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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCN11A
Full Name:
Sodium channel protein type 11 subunit alpha
Alias:
NaN; Nav1.9; Peripheral nerve sodium channel 5; PN5; SC11A; SCN12A; SCNBA; Sensory neuron sodium channel 2; SNS-2; Sodium channel protein type XI alpha; Sodium channel, voltage-gated, type XI, alpha subunit; Voltage-gated sodium channel alpha Nav1.9
Type:
Channel, sodium
Mass (Da):
204922
Number AA:
1791
UniProt ID:
Q9UI33
International Prot ID:
IPI00296063
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001518
Uniprot
OncoNet
Molecular Function:
GO:0031402
GO:0005248
PhosphoSite+
KinaseNET
Biological Process:
GO:0042493
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
E
R
N
F
R
P
F
T
S
D
S
L
A
A
I
Site 2
S23
F
R
P
F
T
S
D
S
L
A
A
I
E
K
R
Site 3
S40
I
Q
K
E
K
K
K
S
K
D
Q
T
G
E
V
Site 4
T44
K
K
K
S
K
D
Q
T
G
E
V
P
Q
P
R
Site 5
Y85
L
E
D
L
D
P
F
Y
R
N
H
K
T
F
M
Site 6
T99
M
V
L
N
R
K
R
T
I
Y
R
F
S
A
K
Site 7
Y101
L
N
R
K
R
T
I
Y
R
F
S
A
K
H
A
Site 8
S104
K
R
T
I
Y
R
F
S
A
K
H
A
L
F
I
Site 9
S292
S
R
D
C
K
N
I
S
N
P
E
A
Y
D
H
Site 10
Y297
N
I
S
N
P
E
A
Y
D
H
C
F
E
K
K
Site 11
Y337
H
T
K
I
N
P
D
Y
N
Y
T
N
F
D
N
Site 12
Y339
K
I
N
P
D
Y
N
Y
T
N
F
D
N
F
G
Site 13
T357
L
A
M
F
R
L
M
T
Q
D
S
W
E
K
L
Site 14
T372
Y
Q
Q
T
L
R
T
T
G
L
Y
S
V
F
F
Site 15
S444
A
M
G
I
D
R
S
S
L
T
S
L
E
T
S
Site 16
T446
G
I
D
R
S
S
L
T
S
L
E
T
S
Y
F
Site 17
S447
I
D
R
S
S
L
T
S
L
E
T
S
Y
F
T
Site 18
T450
S
S
L
T
S
L
E
T
S
Y
F
T
P
K
K
Site 19
S451
S
L
T
S
L
E
T
S
Y
F
T
P
K
K
R
Site 20
Y452
L
T
S
L
E
T
S
Y
F
T
P
K
K
R
K
Site 21
T454
S
L
E
T
S
Y
F
T
P
K
K
R
K
L
F
Site 22
S468
F
G
N
K
K
R
K
S
F
F
L
R
E
S
G
Site 23
S474
K
S
F
F
L
R
E
S
G
K
D
Q
P
P
G
Site 24
S482
G
K
D
Q
P
P
G
S
D
S
D
E
D
C
Q
Site 25
S484
D
Q
P
P
G
S
D
S
D
E
D
C
Q
K
K
Site 26
T498
K
P
Q
L
L
E
Q
T
K
R
L
S
Q
N
L
Site 27
S502
L
E
Q
T
K
R
L
S
Q
N
L
S
L
D
H
Site 28
S506
K
R
L
S
Q
N
L
S
L
D
H
F
D
E
H
Site 29
S539
T
M
K
E
Q
E
K
S
Q
E
P
C
L
P
C
Site 30
Y554
G
E
N
L
A
S
K
Y
L
V
W
N
C
C
P
Site 31
Y634
K
I
I
A
L
D
P
Y
H
Y
F
R
R
G
W
Site 32
Y636
I
A
L
D
P
Y
H
Y
F
R
R
G
W
N
I
Site 33
S683
R
V
F
K
L
A
K
S
W
P
T
L
N
T
L
Site 34
T689
K
S
W
P
T
L
N
T
L
I
K
I
I
G
N
Site 35
S726
G
M
Q
L
F
G
R
S
F
N
S
Q
K
S
P
Site 36
S729
L
F
G
R
S
F
N
S
Q
K
S
P
K
L
C
Site 37
S732
R
S
F
N
S
Q
K
S
P
K
L
C
N
P
T
Site 38
T739
S
P
K
L
C
N
P
T
G
P
T
V
S
C
L
Site 39
S744
N
P
T
G
P
T
V
S
C
L
R
H
W
H
M
Site 40
S813
F
I
A
L
L
L
N
S
F
S
N
E
E
R
N
Site 41
S815
A
L
L
L
N
S
F
S
N
E
E
R
N
G
N
Site 42
T830
L
E
G
E
A
R
K
T
K
V
Q
L
A
L
D
Site 43
S891
V
M
E
M
K
R
G
S
E
T
Q
E
E
L
G
Site 44
T901
Q
E
E
L
G
I
L
T
S
V
P
K
T
L
G
Site 45
T906
I
L
T
S
V
P
K
T
L
G
V
R
H
D
W
Site 46
T914
L
G
V
R
H
D
W
T
W
L
A
P
L
A
E
Site 47
T938
E
D
N
A
Q
R
I
T
Q
P
E
P
E
Q
Q
Site 48
Y947
P
E
P
E
Q
Q
A
Y
E
L
H
Q
E
N
K
Site 49
S958
Q
E
N
K
K
P
T
S
Q
R
V
Q
S
V
E
Site 50
S963
P
T
S
Q
R
V
Q
S
V
E
I
D
M
F
S
Site 51
S970
S
V
E
I
D
M
F
S
E
D
E
P
H
L
T
Site 52
T977
S
E
D
E
P
H
L
T
I
Q
D
P
R
K
K
Site 53
S985
I
Q
D
P
R
K
K
S
D
V
T
S
I
L
S
Site 54
T988
P
R
K
K
S
D
V
T
S
I
L
S
E
C
S
Site 55
S989
R
K
K
S
D
V
T
S
I
L
S
E
C
S
T
Site 56
Y1050
W
N
L
R
K
T
C
Y
Q
I
V
K
H
S
W
Site 57
T1148
M
E
L
K
S
F
R
T
L
R
A
L
R
P
L
Site 58
S1159
L
R
P
L
R
A
L
S
Q
F
E
G
M
K
V
Site 59
Y1217
G
T
D
S
V
I
N
Y
T
I
I
T
N
K
S
Site 60
Y1264
K
G
W
M
D
I
I
Y
A
A
V
D
S
T
E
Site 61
S1269
I
I
Y
A
A
V
D
S
T
E
K
E
Q
Q
P
Site 62
T1326
G
G
Q
D
I
F
M
T
E
E
Q
K
K
Y
Y
Site 63
Y1332
M
T
E
E
Q
K
K
Y
Y
N
A
M
K
K
L
Site 64
Y1388
I
S
M
M
A
E
S
Y
N
Q
P
K
A
M
K
Site 65
Y1423
K
I
F
A
L
R
Q
Y
Y
F
T
N
G
W
N
Site 66
Y1424
I
F
A
L
R
Q
Y
Y
F
T
N
G
W
N
L
Site 67
S1447
S
I
V
S
T
M
I
S
T
L
E
N
Q
E
H
Site 68
S1526
F
S
K
V
N
P
E
S
G
I
D
D
I
F
N
Site 69
S1555
S
T
S
A
G
W
D
S
L
L
S
P
M
L
R
Site 70
S1558
A
G
W
D
S
L
L
S
P
M
L
R
S
K
E
Site 71
S1563
L
L
S
P
M
L
R
S
K
E
S
C
N
S
S
Site 72
S1566
P
M
L
R
S
K
E
S
C
N
S
S
S
E
N
Site 73
S1569
R
S
K
E
S
C
N
S
S
S
E
N
C
H
L
Site 74
S1570
S
K
E
S
C
N
S
S
S
E
N
C
H
L
P
Site 75
S1571
K
E
S
C
N
S
S
S
E
N
C
H
L
P
G
Site 76
T1609
V
I
L
E
N
F
N
T
A
T
E
E
S
E
D
Site 77
S1614
F
N
T
A
T
E
E
S
E
D
P
L
G
E
D
Site 78
Y1627
E
D
D
F
D
I
F
Y
E
V
W
E
K
F
D
Site 79
Y1643
E
A
T
Q
F
I
K
Y
S
A
L
S
D
F
A
Site 80
Y1665
R
V
A
K
P
N
K
Y
Q
F
L
V
M
D
L
Site 81
S1697
T
A
R
V
L
G
G
S
D
G
L
D
S
M
K
Site 82
S1702
G
G
S
D
G
L
D
S
M
K
A
M
M
E
E
Site 83
Y1721
A
N
P
L
K
K
L
Y
E
P
I
V
T
T
T
Site 84
T1726
K
L
Y
E
P
I
V
T
T
T
K
R
K
E
E
Site 85
T1728
Y
E
P
I
V
T
T
T
K
R
K
E
E
E
R
Site 86
Y1747
I
Q
K
A
F
R
K
Y
M
M
K
V
T
K
G
Site 87
S1768
D
L
E
N
G
P
H
S
P
L
Q
T
L
C
N
Site 88
T1772
G
P
H
S
P
L
Q
T
L
C
N
G
D
L
S
Site 89
S1780
L
C
N
G
D
L
S
S
F
G
V
A
K
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation