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Updated November 2019
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Protein Info
Short Name:
MTUS1
Full Name:
Microtubule-associated tumor suppressor 1
Alias:
Angiotensin-II type 2 receptor-interacting protein; AT2 receptor-binding protein; AT2 receptor-interacting protein; AT2R binding protein; ATBP; ATIP1; DKFZp586D1519; FLJ14295; KIAA1288; Microtubule associated tumor suppressor 1; Mitochondrial tumor suppressor 1; Mitochondrial tumor suppressor gene 1; MP44; MTSG1
Type:
Mitochondrial protein
Mass (Da):
141397
Number AA:
1270
UniProt ID:
Q9ULD2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005739
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0005488
GO:0016491
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0009987
GO:0045786
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
K
I
E
D
E
L
Q
T
F
F
T
S
D
K
D
Site 2
S20
E
L
Q
T
F
F
T
S
D
K
D
G
N
T
H
Site 3
T26
T
S
D
K
D
G
N
T
H
A
Y
N
P
K
S
Site 4
Y29
K
D
G
N
T
H
A
Y
N
P
K
S
P
P
T
Site 5
S33
T
H
A
Y
N
P
K
S
P
P
T
Q
N
S
S
Site 6
T36
Y
N
P
K
S
P
P
T
Q
N
S
S
A
S
S
Site 7
S39
K
S
P
P
T
Q
N
S
S
A
S
S
V
N
W
Site 8
S40
S
P
P
T
Q
N
S
S
A
S
S
V
N
W
N
Site 9
S42
P
T
Q
N
S
S
A
S
S
V
N
W
N
S
A
Site 10
S43
T
Q
N
S
S
A
S
S
V
N
W
N
S
A
N
Site 11
S48
A
S
S
V
N
W
N
S
A
N
P
D
D
M
V
Site 12
Y58
P
D
D
M
V
V
D
Y
E
T
D
P
A
V
V
Site 13
S85
E
V
F
G
H
E
K
S
S
S
D
F
I
S
K
Site 14
S86
V
F
G
H
E
K
S
S
S
D
F
I
S
K
Q
Site 15
S87
F
G
H
E
K
S
S
S
D
F
I
S
K
Q
V
Site 16
S91
K
S
S
S
D
F
I
S
K
Q
V
L
D
M
H
Site 17
Y116
V
G
T
E
K
P
K
Y
L
Q
H
S
C
H
S
Site 18
S131
L
E
A
V
E
G
Q
S
V
E
P
S
L
P
F
Site 19
S135
E
G
Q
S
V
E
P
S
L
P
F
V
W
K
P
Site 20
Y151
D
N
L
N
C
A
G
Y
C
D
A
L
E
L
N
Site 21
T160
D
A
L
E
L
N
Q
T
F
D
M
T
V
D
K
Site 22
S181
S
H
H
A
I
G
K
S
Q
S
F
H
T
A
G
Site 23
S183
H
A
I
G
K
S
Q
S
F
H
T
A
G
S
L
Site 24
S189
Q
S
F
H
T
A
G
S
L
P
P
T
G
R
R
Site 25
T193
T
A
G
S
L
P
P
T
G
R
R
S
G
S
T
Site 26
S197
L
P
P
T
G
R
R
S
G
S
T
S
S
L
S
Site 27
S199
P
T
G
R
R
S
G
S
T
S
S
L
S
Y
S
Site 28
T200
T
G
R
R
S
G
S
T
S
S
L
S
Y
S
T
Site 29
S201
G
R
R
S
G
S
T
S
S
L
S
Y
S
T
W
Site 30
S202
R
R
S
G
S
T
S
S
L
S
Y
S
T
W
T
Site 31
S204
S
G
S
T
S
S
L
S
Y
S
T
W
T
S
S
Site 32
Y205
G
S
T
S
S
L
S
Y
S
T
W
T
S
S
H
Site 33
S206
S
T
S
S
L
S
Y
S
T
W
T
S
S
H
S
Site 34
T207
T
S
S
L
S
Y
S
T
W
T
S
S
H
S
D
Site 35
T209
S
L
S
Y
S
T
W
T
S
S
H
S
D
K
T
Site 36
S210
L
S
Y
S
T
W
T
S
S
H
S
D
K
T
H
Site 37
S211
S
Y
S
T
W
T
S
S
H
S
D
K
T
H
A
Site 38
T216
T
S
S
H
S
D
K
T
H
A
R
E
T
T
Y
Site 39
T221
D
K
T
H
A
R
E
T
T
Y
D
R
E
S
F
Site 40
T222
K
T
H
A
R
E
T
T
Y
D
R
E
S
F
E
Site 41
Y223
T
H
A
R
E
T
T
Y
D
R
E
S
F
E
N
Site 42
S227
E
T
T
Y
D
R
E
S
F
E
N
P
Q
V
T
Site 43
T234
S
F
E
N
P
Q
V
T
P
S
E
A
Q
D
M
Site 44
S236
E
N
P
Q
V
T
P
S
E
A
Q
D
M
T
Y
Site 45
T242
P
S
E
A
Q
D
M
T
Y
T
A
F
S
D
V
Site 46
Y243
S
E
A
Q
D
M
T
Y
T
A
F
S
D
V
V
Site 47
S268
G
N
Q
C
A
C
S
S
G
K
V
T
S
E
Y
Site 48
T272
A
C
S
S
G
K
V
T
S
E
Y
T
D
G
S
Site 49
S273
C
S
S
G
K
V
T
S
E
Y
T
D
G
S
Q
Site 50
Y275
S
G
K
V
T
S
E
Y
T
D
G
S
Q
Q
R
Site 51
S279
T
S
E
Y
T
D
G
S
Q
Q
R
L
V
G
E
Site 52
T293
E
K
E
T
Q
A
L
T
P
V
S
D
G
M
E
Site 53
S296
T
Q
A
L
T
P
V
S
D
G
M
E
V
P
N
Site 54
S314
L
Q
E
F
F
C
L
S
H
D
E
S
N
S
E
Site 55
S318
F
C
L
S
H
D
E
S
N
S
E
P
H
S
Q
Site 56
S320
L
S
H
D
E
S
N
S
E
P
H
S
Q
S
S
Site 57
S324
E
S
N
S
E
P
H
S
Q
S
S
Y
R
H
K
Site 58
S327
S
E
P
H
S
Q
S
S
Y
R
H
K
E
M
G
Site 59
Y328
E
P
H
S
Q
S
S
Y
R
H
K
E
M
G
Q
Site 60
T340
M
G
Q
N
L
R
E
T
V
S
Y
C
L
I
D
Site 61
S342
Q
N
L
R
E
T
V
S
Y
C
L
I
D
D
E
Site 62
Y343
N
L
R
E
T
V
S
Y
C
L
I
D
D
E
C
Site 63
S360
M
V
P
A
F
D
K
S
E
A
Q
V
L
N
P
Site 64
T372
L
N
P
E
H
K
V
T
E
T
E
D
T
Q
M
Site 65
T377
K
V
T
E
T
E
D
T
Q
M
V
S
K
G
K
Site 66
S381
T
E
D
T
Q
M
V
S
K
G
K
D
L
G
T
Site 67
T388
S
K
G
K
D
L
G
T
Q
N
H
T
S
E
L
Site 68
T392
D
L
G
T
Q
N
H
T
S
E
L
I
L
S
S
Site 69
S393
L
G
T
Q
N
H
T
S
E
L
I
L
S
S
P
Site 70
S398
H
T
S
E
L
I
L
S
S
P
P
G
Q
K
V
Site 71
S399
T
S
E
L
I
L
S
S
P
P
G
Q
K
V
G
Site 72
S407
P
P
G
Q
K
V
G
S
S
F
G
L
T
W
D
Site 73
S408
P
G
Q
K
V
G
S
S
F
G
L
T
W
D
A
Site 74
T430
D
K
T
M
C
M
S
T
P
V
L
E
P
T
K
Site 75
S441
E
P
T
K
V
T
F
S
V
S
P
I
E
A
T
Site 76
S443
T
K
V
T
F
S
V
S
P
I
E
A
T
E
K
Site 77
S467
G
L
K
N
I
P
D
S
K
E
A
P
V
N
L
Site 78
S478
P
V
N
L
C
K
P
S
L
G
K
S
T
I
K
Site 79
S482
C
K
P
S
L
G
K
S
T
I
K
T
N
T
P
Site 80
T483
K
P
S
L
G
K
S
T
I
K
T
N
T
P
I
Site 81
T486
L
G
K
S
T
I
K
T
N
T
P
I
G
C
K
Site 82
T488
K
S
T
I
K
T
N
T
P
I
G
C
K
V
R
Site 83
T497
I
G
C
K
V
R
K
T
E
I
I
S
Y
P
R
Site 84
S501
V
R
K
T
E
I
I
S
Y
P
R
P
N
F
K
Site 85
Y502
R
K
T
E
I
I
S
Y
P
R
P
N
F
K
N
Site 86
S528
Q
P
K
D
A
A
L
S
K
V
T
P
R
P
Q
Site 87
T531
D
A
A
L
S
K
V
T
P
R
P
Q
Q
T
S
Site 88
T537
V
T
P
R
P
Q
Q
T
S
A
S
S
P
S
S
Site 89
S538
T
P
R
P
Q
Q
T
S
A
S
S
P
S
S
V
Site 90
S540
R
P
Q
Q
T
S
A
S
S
P
S
S
V
N
S
Site 91
S541
P
Q
Q
T
S
A
S
S
P
S
S
V
N
S
R
Site 92
S543
Q
T
S
A
S
S
P
S
S
V
N
S
R
Q
Q
Site 93
S544
T
S
A
S
S
P
S
S
V
N
S
R
Q
Q
T
Site 94
S547
S
S
P
S
S
V
N
S
R
Q
Q
T
V
L
S
Site 95
T551
S
V
N
S
R
Q
Q
T
V
L
S
R
T
P
R
Site 96
S554
S
R
Q
Q
T
V
L
S
R
T
P
R
S
D
L
Site 97
T556
Q
Q
T
V
L
S
R
T
P
R
S
D
L
N
A
Site 98
S559
V
L
S
R
T
P
R
S
D
L
N
A
D
K
K
Site 99
S585
Q
F
N
K
L
I
T
S
Q
A
V
H
V
T
T
Site 100
T591
T
S
Q
A
V
H
V
T
T
H
S
K
N
A
S
Site 101
S594
A
V
H
V
T
T
H
S
K
N
A
S
H
R
V
Site 102
S598
T
T
H
S
K
N
A
S
H
R
V
P
R
T
T
Site 103
T604
A
S
H
R
V
P
R
T
T
S
A
V
K
S
N
Site 104
T605
S
H
R
V
P
R
T
T
S
A
V
K
S
N
Q
Site 105
S606
H
R
V
P
R
T
T
S
A
V
K
S
N
Q
E
Site 106
S610
R
T
T
S
A
V
K
S
N
Q
E
D
V
D
K
Site 107
S619
Q
E
D
V
D
K
A
S
S
S
N
S
A
C
E
Site 108
S621
D
V
D
K
A
S
S
S
N
S
A
C
E
T
G
Site 109
S623
D
K
A
S
S
S
N
S
A
C
E
T
G
S
V
Site 110
S629
N
S
A
C
E
T
G
S
V
S
A
L
F
Q
K
Site 111
T654
S
A
E
C
L
E
M
T
Y
V
P
N
I
D
R
Site 112
Y655
A
E
C
L
E
M
T
Y
V
P
N
I
D
R
I
Site 113
S663
V
P
N
I
D
R
I
S
P
E
K
K
G
E
K
Site 114
S675
G
E
K
E
N
G
T
S
M
E
K
Q
E
L
K
Site 115
T689
K
Q
E
I
M
N
E
T
F
E
Y
G
S
L
F
Site 116
S694
N
E
T
F
E
Y
G
S
L
F
L
G
S
A
S
Site 117
S699
Y
G
S
L
F
L
G
S
A
S
K
T
T
T
T
Site 118
S701
S
L
F
L
G
S
A
S
K
T
T
T
T
S
G
Site 119
T703
F
L
G
S
A
S
K
T
T
T
T
S
G
R
N
Site 120
T704
L
G
S
A
S
K
T
T
T
T
S
G
R
N
I
Site 121
T705
G
S
A
S
K
T
T
T
T
S
G
R
N
I
S
Site 122
S707
A
S
K
T
T
T
T
S
G
R
N
I
S
K
P
Site 123
S712
T
T
S
G
R
N
I
S
K
P
D
S
C
G
L
Site 124
S716
R
N
I
S
K
P
D
S
C
G
L
R
Q
I
A
Site 125
S734
A
K
V
G
P
P
V
S
C
L
R
R
N
S
D
Site 126
S740
V
S
C
L
R
R
N
S
D
N
R
N
P
S
A
Site 127
S746
N
S
D
N
R
N
P
S
A
D
R
A
V
S
P
Site 128
S752
P
S
A
D
R
A
V
S
P
Q
R
I
R
R
V
Site 129
S760
P
Q
R
I
R
R
V
S
S
S
G
K
P
T
S
Site 130
S761
Q
R
I
R
R
V
S
S
S
G
K
P
T
S
L
Site 131
S762
R
I
R
R
V
S
S
S
G
K
P
T
S
L
K
Site 132
T766
V
S
S
S
G
K
P
T
S
L
K
T
A
Q
S
Site 133
S767
S
S
S
G
K
P
T
S
L
K
T
A
Q
S
S
Site 134
T770
G
K
P
T
S
L
K
T
A
Q
S
S
W
V
N
Site 135
S773
T
S
L
K
T
A
Q
S
S
W
V
N
L
P
R
Site 136
S785
L
P
R
P
L
P
K
S
K
A
S
L
K
S
P
Site 137
S788
P
L
P
K
S
K
A
S
L
K
S
P
A
L
R
Site 138
S791
K
S
K
A
S
L
K
S
P
A
L
R
R
T
G
Site 139
T797
K
S
P
A
L
R
R
T
G
S
T
P
S
I
A
Site 140
S799
P
A
L
R
R
T
G
S
T
P
S
I
A
S
T
Site 141
T800
A
L
R
R
T
G
S
T
P
S
I
A
S
T
H
Site 142
S802
R
R
T
G
S
T
P
S
I
A
S
T
H
S
E
Site 143
S805
G
S
T
P
S
I
A
S
T
H
S
E
L
S
T
Site 144
T806
S
T
P
S
I
A
S
T
H
S
E
L
S
T
Y
Site 145
S808
P
S
I
A
S
T
H
S
E
L
S
T
Y
S
N
Site 146
S811
A
S
T
H
S
E
L
S
T
Y
S
N
N
S
G
Site 147
T812
S
T
H
S
E
L
S
T
Y
S
N
N
S
G
N
Site 148
Y813
T
H
S
E
L
S
T
Y
S
N
N
S
G
N
A
Site 149
S814
H
S
E
L
S
T
Y
S
N
N
S
G
N
A
A
Site 150
Y825
G
N
A
A
V
I
K
Y
E
E
K
P
P
K
P
Site 151
S841
F
Q
N
G
S
S
G
S
F
Y
L
K
P
L
V
Site 152
Y843
N
G
S
S
G
S
F
Y
L
K
P
L
V
S
R
Site 153
T858
A
H
V
H
L
M
K
T
P
P
K
G
P
S
R
Site 154
T870
P
S
R
K
N
L
F
T
A
L
N
A
V
E
K
Site 155
S885
S
R
Q
K
N
P
R
S
L
C
I
Q
P
Q
T
Site 156
T892
S
L
C
I
Q
P
Q
T
A
P
D
A
L
P
P
Site 157
T902
D
A
L
P
P
E
K
T
L
E
L
T
Q
Y
K
Site 158
Y908
K
T
L
E
L
T
Q
Y
K
T
K
C
E
N
Q
Site 159
T910
L
E
L
T
Q
Y
K
T
K
C
E
N
Q
S
G
Site 160
S945
V
V
I
Q
H
L
L
S
E
R
E
E
A
L
K
Site 161
T956
E
A
L
K
Q
H
K
T
L
S
Q
E
L
V
N
Site 162
S958
L
K
Q
H
K
T
L
S
Q
E
L
V
N
L
R
Site 163
T970
N
L
R
G
E
L
V
T
A
S
T
T
C
E
K
Site 164
S972
R
G
E
L
V
T
A
S
T
T
C
E
K
L
E
Site 165
T973
G
E
L
V
T
A
S
T
T
C
E
K
L
E
K
Site 166
T987
K
A
R
N
E
L
Q
T
V
Y
E
A
F
V
Q
Site 167
Y989
R
N
E
L
Q
T
V
Y
E
A
F
V
Q
Q
H
Site 168
T1001
Q
Q
H
Q
A
E
K
T
E
R
E
N
R
L
K
Site 169
Y1011
E
N
R
L
K
E
F
Y
T
R
E
Y
E
K
L
Site 170
Y1015
K
E
F
Y
T
R
E
Y
E
K
L
R
D
T
Y
Site 171
T1021
E
Y
E
K
L
R
D
T
Y
I
E
E
A
E
K
Site 172
Y1022
Y
E
K
L
R
D
T
Y
I
E
E
A
E
K
Y
Site 173
Y1029
Y
I
E
E
A
E
K
Y
K
M
Q
L
Q
E
Q
Site 174
S1054
S
K
L
E
I
E
A
S
H
S
E
K
L
E
L
Site 175
S1056
L
E
I
E
A
S
H
S
E
K
L
E
L
L
K
Site 176
Y1066
L
E
L
L
K
K
A
Y
E
A
S
L
S
E
I
Site 177
S1069
L
K
K
A
Y
E
A
S
L
S
E
I
K
K
G
Site 178
S1071
K
A
Y
E
A
S
L
S
E
I
K
K
G
H
E
Site 179
S1083
G
H
E
I
E
K
K
S
L
E
D
L
L
S
E
Site 180
S1089
K
S
L
E
D
L
L
S
E
K
Q
E
S
L
E
Site 181
S1094
L
L
S
E
K
Q
E
S
L
E
K
Q
I
N
D
Site 182
S1104
K
Q
I
N
D
L
K
S
E
N
D
A
L
N
E
Site 183
S1115
A
L
N
E
K
L
K
S
E
E
Q
K
R
R
A
Site 184
Y1135
L
K
N
P
Q
I
M
Y
L
E
Q
E
L
E
S
Site 185
T1172
E
K
L
V
D
N
N
T
A
L
V
D
K
L
K
Site 186
S1203
M
A
I
S
R
Q
L
S
T
E
Q
A
V
L
Q
Site 187
T1204
A
I
S
R
Q
L
S
T
E
Q
A
V
L
Q
E
Site 188
S1212
E
Q
A
V
L
Q
E
S
L
E
K
E
S
K
V
Site 189
S1224
S
K
V
N
K
R
L
S
M
E
N
E
E
L
L
Site 190
S1241
L
H
N
G
D
L
C
S
P
K
R
S
P
T
S
Site 191
S1245
D
L
C
S
P
K
R
S
P
T
S
S
A
I
P
Site 192
T1247
C
S
P
K
R
S
P
T
S
S
A
I
P
L
Q
Site 193
S1248
S
P
K
R
S
P
T
S
S
A
I
P
L
Q
S
Site 194
S1249
P
K
R
S
P
T
S
S
A
I
P
L
Q
S
P
Site 195
S1255
S
S
A
I
P
L
Q
S
P
R
N
S
G
S
F
Site 196
S1259
P
L
Q
S
P
R
N
S
G
S
F
P
S
P
S
Site 197
S1261
Q
S
P
R
N
S
G
S
F
P
S
P
S
I
S
Site 198
S1264
R
N
S
G
S
F
P
S
P
S
I
S
P
R
_
Site 199
S1266
S
G
S
F
P
S
P
S
I
S
P
R
_
_
_
Site 200
S1268
S
F
P
S
P
S
I
S
P
R
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation