KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
INOC1
Full Name:
Putative DNA helicase INO80 complex homolog 1
Alias:
INO80; INO80 complex 1; INO80 complex subunit A; INO80A; KIAA1259
Type:
EC 3.6.1.-; Helicase; DNA binding protein
Mass (Da):
176753
Number AA:
1556
UniProt ID:
Q9ULG1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016887
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006338
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
T
E
L
A
K
P
L
Y
L
Q
Y
L
E
R
A
Site 2
Y24
A
K
P
L
Y
L
Q
Y
L
E
R
A
L
R
L
Site 3
T38
L
D
H
F
L
R
Q
T
S
A
I
F
N
R
N
Site 4
S47
A
I
F
N
R
N
I
S
S
D
D
S
E
D
G
Site 5
S48
I
F
N
R
N
I
S
S
D
D
S
E
D
G
L
Site 6
S51
R
N
I
S
S
D
D
S
E
D
G
L
D
D
S
Site 7
S58
S
E
D
G
L
D
D
S
N
P
L
L
P
Q
S
Site 8
S65
S
N
P
L
L
P
Q
S
G
D
P
L
I
Q
V
Site 9
S79
V
K
E
E
P
P
N
S
L
L
G
E
T
S
G
Site 10
S85
N
S
L
L
G
E
T
S
G
A
G
S
S
G
M
Site 11
S89
G
E
T
S
G
A
G
S
S
G
M
L
N
T
Y
Site 12
S90
E
T
S
G
A
G
S
S
G
M
L
N
T
Y
S
Site 13
Y96
S
S
G
M
L
N
T
Y
S
L
N
G
V
L
Q
Site 14
S97
S
G
M
L
N
T
Y
S
L
N
G
V
L
Q
S
Site 15
S104
S
L
N
G
V
L
Q
S
E
S
K
C
D
K
G
Site 16
S106
N
G
V
L
Q
S
E
S
K
C
D
K
G
N
L
Site 17
Y114
K
C
D
K
G
N
L
Y
N
F
S
K
L
K
K
Site 18
S117
K
G
N
L
Y
N
F
S
K
L
K
K
S
R
K
Site 19
S122
N
F
S
K
L
K
K
S
R
K
W
L
K
S
I
Site 20
S128
K
S
R
K
W
L
K
S
I
L
L
S
D
E
S
Site 21
S132
W
L
K
S
I
L
L
S
D
E
S
S
E
A
D
Site 22
S135
S
I
L
L
S
D
E
S
S
E
A
D
S
Q
S
Site 23
S136
I
L
L
S
D
E
S
S
E
A
D
S
Q
S
E
Site 24
S140
D
E
S
S
E
A
D
S
Q
S
E
D
D
D
E
Site 25
S142
S
S
E
A
D
S
Q
S
E
D
D
D
E
E
E
Site 26
S153
D
E
E
E
L
N
L
S
R
E
E
L
H
N
M
Site 27
Y166
N
M
L
R
L
H
K
Y
K
K
L
H
Q
N
K
Site 28
Y174
K
K
L
H
Q
N
K
Y
S
K
D
K
E
L
Q
Site 29
Y183
K
D
K
E
L
Q
Q
Y
Q
Y
Y
S
A
G
L
Site 30
Y185
K
E
L
Q
Q
Y
Q
Y
Y
S
A
G
L
L
S
Site 31
Y186
E
L
Q
Q
Y
Q
Y
Y
S
A
G
L
L
S
T
Site 32
S192
Y
Y
S
A
G
L
L
S
T
Y
D
P
F
Y
E
Site 33
Y194
S
A
G
L
L
S
T
Y
D
P
F
Y
E
Q
Q
Site 34
Y198
L
S
T
Y
D
P
F
Y
E
Q
Q
R
H
L
L
Site 35
S236
R
R
R
D
E
E
L
S
S
E
E
S
P
R
R
Site 36
S237
R
R
D
E
E
L
S
S
E
E
S
P
R
R
H
Site 37
S240
E
E
L
S
S
E
E
S
P
R
R
H
H
H
Q
Site 38
T248
P
R
R
H
H
H
Q
T
K
V
F
A
K
F
S
Site 39
S255
T
K
V
F
A
K
F
S
H
D
A
P
P
P
G
Site 40
S269
G
T
K
K
K
H
L
S
I
E
Q
L
N
A
R
Site 41
S283
R
R
R
K
V
W
L
S
I
V
K
K
E
L
P
Site 42
S298
K
A
N
K
Q
K
A
S
A
R
N
L
F
L
T
Site 43
T305
S
A
R
N
L
F
L
T
N
S
R
K
L
A
H
Site 44
S307
R
N
L
F
L
T
N
S
R
K
L
A
H
Q
C
Site 45
T340
L
P
R
A
R
R
L
T
K
E
M
L
L
Y
W
Site 46
Y346
L
T
K
E
M
L
L
Y
W
K
K
Y
E
K
V
Site 47
Y350
M
L
L
Y
W
K
K
Y
E
K
V
E
K
E
H
Site 48
T390
R
K
L
N
F
L
I
T
Q
T
E
L
Y
A
H
Site 49
Y395
L
I
T
Q
T
E
L
Y
A
H
F
M
S
R
K
Site 50
S421
I
L
R
K
L
E
D
S
S
T
Q
R
Q
I
D
Site 51
T423
R
K
L
E
D
S
S
T
Q
R
Q
I
D
I
G
Site 52
T438
G
G
V
V
V
N
I
T
Q
E
D
Y
D
S
N
Site 53
Y442
V
N
I
T
Q
E
D
Y
D
S
N
H
F
K
A
Site 54
S468
I
H
Q
A
R
T
R
S
F
D
E
D
A
K
E
Site 55
S487
A
L
R
A
A
N
K
S
G
T
G
F
G
E
S
Site 56
S494
S
G
T
G
F
G
E
S
Y
S
L
A
N
P
S
Site 57
Y495
G
T
G
F
G
E
S
Y
S
L
A
N
P
S
I
Site 58
S496
T
G
F
G
E
S
Y
S
L
A
N
P
S
I
R
Site 59
S501
S
Y
S
L
A
N
P
S
I
R
A
G
E
D
I
Site 60
Y521
F
N
G
K
L
K
G
Y
Q
L
K
G
M
N
W
Site 61
Y533
M
N
W
L
A
N
L
Y
E
Q
G
I
N
G
I
Site 62
T578
L
I
I
S
P
A
S
T
L
N
N
W
H
Q
E
Site 63
S613
K
V
I
R
R
F
W
S
Q
K
T
L
Y
T
Q
Site 64
T616
R
R
F
W
S
Q
K
T
L
Y
T
Q
D
A
P
Site 65
Y618
F
W
S
Q
K
T
L
Y
T
Q
D
A
P
F
H
Site 66
Y640
L
V
V
Q
D
V
K
Y
F
Q
R
V
K
W
Q
Site 67
Y648
F
Q
R
V
K
W
Q
Y
M
V
L
D
E
A
Q
Site 68
S659
D
E
A
Q
A
L
K
S
S
S
S
V
R
W
K
Site 69
S660
E
A
Q
A
L
K
S
S
S
S
V
R
W
K
I
Site 70
S661
A
Q
A
L
K
S
S
S
S
V
R
W
K
I
L
Site 71
S662
Q
A
L
K
S
S
S
S
V
R
W
K
I
L
L
Site 72
T680
C
R
N
R
L
L
L
T
G
T
P
I
Q
N
T
Site 73
T682
N
R
L
L
L
T
G
T
P
I
Q
N
T
M
A
Site 74
S725
E
S
H
A
E
N
K
S
A
I
D
E
N
Q
L
Site 75
S733
A
I
D
E
N
Q
L
S
R
L
H
M
I
L
K
Site 76
S756
K
D
V
E
N
E
L
S
D
K
I
E
I
L
M
Site 77
Y764
D
K
I
E
I
L
M
Y
C
Q
L
T
S
R
Q
Site 78
Y775
T
S
R
Q
K
L
L
Y
Q
A
L
K
N
K
I
Site 79
S783
Q
A
L
K
N
K
I
S
I
E
D
L
L
Q
S
Site 80
S790
S
I
E
D
L
L
Q
S
S
M
G
S
T
Q
Q
Site 81
S794
L
L
Q
S
S
M
G
S
T
Q
Q
A
Q
N
T
Site 82
T795
L
Q
S
S
M
G
S
T
Q
Q
A
Q
N
T
T
Site 83
T801
S
T
Q
Q
A
Q
N
T
T
S
S
L
M
N
L
Site 84
T827
E
L
F
E
R
Q
E
T
W
S
P
F
H
I
S
Site 85
S829
F
E
R
Q
E
T
W
S
P
F
H
I
S
L
K
Site 86
Y845
Y
H
I
S
K
F
I
Y
R
H
G
Q
I
R
V
Site 87
S865
D
R
W
L
R
V
L
S
P
F
A
P
D
Y
I
Site 88
Y871
L
S
P
F
A
P
D
Y
I
Q
R
S
L
F
H
Site 89
S875
A
P
D
Y
I
Q
R
S
L
F
H
R
K
G
I
Site 90
S886
R
K
G
I
N
E
E
S
C
F
S
F
L
R
F
Site 91
S923
L
F
L
S
L
K
A
S
Y
R
L
H
Q
L
R
Site 92
S931
Y
R
L
H
Q
L
R
S
W
G
A
P
E
G
E
Site 93
Y943
E
G
E
S
H
Q
R
Y
L
R
N
K
D
F
L
Site 94
S981
S
S
H
C
K
A
V
S
G
Y
S
D
Q
V
V
Site 95
S993
Q
V
V
H
Q
R
R
S
A
T
S
S
L
R
R
Site 96
T995
V
H
Q
R
R
S
A
T
S
S
L
R
R
C
L
Site 97
S996
H
Q
R
R
S
A
T
S
S
L
R
R
C
L
L
Site 98
S997
Q
R
R
S
A
T
S
S
L
R
R
C
L
L
T
Site 99
S1024
V
T
A
V
P
L
D
S
Y
C
N
D
R
S
A
Site 100
Y1025
T
A
V
P
L
D
S
Y
C
N
D
R
S
A
E
Site 101
S1030
D
S
Y
C
N
D
R
S
A
E
Y
E
R
R
V
Site 102
Y1033
C
N
D
R
S
A
E
Y
E
R
R
V
L
K
E
Site 103
S1043
R
V
L
K
E
G
G
S
L
A
A
K
Q
C
L
Site 104
S1066
A
D
W
L
N
R
R
S
Q
F
F
P
E
P
A
Site 105
S1086
I
R
P
Q
N
G
W
S
F
I
R
I
P
G
K
Site 106
S1095
I
R
I
P
G
K
E
S
L
I
T
D
S
G
K
Site 107
T1098
P
G
K
E
S
L
I
T
D
S
G
K
L
Y
A
Site 108
T1111
Y
A
L
D
V
L
L
T
R
L
K
S
Q
G
H
Site 109
Y1123
Q
G
H
R
V
L
I
Y
S
Q
M
T
R
M
I
Site 110
S1124
G
H
R
V
L
I
Y
S
Q
M
T
R
M
I
D
Site 111
T1127
V
L
I
Y
S
Q
M
T
R
M
I
D
L
L
E
Site 112
Y1136
M
I
D
L
L
E
E
Y
M
V
Y
R
K
H
T
Site 113
Y1139
L
L
E
E
Y
M
V
Y
R
K
H
T
Y
M
R
Site 114
T1143
Y
M
V
Y
R
K
H
T
Y
M
R
L
D
G
S
Site 115
Y1144
M
V
Y
R
K
H
T
Y
M
R
L
D
G
S
S
Site 116
S1150
T
Y
M
R
L
D
G
S
S
K
I
S
E
R
R
Site 117
S1151
Y
M
R
L
D
G
S
S
K
I
S
E
R
R
D
Site 118
S1154
L
D
G
S
S
K
I
S
E
R
R
D
M
V
A
Site 119
Y1194
A
A
D
T
V
I
F
Y
D
S
D
W
N
P
T
Site 120
S1242
L
Q
R
A
K
E
K
S
E
I
Q
R
M
V
I
Site 121
S1250
E
I
Q
R
M
V
I
S
G
G
N
F
K
P
D
Site 122
T1258
G
G
N
F
K
P
D
T
L
K
P
K
E
V
V
Site 123
T1291
E
K
R
Q
Q
E
E
T
N
R
V
K
E
R
K
Site 124
Y1304
R
K
R
K
R
E
K
Y
A
E
K
K
K
K
E
Site 125
S1336
F
V
P
S
A
D
N
S
N
L
S
A
D
G
D
Site 126
S1339
S
A
D
N
S
N
L
S
A
D
G
D
D
S
F
Site 127
S1345
L
S
A
D
G
D
D
S
F
I
S
V
D
S
A
Site 128
S1348
D
G
D
D
S
F
I
S
V
D
S
A
M
P
S
Site 129
S1351
D
S
F
I
S
V
D
S
A
M
P
S
P
F
S
Site 130
S1358
S
A
M
P
S
P
F
S
E
I
S
I
S
S
E
Site 131
S1361
P
S
P
F
S
E
I
S
I
S
S
E
L
H
T
Site 132
S1363
P
F
S
E
I
S
I
S
S
E
L
H
T
G
S
Site 133
T1368
S
I
S
S
E
L
H
T
G
S
I
P
L
D
E
Site 134
S1370
S
S
E
L
H
T
G
S
I
P
L
D
E
S
S
Site 135
S1389
V
I
V
D
D
P
A
S
S
A
P
Q
S
R
A
Site 136
S1390
I
V
D
D
P
A
S
S
A
P
Q
S
R
A
T
Site 137
S1394
P
A
S
S
A
P
Q
S
R
A
T
N
S
P
A
Site 138
T1397
S
A
P
Q
S
R
A
T
N
S
P
A
S
I
T
Site 139
S1399
P
Q
S
R
A
T
N
S
P
A
S
I
T
G
S
Site 140
S1402
R
A
T
N
S
P
A
S
I
T
G
S
V
S
D
Site 141
T1404
T
N
S
P
A
S
I
T
G
S
V
S
D
T
V
Site 142
S1406
S
P
A
S
I
T
G
S
V
S
D
T
V
N
G
Site 143
S1427
P
A
A
G
R
G
H
S
A
R
S
R
G
R
P
Site 144
S1430
G
R
G
H
S
A
R
S
R
G
R
P
K
G
S
Site 145
S1439
G
R
P
K
G
S
G
S
T
A
K
G
A
G
K
Site 146
S1449
K
G
A
G
K
G
R
S
R
K
S
T
A
G
S
Site 147
S1452
G
K
G
R
S
R
K
S
T
A
G
S
A
A
A
Site 148
T1453
K
G
R
S
R
K
S
T
A
G
S
A
A
A
M
Site 149
S1456
S
R
K
S
T
A
G
S
A
A
A
M
A
G
A
Site 150
Y1475
A
A
A
S
A
A
A
Y
A
A
Y
G
Y
N
V
Site 151
Y1478
S
A
A
A
Y
A
A
Y
G
Y
N
V
S
K
G
Site 152
Y1480
A
A
Y
A
A
Y
G
Y
N
V
S
K
G
I
S
Site 153
S1483
A
A
Y
G
Y
N
V
S
K
G
I
S
A
S
S
Site 154
S1487
Y
N
V
S
K
G
I
S
A
S
S
P
L
Q
T
Site 155
S1489
V
S
K
G
I
S
A
S
S
P
L
Q
T
S
L
Site 156
S1490
S
K
G
I
S
A
S
S
P
L
Q
T
S
L
V
Site 157
T1494
S
A
S
S
P
L
Q
T
S
L
V
R
P
A
G
Site 158
S1508
G
L
A
D
F
G
P
S
S
A
S
S
P
L
S
Site 159
S1509
L
A
D
F
G
P
S
S
A
S
S
P
L
S
S
Site 160
S1511
D
F
G
P
S
S
A
S
S
P
L
S
S
P
L
Site 161
S1512
F
G
P
S
S
A
S
S
P
L
S
S
P
L
S
Site 162
S1515
S
S
A
S
S
P
L
S
S
P
L
S
K
G
N
Site 163
S1516
S
A
S
S
P
L
S
S
P
L
S
K
G
N
N
Site 164
S1519
S
P
L
S
S
P
L
S
K
G
N
N
V
P
G
Site 165
S1536
K
N
L
H
M
T
S
S
L
A
P
D
S
L
V
Site 166
S1541
T
S
S
L
A
P
D
S
L
V
R
K
Q
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation