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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TLK1
Full Name:
ISOFORM 2 OF SERINE/THREONINE-PROTEIN KINASE TOUSLED-LIKE 1.
Alias:
EC 2.7.11.1; KIAA0137; Kinase TLK1; PKU-beta; Tousled-like kinase 1
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; TLK family
Mass (Da):
86700
Number AA:
766
UniProt ID:
Q9UKI8
International Prot ID:
IPI00339361
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0016568
GO:0006886
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
V
Q
S
S
S
G
S
L
E
G
Site 2
S6
_
_
M
S
V
Q
S
S
S
G
S
L
E
G
P
Site 3
S7
_
M
S
V
Q
S
S
S
G
S
L
E
G
P
P
Site 4
S9
S
V
Q
S
S
S
G
S
L
E
G
P
P
S
W
Site 5
S15
G
S
L
E
G
P
P
S
W
S
Q
L
S
T
S
Site 6
S17
L
E
G
P
P
S
W
S
Q
L
S
T
S
P
T
Site 7
S20
P
P
S
W
S
Q
L
S
T
S
P
T
P
G
S
Site 8
T21
P
S
W
S
Q
L
S
T
S
P
T
P
G
S
A
Site 9
S22
S
W
S
Q
L
S
T
S
P
T
P
G
S
A
A
Site 10
T24
S
Q
L
S
T
S
P
T
P
G
S
A
A
A
A
Site 11
S27
S
T
S
P
T
P
G
S
A
A
A
A
R
S
L
Site 12
S33
G
S
A
A
A
A
R
S
L
L
N
H
T
P
P
Site 13
T38
A
R
S
L
L
N
H
T
P
P
S
G
R
P
R
Site 14
S41
L
L
N
H
T
P
P
S
G
R
P
R
E
G
A
Site 15
S54
G
A
M
D
E
L
H
S
L
D
P
R
R
Q
E
Site 16
T68
E
L
L
E
A
R
F
T
G
V
A
S
G
S
T
Site 17
S72
A
R
F
T
G
V
A
S
G
S
T
G
S
T
G
Site 18
S74
F
T
G
V
A
S
G
S
T
G
S
T
G
S
C
Site 19
T75
T
G
V
A
S
G
S
T
G
S
T
G
S
C
S
Site 20
S77
V
A
S
G
S
T
G
S
T
G
S
C
S
V
G
Site 21
T78
A
S
G
S
T
G
S
T
G
S
C
S
V
G
A
Site 22
S80
G
S
T
G
S
T
G
S
C
S
V
G
A
K
A
Site 23
S82
T
G
S
T
G
S
C
S
V
G
A
K
A
S
T
Site 24
S88
C
S
V
G
A
K
A
S
T
N
N
E
S
S
N
Site 25
T89
S
V
G
A
K
A
S
T
N
N
E
S
S
N
H
Site 26
S93
K
A
S
T
N
N
E
S
S
N
H
S
F
G
S
Site 27
S94
A
S
T
N
N
E
S
S
N
H
S
F
G
S
L
Site 28
S97
N
N
E
S
S
N
H
S
F
G
S
L
G
S
L
Site 29
S100
S
S
N
H
S
F
G
S
L
G
S
L
S
D
K
Site 30
S103
H
S
F
G
S
L
G
S
L
S
D
K
E
S
E
Site 31
S105
F
G
S
L
G
S
L
S
D
K
E
S
E
T
P
Site 32
S109
G
S
L
S
D
K
E
S
E
T
P
E
K
K
Q
Site 33
T111
L
S
D
K
E
S
E
T
P
E
K
K
Q
S
E
Site 34
S117
E
T
P
E
K
K
Q
S
E
S
S
R
G
R
K
Site 35
S119
P
E
K
K
Q
S
E
S
S
R
G
R
K
R
K
Site 36
S133
K
A
E
N
Q
N
E
S
S
Q
G
F
P
N
L
Site 37
S134
A
E
N
Q
N
E
S
S
Q
G
K
S
I
G
G
Site 38
S138
N
E
S
S
Q
G
K
S
I
G
G
R
G
H
K
Site 39
S147
G
G
R
G
H
K
I
S
D
Y
F
E
Y
Q
G
Site 40
Y149
R
G
H
K
I
S
D
Y
F
E
Y
Q
G
G
N
Site 41
Y152
K
I
S
D
Y
F
E
Y
Q
G
G
N
G
S
S
Site 42
S158
E
Y
Q
G
G
N
G
S
S
P
V
R
G
I
P
Site 43
S159
Y
Q
G
G
N
G
S
S
P
V
R
G
I
P
P
Site 44
S170
G
I
P
P
A
I
R
S
P
Q
N
S
H
S
H
Site 45
S174
A
I
R
S
P
Q
N
S
H
S
H
S
T
P
S
Site 46
S176
R
S
P
Q
N
S
H
S
H
S
T
P
S
S
S
Site 47
S178
P
Q
N
S
H
S
H
S
T
P
S
S
S
V
R
Site 48
T179
Q
N
S
H
S
H
S
T
P
S
S
S
V
R
P
Site 49
S181
S
H
S
H
S
T
P
S
S
S
V
R
P
N
S
Site 50
S182
H
S
H
S
T
P
S
S
S
V
R
P
N
S
P
Site 51
S183
S
H
S
T
P
S
S
S
V
R
P
N
S
P
S
Site 52
S188
S
S
S
V
R
P
N
S
P
S
P
T
A
L
A
Site 53
S190
S
V
R
P
N
S
P
S
P
T
A
L
A
F
G
Site 54
T192
R
P
N
S
P
S
P
T
A
L
A
F
G
D
H
Site 55
S208
I
V
Q
P
K
Q
L
S
F
K
I
I
Q
T
D
Site 56
Y263
Q
Q
K
L
L
E
K
Y
K
E
R
L
N
K
C
Site 57
S272
E
R
L
N
K
C
I
S
M
S
K
K
L
L
I
Site 58
S282
K
K
L
L
I
E
K
S
T
Q
E
K
L
S
S
Site 59
T283
K
L
L
I
E
K
S
T
Q
E
K
L
S
S
R
Site 60
S288
K
S
T
Q
E
K
L
S
S
R
E
K
S
M
Q
Site 61
S289
S
T
Q
E
K
L
S
S
R
E
K
S
M
Q
D
Site 62
S293
K
L
S
S
R
E
K
S
M
Q
D
R
L
R
L
Site 63
T304
R
L
R
L
G
H
F
T
T
V
R
H
G
A
S
Site 64
T305
L
R
L
G
H
F
T
T
V
R
H
G
A
S
F
Site 65
S311
T
T
V
R
H
G
A
S
F
T
E
Q
W
T
D
Site 66
T353
L
A
K
R
K
P
P
T
A
N
N
S
Q
A
P
Site 67
S357
K
P
P
T
A
N
N
S
Q
A
P
S
T
N
S
Site 68
S361
A
N
N
S
Q
A
P
S
T
N
S
E
P
K
Q
Site 69
T392
P
N
L
P
Q
L
L
T
L
A
E
Y
H
E
Q
Site 70
Y396
Q
L
L
T
L
A
E
Y
H
E
Q
E
E
I
F
Site 71
S444
R
I
N
N
E
D
N
S
Q
F
K
D
H
P
T
Site 72
T451
S
Q
F
K
D
H
P
T
L
N
E
R
Y
L
L
Site 73
Y471
R
G
G
F
S
E
V
Y
K
A
F
D
L
Y
E
Site 74
Y477
V
Y
K
A
F
D
L
Y
E
Q
R
Y
A
A
V
Site 75
Y481
F
D
L
Y
E
Q
R
Y
A
A
V
K
I
H
Q
Site 76
S492
K
I
H
Q
L
N
K
S
W
R
D
E
K
K
E
Site 77
Y509
H
K
H
A
C
R
E
Y
R
I
H
K
E
L
D
Site 78
Y524
H
P
R
I
V
K
L
Y
D
Y
F
S
L
D
T
Site 79
Y526
R
I
V
K
L
Y
D
Y
F
S
L
D
T
D
T
Site 80
Y549
E
G
N
D
L
D
F
Y
L
K
Q
H
K
L
M
Site 81
Y585
I
K
P
P
I
I
H
Y
D
L
K
P
G
N
I
Site 82
S618
S
K
I
M
D
D
D
S
Y
G
V
D
G
M
D
Site 83
Y619
K
I
M
D
D
D
S
Y
G
V
D
G
M
D
L
Site 84
T627
G
V
D
G
M
D
L
T
S
Q
G
A
G
T
Y
Site 85
Y636
Q
G
A
G
T
Y
W
Y
L
P
P
E
C
F
V
Site 86
S652
G
K
E
P
P
K
I
S
N
K
V
D
V
W
S
Site 87
Y669
V
I
F
F
Q
C
L
Y
G
R
K
P
F
G
H
Site 88
S679
K
P
F
G
H
N
Q
S
Q
Q
D
I
L
Q
E
Site 89
Y717
F
I
R
R
C
L
A
Y
R
K
E
D
R
F
D
Site 90
Y733
H
Q
L
A
N
D
P
Y
L
L
P
H
M
R
R
Site 91
S741
L
L
P
H
M
R
R
S
N
S
S
G
N
L
H
Site 92
S743
P
H
M
R
R
S
N
S
S
G
N
L
H
M
A
Site 93
S744
H
M
R
R
S
N
S
S
G
N
L
H
M
A
G
Site 94
T753
N
L
H
M
A
G
L
T
A
S
P
T
P
P
S
Site 95
S755
H
M
A
G
L
T
A
S
P
T
P
P
S
S
S
Site 96
S760
T
A
S
P
T
P
P
S
S
S
I
I
T
Y
_
Site 97
S761
A
S
P
T
P
P
S
S
S
I
I
T
Y
_
_
Site 98
S762
S
P
T
P
P
S
S
S
I
I
T
Y
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation