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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INTU
Full Name:
PDZ domain-containing protein 6
Alias:
INT; Inturned planar cell polarity effector; Inturned planar cell polarity effector homolog; KIAA1284; PDZ domain containing 6; PDZD6; PDZK6
Type:
Mass (Da):
105648
Number AA:
942
UniProt ID:
Q9ULD6
International Prot ID:
IPI00008057
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
S
V
A
S
C
D
S
R
P
S
S
Site 2
S9
A
S
V
A
S
C
D
S
R
P
S
S
D
E
L
Site 3
S12
A
S
C
D
S
R
P
S
S
D
E
L
P
G
D
Site 4
S13
S
C
D
S
R
P
S
S
D
E
L
P
G
D
P
Site 5
S21
D
E
L
P
G
D
P
S
S
Q
E
E
D
E
D
Site 6
S22
E
L
P
G
D
P
S
S
Q
E
E
D
E
D
Y
Site 7
Y29
S
Q
E
E
D
E
D
Y
D
F
E
D
R
V
S
Site 8
S36
Y
D
F
E
D
R
V
S
D
S
G
S
Y
S
S
Site 9
S38
F
E
D
R
V
S
D
S
G
S
Y
S
S
A
S
Site 10
S40
D
R
V
S
D
S
G
S
Y
S
S
A
S
S
D
Site 11
Y41
R
V
S
D
S
G
S
Y
S
S
A
S
S
D
Y
Site 12
S42
V
S
D
S
G
S
Y
S
S
A
S
S
D
Y
D
Site 13
S43
S
D
S
G
S
Y
S
S
A
S
S
D
Y
D
D
Site 14
S45
S
G
S
Y
S
S
A
S
S
D
Y
D
D
L
E
Site 15
S46
G
S
Y
S
S
A
S
S
D
Y
D
D
L
E
P
Site 16
Y48
Y
S
S
A
S
S
D
Y
D
D
L
E
P
E
W
Site 17
S58
L
E
P
E
W
L
D
S
V
Q
K
N
G
E
L
Site 18
Y67
Q
K
N
G
E
L
F
Y
L
E
L
S
E
D
E
Site 19
S71
E
L
F
Y
L
E
L
S
E
D
E
E
E
S
L
Site 20
S77
L
S
E
D
E
E
E
S
L
L
P
E
T
P
T
Site 21
T82
E
E
S
L
L
P
E
T
P
T
V
N
H
V
R
Site 22
T84
S
L
L
P
E
T
P
T
V
N
H
V
R
F
S
Site 23
S91
T
V
N
H
V
R
F
S
E
N
E
I
I
I
E
Site 24
Y101
E
I
I
I
E
D
D
Y
K
E
R
K
K
Y
E
Site 25
Y107
D
Y
K
E
R
K
K
Y
E
P
K
L
K
Q
F
Site 26
S133
K
R
C
N
K
K
N
S
N
D
N
G
P
V
S
Site 27
S140
S
N
D
N
G
P
V
S
I
L
K
H
Q
S
N
Site 28
T150
K
H
Q
S
N
Q
K
T
G
V
I
V
Q
Q
R
Site 29
Y164
R
Y
K
D
V
N
V
Y
V
N
P
K
K
L
T
Site 30
T199
T
K
W
S
W
R
R
T
G
K
Q
G
D
G
E
Site 31
S218
H
G
L
L
P
G
G
S
A
M
K
S
G
Q
V
Site 32
S222
P
G
G
S
A
M
K
S
G
Q
V
L
I
G
D
Site 33
T240
A
V
N
D
V
D
V
T
T
E
N
I
E
R
V
Site 34
S249
E
N
I
E
R
V
L
S
C
I
P
G
P
M
Q
Site 35
T260
G
P
M
Q
V
K
L
T
F
E
N
A
Y
D
V
Site 36
Y265
K
L
T
F
E
N
A
Y
D
V
K
R
E
T
S
Site 37
T271
A
Y
D
V
K
R
E
T
S
H
P
R
Q
K
K
Site 38
S272
Y
D
V
K
R
E
T
S
H
P
R
Q
K
K
T
Site 39
T279
S
H
P
R
Q
K
K
T
Q
S
N
T
S
D
L
Site 40
S281
P
R
Q
K
K
T
Q
S
N
T
S
D
L
V
K
Site 41
S284
K
K
T
Q
S
N
T
S
D
L
V
K
L
L
W
Site 42
S301
E
V
E
G
I
Q
Q
S
G
L
N
T
P
H
I
Site 43
S318
Y
L
T
L
Q
L
D
S
E
T
S
K
E
E
Q
Site 44
Y329
K
E
E
Q
E
I
L
Y
H
Y
P
M
S
E
A
Site 45
Y331
E
Q
E
I
L
Y
H
Y
P
M
S
E
A
S
Q
Site 46
S334
I
L
Y
H
Y
P
M
S
E
A
S
Q
K
L
K
Site 47
S337
H
Y
P
M
S
E
A
S
Q
K
L
K
S
V
R
Site 48
S342
E
A
S
Q
K
L
K
S
V
R
G
I
F
L
T
Site 49
T360
M
L
E
N
V
T
G
T
Q
V
T
S
S
S
L
Site 50
S366
G
T
Q
V
T
S
S
S
L
L
L
N
G
K
Q
Site 51
Y378
G
K
Q
I
H
V
A
Y
W
K
E
S
D
K
L
Site 52
S450
L
Q
P
A
K
L
H
S
S
A
S
P
S
A
Q
Site 53
S451
Q
P
A
K
L
H
S
S
A
S
P
S
A
Q
Q
Site 54
S453
A
K
L
H
S
S
A
S
P
S
A
Q
Q
Y
D
Site 55
S455
L
H
S
S
A
S
P
S
A
Q
Q
Y
D
A
S
Site 56
Y459
A
S
P
S
A
Q
Q
Y
D
A
S
S
A
V
L
Site 57
S462
S
A
Q
Q
Y
D
A
S
S
A
V
L
L
D
N
Site 58
S502
A
A
D
F
A
E
L
S
E
D
Y
Y
D
M
R
Site 59
Y505
F
A
E
L
S
E
D
Y
Y
D
M
R
R
L
Y
Site 60
Y506
A
E
L
S
E
D
Y
Y
D
M
R
R
L
Y
T
Site 61
Y512
Y
Y
D
M
R
R
L
Y
T
I
L
G
S
S
L
Site 62
Y521
I
L
G
S
S
L
F
Y
K
G
Y
L
I
C
S
Site 63
Y524
S
S
L
F
Y
K
G
Y
L
I
C
S
H
L
P
Site 64
Y541
D
L
I
D
I
A
V
Y
C
R
H
Y
C
L
L
Site 65
S577
H
L
R
P
L
A
D
S
S
T
E
V
F
P
E
Site 66
S578
L
R
P
L
A
D
S
S
T
E
V
F
P
E
P
Site 67
T579
R
P
L
A
D
S
S
T
E
V
F
P
E
P
E
Site 68
Y624
S
P
G
P
D
C
V
Y
V
D
Q
V
K
T
T
Site 69
S640
H
Q
L
D
G
V
D
S
R
I
D
E
R
L
A
Site 70
S648
R
I
D
E
R
L
A
S
S
P
V
P
C
L
S
Site 71
T662
S
C
A
D
W
F
L
T
G
S
R
E
K
T
D
Site 72
S664
A
D
W
F
L
T
G
S
R
E
K
T
D
S
L
Site 73
T668
L
T
G
S
R
E
K
T
D
S
L
T
T
S
P
Site 74
S670
G
S
R
E
K
T
D
S
L
T
T
S
P
I
L
Site 75
T672
R
E
K
T
D
S
L
T
T
S
P
I
L
S
R
Site 76
S674
K
T
D
S
L
T
T
S
P
I
L
S
R
L
Q
Site 77
S678
L
T
T
S
P
I
L
S
R
L
Q
G
T
S
K
Site 78
S684
L
S
R
L
Q
G
T
S
K
V
A
T
S
P
T
Site 79
T688
Q
G
T
S
K
V
A
T
S
P
T
C
R
R
T
Site 80
S689
G
T
S
K
V
A
T
S
P
T
C
R
R
T
L
Site 81
T691
S
K
V
A
T
S
P
T
C
R
R
T
L
F
G
Site 82
T695
T
S
P
T
C
R
R
T
L
F
G
D
Y
S
L
Site 83
Y700
R
R
T
L
F
G
D
Y
S
L
K
T
R
K
P
Site 84
S701
R
T
L
F
G
D
Y
S
L
K
T
R
K
P
S
Site 85
T704
F
G
D
Y
S
L
K
T
R
K
P
S
P
S
C
Site 86
S708
S
L
K
T
R
K
P
S
P
S
C
S
S
G
G
Site 87
S710
K
T
R
K
P
S
P
S
C
S
S
G
G
S
D
Site 88
S712
R
K
P
S
P
S
C
S
S
G
G
S
D
N
G
Site 89
S716
P
S
C
S
S
G
G
S
D
N
G
C
E
G
G
Site 90
S729
G
G
E
D
D
G
F
S
P
H
T
T
P
D
A
Site 91
T733
D
G
F
S
P
H
T
T
P
D
A
V
R
K
Q
Site 92
S743
A
V
R
K
Q
R
E
S
Q
G
S
D
G
L
E
Site 93
S746
K
Q
R
E
S
Q
G
S
D
G
L
E
E
S
G
Site 94
T754
D
G
L
E
E
S
G
T
L
L
K
V
T
K
K
Site 95
T759
S
G
T
L
L
K
V
T
K
K
K
S
T
L
P
Site 96
S763
L
K
V
T
K
K
K
S
T
L
P
N
P
F
H
Site 97
Y786
P
E
K
E
L
E
I
Y
N
T
V
K
L
T
S
Site 98
T788
K
E
L
E
I
Y
N
T
V
K
L
T
S
G
P
Site 99
Y802
P
E
N
T
L
F
H
Y
V
A
L
E
T
V
Q
Site 100
S824
L
E
E
V
A
Q
L
S
G
S
I
H
P
Q
L
Site 101
S826
E
V
A
Q
L
S
G
S
I
H
P
Q
L
I
K
Site 102
S860
E
K
K
K
G
L
N
S
G
D
H
S
D
S
A
Site 103
S864
G
L
N
S
G
D
H
S
D
S
A
K
S
V
S
Site 104
S866
N
S
G
D
H
S
D
S
A
K
S
V
S
S
L
Site 105
S869
D
H
S
D
S
A
K
S
V
S
S
L
N
P
V
Site 106
S872
D
S
A
K
S
V
S
S
L
N
P
V
K
E
H
Site 107
Y918
H
P
K
P
Q
E
L
Y
V
C
F
H
D
S
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation