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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF221
Full Name:
Zinc finger protein 221
Alias:
ZN221
Type:
Intracellular, Nucleus protein
Mass (Da):
71329
Number AA:
617
UniProt ID:
Q9UK13
International Prot ID:
IPI00007043
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
P
S
L
E
L
L
H
S
G
L
C
K
F
P
E
Site 2
T24
P
E
V
E
G
K
M
T
T
F
K
E
A
V
T
Site 3
Y55
D
P
A
Q
R
K
L
Y
R
D
V
M
L
E
N
Site 4
S68
E
N
F
R
N
L
L
S
V
G
N
Q
P
F
H
Site 5
T92
E
K
F
W
K
M
K
T
T
S
Q
R
E
G
N
Site 6
S94
F
W
K
M
K
T
T
S
Q
R
E
G
N
S
G
Site 7
T110
K
I
Q
I
E
M
E
T
V
P
E
A
G
P
H
Site 8
S131
Q
I
W
E
Q
I
A
S
D
L
T
R
S
Q
N
Site 9
T134
E
Q
I
A
S
D
L
T
R
S
Q
N
S
I
R
Site 10
S136
I
A
S
D
L
T
R
S
Q
N
S
I
R
N
S
Site 11
S139
D
L
T
R
S
Q
N
S
I
R
N
S
S
Q
F
Site 12
S143
S
Q
N
S
I
R
N
S
S
Q
F
F
K
E
G
Site 13
S144
Q
N
S
I
R
N
S
S
Q
F
F
K
E
G
D
Site 14
S161
C
Q
I
E
A
R
L
S
I
S
H
V
Q
Q
K
Site 15
Y170
S
H
V
Q
Q
K
P
Y
R
C
N
E
C
K
Q
Site 16
S178
R
C
N
E
C
K
Q
S
I
S
D
V
S
V
F
Site 17
S180
N
E
C
K
Q
S
I
S
D
V
S
V
F
D
L
Site 18
S183
K
Q
S
I
S
D
V
S
V
F
D
L
H
Q
Q
Site 19
S191
V
F
D
L
H
Q
Q
S
H
S
G
E
K
S
H
Site 20
S193
D
L
H
Q
Q
S
H
S
G
E
K
S
H
T
C
Site 21
S197
Q
S
H
S
G
E
K
S
H
T
C
G
E
C
G
Site 22
T199
H
S
G
E
K
S
H
T
C
G
E
C
G
K
S
Site 23
Y226
V
H
M
G
E
K
C
Y
K
C
D
V
C
G
K
Site 24
S239
G
K
E
F
N
Q
S
S
H
L
Q
T
H
Q
R
Site 25
T243
N
Q
S
S
H
L
Q
T
H
Q
R
V
H
T
G
Site 26
T249
Q
T
H
Q
R
V
H
T
G
E
K
P
F
K
R
Site 27
S267
G
K
G
F
H
S
R
S
A
L
N
V
H
C
K
Site 28
T277
N
V
H
C
K
L
H
T
G
E
K
P
Y
N
C
Site 29
Y282
L
H
T
G
E
K
P
Y
N
C
E
E
C
G
K
Site 30
S295
G
K
A
F
I
H
D
S
Q
L
Q
E
H
Q
R
Site 31
T305
Q
E
H
Q
R
I
H
T
G
E
K
P
F
K
C
Site 32
S318
K
C
D
I
C
G
K
S
F
R
V
R
S
R
L
Site 33
S323
G
K
S
F
R
V
R
S
R
L
N
R
H
S
M
Site 34
S329
R
S
R
L
N
R
H
S
M
V
H
T
G
E
K
Site 35
T333
N
R
H
S
M
V
H
T
G
E
K
P
F
R
C
Site 36
T342
E
K
P
F
R
C
D
T
C
G
K
N
F
R
Q
Site 37
S351
G
K
N
F
R
Q
R
S
A
L
N
S
H
S
M
Site 38
S355
R
Q
R
S
A
L
N
S
H
S
M
V
H
I
E
Site 39
S357
R
S
A
L
N
S
H
S
M
V
H
I
E
E
K
Site 40
Y366
V
H
I
E
E
K
P
Y
K
C
E
Q
C
G
K
Site 41
T389
C
K
H
Q
M
V
H
T
G
E
K
P
Y
N
C
Site 42
Y394
V
H
T
G
E
K
P
Y
N
C
K
E
C
G
K
Site 43
S421
Q
V
H
S
G
Q
K
S
F
K
C
E
E
C
G
Site 44
Y432
E
E
C
G
K
G
F
Y
T
N
S
R
R
S
S
Site 45
T433
E
C
G
K
G
F
Y
T
N
S
R
R
S
S
H
Site 46
S435
G
K
G
F
Y
T
N
S
R
R
S
S
H
Q
R
Site 47
S438
F
Y
T
N
S
R
R
S
S
H
Q
R
S
H
N
Site 48
S439
Y
T
N
S
R
R
S
S
H
Q
R
S
H
N
G
Site 49
S443
R
R
S
S
H
Q
R
S
H
N
G
E
K
P
Y
Site 50
Y450
S
H
N
G
E
K
P
Y
N
C
E
E
C
G
K
Site 51
Y459
C
E
E
C
G
K
D
Y
K
R
R
L
D
L
E
Site 52
T473
E
F
H
Q
R
V
H
T
G
E
R
P
Y
N
C
Site 53
Y478
V
H
T
G
E
R
P
Y
N
C
K
E
C
G
K
Site 54
S491
G
K
S
F
G
W
A
S
C
L
L
K
H
Q
R
Site 55
S501
L
K
H
Q
R
L
H
S
G
E
K
P
F
K
C
Site 56
T516
E
E
C
G
K
R
F
T
Q
S
T
Q
L
H
S
Site 57
T519
G
K
R
F
T
Q
S
T
Q
L
H
S
H
Q
T
Site 58
Y534
C
H
T
G
E
K
L
Y
K
C
E
Q
C
E
K
Site 59
Y562
V
H
R
G
E
R
P
Y
N
C
K
E
C
G
K
Site 60
S585
L
K
H
Q
R
L
H
S
G
E
K
P
L
K
S
Site 61
S592
S
G
E
K
P
L
K
S
G
V
W
E
E
I
Y
Site 62
Y599
S
G
V
W
E
E
I
Y
S
E
F
T
A
S
F
Site 63
S608
E
F
T
A
S
F
T
S
V
S
L
C
G
R
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation