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Updated November 2019
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Protein Info
Short Name:
C3orf63
Full Name:
Uncharacterized protein C3orf63
Alias:
CC063; Chromosome 3 open reading frame 63; CTCL tumor antigen se89-1; KIAA1105; RAP140; Retinoblastoma-associated protein 140; Retinoblastoma-associated protein RAP140; Se89-1
Type:
Unknown function
Mass (Da):
189032
Number AA:
1670
UniProt ID:
Q9UK61
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
A
C
Q
P
T
D
A
S
W
E
S
G
G
G
G
Site 2
S36
Q
A
L
P
E
L
E
S
S
Q
Q
N
G
G
G
Site 3
S37
A
L
P
E
L
E
S
S
Q
Q
N
G
G
G
G
Site 4
S68
A
G
A
E
A
A
Q
S
L
S
H
E
Q
P
Q
Site 5
S70
A
E
A
A
Q
S
L
S
H
E
Q
P
Q
D
S
Site 6
S77
S
H
E
Q
P
Q
D
S
S
E
A
G
A
A
A
Site 7
S99
P
E
R
P
V
R
R
S
F
Q
I
P
R
K
S
Site 8
S106
S
F
Q
I
P
R
K
S
R
E
K
K
A
L
F
Site 9
T117
K
A
L
F
Q
P
L
T
P
G
S
R
E
F
E
Site 10
S120
F
Q
P
L
T
P
G
S
R
E
F
E
D
V
V
Site 11
S139
S
S
Y
L
E
P
T
S
V
T
N
F
N
Y
R
Site 12
Y145
T
S
V
T
N
F
N
Y
R
R
A
C
L
V
H
Site 13
T161
E
L
L
E
K
E
F
T
E
K
R
R
E
L
K
Site 14
S178
G
R
L
D
K
E
L
S
E
S
Y
A
F
L
M
Site 15
S180
L
D
K
E
L
S
E
S
Y
A
F
L
M
V
D
Site 16
T193
V
D
R
Y
Q
V
Q
T
I
C
E
K
G
L
H
Site 17
T207
H
V
G
Q
S
K
I
T
I
L
G
S
P
S
M
Site 18
Y217
G
S
P
S
M
G
V
Y
L
S
R
Y
A
D
L
Site 19
S219
P
S
M
G
V
Y
L
S
R
Y
A
D
L
L
Q
Site 20
Y221
M
G
V
Y
L
S
R
Y
A
D
L
L
Q
A
N
Site 21
Y252
K
G
K
I
K
S
I
Y
D
P
M
G
V
K
S
Site 22
S259
Y
D
P
M
G
V
K
S
L
E
S
M
L
N
K
Site 23
T272
N
K
S
A
L
D
P
T
P
K
H
E
C
H
V
Site 24
T287
S
K
N
A
N
R
I
T
S
L
L
A
Y
R
A
Site 25
S288
K
N
A
N
R
I
T
S
L
L
A
Y
R
A
Y
Site 26
Y292
R
I
T
S
L
L
A
Y
R
A
Y
E
L
T
Q
Site 27
Y295
S
L
L
A
Y
R
A
Y
E
L
T
Q
Y
Y
F
Site 28
Y300
R
A
Y
E
L
T
Q
Y
Y
F
Y
E
Y
G
F
Site 29
Y301
A
Y
E
L
T
Q
Y
Y
F
Y
E
Y
G
F
D
Site 30
Y303
E
L
T
Q
Y
Y
F
Y
E
Y
G
F
D
E
L
Site 31
Y305
T
Q
Y
Y
F
Y
E
Y
G
F
D
E
L
R
R
Site 32
Y320
R
P
R
H
V
C
P
Y
A
V
V
S
F
T
Y
Site 33
T333
T
Y
K
D
D
I
Q
T
P
K
F
V
P
S
S
Site 34
S339
Q
T
P
K
F
V
P
S
S
R
S
N
S
F
N
Site 35
S340
T
P
K
F
V
P
S
S
R
S
N
S
F
N
T
Site 36
S342
K
F
V
P
S
S
R
S
N
S
F
N
T
D
R
Site 37
S344
V
P
S
S
R
S
N
S
F
N
T
D
R
N
I
Site 38
T347
S
R
S
N
S
F
N
T
D
R
N
I
D
K
Y
Site 39
Y354
T
D
R
N
I
D
K
Y
N
Y
T
L
W
K
G
Site 40
Y356
R
N
I
D
K
Y
N
Y
T
L
W
K
G
Q
L
Site 41
Y372
N
K
G
K
L
L
C
Y
I
S
L
R
S
A
T
Site 42
T395
P
E
K
L
D
V
E
T
V
M
S
I
D
H
L
Site 43
Y412
K
I
P
P
A
L
F
Y
K
E
T
Y
L
G
P
Site 44
Y416
A
L
F
Y
K
E
T
Y
L
G
P
N
E
V
L
Site 45
S430
L
K
N
G
M
Y
C
S
L
Y
E
V
V
E
K
Site 46
Y432
N
G
M
Y
C
S
L
Y
E
V
V
E
K
T
R
Site 47
T438
L
Y
E
V
V
E
K
T
R
I
G
S
N
M
E
Site 48
S442
V
E
K
T
R
I
G
S
N
M
E
S
L
L
Q
Site 49
S446
R
I
G
S
N
M
E
S
L
L
Q
K
L
D
R
Site 50
Y467
K
P
L
G
D
R
G
Y
L
F
L
L
S
P
Y
Site 51
Y474
Y
L
F
L
L
S
P
Y
Q
M
V
P
P
Y
E
Site 52
Y480
P
Y
Q
M
V
P
P
Y
E
Y
Q
T
A
K
S
Site 53
Y482
Q
M
V
P
P
Y
E
Y
Q
T
A
K
S
R
V
Site 54
S487
Y
E
Y
Q
T
A
K
S
R
V
L
H
A
L
F
Site 55
S501
F
L
F
Q
E
P
R
S
I
V
T
S
Q
K
G
Site 56
S505
E
P
R
S
I
V
T
S
Q
K
G
S
T
N
A
Site 57
S509
I
V
T
S
Q
K
G
S
T
N
A
A
P
Q
E
Site 58
S520
A
P
Q
E
R
H
E
S
M
P
D
V
L
K
I
Site 59
S546
R
K
E
F
K
N
I
S
A
I
N
F
H
S
V
Site 60
Y557
F
H
S
V
V
E
K
Y
V
S
E
F
F
K
R
Site 61
S559
S
V
V
E
K
Y
V
S
E
F
F
K
R
G
F
Site 62
S568
F
F
K
R
G
F
G
S
G
K
R
E
F
I
M
Site 63
Y578
R
E
F
I
M
F
P
Y
D
S
R
L
D
D
K
Site 64
Y589
L
D
D
K
K
F
L
Y
S
A
P
R
N
K
S
Site 65
S590
D
D
K
K
F
L
Y
S
A
P
R
N
K
S
H
Site 66
S596
Y
S
A
P
R
N
K
S
H
I
D
T
C
L
H
Site 67
T600
R
N
K
S
H
I
D
T
C
L
H
A
Y
I
F
Site 68
S633
N
R
K
L
Q
Q
F
S
P
L
S
D
Y
E
G
Site 69
S636
L
Q
Q
F
S
P
L
S
D
Y
E
G
Q
E
E
Site 70
Y638
Q
F
S
P
L
S
D
Y
E
G
Q
E
E
E
M
Site 71
T648
Q
E
E
E
M
N
G
T
K
M
K
F
G
K
R
Site 72
S658
K
F
G
K
R
N
N
S
R
G
E
A
I
I
S
Site 73
S665
S
R
G
E
A
I
I
S
G
K
Q
R
S
S
H
Site 74
S670
I
I
S
G
K
Q
R
S
S
H
S
L
D
Y
D
Site 75
S671
I
S
G
K
Q
R
S
S
H
S
L
D
Y
D
K
Site 76
S673
G
K
Q
R
S
S
H
S
L
D
Y
D
K
D
R
Site 77
Y676
R
S
S
H
S
L
D
Y
D
K
D
R
V
K
E
Site 78
S694
L
I
Q
C
R
K
K
S
V
G
G
D
S
D
T
Site 79
S699
K
K
S
V
G
G
D
S
D
T
E
D
M
R
S
Site 80
T701
S
V
G
G
D
S
D
T
E
D
M
R
S
K
T
Site 81
S706
S
D
T
E
D
M
R
S
K
T
V
L
K
R
K
Site 82
T708
T
E
D
M
R
S
K
T
V
L
K
R
K
L
E
Site 83
T727
N
M
R
K
L
A
K
T
S
N
L
S
E
N
C
Site 84
Y737
L
S
E
N
C
H
L
Y
E
E
S
P
Q
P
I
Site 85
S740
N
C
H
L
Y
E
E
S
P
Q
P
I
G
S
L
Site 86
S746
E
S
P
Q
P
I
G
S
L
G
H
D
A
D
L
Site 87
T760
L
R
R
Q
Q
Q
D
T
C
N
S
G
I
A
D
Site 88
S776
H
R
L
F
N
W
L
S
E
T
L
A
N
A
R
Site 89
T778
L
F
N
W
L
S
E
T
L
A
N
A
R
H
S
Site 90
S785
T
L
A
N
A
R
H
S
D
A
S
L
T
D
T
Site 91
S788
N
A
R
H
S
D
A
S
L
T
D
T
V
N
K
Site 92
T790
R
H
S
D
A
S
L
T
D
T
V
N
K
A
L
Site 93
T792
S
D
A
S
L
T
D
T
V
N
K
A
L
G
L
Site 94
Y805
G
L
S
T
D
D
A
Y
E
E
L
R
Q
K
H
Site 95
Y814
E
L
R
Q
K
H
E
Y
E
L
N
S
T
P
D
Site 96
T819
H
E
Y
E
L
N
S
T
P
D
K
K
D
Y
E
Site 97
Y825
S
T
P
D
K
K
D
Y
E
Q
P
T
C
A
K
Site 98
S843
A
Q
F
K
G
T
Q
S
L
L
L
E
V
D
A
Site 99
Y854
E
V
D
A
T
S
K
Y
S
V
A
I
S
T
S
Site 100
S855
V
D
A
T
S
K
Y
S
V
A
I
S
T
S
E
Site 101
S859
S
K
Y
S
V
A
I
S
T
S
E
V
G
T
D
Site 102
S861
Y
S
V
A
I
S
T
S
E
V
G
T
D
H
K
Site 103
T865
I
S
T
S
E
V
G
T
D
H
K
L
H
L
K
Site 104
S879
K
E
D
P
N
L
I
S
V
N
N
F
E
D
C
Site 105
S891
E
D
C
S
L
C
P
S
V
P
I
E
H
G
F
Site 106
S903
H
G
F
R
R
Q
Q
S
K
S
N
N
V
E
E
Site 107
S905
F
R
R
Q
Q
S
K
S
N
N
V
E
E
T
E
Site 108
T911
K
S
N
N
V
E
E
T
E
I
H
W
K
L
I
Site 109
T921
H
W
K
L
I
P
I
T
G
G
N
A
R
S
P
Site 110
S927
I
T
G
G
N
A
R
S
P
E
D
Q
L
G
K
Site 111
T940
G
K
H
G
E
K
Q
T
P
G
M
K
S
P
E
Site 112
S945
K
Q
T
P
G
M
K
S
P
E
E
Q
L
V
C
Site 113
S971
R
V
I
N
R
Q
R
S
S
D
Y
Q
F
P
S
Site 114
S972
V
I
N
R
Q
R
S
S
D
Y
Q
F
P
S
S
Site 115
Y974
N
R
Q
R
S
S
D
Y
Q
F
P
S
S
P
F
Site 116
S978
S
S
D
Y
Q
F
P
S
S
P
F
T
D
T
L
Site 117
S979
S
D
Y
Q
F
P
S
S
P
F
T
D
T
L
K
Site 118
T982
Q
F
P
S
S
P
F
T
D
T
L
K
G
T
T
Site 119
T984
P
S
S
P
F
T
D
T
L
K
G
T
T
E
D
Site 120
T995
T
T
E
D
D
V
L
T
G
Q
V
E
E
Q
C
Site 121
T1020
V
S
E
T
T
E
R
T
V
L
G
E
Y
N
L
Site 122
S1042
I
L
K
Q
K
N
V
S
Y
V
S
T
V
S
T
Site 123
Y1043
L
K
Q
K
N
V
S
Y
V
S
T
V
S
T
P
Site 124
S1045
Q
K
N
V
S
Y
V
S
T
V
S
T
P
I
F
Site 125
T1049
S
Y
V
S
T
V
S
T
P
I
F
S
T
Q
E
Site 126
S1062
Q
E
K
M
K
R
L
S
E
F
I
Y
S
K
T
Site 127
Y1066
K
R
L
S
E
F
I
Y
S
K
T
S
K
A
G
Site 128
S1067
R
L
S
E
F
I
Y
S
K
T
S
K
A
G
V
Site 129
S1093
N
T
I
I
I
K
A
S
A
K
G
G
N
L
P
Site 130
S1103
G
G
N
L
P
P
V
S
P
N
D
S
G
A
K
Site 131
S1107
P
P
V
S
P
N
D
S
G
A
K
I
A
S
N
Site 132
S1113
D
S
G
A
K
I
A
S
N
P
L
E
R
H
V
Site 133
S1124
E
R
H
V
I
P
V
S
S
S
D
F
N
N
K
Site 134
S1126
H
V
I
P
V
S
S
S
D
F
N
N
K
H
L
Site 135
S1139
H
L
L
E
P
L
C
S
D
P
L
K
D
T
N
Site 136
T1145
C
S
D
P
L
K
D
T
N
S
D
E
Q
H
S
Site 137
S1147
D
P
L
K
D
T
N
S
D
E
Q
H
S
T
S
Site 138
T1153
N
S
D
E
Q
H
S
T
S
A
L
T
E
V
E
Site 139
T1191
R
E
P
V
E
E
T
T
K
S
P
S
D
V
N
Site 140
S1193
P
V
E
E
T
T
K
S
P
S
D
V
N
I
S
Site 141
S1195
E
E
T
T
K
S
P
S
D
V
N
I
S
A
Q
Site 142
S1200
S
P
S
D
V
N
I
S
A
Q
P
A
L
S
N
Site 143
S1219
L
E
P
E
V
F
N
S
L
V
K
I
M
K
D
Site 144
S1242
Y
I
H
E
E
E
E
S
V
L
C
K
E
I
K
Site 145
Y1251
L
C
K
E
I
K
E
Y
L
I
K
L
G
N
T
Site 146
S1270
E
Q
F
L
E
R
R
S
K
L
D
K
L
L
I
Site 147
S1310
V
S
F
A
G
V
D
S
L
D
D
V
K
N
H
Site 148
Y1319
D
D
V
K
N
H
T
Y
N
E
L
F
V
S
G
Site 149
S1325
T
Y
N
E
L
F
V
S
G
G
F
I
V
S
D
Site 150
S1334
G
F
I
V
S
D
E
S
I
L
N
P
E
V
V
Site 151
T1351
E
N
L
K
N
F
L
T
F
L
E
E
L
S
T
Site 152
T1358
T
F
L
E
E
L
S
T
P
E
G
K
W
Q
W
Site 153
Y1406
H
L
V
E
I
L
S
Y
H
N
C
D
S
Q
T
Site 154
S1411
L
S
Y
H
N
C
D
S
Q
T
R
N
A
P
E
Site 155
T1477
V
G
Y
H
N
S
I
T
E
E
N
L
P
Q
L
Site 156
S1492
G
A
N
E
N
L
E
S
Q
S
A
L
L
E
N
Site 157
S1508
E
K
D
E
E
D
M
S
L
D
S
G
D
E
I
Site 158
S1511
E
E
D
M
S
L
D
S
G
D
E
I
S
H
I
Site 159
S1516
L
D
S
G
D
E
I
S
H
I
E
V
C
S
N
Site 160
T1539
E
T
K
G
S
R
G
T
D
Q
K
K
N
T
Q
Site 161
S1552
T
Q
I
E
L
Q
S
S
P
D
V
Q
N
S
L
Site 162
S1558
S
S
P
D
V
Q
N
S
L
L
E
D
K
T
Y
Site 163
T1564
N
S
L
L
E
D
K
T
Y
L
D
S
E
E
R
Site 164
Y1565
S
L
L
E
D
K
T
Y
L
D
S
E
E
R
T
Site 165
S1568
E
D
K
T
Y
L
D
S
E
E
R
T
S
I
D
Site 166
T1572
Y
L
D
S
E
E
R
T
S
I
D
I
V
C
S
Site 167
S1573
L
D
S
E
E
R
T
S
I
D
I
V
C
S
E
Site 168
S1584
V
C
S
E
G
E
N
S
N
S
T
E
Q
D
S
Site 169
S1586
S
E
G
E
N
S
N
S
T
E
Q
D
S
Y
S
Site 170
T1587
E
G
E
N
S
N
S
T
E
Q
D
S
Y
S
N
Site 171
S1591
S
N
S
T
E
Q
D
S
Y
S
N
F
Q
V
Y
Site 172
Y1592
N
S
T
E
Q
D
S
Y
S
N
F
Q
V
Y
H
Site 173
S1593
S
T
E
Q
D
S
Y
S
N
F
Q
V
Y
H
S
Site 174
Y1598
S
Y
S
N
F
Q
V
Y
H
S
Q
L
N
M
S
Site 175
T1622
T
H
Q
T
F
L
G
T
P
Y
A
L
S
S
S
Site 176
Y1624
Q
T
F
L
G
T
P
Y
A
L
S
S
S
Q
S
Site 177
S1627
L
G
T
P
Y
A
L
S
S
S
Q
S
Q
E
N
Site 178
S1628
G
T
P
Y
A
L
S
S
S
Q
S
Q
E
N
E
Site 179
S1629
T
P
Y
A
L
S
S
S
Q
S
Q
E
N
E
N
Site 180
S1631
Y
A
L
S
S
S
Q
S
Q
E
N
E
N
Y
F
Site 181
Y1637
Q
S
Q
E
N
E
N
Y
F
L
S
A
Y
T
E
Site 182
S1640
E
N
E
N
Y
F
L
S
A
Y
T
E
S
L
D
Site 183
Y1642
E
N
Y
F
L
S
A
Y
T
E
S
L
D
R
D
Site 184
S1645
F
L
S
A
Y
T
E
S
L
D
R
D
K
S
P
Site 185
S1651
E
S
L
D
R
D
K
S
P
P
P
L
S
W
G
Site 186
S1656
D
K
S
P
P
P
L
S
W
G
K
S
D
S
S
Site 187
S1660
P
P
L
S
W
G
K
S
D
S
S
R
P
Y
S
Site 188
S1662
L
S
W
G
K
S
D
S
S
R
P
Y
S
Q
E
Site 189
S1663
S
W
G
K
S
D
S
S
R
P
Y
S
Q
E
K
Site 190
Y1666
K
S
D
S
S
R
P
Y
S
Q
E
K
_
_
_
Site 191
S1667
S
D
S
S
R
P
Y
S
Q
E
K
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation