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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANAPC5
Full Name:
Anaphase-promoting complex subunit 5
Alias:
Anaphase promoting complex subunit 5; ANC5; APC5; Similar to anaphase-promoting complex subunit 5
Type:
Ubiquitin conjugating protein, cell cycle regulation
Mass (Da):
85077
Number AA:
755
UniProt ID:
Q9UJX4
International Prot ID:
IPI00008247
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005680
GO:0005829
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0000086
GO:0031145
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
A
S
V
H
E
S
L
Y
F
N
P
M
M
T
N
Site 2
T15
L
Y
F
N
P
M
M
T
N
G
V
V
H
A
N
Site 3
T47
L
L
N
E
M
S
R
T
G
E
G
A
V
S
L
Site 4
S53
R
T
G
E
G
A
V
S
L
M
E
R
R
R
L
Site 5
S76
Q
G
P
D
I
T
L
S
K
L
Y
K
L
I
E
Site 6
S116
E
Q
F
F
D
D
L
S
D
S
F
S
G
T
E
Site 7
S118
F
F
D
D
L
S
D
S
F
S
G
T
E
P
E
Site 8
S120
D
D
L
S
D
S
F
S
G
T
E
P
E
V
H
Site 9
T122
L
S
D
S
F
S
G
T
E
P
E
V
H
K
T
Site 10
S149
A
Y
S
K
L
S
F
S
Q
V
F
K
L
Y
T
Site 11
Y161
L
Y
T
A
L
Q
Q
Y
F
Q
N
G
E
K
K
Site 12
T169
F
Q
N
G
E
K
K
T
V
E
D
A
D
M
E
Site 13
T178
E
D
A
D
M
E
L
T
S
R
D
E
G
E
R
Site 14
S179
D
A
D
M
E
L
T
S
R
D
E
G
E
R
K
Site 15
S195
E
K
E
E
L
D
V
S
V
R
E
E
E
V
S
Site 16
S202
S
V
R
E
E
E
V
S
C
S
G
P
L
S
Q
Site 17
S204
R
E
E
E
V
S
C
S
G
P
L
S
Q
K
Q
Site 18
S208
V
S
C
S
G
P
L
S
Q
K
Q
A
E
F
F
Site 19
S217
K
Q
A
E
F
F
L
S
Q
Q
A
S
L
L
K
Site 20
S221
F
F
L
S
Q
Q
A
S
L
L
K
N
D
E
T
Site 21
T228
S
L
L
K
N
D
E
T
K
A
L
T
P
A
S
Site 22
T232
N
D
E
T
K
A
L
T
P
A
S
L
Q
K
E
Site 23
S235
T
K
A
L
T
P
A
S
L
Q
K
E
L
N
N
Site 24
Y255
P
D
F
A
E
A
H
Y
L
S
Y
L
N
N
L
Site 25
S257
F
A
E
A
H
Y
L
S
Y
L
N
N
L
R
V
Site 26
Y258
A
E
A
H
Y
L
S
Y
L
N
N
L
R
V
Q
Site 27
S269
L
R
V
Q
D
V
F
S
S
T
H
S
L
L
H
Site 28
S270
R
V
Q
D
V
F
S
S
T
H
S
L
L
H
Y
Site 29
S273
D
V
F
S
S
T
H
S
L
L
H
Y
F
D
R
Site 30
Y277
S
T
H
S
L
L
H
Y
F
D
R
L
I
L
T
Site 31
T284
Y
F
D
R
L
I
L
T
G
A
E
S
K
S
N
Site 32
S288
L
I
L
T
G
A
E
S
K
S
N
G
E
E
G
Site 33
S290
L
T
G
A
E
S
K
S
N
G
E
E
G
Y
G
Site 34
Y296
K
S
N
G
E
E
G
Y
G
R
S
L
R
Y
A
Site 35
S299
G
E
E
G
Y
G
R
S
L
R
Y
A
A
L
N
Site 36
Y348
Q
H
C
L
S
W
L
Y
V
L
G
Q
K
R
S
Site 37
S355
Y
V
L
G
Q
K
R
S
D
S
Y
V
L
L
E
Site 38
S357
L
G
Q
K
R
S
D
S
Y
V
L
L
E
H
S
Site 39
Y358
G
Q
K
R
S
D
S
Y
V
L
L
E
H
S
V
Site 40
S413
D
L
L
H
W
K
H
S
L
S
E
L
I
D
I
Site 41
S421
L
S
E
L
I
D
I
S
I
A
Q
K
T
A
I
Site 42
Y432
K
T
A
I
W
R
L
Y
G
R
S
T
M
A
L
Site 43
T436
W
R
L
Y
G
R
S
T
M
A
L
Q
Q
A
Q
Site 44
Y525
R
A
M
N
D
G
K
Y
H
L
A
D
S
L
V
Site 45
S540
T
G
I
T
A
L
N
S
I
E
G
V
Y
R
K
Site 46
Y591
L
L
S
V
A
E
L
Y
W
R
S
S
S
P
T
Site 47
S595
A
E
L
Y
W
R
S
S
S
P
T
I
A
L
P
Site 48
S596
E
L
Y
W
R
S
S
S
P
T
I
A
L
P
M
Site 49
S611
L
L
Q
A
L
A
L
S
K
E
Y
R
L
Q
Y
Site 50
Y618
S
K
E
Y
R
L
Q
Y
L
A
S
E
T
V
L
Site 51
S674
V
A
K
C
Q
V
A
S
A
A
S
Y
D
Q
P
Site 52
Y678
Q
V
A
S
A
A
S
Y
D
Q
P
K
K
A
E
Site 53
Y700
N
L
N
E
A
K
N
Y
F
A
K
V
D
C
K
Site 54
Y715
E
R
I
R
D
V
V
Y
F
Q
A
R
L
Y
H
Site 55
Y721
V
Y
F
Q
A
R
L
Y
H
T
L
G
K
T
Q
Site 56
T727
L
Y
H
T
L
G
K
T
Q
E
R
N
R
C
A
Site 57
S746
Q
L
H
Q
E
L
P
S
H
G
V
P
L
I
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation