
N
I
V
Q
S
L
R
E
K
F
Q
C
Site 211
S1380
R
E
K
F
Q
C
L
S
S
S
S
F
A
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation