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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CASP8AP2
Full Name:
CASP8-associated protein 2
Alias:
C8AP2; CED-4; FLASH; FLASH homolog RIP25; FLICE associated huge; FLICE-associated huge protein; RIP25
Type:
Nuclear receptor co-regulator, Apoptosis
Mass (Da):
222658
Number AA:
1982
UniProt ID:
Q9UKL3
International Prot ID:
IPI00100798
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008656
GO:0005123
GO:0003714
PhosphoSite+
KinaseNET
Biological Process:
GO:0006919
GO:0007049
GO:0008625
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
D
D
N
G
D
G
T
S
L
F
D
V
F
S
A
Site 2
S18
T
S
L
F
D
V
F
S
A
S
P
L
K
N
N
Site 3
S20
L
F
D
V
F
S
A
S
P
L
K
N
N
D
E
Site 4
Y33
D
E
G
S
L
D
I
Y
A
G
L
D
S
A
V
Site 5
S38
D
I
Y
A
G
L
D
S
A
V
S
D
S
A
S
Site 6
S41
A
G
L
D
S
A
V
S
D
S
A
S
K
S
C
Site 7
S43
L
D
S
A
V
S
D
S
A
S
K
S
C
V
P
Site 8
S45
S
A
V
S
D
S
A
S
K
S
C
V
P
S
R
Site 9
S47
V
S
D
S
A
S
K
S
C
V
P
S
R
N
C
Site 10
S51
A
S
K
S
C
V
P
S
R
N
C
L
D
L
Y
Site 11
Y58
S
R
N
C
L
D
L
Y
E
E
I
L
T
E
E
Site 12
T63
D
L
Y
E
E
I
L
T
E
E
G
T
A
K
E
Site 13
T99
K
K
F
K
E
I
Q
T
Q
N
F
S
L
I
N
Site 14
S103
E
I
Q
T
Q
N
F
S
L
I
N
E
N
Q
S
Site 15
S110
S
L
I
N
E
N
Q
S
L
K
K
N
I
S
A
Site 16
S116
Q
S
L
K
K
N
I
S
A
L
I
K
T
A
R
Site 17
T121
N
I
S
A
L
I
K
T
A
R
V
E
I
N
R
Site 18
S141
S
N
L
H
Q
R
L
S
E
F
P
H
F
R
N
Site 19
T158
K
T
A
R
T
F
D
T
V
K
T
K
D
L
K
Site 20
T161
R
T
F
D
T
V
K
T
K
D
L
K
S
R
S
Site 21
S166
V
K
T
K
D
L
K
S
R
S
P
H
L
D
D
Site 22
S168
T
K
D
L
K
S
R
S
P
H
L
D
D
C
S
Site 23
S175
S
P
H
L
D
D
C
S
K
T
D
H
R
A
K
Site 24
T177
H
L
D
D
C
S
K
T
D
H
R
A
K
S
D
Site 25
S183
K
T
D
H
R
A
K
S
D
V
S
K
D
V
H
Site 26
S192
V
S
K
D
V
H
H
S
T
S
L
P
N
L
E
Site 27
S194
K
D
V
H
H
S
T
S
L
P
N
L
E
K
E
Site 28
S206
E
K
E
G
K
P
H
S
D
K
R
S
T
S
H
Site 29
S210
K
P
H
S
D
K
R
S
T
S
H
L
P
T
S
Site 30
T211
P
H
S
D
K
R
S
T
S
H
L
P
T
S
V
Site 31
S212
H
S
D
K
R
S
T
S
H
L
P
T
S
V
E
Site 32
T216
R
S
T
S
H
L
P
T
S
V
E
K
H
C
T
Site 33
S217
S
T
S
H
L
P
T
S
V
E
K
H
C
T
N
Site 34
T223
T
S
V
E
K
H
C
T
N
G
V
W
S
R
S
Site 35
S230
T
N
G
V
W
S
R
S
H
Y
Q
V
G
E
G
Site 36
Y232
G
V
W
S
R
S
H
Y
Q
V
G
E
G
S
S
Site 37
S239
Y
Q
V
G
E
G
S
S
N
E
D
S
R
R
G
Site 38
S243
E
G
S
S
N
E
D
S
R
R
G
R
K
D
I
Site 39
S253
G
R
K
D
I
R
H
S
Q
F
N
R
G
T
E
Site 40
T259
H
S
Q
F
N
R
G
T
E
R
V
R
K
D
L
Site 41
S267
E
R
V
R
K
D
L
S
T
G
C
G
D
G
E
Site 42
T268
R
V
R
K
D
L
S
T
G
C
G
D
G
E
P
Site 43
S281
E
P
R
I
L
E
A
S
Q
R
L
Q
G
H
P
Site 44
Y291
L
Q
G
H
P
E
K
Y
G
K
G
E
P
K
T
Site 45
T298
Y
G
K
G
E
P
K
T
E
S
K
S
S
K
F
Site 46
S300
K
G
E
P
K
T
E
S
K
S
S
K
F
K
S
Site 47
S302
E
P
K
T
E
S
K
S
S
K
F
K
S
N
S
Site 48
S303
P
K
T
E
S
K
S
S
K
F
K
S
N
S
D
Site 49
S307
S
K
S
S
K
F
K
S
N
S
D
S
D
Y
K
Site 50
S309
S
S
K
F
K
S
N
S
D
S
D
Y
K
G
E
Site 51
S311
K
F
K
S
N
S
D
S
D
Y
K
G
E
R
I
Site 52
Y313
K
S
N
S
D
S
D
Y
K
G
E
R
I
N
S
Site 53
S320
Y
K
G
E
R
I
N
S
S
W
E
K
E
T
P
Site 54
S321
K
G
E
R
I
N
S
S
W
E
K
E
T
P
G
Site 55
T326
N
S
S
W
E
K
E
T
P
G
E
R
S
H
S
Site 56
S331
K
E
T
P
G
E
R
S
H
S
R
V
D
S
Q
Site 57
S333
T
P
G
E
R
S
H
S
R
V
D
S
Q
S
D
Site 58
S337
R
S
H
S
R
V
D
S
Q
S
D
K
K
L
E
Site 59
S339
H
S
R
V
D
S
Q
S
D
K
K
L
E
R
Q
Site 60
S347
D
K
K
L
E
R
Q
S
E
R
S
Q
N
I
N
Site 61
S350
L
E
R
Q
S
E
R
S
Q
N
I
N
R
K
E
Site 62
S360
I
N
R
K
E
V
K
S
Q
D
K
E
E
R
K
Site 63
S374
K
V
D
Q
K
P
K
S
V
V
K
D
Q
D
H
Site 64
S385
D
Q
D
H
W
R
R
S
E
R
A
S
L
P
H
Site 65
S389
W
R
R
S
E
R
A
S
L
P
H
S
K
N
E
Site 66
S393
E
R
A
S
L
P
H
S
K
N
E
I
T
F
S
Site 67
T398
P
H
S
K
N
E
I
T
F
S
H
N
S
S
K
Site 68
S400
S
K
N
E
I
T
F
S
H
N
S
S
K
Y
H
Site 69
S404
I
T
F
S
H
N
S
S
K
Y
H
L
E
E
R
Site 70
S422
E
D
C
K
R
D
K
S
V
N
S
H
S
F
Q
Site 71
S427
D
K
S
V
N
S
H
S
F
Q
D
G
R
C
P
Site 72
S435
F
Q
D
G
R
C
P
S
S
L
S
N
S
R
T
Site 73
S436
Q
D
G
R
C
P
S
S
L
S
N
S
R
T
H
Site 74
S438
G
R
C
P
S
S
L
S
N
S
R
T
H
K
N
Site 75
S440
C
P
S
S
L
S
N
S
R
T
H
K
N
I
D
Site 76
T442
S
S
L
S
N
S
R
T
H
K
N
I
D
S
K
Site 77
S448
R
T
H
K
N
I
D
S
K
E
V
D
A
M
H
Site 78
T460
A
M
H
Q
W
E
N
T
P
L
K
A
E
R
H
Site 79
T469
L
K
A
E
R
H
R
T
E
D
K
R
K
R
E
Site 80
S479
K
R
K
R
E
Q
E
S
K
E
E
N
R
H
I
Site 81
T494
R
N
E
K
R
V
P
T
E
H
L
Q
K
T
N
Site 82
T507
T
N
K
E
T
K
K
T
T
T
D
L
K
K
Q
Site 83
T509
K
E
T
K
K
T
T
T
D
L
K
K
Q
N
E
Site 84
T519
K
K
Q
N
E
P
K
T
D
K
G
E
V
L
D
Site 85
S557
K
N
K
D
L
K
L
S
F
M
K
K
L
N
L
Site 86
T565
F
M
K
K
L
N
L
T
L
S
P
A
K
K
Q
Site 87
S567
K
K
L
N
L
T
L
S
P
A
K
K
Q
P
V
Site 88
S575
P
A
K
K
Q
P
V
S
Q
D
N
Q
H
K
I
Site 89
T583
Q
D
N
Q
H
K
I
T
D
I
P
K
S
S
G
Site 90
S588
K
I
T
D
I
P
K
S
S
G
V
C
D
S
E
Site 91
S594
K
S
S
G
V
C
D
S
E
S
S
M
Q
V
K
Site 92
S596
S
G
V
C
D
S
E
S
S
M
Q
V
K
T
V
Site 93
Y605
M
Q
V
K
T
V
A
Y
V
P
S
I
S
E
H
Site 94
S620
I
L
G
E
A
A
V
S
E
H
T
M
G
E
T
Site 95
S629
H
T
M
G
E
T
K
S
T
L
L
E
P
K
V
Site 96
S658
T
N
K
E
D
E
N
S
L
L
V
R
S
V
D
Site 97
S663
E
N
S
L
L
V
R
S
V
D
N
T
M
H
C
Site 98
T667
L
V
R
S
V
D
N
T
M
H
C
E
E
P
I
Site 99
T677
C
E
E
P
I
C
G
T
E
T
S
F
P
S
P
Site 100
T679
E
P
I
C
G
T
E
T
S
F
P
S
P
M
E
Site 101
S680
P
I
C
G
T
E
T
S
F
P
S
P
M
E
I
Site 102
S683
G
T
E
T
S
F
P
S
P
M
E
I
Q
Q
T
Site 103
T690
S
P
M
E
I
Q
Q
T
E
S
L
F
P
S
T
Site 104
S692
M
E
I
Q
Q
T
E
S
L
F
P
S
T
G
M
Site 105
S696
Q
T
E
S
L
F
P
S
T
G
M
K
Q
T
I
Site 106
S722
D
V
L
Q
T
D
V
S
Q
N
F
G
L
E
L
Site 107
T731
N
F
G
L
E
L
D
T
K
R
N
D
N
S
D
Site 108
S737
D
T
K
R
N
D
N
S
D
Y
C
G
I
S
E
Site 109
Y739
K
R
N
D
N
S
D
Y
C
G
I
S
E
G
M
Site 110
T755
M
K
V
A
L
S
T
T
V
S
E
T
T
E
S
Site 111
S762
T
V
S
E
T
T
E
S
I
L
Q
P
S
I
E
Site 112
S779
D
I
L
P
I
M
L
S
E
D
N
N
P
K
F
Site 113
S800
T
P
L
V
E
S
K
S
C
H
L
E
P
C
L
Site 114
T811
E
P
C
L
P
K
E
T
L
D
S
S
L
Q
Q
Site 115
S814
L
P
K
E
T
L
D
S
S
L
Q
Q
T
E
L
Site 116
S815
P
K
E
T
L
D
S
S
L
Q
Q
T
E
L
M
Site 117
T819
L
D
S
S
L
Q
Q
T
E
L
M
D
H
R
M
Site 118
T828
L
M
D
H
R
M
A
T
G
E
T
N
S
V
Y
Site 119
Y835
T
G
E
T
N
S
V
Y
H
D
D
D
N
S
V
Site 120
S841
V
Y
H
D
D
D
N
S
V
L
S
I
D
L
N
Site 121
S858
R
P
I
P
E
A
I
S
P
L
N
S
P
V
R
Site 122
S862
E
A
I
S
P
L
N
S
P
V
R
P
V
A
K
Site 123
S875
A
K
V
L
R
N
E
S
P
P
Q
V
P
V
Y
Site 124
Y882
S
P
P
Q
V
P
V
Y
N
N
S
H
K
D
V
Site 125
S885
Q
V
P
V
Y
N
N
S
H
K
D
V
F
L
P
Site 126
S894
K
D
V
F
L
P
N
S
A
H
S
T
S
K
S
Site 127
S897
F
L
P
N
S
A
H
S
T
S
K
S
Q
S
D
Site 128
T898
L
P
N
S
A
H
S
T
S
K
S
Q
S
D
L
Site 129
S899
P
N
S
A
H
S
T
S
K
S
Q
S
D
L
N
Site 130
S901
S
A
H
S
T
S
K
S
Q
S
D
L
N
K
E
Site 131
S903
H
S
T
S
K
S
Q
S
D
L
N
K
E
N
Q
Site 132
Y914
K
E
N
Q
K
P
I
Y
K
S
D
K
C
T
E
Site 133
S916
N
Q
K
P
I
Y
K
S
D
K
C
T
E
A
D
Site 134
T920
I
Y
K
S
D
K
C
T
E
A
D
T
C
K
N
Site 135
T924
D
K
C
T
E
A
D
T
C
K
N
S
P
L
D
Site 136
S928
E
A
D
T
C
K
N
S
P
L
D
E
L
E
E
Site 137
S940
L
E
E
G
E
I
R
S
D
S
E
T
S
K
P
Site 138
S942
E
G
E
I
R
S
D
S
E
T
S
K
P
Q
E
Site 139
T944
E
I
R
S
D
S
E
T
S
K
P
Q
E
S
F
Site 140
S950
E
T
S
K
P
Q
E
S
F
E
K
N
S
K
R
Site 141
S955
Q
E
S
F
E
K
N
S
K
R
R
V
S
A
D
Site 142
S960
K
N
S
K
R
R
V
S
A
D
V
R
K
S
K
Site 143
S966
V
S
A
D
V
R
K
S
K
T
I
P
R
R
G
Site 144
T968
A
D
V
R
K
S
K
T
I
P
R
R
G
K
S
Site 145
S975
T
I
P
R
R
G
K
S
T
V
C
L
D
K
D
Site 146
T976
I
P
R
R
G
K
S
T
V
C
L
D
K
D
S
Site 147
S983
T
V
C
L
D
K
D
S
R
K
T
H
V
R
I
Site 148
T986
L
D
K
D
S
R
K
T
H
V
R
I
H
Q
T
Site 149
S1004
W
N
K
R
P
D
K
S
S
R
S
S
K
T
E
Site 150
S1005
N
K
R
P
D
K
S
S
R
S
S
K
T
E
K
Site 151
S1008
P
D
K
S
S
R
S
S
K
T
E
K
K
D
K
Site 152
S1018
E
K
K
D
K
V
M
S
T
S
S
L
E
K
I
Site 153
Y1053
R
K
H
V
R
K
N
Y
M
K
F
K
A
K
F
Site 154
S1091
N
L
H
K
I
S
K
S
V
T
T
L
Q
K
N
Site 155
T1093
H
K
I
S
K
S
V
T
T
L
Q
K
N
L
C
Site 156
Y1141
F
V
D
D
Q
L
D
Y
L
F
A
K
L
K
K
Site 157
S1154
K
K
I
L
V
C
D
S
K
S
F
G
R
D
S
Site 158
S1156
I
L
V
C
D
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S
F
G
R
D
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D
E
Site 159
S1161
S
K
S
F
G
R
D
S
D
E
G
K
L
E
K
Site 160
S1177
S
K
Q
N
A
Q
Y
S
N
S
Q
K
R
S
V
Site 161
S1179
Q
N
A
Q
Y
S
N
S
Q
K
R
S
V
D
N
Site 162
S1183
Y
S
N
S
Q
K
R
S
V
D
N
S
N
R
E
Site 163
S1187
Q
K
R
S
V
D
N
S
N
R
E
L
L
K
E
Site 164
S1197
E
L
L
K
E
K
L
S
K
S
E
D
P
V
H
Site 165
S1199
L
K
E
K
L
S
K
S
E
D
P
V
H
Y
K
Site 166
Y1205
K
S
E
D
P
V
H
Y
K
S
L
V
G
C
K
Site 167
S1207
E
D
P
V
H
Y
K
S
L
V
G
C
K
K
S
Site 168
S1214
S
L
V
G
C
K
K
S
E
E
N
Y
Q
D
Q
Site 169
Y1218
C
K
K
S
E
E
N
Y
Q
D
Q
N
N
S
S
Site 170
T1228
Q
N
N
S
S
I
N
T
V
K
H
D
I
K
K
Site 171
S1247
C
F
D
N
I
K
N
S
Q
S
E
E
R
S
L
Site 172
S1249
D
N
I
K
N
S
Q
S
E
E
R
S
L
E
V
Site 173
S1253
N
S
Q
S
E
E
R
S
L
E
V
H
C
P
S
Site 174
S1260
S
L
E
V
H
C
P
S
T
P
K
S
E
K
N
Site 175
T1261
L
E
V
H
C
P
S
T
P
K
S
E
K
N
E
Site 176
S1264
H
C
P
S
T
P
K
S
E
K
N
E
G
S
S
Site 177
T1277
S
S
I
E
D
A
Q
T
S
Q
H
A
T
L
K
Site 178
S1278
S
I
E
D
A
Q
T
S
Q
H
A
T
L
K
P
Site 179
T1282
A
Q
T
S
Q
H
A
T
L
K
P
E
R
S
F
Site 180
S1288
A
T
L
K
P
E
R
S
F
E
I
L
T
E
Q
Site 181
T1293
E
R
S
F
E
I
L
T
E
Q
Q
A
S
S
L
Site 182
S1299
L
T
E
Q
Q
A
S
S
L
T
F
N
L
V
S
Site 183
T1301
E
Q
Q
A
S
S
L
T
F
N
L
V
S
D
A
Site 184
S1316
Q
M
G
E
I
F
K
S
L
L
Q
G
S
D
L
Site 185
S1326
Q
G
S
D
L
L
D
S
S
V
N
C
T
E
K
Site 186
S1327
G
S
D
L
L
D
S
S
V
N
C
T
E
K
S
Site 187
T1331
L
D
S
S
V
N
C
T
E
K
S
E
W
E
L
Site 188
T1340
K
S
E
W
E
L
K
T
P
E
K
Q
L
L
E
Site 189
T1348
P
E
K
Q
L
L
E
T
L
K
C
E
S
I
P
Site 190
S1375
S
P
C
P
K
M
I
S
D
D
N
W
S
L
L
Site 191
S1380
M
I
S
D
D
N
W
S
L
L
S
S
E
K
G
Site 192
S1383
D
D
N
W
S
L
L
S
S
E
K
G
P
S
L
Site 193
S1384
D
N
W
S
L
L
S
S
E
K
G
P
S
L
S
Site 194
S1389
L
S
S
E
K
G
P
S
L
S
S
G
L
S
L
Site 195
S1391
S
E
K
G
P
S
L
S
S
G
L
S
L
P
V
Site 196
S1392
E
K
G
P
S
L
S
S
G
L
S
L
P
V
H
Site 197
S1406
H
P
D
V
L
D
E
S
C
M
F
E
V
S
T
Site 198
S1412
E
S
C
M
F
E
V
S
T
N
L
P
L
S
K
Site 199
T1413
S
C
M
F
E
V
S
T
N
L
P
L
S
K
D
Site 200
S1424
L
S
K
D
N
V
C
S
V
E
K
S
K
P
C
Site 201
S1428
N
V
C
S
V
E
K
S
K
P
C
V
S
S
I
Site 202
S1448
A
V
S
L
T
V
P
S
P
L
K
S
D
G
H
Site 203
S1452
T
V
P
S
P
L
K
S
D
G
H
L
S
F
L
Site 204
S1457
L
K
S
D
G
H
L
S
F
L
K
P
D
M
S
Site 205
S1464
S
F
L
K
P
D
M
S
S
S
S
T
P
E
E
Site 206
S1465
F
L
K
P
D
M
S
S
S
S
T
P
E
E
V
Site 207
S1466
L
K
P
D
M
S
S
S
S
T
P
E
E
V
I
Site 208
S1467
K
P
D
M
S
S
S
S
T
P
E
E
V
I
S
Site 209
T1468
P
D
M
S
S
S
S
T
P
E
E
V
I
S
A
Site 210
S1474
S
T
P
E
E
V
I
S
A
H
F
S
E
D
A
Site 211
S1478
E
V
I
S
A
H
F
S
E
D
A
L
L
E
E
Site 212
S1489
L
L
E
E
E
D
A
S
E
Q
D
I
H
L
A
Site 213
S1499
D
I
H
L
A
L
E
S
D
N
S
S
S
K
S
Site 214
S1502
L
A
L
E
S
D
N
S
S
S
K
S
S
C
S
Site 215
S1503
A
L
E
S
D
N
S
S
S
K
S
S
C
S
S
Site 216
S1504
L
E
S
D
N
S
S
S
K
S
S
C
S
S
S
Site 217
S1506
S
D
N
S
S
S
K
S
S
C
S
S
S
W
T
Site 218
S1507
D
N
S
S
S
K
S
S
C
S
S
S
W
T
S
Site 219
S1509
S
S
S
K
S
S
C
S
S
S
W
T
S
R
S
Site 220
S1510
S
S
K
S
S
C
S
S
S
W
T
S
R
S
V
Site 221
S1511
S
K
S
S
C
S
S
S
W
T
S
R
S
V
A
Site 222
T1513
S
S
C
S
S
S
W
T
S
R
S
V
A
P
G
Site 223
S1514
S
C
S
S
S
W
T
S
R
S
V
A
P
G
F
Site 224
S1516
S
S
S
W
T
S
R
S
V
A
P
G
F
Q
Y
Site 225
Y1523
S
V
A
P
G
F
Q
Y
H
P
N
L
P
M
H
Site 226
T1549
I
V
K
I
R
R
A
T
P
S
T
S
S
G
L
Site 227
S1551
K
I
R
R
A
T
P
S
T
S
S
G
L
K
Q
Site 228
T1552
I
R
R
A
T
P
S
T
S
S
G
L
K
Q
S
Site 229
S1553
R
R
A
T
P
S
T
S
S
G
L
K
Q
S
M
Site 230
S1554
R
A
T
P
S
T
S
S
G
L
K
Q
S
M
M
Site 231
S1559
T
S
S
G
L
K
Q
S
M
M
P
D
E
L
L
Site 232
T1567
M
M
P
D
E
L
L
T
S
L
P
R
H
G
K
Site 233
S1568
M
P
D
E
L
L
T
S
L
P
R
H
G
K
E
Site 234
Y1584
D
E
G
P
E
K
E
Y
I
S
C
Q
N
T
V
Site 235
T1590
E
Y
I
S
C
Q
N
T
V
F
K
S
V
E
E
Site 236
S1594
C
Q
N
T
V
F
K
S
V
E
E
L
E
N
S
Site 237
S1601
S
V
E
E
L
E
N
S
N
K
N
V
D
G
S
Site 238
S1610
K
N
V
D
G
S
K
S
T
H
E
E
Q
S
S
Site 239
S1617
S
T
H
E
E
Q
S
S
M
I
Q
T
Q
V
P
Site 240
T1621
E
Q
S
S
M
I
Q
T
Q
V
P
D
I
Y
E
Site 241
Y1627
Q
T
Q
V
P
D
I
Y
E
F
L
K
D
A
S
Site 242
S1634
Y
E
F
L
K
D
A
S
D
K
M
G
H
S
D
Site 243
S1640
A
S
D
K
M
G
H
S
D
E
V
A
D
E
C
Site 244
T1656
K
L
H
Q
V
W
E
T
K
V
P
E
S
I
E
Site 245
S1661
W
E
T
K
V
P
E
S
I
E
E
L
P
S
M
Site 246
S1667
E
S
I
E
E
L
P
S
M
E
E
I
S
H
S
Site 247
S1674
S
M
E
E
I
S
H
S
V
G
E
H
L
P
N
Site 248
T1682
V
G
E
H
L
P
N
T
Y
V
D
L
T
K
D
Site 249
Y1683
G
E
H
L
P
N
T
Y
V
D
L
T
K
D
P
Site 250
T1687
P
N
T
Y
V
D
L
T
K
D
P
V
T
E
T
Site 251
T1692
D
L
T
K
D
P
V
T
E
T
K
N
L
G
E
Site 252
S1721
S
G
G
N
L
N
Q
S
A
Q
I
L
D
N
S
Site 253
S1728
S
A
Q
I
L
D
N
S
L
Q
A
D
T
V
G
Site 254
S1745
I
D
L
T
Q
D
A
S
S
E
A
K
S
E
G
Site 255
S1746
D
L
T
Q
D
A
S
S
E
A
K
S
E
G
N
Site 256
S1750
D
A
S
S
E
A
K
S
E
G
N
H
P
A
L
Site 257
T1798
E
E
T
Y
I
D
L
T
T
E
S
P
S
S
C
Site 258
T1799
E
T
Y
I
D
L
T
T
E
S
P
S
S
C
E
Site 259
S1801
Y
I
D
L
T
T
E
S
P
S
S
C
E
V
K
Site 260
S1804
L
T
T
E
S
P
S
S
C
E
V
K
K
D
E
Site 261
S1814
V
K
K
D
E
L
K
S
E
P
G
S
N
C
D
Site 262
S1818
E
L
K
S
E
P
G
S
N
C
D
N
S
E
L
Site 263
S1823
P
G
S
N
C
D
N
S
E
L
P
G
T
L
H
Site 264
T1828
D
N
S
E
L
P
G
T
L
H
N
S
H
K
K
Site 265
S1832
L
P
G
T
L
H
N
S
H
K
K
R
R
N
I
Site 266
S1840
H
K
K
R
R
N
I
S
D
L
N
H
P
H
K
Site 267
T1853
H
K
K
Q
R
K
E
T
D
L
T
N
K
E
K
Site 268
T1856
Q
R
K
E
T
D
L
T
N
K
E
K
T
K
K
Site 269
S1868
T
K
K
P
T
Q
D
S
C
E
N
T
E
A
H
Site 270
T1872
T
Q
D
S
C
E
N
T
E
A
H
Q
K
K
A
Site 271
T1888
K
K
K
A
P
P
V
T
K
D
P
S
S
L
K
Site 272
S1892
P
P
V
T
K
D
P
S
S
L
K
A
T
P
G
Site 273
S1893
P
V
T
K
D
P
S
S
L
K
A
T
P
G
I
Site 274
T1897
D
P
S
S
L
K
A
T
P
G
I
K
D
S
S
Site 275
S1903
A
T
P
G
I
K
D
S
S
A
A
L
A
T
S
Site 276
S1910
S
S
A
A
L
A
T
S
T
S
L
S
A
K
N
Site 277
S1914
L
A
T
S
T
S
L
S
A
K
N
V
I
K
K
Site 278
S1947
E
C
Q
K
R
G
P
S
F
K
T
F
A
Y
L
Site 279
T1950
K
R
G
P
S
F
K
T
F
A
Y
L
A
A
K
Site 280
Y1953
P
S
F
K
T
F
A
Y
L
A
A
K
L
D
K
Site 281
S1966
D
K
N
P
N
Q
V
S
E
R
F
Q
Q
L
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation