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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC12A6
Full Name:
Solute carrier family 12 member 6
Alias:
ACCPN; Agenesis of corpus callosum and peripheral neuropathy (Andermann syndrome); Electroneutral potassium-chloride cotransporter 3; KCC3; KCC3A; KCC3B; K-Cl cotransporter 3; Potassium chloride cotransporter KCC3; Potassium chloride cotransporter KCC3a-S3; S12A6; Solute carrier family 12 (potassium/chloride transporters) member 6; Solute carrier family 12 (potassium/chloride transporters), member 6
Type:
Ion channel cotransporter; Membrane fraction, membrane, integral plasma membrane protein
Mass (Da):
127617
Number AA:
1150
UniProt ID:
Q9UHW9
International Prot ID:
IPI00465299
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0030955
GO:0015379
PhosphoSite+
KinaseNET
Biological Process:
GO:0006884
GO:0006873
GO:0006821
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
H
P
P
E
T
T
T
K
M
A
S
V
R
F
Site 2
S12
E
T
T
T
K
M
A
S
V
R
F
M
V
T
P
Site 3
S29
I
D
D
I
P
G
L
S
D
T
S
P
D
L
S
Site 4
T31
D
I
P
G
L
S
D
T
S
P
D
L
S
S
R
Site 5
S32
I
P
G
L
S
D
T
S
P
D
L
S
S
R
S
Site 6
S36
S
D
T
S
P
D
L
S
S
R
S
S
S
R
V
Site 7
S37
D
T
S
P
D
L
S
S
R
S
S
S
R
V
R
Site 8
S39
S
P
D
L
S
S
R
S
S
S
R
V
R
F
S
Site 9
S40
P
D
L
S
S
R
S
S
S
R
V
R
F
S
S
Site 10
S41
D
L
S
S
R
S
S
S
R
V
R
F
S
S
R
Site 11
S46
S
S
S
R
V
R
F
S
S
R
E
S
V
P
E
Site 12
S47
S
S
R
V
R
F
S
S
R
E
S
V
P
E
T
Site 13
S50
V
R
F
S
S
R
E
S
V
P
E
T
S
R
S
Site 14
T54
S
R
E
S
V
P
E
T
S
R
S
E
P
M
S
Site 15
S55
R
E
S
V
P
E
T
S
R
S
E
P
M
S
E
Site 16
S57
S
V
P
E
T
S
R
S
E
P
M
S
E
M
S
Site 17
S61
T
S
R
S
E
P
M
S
E
M
S
G
A
T
T
Site 18
S64
S
E
P
M
S
E
M
S
G
A
T
T
S
L
A
Site 19
S79
T
V
A
L
D
P
P
S
D
R
T
S
H
P
Q
Site 20
T82
L
D
P
P
S
D
R
T
S
H
P
Q
D
V
I
Site 21
S83
D
P
P
S
D
R
T
S
H
P
Q
D
V
I
E
Site 22
S93
Q
D
V
I
E
D
L
S
Q
N
S
I
T
G
E
Site 23
S96
I
E
D
L
S
Q
N
S
I
T
G
E
H
S
Q
Site 24
Y116
H
K
K
A
R
N
A
Y
L
N
N
S
N
Y
E
Site 25
S120
R
N
A
Y
L
N
N
S
N
Y
E
E
G
D
E
Site 26
Y122
A
Y
L
N
N
S
N
Y
E
E
G
D
E
Y
F
Site 27
Y128
N
Y
E
E
G
D
E
Y
F
D
K
N
L
A
L
Site 28
T142
L
F
E
E
E
M
D
T
R
P
K
V
S
S
L
Site 29
S148
D
T
R
P
K
V
S
S
L
L
N
R
M
A
N
Site 30
Y156
L
L
N
R
M
A
N
Y
T
N
L
T
Q
G
A
Site 31
T157
L
N
R
M
A
N
Y
T
N
L
T
Q
G
A
K
Site 32
T182
G
K
K
K
P
T
K
T
P
Q
M
G
T
F
M
Site 33
T187
T
K
T
P
Q
M
G
T
F
M
G
V
Y
L
P
Site 34
S304
P
R
A
A
I
F
H
S
D
D
A
L
K
E
S
Site 35
Y321
M
L
N
N
M
R
V
Y
G
T
A
F
L
V
L
Site 36
T323
N
N
M
R
V
Y
G
T
A
F
L
V
L
M
V
Site 37
S366
Y
A
G
A
I
K
S
S
F
A
P
P
H
F
P
Site 38
T381
V
C
M
L
G
N
R
T
L
S
S
R
H
I
D
Site 39
S383
M
L
G
N
R
T
L
S
S
R
H
I
D
V
C
Site 40
S384
L
G
N
R
T
L
S
S
R
H
I
D
V
C
S
Site 41
S391
S
R
H
I
D
V
C
S
K
T
K
E
I
N
N
Site 42
T400
T
K
E
I
N
N
M
T
V
P
S
K
L
W
G
Site 43
Y423
F
N
A
T
C
D
E
Y
F
V
H
N
N
V
T
Site 44
Y451
T
E
N
L
W
S
N
Y
L
P
K
G
E
I
I
Site 45
S462
G
E
I
I
E
K
P
S
A
K
S
S
D
V
L
Site 46
S465
I
E
K
P
S
A
K
S
S
D
V
L
G
S
L
Site 47
S466
E
K
P
S
A
K
S
S
D
V
L
G
S
L
N
Site 48
S471
K
S
S
D
V
L
G
S
L
N
H
E
Y
V
L
Site 49
S503
V
T
G
I
M
A
G
S
N
R
S
G
D
L
K
Site 50
S515
D
L
K
D
A
Q
K
S
I
P
I
G
T
I
L
Site 51
T563
K
G
N
L
V
V
G
T
L
S
W
P
S
P
W
Site 52
S613
F
L
R
V
F
G
H
S
K
A
N
G
E
P
T
Site 53
T669
A
L
Q
T
L
L
R
T
P
N
W
R
P
R
F
Site 54
Y716
I
A
G
M
I
Y
K
Y
I
E
Y
Q
G
A
E
Site 55
S734
G
D
G
I
R
G
L
S
L
S
A
A
R
F
A
Site 56
T752
L
E
E
G
P
P
H
T
K
N
W
R
P
Q
L
Site 57
T778
V
K
H
P
R
L
L
T
F
A
S
Q
L
K
A
Site 58
S781
P
R
L
L
T
F
A
S
Q
L
K
A
G
K
G
Site 59
Y804
V
G
N
F
L
E
N
Y
G
E
A
L
A
A
E
Site 60
S840
A
K
L
R
E
G
I
S
H
L
I
Q
S
C
G
Site 61
T875
E
D
A
R
A
W
K
T
F
I
G
T
V
R
V
Site 62
S901
K
N
I
S
F
F
P
S
N
V
E
Q
F
S
E
Site 63
T945
K
C
S
I
R
I
F
T
V
A
Q
L
E
D
N
Site 64
T962
Q
M
K
K
D
L
A
T
F
L
Y
H
L
R
I
Site 65
Y965
K
D
L
A
T
F
L
Y
H
L
R
I
E
A
E
Site 66
S981
E
V
V
E
M
H
D
S
D
I
S
A
Y
T
Y
Site 67
T987
D
S
D
I
S
A
Y
T
Y
E
R
T
L
M
M
Site 68
Y988
S
D
I
S
A
Y
T
Y
E
R
T
L
M
M
E
Site 69
T991
S
A
Y
T
Y
E
R
T
L
M
M
E
Q
R
S
Site 70
S1007
M
L
R
H
M
R
L
S
K
T
E
R
D
R
E
Site 71
T1009
R
H
M
R
L
S
K
T
E
R
D
R
E
A
Q
Site 72
S1023
Q
L
V
K
D
R
N
S
M
L
R
L
T
S
I
Site 73
T1028
R
N
S
M
L
R
L
T
S
I
G
S
D
E
D
Site 74
S1029
N
S
M
L
R
L
T
S
I
G
S
D
E
D
E
Site 75
S1032
L
R
L
T
S
I
G
S
D
E
D
E
E
T
E
Site 76
T1038
G
S
D
E
D
E
E
T
E
T
Y
Q
E
K
V
Site 77
T1040
D
E
D
E
E
T
E
T
Y
Q
E
K
V
H
M
Site 78
Y1041
E
D
E
E
T
E
T
Y
Q
E
K
V
H
M
T
Site 79
T1048
Y
Q
E
K
V
H
M
T
W
T
K
D
K
Y
M
Site 80
T1050
E
K
V
H
M
T
W
T
K
D
K
Y
M
A
S
Site 81
Y1054
M
T
W
T
K
D
K
Y
M
A
S
R
G
Q
K
Site 82
S1057
T
K
D
K
Y
M
A
S
R
G
Q
K
A
K
S
Site 83
S1064
S
R
G
Q
K
A
K
S
M
E
G
F
Q
D
L
Site 84
T1086
S
N
V
R
R
M
H
T
A
V
K
L
N
E
V
Site 85
S1098
N
E
V
I
V
N
K
S
H
E
A
K
L
V
L
Site 86
Y1121
N
P
E
G
D
E
N
Y
M
E
F
L
E
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation