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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF2C1
Full Name:
Protein argonaute-1
Alias:
AGO1; Dkfzp686m13167; Eif2c; Eif2c1; Eukaryotic translation initiation factor 2c, 1; Gerp95; Q99
Type:
Eukaryotic translation initiation factor 2 complex protein
Mass (Da):
97214
Number AA:
857
UniProt ID:
Q9UL18
International Prot ID:
IPI00007736
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000932
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0035278
GO:0000956
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T31
P
R
R
P
G
I
G
T
V
G
K
P
I
K
L
Site 2
Y53
D
I
P
K
I
D
V
Y
H
Y
E
V
D
I
K
Site 3
Y55
P
K
I
D
V
Y
H
Y
E
V
D
I
K
P
D
Site 4
Y75
V
N
R
E
V
V
E
Y
M
V
Q
H
F
K
P
Site 5
Y92
F
G
D
R
K
P
V
Y
D
G
K
K
N
I
Y
Site 6
T100
D
G
K
K
N
I
Y
T
V
T
A
L
P
I
G
Site 7
T102
K
K
N
I
Y
T
V
T
A
L
P
I
G
N
E
Site 8
Y172
R
H
L
A
S
M
R
Y
T
P
V
G
R
S
F
Site 9
T173
H
L
A
S
M
R
Y
T
P
V
G
R
S
F
F
Site 10
S178
R
Y
T
P
V
G
R
S
F
F
S
P
P
E
G
Site 11
S181
P
V
G
R
S
F
F
S
P
P
E
G
Y
Y
H
Site 12
Y186
F
F
S
P
P
E
G
Y
Y
H
P
L
G
G
G
Site 13
Y187
F
S
P
P
E
G
Y
Y
H
P
L
G
G
G
R
Site 14
T249
D
E
Q
P
K
P
L
T
D
S
Q
R
V
R
F
Site 15
S251
Q
P
K
P
L
T
D
S
Q
R
V
R
F
T
K
Site 16
T257
D
S
Q
R
V
R
F
T
K
E
I
K
G
L
K
Site 17
T268
K
G
L
K
V
E
V
T
H
C
G
Q
M
K
R
Site 18
Y277
C
G
Q
M
K
R
K
Y
R
V
C
N
V
T
R
Site 19
T283
K
Y
R
V
C
N
V
T
R
R
P
A
S
H
Q
Site 20
S288
N
V
T
R
R
P
A
S
H
Q
T
F
P
L
Q
Site 21
T291
R
R
P
A
S
H
Q
T
F
P
L
Q
L
E
S
Site 22
T301
L
Q
L
E
S
G
Q
T
V
E
C
T
V
A
Q
Site 23
T305
S
G
Q
T
V
E
C
T
V
A
Q
Y
F
K
Q
Site 24
Y309
V
E
C
T
V
A
Q
Y
F
K
Q
K
Y
N
L
Site 25
Y314
A
Q
Y
F
K
Q
K
Y
N
L
Q
L
K
Y
P
Site 26
Y320
K
Y
N
L
Q
L
K
Y
P
H
L
P
C
L
Q
Site 27
T335
V
G
Q
E
Q
K
H
T
Y
L
P
L
E
V
C
Site 28
Y336
G
Q
E
Q
K
H
T
Y
L
P
L
E
V
C
N
Site 29
T355
Q
R
C
I
K
K
L
T
D
N
Q
T
S
T
M
Site 30
T359
K
K
L
T
D
N
Q
T
S
T
M
I
K
A
T
Site 31
S360
K
L
T
D
N
Q
T
S
T
M
I
K
A
T
A
Site 32
T366
T
S
T
M
I
K
A
T
A
R
S
A
P
D
R
Site 33
S378
P
D
R
Q
E
E
I
S
R
L
M
K
N
A
S
Site 34
S385
S
R
L
M
K
N
A
S
Y
N
L
D
P
Y
I
Site 35
Y391
A
S
Y
N
L
D
P
Y
I
Q
E
F
G
I
K
Site 36
T404
I
K
V
K
D
D
M
T
E
V
T
G
R
V
L
Site 37
T407
K
D
D
M
T
E
V
T
G
R
V
L
P
A
P
Site 38
T427
G
R
N
R
A
I
A
T
P
N
Q
G
V
W
D
Site 39
Y441
D
M
R
G
K
Q
F
Y
N
G
I
E
I
K
V
Site 40
S476
T
D
Q
L
R
K
I
S
K
D
A
G
M
P
I
Site 41
Y492
G
Q
P
C
F
C
K
Y
A
Q
G
A
D
S
V
Site 42
S498
K
Y
A
Q
G
A
D
S
V
E
P
M
F
R
H
Site 43
T509
M
F
R
H
L
K
N
T
Y
S
G
L
Q
L
I
Site 44
T524
I
V
I
L
P
G
K
T
P
V
Y
A
E
V
K
Site 45
Y527
L
P
G
K
T
P
V
Y
A
E
V
K
R
V
G
Site 46
S554
V
K
N
V
V
K
T
S
P
Q
T
L
S
N
L
Site 47
S559
K
T
S
P
Q
T
L
S
N
L
C
L
K
I
N
Site 48
S608
A
G
D
G
K
K
P
S
I
T
A
V
V
G
S
Site 49
T610
D
G
K
K
P
S
I
T
A
V
V
G
S
M
D
Site 50
S615
S
I
T
A
V
V
G
S
M
D
A
H
P
S
R
Site 51
S621
G
S
M
D
A
H
P
S
R
Y
C
A
T
V
R
Site 52
T626
H
P
S
R
Y
C
A
T
V
R
V
Q
R
P
R
Site 53
Y652
R
E
L
L
I
Q
F
Y
K
S
T
R
F
K
P
Site 54
S654
L
L
I
Q
F
Y
K
S
T
R
F
K
P
T
R
Site 55
Y696
C
I
K
L
E
K
D
Y
Q
P
G
I
T
Y
I
Site 56
Y702
D
Y
Q
P
G
I
T
Y
I
V
V
Q
K
R
H
Site 57
T711
V
V
Q
K
R
H
H
T
R
L
F
C
A
D
K
Site 58
T732
S
G
N
I
P
A
G
T
T
V
D
T
N
I
T
Site 59
T736
P
A
G
T
T
V
D
T
N
I
T
H
P
F
E
Site 60
T757
S
H
A
G
I
Q
G
T
S
R
P
S
H
Y
Y
Site 61
Y763
G
T
S
R
P
S
H
Y
Y
V
L
W
D
D
N
Site 62
Y764
T
S
R
P
S
H
Y
Y
V
L
W
D
D
N
R
Site 63
T773
L
W
D
D
N
R
F
T
A
D
E
L
Q
I
L
Site 64
T787
L
T
Y
Q
L
C
H
T
Y
V
R
C
T
R
S
Site 65
Y788
T
Y
Q
L
C
H
T
Y
V
R
C
T
R
S
V
Site 66
S794
T
Y
V
R
C
T
R
S
V
S
I
P
A
P
A
Site 67
S796
V
R
C
T
R
S
V
S
I
P
A
P
A
Y
Y
Site 68
Y813
L
V
A
F
R
A
R
Y
H
L
V
D
K
E
H
Site 69
S822
L
V
D
K
E
H
D
S
G
E
G
S
H
I
S
Site 70
S826
E
H
D
S
G
E
G
S
H
I
S
G
Q
S
N
Site 71
S829
S
G
E
G
S
H
I
S
G
Q
S
N
G
R
D
Site 72
T850
A
V
Q
V
H
Q
D
T
L
R
T
M
Y
F
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation