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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MUTYH
Full Name:
MutY homolog
Alias:
A/G-specific adenine DNA glycosylase; EC 3.2.2.-; MGC4416; MYH
Type:
DNA repair, Hydrolase, Mitochondrial
Mass (Da):
60069
Number AA:
546
UniProt ID:
Q9UIF7
International Prot ID:
IPI00414234
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0051539
GO:0019104
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0045007
GO:0006298
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
T
P
L
V
S
R
L
S
R
L
W
A
Site 2
S9
T
P
L
V
S
R
L
S
R
L
W
A
I
M
R
Site 3
S24
K
P
R
A
A
V
G
S
G
H
R
K
Q
A
A
Site 4
S32
G
H
R
K
Q
A
A
S
Q
E
G
R
Q
K
H
Site 5
S44
Q
K
H
A
K
N
N
S
Q
A
K
P
S
A
C
Site 6
S96
E
V
T
A
F
R
G
S
L
L
S
W
Y
D
Q
Site 7
S99
A
F
R
G
S
L
L
S
W
Y
D
Q
E
K
R
Site 8
Y101
R
G
S
L
L
S
W
Y
D
Q
E
K
R
D
L
Site 9
Y125
M
D
L
D
R
R
A
Y
A
V
W
V
S
E
V
Site 10
T155
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
Site 11
S161
P
T
L
Q
D
L
A
S
A
S
L
E
E
V
N
Site 12
S163
L
Q
D
L
A
S
A
S
L
E
E
V
N
Q
L
Site 13
Y176
Q
L
W
A
G
L
G
Y
Y
S
R
G
R
R
L
Site 14
Y177
L
W
A
G
L
G
Y
Y
S
R
G
R
R
L
Q
Site 15
T201
L
G
G
H
M
P
R
T
A
E
T
L
Q
Q
L
Site 16
S251
R
A
I
G
A
D
P
S
S
T
L
V
S
Q
Q
Site 17
T253
I
G
A
D
P
S
S
T
L
V
S
Q
Q
L
W
Site 18
S256
D
P
S
S
T
L
V
S
Q
Q
L
W
G
L
A
Site 19
T288
E
L
G
A
T
V
C
T
P
Q
R
P
L
C
S
Site 20
S295
T
P
Q
R
P
L
C
S
Q
C
P
V
E
S
L
Site 21
S301
C
S
Q
C
P
V
E
S
L
C
R
A
R
Q
R
Site 22
S317
E
Q
E
Q
L
L
A
S
G
S
L
S
G
S
P
Site 23
S319
E
Q
L
L
A
S
G
S
L
S
G
S
P
D
V
Site 24
S321
L
L
A
S
G
S
L
S
G
S
P
D
V
E
E
Site 25
S323
A
S
G
S
L
S
G
S
P
D
V
E
E
C
A
Site 26
T349
P
S
E
P
W
D
Q
T
L
G
V
V
N
F
P
Site 27
S360
V
N
F
P
R
K
A
S
R
K
P
P
R
E
E
Site 28
S368
R
K
P
P
R
E
E
S
S
A
T
C
V
L
E
Site 29
T371
P
R
E
E
S
S
A
T
C
V
L
E
Q
P
G
Site 30
S403
A
G
L
W
E
F
P
S
V
T
W
E
P
S
E
Site 31
T405
L
W
E
F
P
S
V
T
W
E
P
S
E
Q
L
Site 32
T431
W
A
G
P
L
P
A
T
H
L
R
H
L
G
E
Site 33
T464
L
E
G
Q
T
P
V
T
T
V
P
P
G
A
R
Site 34
T465
E
G
Q
T
P
V
T
T
V
P
P
G
A
R
W
Site 35
T474
P
P
G
A
R
W
L
T
Q
E
E
F
H
T
A
Site 36
Y494
M
K
K
V
F
R
V
Y
Q
G
Q
Q
P
G
T
Site 37
T501
Y
Q
G
Q
Q
P
G
T
C
M
G
S
K
R
S
Site 38
S505
Q
P
G
T
C
M
G
S
K
R
S
Q
V
S
S
Site 39
S508
T
C
M
G
S
K
R
S
Q
V
S
S
P
C
S
Site 40
S511
G
S
K
R
S
Q
V
S
S
P
C
S
R
K
K
Site 41
S512
S
K
R
S
Q
V
S
S
P
C
S
R
K
K
P
Site 42
S515
S
Q
V
S
S
P
C
S
R
K
K
P
R
M
G
Site 43
S535
N
F
F
R
S
H
I
S
T
D
A
H
S
L
N
Site 44
T536
F
F
R
S
H
I
S
T
D
A
H
S
L
N
S
Site 45
S540
H
I
S
T
D
A
H
S
L
N
S
A
A
Q
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation