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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Kv4.3
Full Name:
Potassium voltage-gated channel subfamily D member 3
Alias:
KCND3; KSHIVB; Potassium voltage-gated channel subfamily D 3; Potassium voltage-gated channel, Shal-related subfamily, member 3; Voltage-gated potassium channel Kv4.3; Voltage-gated potassium channel subunit Kv4.3
Type:
Channel protein, potassium
Mass (Da):
73451
Number AA:
655
UniProt ID:
Q9UK17
International Prot ID:
IPI00383327
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042383
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0005250
GO:0030955
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S47
E
L
I
V
L
N
V
S
G
R
R
F
Q
T
W
Site 2
T53
V
S
G
R
R
F
Q
T
W
R
T
T
L
E
R
Site 3
T57
R
F
Q
T
W
R
T
T
L
E
R
Y
P
D
T
Site 4
Y61
W
R
T
T
L
E
R
Y
P
D
T
L
L
G
S
Site 5
T64
T
L
E
R
Y
P
D
T
L
L
G
S
T
E
K
Site 6
S68
Y
P
D
T
L
L
G
S
T
E
K
E
F
F
F
Site 7
Y82
F
N
E
D
T
K
E
Y
F
F
D
R
D
P
E
Site 8
Y98
F
R
C
V
L
N
F
Y
R
T
G
K
L
H
Y
Site 9
Y105
Y
R
T
G
K
L
H
Y
P
R
Y
E
C
I
S
Site 10
Y108
G
K
L
H
Y
P
R
Y
E
C
I
S
A
Y
D
Site 11
S112
Y
P
R
Y
E
C
I
S
A
Y
D
D
E
L
A
Site 12
Y114
R
Y
E
C
I
S
A
Y
D
D
E
L
A
F
Y
Site 13
Y133
E
I
I
G
D
C
C
Y
E
E
Y
K
D
R
K
Site 14
Y136
G
D
C
C
Y
E
E
Y
K
D
R
K
R
E
N
Site 15
S153
R
L
M
D
D
N
D
S
E
N
N
Q
E
S
M
Site 16
S159
D
S
E
N
N
Q
E
S
M
P
S
L
S
F
R
Site 17
S162
N
N
Q
E
S
M
P
S
L
S
F
R
Q
T
M
Site 18
S164
Q
E
S
M
P
S
L
S
F
R
Q
T
M
W
R
Site 19
T168
P
S
L
S
F
R
Q
T
M
W
R
A
F
E
N
Site 20
S213
P
C
G
T
V
P
G
S
K
E
L
P
C
G
E
Site 21
S250
L
R
L
F
A
A
P
S
R
Y
R
F
I
R
S
Site 22
S283
M
T
N
N
E
D
V
S
G
A
F
V
T
L
R
Site 23
T288
D
V
S
G
A
F
V
T
L
R
V
F
R
V
F
Site 24
S301
V
F
R
I
F
K
F
S
R
H
S
Q
G
L
R
Site 25
S304
I
F
K
F
S
R
H
S
Q
G
L
R
I
L
G
Site 26
Y312
Q
G
L
R
I
L
G
Y
T
L
K
S
C
A
S
Site 27
T313
G
L
R
I
L
G
Y
T
L
K
S
C
A
S
E
Site 28
S347
F
Y
A
E
K
G
S
S
A
S
K
F
T
S
I
Site 29
S353
S
S
A
S
K
F
T
S
I
P
A
S
F
W
Y
Site 30
Y410
V
S
N
F
S
R
I
Y
H
Q
N
Q
R
A
D
Site 31
T435
A
R
I
R
V
A
K
T
G
S
S
N
A
Y
L
Site 32
S437
I
R
V
A
K
T
G
S
S
N
A
Y
L
H
S
Site 33
Y441
K
T
G
S
S
N
A
Y
L
H
S
K
R
N
G
Site 34
S444
S
S
N
A
Y
L
H
S
K
R
N
G
L
L
N
Site 35
T457
L
N
E
A
L
E
L
T
G
T
P
E
E
E
H
Site 36
T459
E
A
L
E
L
T
G
T
P
E
E
E
H
M
G
Site 37
S470
E
H
M
G
K
T
T
S
L
I
E
S
Q
H
H
Site 38
S474
K
T
T
S
L
I
E
S
Q
H
H
H
L
L
H
Site 39
T486
L
L
H
C
L
E
K
T
T
G
L
S
Y
L
V
Site 40
Y491
E
K
T
T
G
L
S
Y
L
V
D
D
P
L
L
Site 41
S499
L
V
D
D
P
L
L
S
V
R
T
S
T
I
K
Site 42
S503
P
L
L
S
V
R
T
S
T
I
K
N
H
E
F
Site 43
T504
L
L
S
V
R
T
S
T
I
K
N
H
E
F
I
Site 44
Y528
M
E
S
S
M
Q
N
Y
P
S
T
R
S
P
S
Site 45
S530
S
S
M
Q
N
Y
P
S
T
R
S
P
S
L
S
Site 46
T531
S
M
Q
N
Y
P
S
T
R
S
P
S
L
S
S
Site 47
S533
Q
N
Y
P
S
T
R
S
P
S
L
S
S
H
P
Site 48
S535
Y
P
S
T
R
S
P
S
L
S
S
H
P
G
L
Site 49
S537
S
T
R
S
P
S
L
S
S
H
P
G
L
T
T
Site 50
S538
T
R
S
P
S
L
S
S
H
P
G
L
T
T
T
Site 51
T543
L
S
S
H
P
G
L
T
T
T
C
C
S
R
R
Site 52
T544
S
S
H
P
G
L
T
T
T
C
C
S
R
R
S
Site 53
T545
S
H
P
G
L
T
T
T
C
C
S
R
R
S
K
Site 54
S548
G
L
T
T
T
C
C
S
R
R
S
K
K
T
T
Site 55
S551
T
T
C
C
S
R
R
S
K
K
T
T
H
L
P
Site 56
T554
C
S
R
R
S
K
K
T
T
H
L
P
N
S
N
Site 57
T555
S
R
R
S
K
K
T
T
H
L
P
N
S
N
L
Site 58
S560
K
T
T
H
L
P
N
S
N
L
P
A
T
R
L
Site 59
T565
P
N
S
N
L
P
A
T
R
L
R
S
M
Q
E
Site 60
S569
L
P
A
T
R
L
R
S
M
Q
E
L
S
T
I
Site 61
S574
L
R
S
M
Q
E
L
S
T
I
H
I
Q
G
S
Site 62
S581
S
T
I
H
I
Q
G
S
E
Q
P
S
L
T
T
Site 63
S585
I
Q
G
S
E
Q
P
S
L
T
T
S
R
S
S
Site 64
T587
G
S
E
Q
P
S
L
T
T
S
R
S
S
L
N
Site 65
T588
S
E
Q
P
S
L
T
T
S
R
S
S
L
N
L
Site 66
S589
E
Q
P
S
L
T
T
S
R
S
S
L
N
L
K
Site 67
S591
P
S
L
T
T
S
R
S
S
L
N
L
K
A
D
Site 68
S592
S
L
T
T
S
R
S
S
L
N
L
K
A
D
D
Site 69
T607
G
L
R
P
N
C
K
T
S
Q
I
T
T
A
I
Site 70
T619
T
A
I
I
S
I
P
T
P
P
A
L
T
P
E
Site 71
T624
I
P
T
P
P
A
L
T
P
E
G
E
S
R
P
Site 72
S635
E
S
R
P
P
P
A
S
P
G
P
N
T
N
I
Site 73
T640
P
A
S
P
G
P
N
T
N
I
P
S
I
A
S
Site 74
S644
G
P
N
T
N
I
P
S
I
A
S
N
V
V
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation