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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HERC5
Full Name:
Alias:
Cyclin-E-binding protein 1;HECT domain and RCC1-like domain-containing protein 5
Type:
Mass (Da):
116852
Number AA:
1024
UniProt ID:
Q9UII4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
R
R
S
R
R
K
S
R
R
N
G
R
S
T
Site 2
S15
K
S
R
R
N
G
R
S
T
A
G
K
A
A
A
Site 3
T16
S
R
R
N
G
R
S
T
A
G
K
A
A
A
T
Site 4
S28
A
A
T
Q
P
A
K
S
P
G
A
Q
L
W
L
Site 5
T53
L
L
R
R
V
E
V
T
R
Q
L
C
C
S
P
Site 6
T87
A
G
S
G
G
A
R
T
P
K
C
I
K
L
G
Site 7
S101
G
K
N
M
K
I
H
S
V
D
Q
G
A
E
H
Site 8
S113
A
E
H
M
L
I
L
S
S
D
G
K
P
F
E
Site 9
S114
E
H
M
L
I
L
S
S
D
G
K
P
F
E
Y
Site 10
Y121
S
D
G
K
P
F
E
Y
D
N
Y
S
M
K
H
Site 11
Y124
K
P
F
E
Y
D
N
Y
S
M
K
H
L
R
F
Site 12
S133
M
K
H
L
R
F
E
S
I
L
Q
E
K
K
I
Site 13
S150
I
T
C
G
D
Y
H
S
L
A
L
S
K
G
G
Site 14
S154
D
Y
H
S
L
A
L
S
K
G
G
E
L
F
A
Site 15
T179
V
G
R
K
F
P
S
T
T
T
P
Q
I
V
E
Site 16
T181
R
K
F
P
S
T
T
T
P
Q
I
V
E
H
L
Site 17
S207
E
A
H
S
M
A
L
S
M
S
G
N
I
Y
S
Site 18
Y213
L
S
M
S
G
N
I
Y
S
W
G
K
N
E
C
Site 19
S230
L
G
L
G
H
T
E
S
K
D
D
P
S
L
I
Site 20
S235
T
E
S
K
D
D
P
S
L
I
E
G
L
D
N
Site 21
T266
T
Q
D
G
L
L
F
T
F
G
A
G
K
H
G
Site 22
Y310
G
R
W
H
T
L
A
Y
V
S
D
L
G
K
V
Site 23
S319
S
D
L
G
K
V
F
S
F
G
S
G
K
D
G
Site 24
S322
G
K
V
F
S
F
G
S
G
K
D
G
Q
L
G
Site 25
S345
M
P
L
P
V
K
V
S
S
S
E
E
L
K
L
Site 26
S347
L
P
V
K
V
S
S
S
E
E
L
K
L
E
S
Site 27
S357
L
K
L
E
S
H
T
S
E
K
E
L
I
M
I
Site 28
Y381
W
I
K
K
E
N
S
Y
V
N
L
K
R
T
I
Site 29
T405
R
W
I
A
D
V
E
T
K
R
W
Q
S
T
K
Site 30
S410
V
E
T
K
R
W
Q
S
T
K
R
E
I
Q
E
Site 31
S428
S
P
A
C
L
T
G
S
F
L
R
K
R
R
T
Site 32
T435
S
F
L
R
K
R
R
T
T
E
M
M
P
V
Y
Site 33
T436
F
L
R
K
R
R
T
T
E
M
M
P
V
Y
L
Site 34
Y442
T
T
E
M
M
P
V
Y
L
D
L
N
K
A
R
Site 35
T456
R
N
I
F
R
E
L
T
Q
K
D
W
I
T
N
Site 36
S481
L
K
R
L
P
F
H
S
P
P
Q
E
A
L
E
Site 37
S524
C
K
M
S
D
Q
S
S
L
V
L
E
E
Y
W
Site 38
Y530
S
S
L
V
L
E
E
Y
W
A
T
L
Q
E
S
Site 39
T533
V
L
E
E
Y
W
A
T
L
Q
E
S
T
F
S
Site 40
T538
W
A
T
L
Q
E
S
T
F
S
K
L
V
Q
M
Site 41
Y556
A
V
I
C
Q
L
D
Y
W
D
E
S
A
E
E
Site 42
T616
R
R
Y
L
W
K
M
T
V
D
A
S
E
N
V
Site 43
T649
I
K
L
L
H
T
D
T
L
L
K
I
E
S
K
Site 44
S655
D
T
L
L
K
I
E
S
K
K
H
K
A
Y
L
Site 45
Y661
E
S
K
K
H
K
A
Y
L
R
S
A
A
I
E
Site 46
S673
A
I
E
E
E
R
E
S
E
F
A
L
R
P
T
Site 47
T680
S
E
F
A
L
R
P
T
F
D
L
T
V
R
R
Site 48
T684
L
R
P
T
F
D
L
T
V
R
R
N
H
L
I
Site 49
S699
E
D
V
L
N
Q
L
S
Q
F
E
N
E
D
L
Site 50
S713
L
R
K
E
L
W
V
S
F
S
G
E
I
G
Y
Site 51
S715
K
E
L
W
V
S
F
S
G
E
I
G
Y
D
L
Site 52
Y720
S
F
S
G
E
I
G
Y
D
L
G
G
V
K
K
Site 53
Y742
A
E
M
I
Q
P
E
Y
G
M
F
M
Y
P
E
Site 54
Y767
P
K
F
E
K
K
R
Y
F
F
F
G
V
L
C
Site 55
S802
K
L
L
D
Q
M
P
S
L
E
D
L
K
E
L
Site 56
S810
L
E
D
L
K
E
L
S
P
D
L
G
K
N
L
Site 57
T845
V
H
W
D
R
N
D
T
N
L
I
P
N
G
S
Site 58
Y864
N
Q
T
N
K
R
D
Y
V
S
K
Y
I
N
Y
Site 59
Y868
K
R
D
Y
V
S
K
Y
I
N
Y
I
F
N
D
Site 60
Y881
N
D
S
V
K
A
V
Y
E
E
F
R
R
G
F
Site 61
Y889
E
E
F
R
R
G
F
Y
K
M
C
D
E
D
I
Site 62
Y915
V
I
V
G
N
T
D
Y
D
W
K
T
F
E
K
Site 63
Y926
T
F
E
K
N
A
R
Y
E
P
G
Y
N
S
S
Site 64
Y930
N
A
R
Y
E
P
G
Y
N
S
S
H
P
T
I
Site 65
T1008
P
K
Y
S
T
M
E
T
V
E
E
A
L
Q
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation