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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
APPL
Full Name:
DCC-interacting protein 13-alpha
Alias:
Adapter protein containing PH domain, PTB domain and leucine zipper motif 1; Adaptor protein APPL; Adaptor protein containing pH domain, PTB domain and leucine zipper motif; Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; DIP13 alpha; DP13A; KIAA1428; Signaling adaptor protein DIP13alpha
Type:
Adaptor/scaffold; Nuclear receptor co-regulator
Mass (Da):
79663
Number AA:
709
UniProt ID:
Q9UKG1
International Prot ID:
IPI00015836
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0010008
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0043422
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0008283
GO:0008286
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
D
K
L
P
I
E
E
T
L
E
D
S
P
Q
T
Site 2
S16
I
E
E
T
L
E
D
S
P
Q
T
R
S
L
L
Site 3
S21
E
D
S
P
Q
T
R
S
L
L
G
V
F
E
E
Site 4
T31
G
V
F
E
E
D
A
T
A
I
S
N
Y
M
N
Site 5
Y41
S
N
Y
M
N
Q
L
Y
Q
A
M
H
R
I
Y
Site 6
Y48
Y
Q
A
M
H
R
I
Y
D
A
Q
N
E
L
S
Site 7
S84
G
D
D
E
V
M
S
S
T
L
Q
Q
F
S
K
Site 8
T85
D
D
E
V
M
S
S
T
L
Q
Q
F
S
K
V
Site 9
S97
S
K
V
I
D
E
L
S
S
C
H
A
V
L
S
Site 10
S98
K
V
I
D
E
L
S
S
C
H
A
V
L
S
T
Site 11
T128
R
D
L
K
E
I
L
T
L
K
E
V
F
Q
I
Site 12
Y147
H
D
A
A
I
N
R
Y
S
R
L
S
K
K
R
Site 13
S148
D
A
A
I
N
R
Y
S
R
L
S
K
K
R
E
Site 14
S151
I
N
R
Y
S
R
L
S
K
K
R
E
N
D
K
Site 15
Y161
R
E
N
D
K
V
K
Y
E
V
T
E
D
V
Y
Site 16
Y168
Y
E
V
T
E
D
V
Y
T
S
R
K
K
Q
H
Site 17
T169
E
V
T
E
D
V
Y
T
S
R
K
K
Q
H
Q
Site 18
S242
N
V
R
R
E
M
D
S
D
I
E
T
M
Q
Q
Site 19
T246
E
M
D
S
D
I
E
T
M
Q
Q
T
I
E
D
Site 20
Y262
E
V
A
S
D
P
L
Y
V
P
D
P
D
P
T
Site 21
T269
Y
V
P
D
P
D
P
T
K
F
P
V
N
R
N
Site 22
T278
F
P
V
N
R
N
L
T
R
K
A
G
Y
L
N
Site 23
T290
Y
L
N
A
R
N
K
T
G
L
V
S
S
T
W
Site 24
T296
K
T
G
L
V
S
S
T
W
D
R
Q
F
Y
F
Site 25
Y302
S
T
W
D
R
Q
F
Y
F
T
Q
G
G
N
L
Site 26
S311
T
Q
G
G
N
L
M
S
Q
A
R
G
D
V
A
Site 27
Y340
V
D
C
E
D
R
R
Y
C
F
Q
I
T
S
F
Site 28
S346
R
Y
C
F
Q
I
T
S
F
D
G
K
K
S
S
Site 29
S352
T
S
F
D
G
K
K
S
S
I
L
Q
A
E
S
Site 30
S353
S
F
D
G
K
K
S
S
I
L
Q
A
E
S
K
Site 31
S374
I
C
T
I
N
N
I
S
K
Q
I
Y
L
S
E
Site 32
Y378
N
N
I
S
K
Q
I
Y
L
S
E
N
P
E
E
Site 33
S380
I
S
K
Q
I
Y
L
S
E
N
P
E
E
T
A
Site 34
T399
Q
S
A
L
E
A
V
T
P
S
P
S
F
Q
Q
Site 35
S401
A
L
E
A
V
T
P
S
P
S
F
Q
Q
R
H
Site 36
S403
E
A
V
T
P
S
P
S
F
Q
Q
R
H
E
S
Site 37
S410
S
F
Q
Q
R
H
E
S
L
R
P
A
A
G
Q
Site 38
S418
L
R
P
A
A
G
Q
S
R
P
P
T
A
R
T
Site 39
T422
A
G
Q
S
R
P
P
T
A
R
T
S
S
S
G
Site 40
T425
S
R
P
P
T
A
R
T
S
S
S
G
S
L
G
Site 41
S426
R
P
P
T
A
R
T
S
S
S
G
S
L
G
S
Site 42
S427
P
P
T
A
R
T
S
S
S
G
S
L
G
S
E
Site 43
S428
P
T
A
R
T
S
S
S
G
S
L
G
S
E
S
Site 44
S430
A
R
T
S
S
S
G
S
L
G
S
E
S
T
N
Site 45
S433
S
S
S
G
S
L
G
S
E
S
T
N
L
A
A
Site 46
S459
P
I
Q
F
D
I
I
S
P
V
C
E
D
Q
P
Site 47
T479
F
G
Q
G
G
R
R
T
N
P
F
G
E
S
G
Site 48
S488
P
F
G
E
S
G
G
S
T
K
S
E
T
E
D
Site 49
T489
F
G
E
S
G
G
S
T
K
S
E
T
E
D
S
Site 50
S491
E
S
G
G
S
T
K
S
E
T
E
D
S
I
L
Site 51
T493
G
G
S
T
K
S
E
T
E
D
S
I
L
H
Q
Site 52
S496
T
K
S
E
T
E
D
S
I
L
H
Q
L
F
I
Site 53
S509
F
I
V
R
F
L
G
S
M
E
V
K
S
D
D
Site 54
S514
L
G
S
M
E
V
K
S
D
D
H
P
D
V
V
Site 55
Y522
D
D
H
P
D
V
V
Y
E
T
M
R
Q
I
L
Site 56
T524
H
P
D
V
V
Y
E
T
M
R
Q
I
L
A
A
Site 57
T559
L
K
L
I
D
P
Q
T
Q
V
T
R
L
T
F
Site 58
Y574
P
L
P
C
V
V
L
Y
A
T
H
Q
E
N
K
Site 59
T590
L
F
G
F
V
L
R
T
S
S
G
R
S
E
S
Site 60
S591
F
G
F
V
L
R
T
S
S
G
R
S
E
S
N
Site 61
S592
G
F
V
L
R
T
S
S
G
R
S
E
S
N
L
Site 62
S595
L
R
T
S
S
G
R
S
E
S
N
L
S
S
V
Site 63
S597
T
S
S
G
R
S
E
S
N
L
S
S
V
C
Y
Site 64
S600
G
R
S
E
S
N
L
S
S
V
C
Y
I
F
E
Site 65
S601
R
S
E
S
N
L
S
S
V
C
Y
I
F
E
S
Site 66
Y604
S
N
L
S
S
V
C
Y
I
F
E
S
N
N
E
Site 67
S618
E
G
E
K
I
C
D
S
V
G
L
A
K
Q
I
Site 68
S636
A
E
L
D
R
R
A
S
E
K
Q
K
E
I
E
Site 69
S673
Q
S
R
L
I
A
A
S
S
R
P
N
Q
A
S
Site 70
S674
S
R
L
I
A
A
S
S
R
P
N
Q
A
S
S
Site 71
S680
S
S
R
P
N
Q
A
S
S
E
G
Q
F
V
V
Site 72
S681
S
R
P
N
Q
A
S
S
E
G
Q
F
V
V
L
Site 73
S689
E
G
Q
F
V
V
L
S
S
S
Q
S
E
E
S
Site 74
S690
G
Q
F
V
V
L
S
S
S
Q
S
E
E
S
D
Site 75
S691
Q
F
V
V
L
S
S
S
Q
S
E
E
S
D
L
Site 76
S693
V
V
L
S
S
S
Q
S
E
E
S
D
L
G
E
Site 77
S696
S
S
S
Q
S
E
E
S
D
L
G
E
G
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation