KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
EIF2B4
Full Name:
Translation initiation factor eIF-2B subunit delta
Alias:
DKFZp586J0119; EI2BD; EIF2B; EIF-2B; EIF-2B GDP-GTP exchange factor delta EIF2B; EIF2BD; EIF2Bdelta; Eukaryotic translation initiation factor 2B, 4 delta, 67kDa; Eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa; Translation initiation factor eIF-2 delta
Type:
Mass (Da):
57560
Number AA:
UniProt ID:
Q9UI10
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005851
Uniprot
OncoNet
Molecular Function:
GO:0003743
GO:0031369
PhosphoSite+
KinaseNET
Biological Process:
GO:0042552
GO:0032057
GO:0014003
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
A
V
A
V
R
E
D
S
G
S
G
M
K
A
E
Site 2
S14
A
V
R
E
D
S
G
S
G
M
K
A
E
L
P
Site 3
T32
G
A
V
G
R
E
M
T
K
E
E
K
L
Q
L
Site 4
T60
E
K
G
A
E
P
E
T
G
S
A
V
S
A
A
Site 5
S62
G
A
E
P
E
T
G
S
A
V
S
A
A
Q
C
Site 6
S80
P
T
R
E
L
P
E
S
G
I
Q
L
G
T
P
Site 7
T86
E
S
G
I
Q
L
G
T
P
R
E
K
V
P
A
Site 8
S130
G
G
P
P
P
K
A
S
P
S
T
A
G
E
T
Site 9
S132
P
P
P
K
A
S
P
S
T
A
G
E
T
P
S
Site 10
T133
P
P
K
A
S
P
S
T
A
G
E
T
P
S
G
Site 11
T137
S
P
S
T
A
G
E
T
P
S
G
V
K
R
L
Site 12
S139
S
T
A
G
E
T
P
S
G
V
K
R
L
P
E
Site 13
Y147
G
V
K
R
L
P
E
Y
P
Q
V
D
D
L
L
Site 14
T169
P
E
R
Q
Q
V
P
T
R
K
D
Y
G
S
K
Site 15
Y173
Q
V
P
T
R
K
D
Y
G
S
K
V
S
L
F
Site 16
S175
P
T
R
K
D
Y
G
S
K
V
S
L
F
S
H
Site 17
S178
K
D
Y
G
S
K
V
S
L
F
S
H
L
P
Q
Site 18
S181
G
S
K
V
S
L
F
S
H
L
P
Q
Y
S
R
Site 19
Y186
L
F
S
H
L
P
Q
Y
S
R
Q
N
S
L
T
Site 20
S187
F
S
H
L
P
Q
Y
S
R
Q
N
S
L
T
Q
Site 21
S191
P
Q
Y
S
R
Q
N
S
L
T
Q
F
M
S
I
Site 22
T193
Y
S
R
Q
N
S
L
T
Q
F
M
S
I
P
S
Site 23
Y240
L
Q
Q
V
I
Q
D
Y
T
T
P
P
N
E
E
Site 24
T241
Q
Q
V
I
Q
D
Y
T
T
P
P
N
E
E
L
Site 25
T242
Q
V
I
Q
D
Y
T
T
P
P
N
E
E
L
S
Site 26
S261
N
K
L
K
P
Y
M
S
F
L
T
Q
C
R
P
Site 27
T264
K
P
Y
M
S
F
L
T
Q
C
R
P
L
S
A
Site 28
S270
L
T
Q
C
R
P
L
S
A
S
M
H
N
A
I
Site 29
S272
Q
C
R
P
L
S
A
S
M
H
N
A
I
K
F
Site 30
T285
K
F
L
N
K
E
I
T
S
V
G
S
S
K
R
Site 31
S286
F
L
N
K
E
I
T
S
V
G
S
S
K
R
E
Site 32
S290
E
I
T
S
V
G
S
S
K
R
E
E
E
A
K
Site 33
S298
K
R
E
E
E
A
K
S
E
L
R
A
A
I
D
Site 34
Y324
Q
A
I
S
R
F
A
Y
Q
K
I
S
N
G
D
Site 35
T351
R
I
L
Q
E
A
W
T
E
G
R
R
F
R
V
Site 36
T372
P
W
L
E
G
R
H
T
L
R
S
L
V
H
A
Site 37
S375
E
G
R
H
T
L
R
S
L
V
H
A
G
V
P
Site 38
S384
V
H
A
G
V
P
A
S
Y
L
L
I
P
A
A
Site 39
Y385
H
A
G
V
P
A
S
Y
L
L
I
P
A
A
S
Site 40
S399
S
Y
V
L
P
E
V
S
K
V
L
L
G
A
H
Site 41
T449
K
F
C
E
R
V
Q
T
D
A
F
V
S
N
E
Site 42
S481
A
N
W
Q
N
H
A
S
L
R
L
L
N
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation