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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACSL5
Full Name:
Long-chain-fatty-acid--CoA ligase 5
Alias:
ACS2; ACS5; Acyl-CoA synthetase long-chain family member 5; EC 6.2.1.3; FACL5; FACL5 for fatty acid coenzyme A ligase 5; Fatty-acid-Coenzyme A ligase, long-chain 5; LACS 5; Long-chain acyl-CoA synthetase 5; Long-chain fatty acid coenzyme A ligase 5; Long-chain-fatty-acid-CoA ligase 5
Type:
EC 6.2.1.3; Ligase; Lipid Metabolism - fatty acid
Mass (Da):
75991
Number AA:
683
UniProt ID:
Q9ULC5
International Prot ID:
IPI00008037
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0016021
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004467
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006631
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S60
G
G
A
R
K
G
V
S
Q
K
N
N
D
L
T
Site 2
T67
S
Q
K
N
N
D
L
T
S
C
C
F
S
D
A
Site 3
Y78
F
S
D
A
K
T
M
Y
E
V
F
Q
R
G
L
Site 4
S88
F
Q
R
G
L
A
V
S
D
N
G
P
C
L
G
Site 5
Y96
D
N
G
P
C
L
G
Y
R
K
P
N
Q
P
Y
Site 6
S107
N
Q
P
Y
R
W
L
S
Y
K
Q
V
S
D
R
Site 7
S112
W
L
S
Y
K
Q
V
S
D
R
A
E
Y
L
G
Site 8
Y117
Q
V
S
D
R
A
E
Y
L
G
S
C
L
L
H
Site 9
S120
D
R
A
E
Y
L
G
S
C
L
L
H
K
G
Y
Site 10
Y127
S
C
L
L
H
K
G
Y
K
S
S
P
D
Q
F
Site 11
S129
L
L
H
K
G
Y
K
S
S
P
D
Q
F
V
G
Site 12
S130
L
H
K
G
Y
K
S
S
P
D
Q
F
V
G
I
Site 13
Y163
S
M
V
A
V
P
L
Y
D
T
L
G
P
E
A
Site 14
S226
L
K
Q
R
G
E
K
S
G
I
E
I
L
S
L
Site 15
S232
K
S
G
I
E
I
L
S
L
Y
D
A
E
N
L
Site 16
Y234
G
I
E
I
L
S
L
Y
D
A
E
N
L
G
K
Site 17
S251
F
R
K
P
V
P
P
S
P
E
D
L
S
V
I
Site 18
S256
P
P
S
P
E
D
L
S
V
I
C
F
T
S
G
Site 19
T296
V
E
H
A
Y
E
P
T
P
D
D
V
A
I
S
Site 20
T346
D
M
K
T
L
K
P
T
L
F
P
A
V
P
R
Site 21
Y359
P
R
L
L
N
R
I
Y
D
K
V
Q
N
E
A
Site 22
T368
K
V
Q
N
E
A
K
T
P
L
K
K
F
L
L
Site 23
Y440
A
A
M
G
C
Q
V
Y
E
A
Y
G
Q
T
E
Site 24
T461
F
T
L
P
G
D
W
T
S
G
H
V
G
V
P
Site 25
Y484
E
D
V
A
D
M
N
Y
F
T
V
N
N
E
G
Site 26
T486
V
A
D
M
N
Y
F
T
V
N
N
E
G
E
V
Site 27
S517
K
T
Q
E
A
L
D
S
D
G
W
L
H
T
G
Site 28
Y552
F
K
L
A
Q
G
E
Y
I
A
P
E
K
I
E
Site 29
Y562
P
E
K
I
E
N
I
Y
N
R
S
Q
P
V
L
Site 30
S580
V
H
G
E
S
L
R
S
S
L
V
G
V
V
V
Site 31
S605
A
K
L
G
V
K
G
S
F
E
E
L
C
Q
N
Site 32
T634
G
K
E
S
G
L
K
T
F
E
Q
V
K
A
I
Site 33
T656
S
I
E
N
G
L
L
T
P
T
L
K
A
K
R
Site 34
S667
K
A
K
R
G
E
L
S
K
Y
F
R
T
Q
I
Site 35
Y669
K
R
G
E
L
S
K
Y
F
R
T
Q
I
D
S
Site 36
T672
E
L
S
K
Y
F
R
T
Q
I
D
S
L
Y
E
Site 37
Y678
R
T
Q
I
D
S
L
Y
E
H
I
Q
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation