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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MCM8
Full Name:
DNA replication licensing factor MCM8
Alias:
C20orf154; DJ967N21.5; MGC119522; MGC119523; MGC12866; MGC4816; Minichromosome maintenance 8; Minichromosome maintenance complex component 8; REC
Type:
Cell cycle regulation
Mass (Da):
93700
Number AA:
UniProt ID:
Q9UJA3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0017111
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0007049
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
F
G
R
G
R
F
Q
S
W
K
R
G
R
G
G
Site 2
S28
G
R
G
G
G
N
F
S
G
K
W
R
E
R
E
Site 3
T43
H
R
P
D
L
S
K
T
T
G
K
R
T
S
E
Site 4
S49
K
T
T
G
K
R
T
S
E
Q
T
P
Q
F
L
Site 5
T52
G
K
R
T
S
E
Q
T
P
Q
F
L
L
S
T
Site 6
S58
Q
T
P
Q
F
L
L
S
T
K
T
P
Q
S
M
Site 7
T59
T
P
Q
F
L
L
S
T
K
T
P
Q
S
M
Q
Site 8
T61
Q
F
L
L
S
T
K
T
P
Q
S
M
Q
S
T
Site 9
S64
L
S
T
K
T
P
Q
S
M
Q
S
T
L
D
R
Site 10
T68
T
P
Q
S
M
Q
S
T
L
D
R
F
I
P
Y
Site 11
Y75
T
L
D
R
F
I
P
Y
K
G
W
K
L
Y
F
Site 12
Y81
P
Y
K
G
W
K
L
Y
F
S
E
V
Y
S
D
Site 13
S83
K
G
W
K
L
Y
F
S
E
V
Y
S
D
S
S
Site 14
Y86
K
L
Y
F
S
E
V
Y
S
D
S
S
P
L
I
Site 15
S87
L
Y
F
S
E
V
Y
S
D
S
S
P
L
I
E
Site 16
S89
F
S
E
V
Y
S
D
S
S
P
L
I
E
K
I
Site 17
S90
S
E
V
Y
S
D
S
S
P
L
I
E
K
I
Q
Site 18
Y110
F
T
R
H
I
D
L
Y
D
K
D
E
I
E
R
Site 19
S120
D
E
I
E
R
K
G
S
I
L
V
D
F
K
E
Site 20
T187
G
L
S
N
D
G
E
T
M
V
N
V
P
H
I
Site 21
Y199
P
H
I
H
A
R
V
Y
N
Y
E
P
L
T
Q
Site 22
Y201
I
H
A
R
V
Y
N
Y
E
P
L
T
Q
L
K
Site 23
T205
V
Y
N
Y
E
P
L
T
Q
L
K
N
V
R
A
Site 24
Y214
L
K
N
V
R
A
N
Y
Y
G
K
Y
I
A
L
Site 25
Y215
K
N
V
R
A
N
Y
Y
G
K
Y
I
A
L
R
Site 26
Y218
R
A
N
Y
Y
G
K
Y
I
A
L
R
G
T
V
Site 27
S250
A
A
C
G
E
I
Q
S
F
P
L
P
D
G
K
Site 28
Y258
F
P
L
P
D
G
K
Y
S
L
P
T
K
C
P
Site 29
S259
P
L
P
D
G
K
Y
S
L
P
T
K
C
P
V
Site 30
T262
D
G
K
Y
S
L
P
T
K
C
P
V
P
V
C
Site 31
S273
V
P
V
C
R
G
R
S
F
T
A
L
R
S
S
Site 32
T275
V
C
R
G
R
S
F
T
A
L
R
S
S
P
L
Site 33
T283
A
L
R
S
S
P
L
T
V
T
M
D
W
Q
S
Site 34
T285
R
S
S
P
L
T
V
T
M
D
W
Q
S
I
K
Site 35
S298
I
K
I
Q
E
L
M
S
D
D
Q
R
E
A
G
Site 36
T310
E
A
G
R
I
P
R
T
I
E
C
E
L
V
H
Site 37
S361
L
L
Y
I
E
A
N
S
I
S
N
S
K
G
Q
Site 38
S363
Y
I
E
A
N
S
I
S
N
S
K
G
Q
K
T
Site 39
S365
E
A
N
S
I
S
N
S
K
G
Q
K
T
K
S
Site 40
T370
S
N
S
K
G
Q
K
T
K
S
S
E
D
G
C
Site 41
S372
S
K
G
Q
K
T
K
S
S
E
D
G
C
K
H
Site 42
S373
K
G
Q
K
T
K
S
S
E
D
G
C
K
H
G
Site 43
Y391
E
F
S
L
K
D
L
Y
A
I
Q
E
I
Q
A
Site 44
Y435
L
F
G
G
S
Q
K
Y
A
D
D
K
N
R
I
Site 45
S461
G
D
P
G
L
G
K
S
Q
M
L
Q
A
A
C
Site 46
Y476
N
V
A
P
R
G
V
Y
V
C
G
N
T
T
T
Site 47
T488
T
T
T
T
S
G
L
T
V
T
L
S
K
D
S
Site 48
T490
T
T
S
G
L
T
V
T
L
S
K
D
S
S
S
Site 49
S492
S
G
L
T
V
T
L
S
K
D
S
S
S
G
D
Site 50
S496
V
T
L
S
K
D
S
S
S
G
D
F
A
L
E
Site 51
S497
T
L
S
K
D
S
S
S
G
D
F
A
L
E
A
Site 52
T572
G
H
Y
N
K
A
K
T
V
S
E
N
L
K
M
Site 53
S581
S
E
N
L
K
M
G
S
A
L
L
S
R
F
D
Site 54
T596
L
V
F
I
L
L
D
T
P
N
E
H
H
D
H
Site 55
S606
E
H
H
D
H
L
L
S
E
H
V
I
A
I
R
Site 56
T619
I
R
A
G
K
Q
R
T
I
S
S
A
T
V
A
Site 57
S621
A
G
K
Q
R
T
I
S
S
A
T
V
A
R
M
Site 58
S622
G
K
Q
R
T
I
S
S
A
T
V
A
R
M
N
Site 59
T624
Q
R
T
I
S
S
A
T
V
A
R
M
N
S
Q
Site 60
S630
A
T
V
A
R
M
N
S
Q
D
S
N
T
S
V
Site 61
S633
A
R
M
N
S
Q
D
S
N
T
S
V
L
E
V
Site 62
S636
N
S
Q
D
S
N
T
S
V
L
E
V
V
S
E
Site 63
S642
T
S
V
L
E
V
V
S
E
K
P
L
S
E
R
Site 64
S647
V
V
S
E
K
P
L
S
E
R
L
K
V
V
P
Site 65
T657
L
K
V
V
P
G
E
T
I
D
P
I
P
H
Q
Site 66
Y669
P
H
Q
L
L
R
K
Y
I
G
Y
A
R
Q
Y
Site 67
Y672
L
L
R
K
Y
I
G
Y
A
R
Q
Y
V
Y
P
Site 68
Y676
Y
I
G
Y
A
R
Q
Y
V
Y
P
R
L
S
T
Site 69
Y678
G
Y
A
R
Q
Y
V
Y
P
R
L
S
T
E
A
Site 70
S682
Q
Y
V
Y
P
R
L
S
T
E
A
A
R
V
L
Site 71
T683
Y
V
Y
P
R
L
S
T
E
A
A
R
V
L
Q
Site 72
Y693
A
R
V
L
Q
D
F
Y
L
E
L
R
K
Q
S
Site 73
S700
Y
L
E
L
R
K
Q
S
Q
R
L
N
S
S
P
Site 74
S705
K
Q
S
Q
R
L
N
S
S
P
I
T
T
R
Q
Site 75
S706
Q
S
Q
R
L
N
S
S
P
I
T
T
R
Q
L
Site 76
T709
R
L
N
S
S
P
I
T
T
R
Q
L
E
S
L
Site 77
T710
L
N
S
S
P
I
T
T
R
Q
L
E
S
L
I
Site 78
S715
I
T
T
R
Q
L
E
S
L
I
R
L
T
E
A
Site 79
T720
L
E
S
L
I
R
L
T
E
A
R
A
R
L
E
Site 80
T751
M
K
Y
S
M
L
G
T
Y
S
D
E
F
G
N
Site 81
Y752
K
Y
S
M
L
G
T
Y
S
D
E
F
G
N
L
Site 82
S753
Y
S
M
L
G
T
Y
S
D
E
F
G
N
L
D
Site 83
S764
G
N
L
D
F
E
R
S
Q
H
G
S
G
M
S
Site 84
S768
F
E
R
S
Q
H
G
S
G
M
S
N
R
S
T
Site 85
S771
S
Q
H
G
S
G
M
S
N
R
S
T
A
K
R
Site 86
S774
G
S
G
M
S
N
R
S
T
A
K
R
F
I
S
Site 87
T775
S
G
M
S
N
R
S
T
A
K
R
F
I
S
A
Site 88
S781
S
T
A
K
R
F
I
S
A
L
N
N
V
A
E
Site 89
Y791
N
N
V
A
E
R
T
Y
N
N
I
F
Q
F
H
Site 90
S820
D
F
E
N
F
I
G
S
L
N
D
Q
G
Y
L
Site 91
Y826
G
S
L
N
D
Q
G
Y
L
L
K
K
G
P
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation