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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VAV3
Full Name:
Guanine nucleotide exchange factor VAV3
Alias:
vav 3 guanine nucleotide exchange factor; Vav-3 protein
Type:
Nuclear receptor co-regulator; Actin binding protein; Adaptor/scaffold; Activator protein
Mass (Da):
97776
Number AA:
847
UniProt ID:
Q9UKW4
International Prot ID:
IPI00299763
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005070
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
L
P
T
N
H
R
V
T
W
D
S
A
Q
V
F
Site 2
S54
L
N
N
L
R
A
H
S
I
N
L
K
E
I
N
Site 3
S91
E
T
F
G
M
R
K
S
E
L
F
E
A
F
D
Site 4
T111
D
F
G
K
V
I
E
T
L
S
R
L
S
R
T
Site 5
S113
G
K
V
I
E
T
L
S
R
L
S
R
T
P
I
Site 6
T131
T
G
I
R
P
F
P
T
E
E
S
I
N
D
E
Site 7
S134
R
P
F
P
T
E
E
S
I
N
D
E
D
I
Y
Site 8
Y141
S
I
N
D
E
D
I
Y
K
G
L
P
D
L
I
Site 9
T151
L
P
D
L
I
D
E
T
L
V
E
D
E
E
D
Site 10
Y160
V
E
D
E
E
D
L
Y
D
C
V
Y
G
E
D
Site 11
Y164
E
D
L
Y
D
C
V
Y
G
E
D
E
G
G
E
Site 12
Y173
E
D
E
G
G
E
V
Y
E
D
L
M
K
A
E
Site 13
T203
C
L
A
E
I
K
Q
T
E
E
K
Y
T
E
T
Site 14
Y207
I
K
Q
T
E
E
K
Y
T
E
T
L
E
S
I
Site 15
T208
K
Q
T
E
E
K
Y
T
E
T
L
E
S
I
E
Site 16
T210
T
E
E
K
Y
T
E
T
L
E
S
I
E
K
Y
Site 17
S213
K
Y
T
E
T
L
E
S
I
E
K
Y
F
M
A
Site 18
Y217
T
L
E
S
I
E
K
Y
F
M
A
P
L
K
R
Site 19
Y265
N
K
N
D
Q
N
L
Y
Q
V
F
I
N
Y
K
Site 20
Y278
Y
K
E
R
L
V
I
Y
G
Q
Y
C
S
G
V
Site 21
S287
Q
Y
C
S
G
V
E
S
A
I
S
S
L
D
Y
Site 22
S290
S
G
V
E
S
A
I
S
S
L
D
Y
I
S
K
Site 23
S291
G
V
E
S
A
I
S
S
L
D
Y
I
S
K
T
Site 24
Y294
S
A
I
S
S
L
D
Y
I
S
K
T
K
E
D
Site 25
S296
I
S
S
L
D
Y
I
S
K
T
K
E
D
V
K
Site 26
S310
K
L
K
L
E
E
C
S
K
R
A
N
N
G
K
Site 27
T319
R
A
N
N
G
K
F
T
L
R
D
L
L
V
V
Site 28
Y334
P
M
Q
R
V
L
K
Y
H
L
L
L
Q
E
L
Site 29
T349
V
K
H
T
T
D
P
T
E
K
A
N
L
K
L
Site 30
Y367
A
M
K
D
L
A
Q
Y
V
N
E
V
K
R
D
Site 31
T377
E
V
K
R
D
N
E
T
L
R
E
I
K
Q
F
Site 32
T410
G
D
G
E
I
R
I
T
T
L
D
K
H
T
K
Site 33
T411
D
G
E
I
R
I
T
T
L
D
K
H
T
K
Q
Site 34
Y439
C
K
R
K
G
D
N
Y
E
M
K
E
I
I
D
Site 35
Y470
K
K
W
S
Y
G
F
Y
L
I
H
T
Q
G
Q
Site 36
S502
E
Q
F
E
M
A
L
S
N
I
R
P
D
Y
A
Site 37
Y508
L
S
N
I
R
P
D
Y
A
D
S
N
F
H
D
Site 38
S511
I
R
P
D
Y
A
D
S
N
F
H
D
F
K
M
Site 39
T520
F
H
D
F
K
M
H
T
F
T
R
V
T
S
C
Site 40
T522
D
F
K
M
H
T
F
T
R
V
T
S
C
K
V
Site 41
Y542
R
G
T
F
Y
Q
G
Y
L
C
F
K
C
G
A
Site 42
S567
D
N
C
G
R
V
N
S
G
E
Q
G
T
L
K
Site 43
T586
R
T
N
G
L
R
R
T
P
K
Q
V
D
P
G
Site 44
Y603
K
M
Q
V
I
R
N
Y
S
G
T
P
P
P
A
Site 45
S604
M
Q
V
I
R
N
Y
S
G
T
P
P
P
A
L
Site 46
T606
V
I
R
N
Y
S
G
T
P
P
P
A
L
H
E
Site 47
T624
L
Q
L
Q
A
G
D
T
V
E
L
L
K
G
D
Site 48
S634
L
L
K
G
D
A
H
S
L
F
W
Q
G
R
N
Site 49
S652
G
E
V
G
F
F
P
S
D
A
V
K
P
C
P
Site 50
Y667
C
V
P
K
P
V
D
Y
S
C
Q
P
W
Y
A
Site 51
Y673
D
Y
S
C
Q
P
W
Y
A
G
A
M
E
R
L
Site 52
S692
E
L
I
N
R
V
N
S
T
Y
L
V
R
H
R
Site 53
Y694
I
N
R
V
N
S
T
Y
L
V
R
H
R
T
K
Site 54
T700
T
Y
L
V
R
H
R
T
K
E
S
G
E
Y
A
Site 55
Y706
R
T
K
E
S
G
E
Y
A
I
S
I
K
Y
N
Site 56
S709
E
S
G
E
Y
A
I
S
I
K
Y
N
N
E
A
Site 57
Y712
E
Y
A
I
S
I
K
Y
N
N
E
A
K
H
I
Site 58
S738
A
E
N
R
K
F
K
S
L
M
E
L
V
E
Y
Site 59
Y745
S
L
M
E
L
V
E
Y
Y
K
H
H
S
L
K
Site 60
Y746
L
M
E
L
V
E
Y
Y
K
H
H
S
L
K
E
Site 61
T757
S
L
K
E
G
F
R
T
L
D
T
T
L
Q
F
Site 62
T760
E
G
F
R
T
L
D
T
T
L
Q
F
P
Y
K
Site 63
T761
G
F
R
T
L
D
T
T
L
Q
F
P
Y
K
E
Site 64
Y766
D
T
T
L
Q
F
P
Y
K
E
P
E
H
S
A
Site 65
S772
P
Y
K
E
P
E
H
S
A
G
Q
R
G
N
R
Site 66
S783
R
G
N
R
A
G
N
S
L
L
S
P
K
V
L
Site 67
S786
R
A
G
N
S
L
L
S
P
K
V
L
G
I
A
Site 68
Y797
L
G
I
A
I
A
R
Y
D
F
C
A
R
D
M
Site 69
S808
A
R
D
M
R
E
L
S
L
L
K
G
D
V
V
Site 70
Y818
K
G
D
V
V
K
I
Y
T
K
M
S
A
N
G
Site 71
S840
G
R
V
G
W
F
P
S
T
Y
V
E
E
D
E
Site 72
T841
R
V
G
W
F
P
S
T
Y
V
E
E
D
E
_
Site 73
Y842
V
G
W
F
P
S
T
Y
V
E
E
D
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation