KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SARDH
Full Name:
Sarcosine dehydrogenase, mitochondrial precursor
Alias:
BPR-2; DMGDHL1; sarcosine dehydrogenase; Sarcosine dehydrogenase, mitochondrial; SDH
Type:
Amino Acid Metabolism - glycine, serine and threonine; EC 1.5.99.1; Oxidoreductase
Mass (Da):
101037
Number AA:
918
UniProt ID:
Q9UL12
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0004047
GO:0008480
PhosphoSite+
KinaseNET
Biological Process:
GO:0006546
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
L
S
R
A
L
R
V
Site 2
S18
A
A
A
H
P
R
Q
S
P
T
R
G
M
G
P
Site 3
S30
M
G
P
C
N
L
S
S
A
A
G
P
T
A
E
Site 4
S39
A
G
P
T
A
E
K
S
V
P
Y
Q
R
T
L
Site 5
T52
T
L
K
E
G
Q
G
T
S
V
V
A
Q
G
P
Site 6
S53
L
K
E
G
Q
G
T
S
V
V
A
Q
G
P
S
Site 7
T102
L
L
E
R
E
R
L
T
S
G
T
T
W
H
T
Site 8
S103
L
E
R
E
R
L
T
S
G
T
T
W
H
T
A
Site 9
T105
R
E
R
L
T
S
G
T
T
W
H
T
A
G
L
Site 10
S134
A
H
T
R
R
V
V
S
R
E
L
E
E
E
T
Site 11
S157
N
G
G
L
F
I
A
S
N
R
Q
R
L
D
E
Site 12
Y165
N
R
Q
R
L
D
E
Y
K
R
L
M
S
L
G
Site 13
S170
D
E
Y
K
R
L
M
S
L
G
K
A
Y
G
V
Site 14
S179
G
K
A
Y
G
V
E
S
H
V
L
S
P
A
E
Site 15
S183
G
V
E
S
H
V
L
S
P
A
E
T
K
T
L
Site 16
Y191
P
A
E
T
K
T
L
Y
P
L
M
N
V
D
D
Site 17
Y204
D
D
L
Y
G
T
L
Y
V
P
H
D
G
T
M
Site 18
T210
L
Y
V
P
H
D
G
T
M
D
P
A
G
T
C
Site 19
S225
T
T
L
A
R
A
A
S
A
R
G
A
Q
V
I
Site 20
T244
V
T
G
I
R
V
W
T
D
D
F
G
V
R
R
Site 21
T257
R
R
V
A
G
V
E
T
Q
H
G
S
I
Q
T
Site 22
T298
M
H
H
A
Y
V
V
T
E
R
I
E
G
I
Q
Site 23
S316
N
V
R
D
H
D
A
S
V
Y
L
R
L
Q
G
Site 24
Y318
R
D
H
D
A
S
V
Y
L
R
L
Q
G
D
A
Site 25
S327
R
L
Q
G
D
A
L
S
V
G
G
Y
E
A
N
Site 26
S378
L
E
K
T
G
I
K
S
T
V
C
G
P
E
S
Site 27
T379
E
K
T
G
I
K
S
T
V
C
G
P
E
S
F
Site 28
S385
S
T
V
C
G
P
E
S
F
T
P
D
H
K
P
Site 29
T387
V
C
G
P
E
S
F
T
P
D
H
K
P
L
M
Site 30
Y440
P
E
K
D
M
H
G
Y
D
I
R
R
F
H
H
Site 31
S460
P
R
W
I
R
E
R
S
H
E
S
Y
A
K
N
Site 32
S463
I
R
E
R
S
H
E
S
Y
A
K
N
Y
S
V
Site 33
Y464
R
E
R
S
H
E
S
Y
A
K
N
Y
S
V
V
Site 34
Y468
H
E
S
Y
A
K
N
Y
S
V
V
F
P
H
D
Site 35
Y522
G
P
A
P
V
L
E
Y
D
Y
Y
G
A
Y
G
Site 36
Y524
A
P
V
L
E
Y
D
Y
Y
G
A
Y
G
S
R
Site 37
Y525
P
V
L
E
Y
D
Y
Y
G
A
Y
G
S
R
A
Site 38
Y528
E
Y
D
Y
Y
G
A
Y
G
S
R
A
H
E
D
Site 39
Y536
G
S
R
A
H
E
D
Y
A
Y
R
R
L
L
A
Site 40
Y538
R
A
H
E
D
Y
A
Y
R
R
L
L
A
D
E
Site 41
Y546
R
R
L
L
A
D
E
Y
T
F
A
F
P
P
H
Site 42
T547
R
L
L
A
D
E
Y
T
F
A
F
P
P
H
H
Site 43
T556
A
F
P
P
H
H
D
T
I
K
K
E
C
L
A
Site 44
S595
K
A
A
D
W
L
F
S
A
D
V
S
R
P
P
Site 45
S599
W
L
F
S
A
D
V
S
R
P
P
G
S
T
V
Site 46
S604
D
V
S
R
P
P
G
S
T
V
Y
T
C
M
L
Site 47
T605
V
S
R
P
P
G
S
T
V
Y
T
C
M
L
N
Site 48
Y607
R
P
P
G
S
T
V
Y
T
C
M
L
N
H
R
Site 49
T608
P
P
G
S
T
V
Y
T
C
M
L
N
H
R
G
Site 50
T617
M
L
N
H
R
G
G
T
E
S
D
L
T
V
S
Site 51
S619
N
H
R
G
G
T
E
S
D
L
T
V
S
R
L
Site 52
T622
G
G
T
E
S
D
L
T
V
S
R
L
A
P
S
Site 53
S624
T
E
S
D
L
T
V
S
R
L
A
P
S
H
Q
Site 54
S629
T
V
S
R
L
A
P
S
H
Q
A
S
P
L
A
Site 55
S633
L
A
P
S
H
Q
A
S
P
L
A
P
A
F
E
Site 56
T662
H
N
W
S
H
I
T
T
V
L
Q
D
Q
K
S
Site 57
S669
T
V
L
Q
D
Q
K
S
Q
C
Q
L
I
D
S
Site 58
S676
S
Q
C
Q
L
I
D
S
S
E
D
L
G
M
I
Site 59
S677
Q
C
Q
L
I
D
S
S
E
D
L
G
M
I
S
Site 60
S684
S
E
D
L
G
M
I
S
I
Q
G
P
A
S
R
Site 61
S703
E
V
L
D
A
D
L
S
N
E
A
F
P
F
S
Site 62
S710
S
N
E
A
F
P
F
S
T
H
K
L
L
R
A
Site 63
Y765
H
G
L
I
N
A
G
Y
R
A
I
D
S
L
S
Site 64
S770
A
G
Y
R
A
I
D
S
L
S
I
E
K
G
Y
Site 65
S772
Y
R
A
I
D
S
L
S
I
E
K
G
Y
R
H
Site 66
S789
A
D
L
R
P
D
D
S
P
L
E
A
G
L
A
Site 67
T829
R
R
R
L
V
C
F
T
M
E
D
K
V
P
M
Site 68
T864
F
G
F
A
I
D
K
T
I
A
Y
G
Y
I
H
Site 69
Y867
A
I
D
K
T
I
A
Y
G
Y
I
H
D
P
S
Site 70
Y869
D
K
T
I
A
Y
G
Y
I
H
D
P
S
G
G
Site 71
S874
Y
G
Y
I
H
D
P
S
G
G
P
V
S
L
D
Site 72
S879
D
P
S
G
G
P
V
S
L
D
F
V
K
S
G
Site 73
S885
V
S
L
D
F
V
K
S
G
D
Y
A
L
E
R
Site 74
Y888
D
F
V
K
S
G
D
Y
A
L
E
R
M
G
V
Site 75
Y897
L
E
R
M
G
V
T
Y
G
A
Q
A
H
L
K
Site 76
S905
G
A
Q
A
H
L
K
S
P
F
D
P
N
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation