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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CROT
Full Name:
Alias:
Type:
Mass (Da):
70178
Number AA:
612
UniProt ID:
Q9UKG9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
N
Q
L
A
K
S
T
E
E
R
T
F
Q
Site 2
T13
A
K
S
T
E
E
R
T
F
Q
Y
Q
D
S
L
Site 3
Y16
T
E
E
R
T
F
Q
Y
Q
D
S
L
P
S
L
Site 4
S19
R
T
F
Q
Y
Q
D
S
L
P
S
L
P
V
P
Site 5
S22
Q
Y
Q
D
S
L
P
S
L
P
V
P
S
L
E
Site 6
S27
L
P
S
L
P
V
P
S
L
E
E
S
L
K
K
Site 7
S31
P
V
P
S
L
E
E
S
L
K
K
Y
L
E
S
Site 8
Y35
L
E
E
S
L
K
K
Y
L
E
S
V
K
P
F
Site 9
S38
S
L
K
K
Y
L
E
S
V
K
P
F
A
N
Q
Site 10
T51
N
Q
E
E
Y
K
K
T
E
E
I
V
Q
K
F
Site 11
Y113
P
A
A
H
F
E
H
Y
W
P
P
K
E
G
T
Site 12
S126
G
T
Q
L
E
R
G
S
I
T
L
W
H
N
L
Site 13
T128
Q
L
E
R
G
S
I
T
L
W
H
N
L
N
Y
Site 14
T152
P
V
H
K
V
G
N
T
P
L
D
M
N
Q
F
Site 15
Y179
T
R
D
S
I
M
N
Y
F
R
T
E
S
E
G
Site 16
T182
S
I
M
N
Y
F
R
T
E
S
E
G
R
S
P
Site 17
S184
M
N
Y
F
R
T
E
S
E
G
R
S
P
N
H
Site 18
S188
R
T
E
S
E
G
R
S
P
N
H
I
V
V
L
Site 19
T213
I
H
E
G
C
L
V
T
P
P
E
L
L
R
Q
Site 20
T222
P
E
L
L
R
Q
L
T
Y
I
H
K
K
C
H
Site 21
Y223
E
L
L
R
Q
L
T
Y
I
H
K
K
C
H
S
Site 22
S230
Y
I
H
K
K
C
H
S
E
P
D
G
P
G
I
Site 23
S242
P
G
I
A
A
L
T
S
E
E
R
T
R
W
A
Site 24
Y254
R
W
A
K
A
R
E
Y
L
I
G
L
D
P
E
Site 25
Y276
I
Q
S
S
L
L
V
Y
S
M
E
D
S
S
P
Site 26
S277
Q
S
S
L
L
V
Y
S
M
E
D
S
S
P
H
Site 27
S281
L
V
Y
S
M
E
D
S
S
P
H
V
T
P
E
Site 28
S282
V
Y
S
M
E
D
S
S
P
H
V
T
P
E
D
Site 29
T286
E
D
S
S
P
H
V
T
P
E
D
Y
S
E
I
Site 30
T303
A
I
L
I
G
D
P
T
V
R
W
G
D
K
S
Site 31
S310
T
V
R
W
G
D
K
S
Y
N
L
I
S
F
S
Site 32
Y311
V
R
W
G
D
K
S
Y
N
L
I
S
F
S
N
Site 33
S315
D
K
S
Y
N
L
I
S
F
S
N
G
V
F
G
Site 34
Y387
I
N
Q
A
K
A
Q
Y
L
R
E
A
S
D
L
Site 35
S392
A
Q
Y
L
R
E
A
S
D
L
Q
I
A
A
Y
Site 36
T409
T
S
F
G
K
K
L
T
K
N
K
M
L
H
P
Site 37
T418
N
K
M
L
H
P
D
T
F
I
Q
L
A
L
Q
Site 38
Y428
Q
L
A
L
Q
L
A
Y
Y
R
L
H
G
H
P
Site 39
Y429
L
A
L
Q
L
A
Y
Y
R
L
H
G
H
P
G
Site 40
T444
C
C
Y
E
T
A
M
T
R
H
F
Y
H
G
R
Site 41
T454
F
Y
H
G
R
T
E
T
M
R
S
C
T
V
E
Site 42
S457
G
R
T
E
T
M
R
S
C
T
V
E
A
V
R
Site 43
T459
T
E
T
M
R
S
C
T
V
E
A
V
R
W
C
Site 44
S473
C
Q
S
M
Q
D
P
S
V
N
L
R
E
R
Q
Site 45
S531
L
F
T
D
P
L
F
S
K
S
G
G
G
G
N
Site 46
S533
T
D
P
L
F
S
K
S
G
G
G
G
N
F
V
Site 47
S583
V
A
C
S
A
W
K
S
C
P
E
T
D
A
E
Site 48
T587
A
W
K
S
C
P
E
T
D
A
E
K
L
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation