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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMEM2
Full Name:
Transmembrane protein 2
Alias:
Type:
Mass (Da):
154374
Number AA:
1383
UniProt ID:
Q9UHN6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
T
D
S
R
G
H
S
P
A
F
L
Q
P
Q
Site 2
S21
L
Q
P
Q
N
G
N
S
R
H
P
S
G
Y
V
Site 3
S25
N
G
N
S
R
H
P
S
G
Y
V
P
G
K
V
Site 4
Y27
N
S
R
H
P
S
G
Y
V
P
G
K
V
V
P
Site 5
S43
R
P
P
P
P
P
K
S
Q
A
S
A
K
F
T
Site 6
S46
P
P
P
K
S
Q
A
S
A
K
F
T
S
I
R
Site 7
S51
Q
A
S
A
K
F
T
S
I
R
R
E
D
R
A
Site 8
T59
I
R
R
E
D
R
A
T
F
A
F
S
P
E
E
Site 9
S63
D
R
A
T
F
A
F
S
P
E
E
Q
Q
A
Q
Site 10
S73
E
Q
Q
A
Q
R
E
S
Q
K
Q
K
R
H
K
Site 11
S129
N
W
D
P
G
Q
D
S
A
K
Q
V
V
I
K
Site 12
T144
E
G
D
M
L
R
L
T
S
D
A
T
V
H
S
Site 13
S145
G
D
M
L
R
L
T
S
D
A
T
V
H
S
I
Site 14
S151
T
S
D
A
T
V
H
S
I
V
I
Q
D
G
G
Site 15
S169
F
G
D
N
K
D
G
S
R
N
I
T
L
R
T
Site 16
T173
K
D
G
S
R
N
I
T
L
R
T
H
Y
I
L
Site 17
Y178
N
I
T
L
R
T
H
Y
I
L
I
Q
D
G
G
Site 18
Y196
I
G
A
E
K
C
R
Y
K
S
K
A
T
I
T
Site 19
S198
A
E
K
C
R
Y
K
S
K
A
T
I
T
L
Y
Site 20
T203
Y
K
S
K
A
T
I
T
L
Y
G
K
S
D
E
Site 21
Y205
S
K
A
T
I
T
L
Y
G
K
S
D
E
G
E
Site 22
S208
T
I
T
L
Y
G
K
S
D
E
G
E
S
M
P
Site 23
S213
G
K
S
D
E
G
E
S
M
P
T
F
G
K
K
Site 24
T216
D
E
G
E
S
M
P
T
F
G
K
K
F
I
G
Site 25
S239
L
H
G
A
R
K
A
S
W
T
L
L
A
R
T
Site 26
T241
G
A
R
K
A
S
W
T
L
L
A
R
T
L
N
Site 27
T246
S
W
T
L
L
A
R
T
L
N
S
S
G
L
P
Site 28
S250
L
A
R
T
L
N
S
S
G
L
P
F
G
S
Y
Site 29
Y257
S
G
L
P
F
G
S
Y
T
F
E
K
D
F
S
Site 30
T258
G
L
P
F
G
S
Y
T
F
E
K
D
F
S
R
Site 31
S264
Y
T
F
E
K
D
F
S
R
G
L
N
V
R
V
Site 32
T276
V
R
V
I
D
Q
D
T
A
K
I
L
E
S
E
Site 33
S282
D
T
A
K
I
L
E
S
E
R
F
D
T
H
E
Site 34
T287
L
E
S
E
R
F
D
T
H
E
Y
R
N
E
S
Site 35
Y290
E
R
F
D
T
H
E
Y
R
N
E
S
R
R
L
Site 36
S294
T
H
E
Y
R
N
E
S
R
R
L
Q
E
F
L
Site 37
T326
A
K
S
L
L
Q
G
T
I
Q
M
I
Q
E
R
Site 38
S360
V
I
D
G
G
S
T
S
C
N
E
S
V
R
N
Site 39
S364
G
S
T
S
C
N
E
S
V
R
N
Y
E
N
H
Site 40
Y368
C
N
E
S
V
R
N
Y
E
N
H
S
S
G
G
Site 41
S373
R
N
Y
E
N
H
S
S
G
G
K
A
L
A
Q
Site 42
Y384
A
L
A
Q
R
E
F
Y
T
V
D
G
Q
K
F
Site 43
S392
T
V
D
G
Q
K
F
S
V
T
A
Y
S
E
W
Site 44
Y396
Q
K
F
S
V
T
A
Y
S
E
W
I
E
G
V
Site 45
S397
K
F
S
V
T
A
Y
S
E
W
I
E
G
V
S
Site 46
S404
S
E
W
I
E
G
V
S
L
S
G
F
R
V
E
Site 47
S425
L
N
L
L
D
D
V
S
S
W
K
P
G
D
Q
Site 48
S426
N
L
L
D
D
V
S
S
W
K
P
G
D
Q
I
Site 49
Y440
I
V
V
A
S
T
D
Y
S
M
Y
Q
A
E
E
Site 50
S441
V
V
A
S
T
D
Y
S
M
Y
Q
A
E
E
F
Site 51
T466
F
Q
V
K
V
K
E
T
P
Q
F
L
H
M
G
Site 52
Y503
G
E
V
E
D
S
C
Y
A
E
N
Q
C
Q
F
Site 53
S532
N
F
T
S
V
H
L
S
Y
V
E
L
K
H
M
Site 54
Y559
H
L
C
G
D
V
D
Y
K
G
G
Y
R
H
A
Site 55
T567
K
G
G
Y
R
H
A
T
F
V
D
G
L
S
I
Site 56
S573
A
T
F
V
D
G
L
S
I
H
H
S
F
S
R
Site 57
T583
H
S
F
S
R
C
I
T
V
H
G
T
N
G
L
Site 58
T616
D
G
I
E
Q
R
N
T
L
F
H
N
L
G
L
Site 59
T629
G
L
L
T
K
P
G
T
L
L
P
T
D
R
N
Site 60
T633
K
P
G
T
L
L
P
T
D
R
N
N
S
M
C
Site 61
S638
L
P
T
D
R
N
N
S
M
C
T
T
M
R
D
Site 62
Y689
S
Q
D
A
G
I
W
Y
L
F
H
K
E
P
T
Site 63
Y717
L
T
P
L
G
I
F
Y
N
N
R
V
H
S
N
Site 64
T737
F
I
D
K
G
V
K
T
T
N
S
S
A
A
D
Site 65
S740
K
G
V
K
T
T
N
S
S
A
A
D
P
R
E
Site 66
S741
G
V
K
T
T
N
S
S
A
A
D
P
R
E
Y
Site 67
Y748
S
A
A
D
P
R
E
Y
L
C
L
D
N
S
A
Site 68
S812
G
I
G
L
T
F
A
S
D
G
S
F
P
S
D
Site 69
S815
L
T
F
A
S
D
G
S
F
P
S
D
E
G
S
Site 70
S818
A
S
D
G
S
F
P
S
D
E
G
S
S
Q
E
Site 71
S822
S
F
P
S
D
E
G
S
S
Q
E
V
S
E
S
Site 72
S823
F
P
S
D
E
G
S
S
Q
E
V
S
E
S
L
Site 73
S827
E
G
S
S
Q
E
V
S
E
S
L
F
V
G
E
Site 74
S829
S
S
Q
E
V
S
E
S
L
F
V
G
E
S
R
Site 75
S835
E
S
L
F
V
G
E
S
R
N
Y
G
F
Q
G
Site 76
Y838
F
V
G
E
S
R
N
Y
G
F
Q
G
G
Q
N
Site 77
Y847
F
Q
G
G
Q
N
K
Y
V
G
T
G
G
I
D
Site 78
T859
G
I
D
Q
K
P
R
T
L
P
R
N
R
T
F
Site 79
T865
R
T
L
P
R
N
R
T
F
P
I
R
G
F
Q
Site 80
Y874
P
I
R
G
F
Q
I
Y
D
G
P
I
H
L
T
Site 81
T881
Y
D
G
P
I
H
L
T
R
S
T
F
K
K
Y
Site 82
S883
G
P
I
H
L
T
R
S
T
F
K
K
Y
V
P
Site 83
T884
P
I
H
L
T
R
S
T
F
K
K
Y
V
P
T
Site 84
Y888
T
R
S
T
F
K
K
Y
V
P
T
P
D
R
Y
Site 85
T891
T
F
K
K
Y
V
P
T
P
D
R
Y
S
S
A
Site 86
Y895
Y
V
P
T
P
D
R
Y
S
S
A
I
G
F
L
Site 87
S897
P
T
P
D
R
Y
S
S
A
I
G
F
L
M
K
Site 88
T910
M
K
N
S
W
Q
I
T
P
R
N
N
I
S
L
Site 89
S916
I
T
P
R
N
N
I
S
L
V
K
F
G
P
H
Site 90
S956
I
F
H
D
I
D
G
S
V
T
G
Y
K
D
A
Site 91
Y960
I
D
G
S
V
T
G
Y
K
D
A
Y
V
G
R
Site 92
Y964
V
T
G
Y
K
D
A
Y
V
G
R
M
D
N
Y
Site 93
Y971
Y
V
G
R
M
D
N
Y
L
I
R
H
P
S
C
Site 94
Y997
S
G
T
Y
A
Q
V
Y
V
Q
T
W
S
T
Q
Site 95
T1009
S
T
Q
N
L
S
M
T
I
T
R
D
E
Y
P
Site 96
T1011
Q
N
L
S
M
T
I
T
R
D
E
Y
P
S
N
Site 97
Y1015
M
T
I
T
R
D
E
Y
P
S
N
P
M
V
L
Site 98
S1017
I
T
R
D
E
Y
P
S
N
P
M
V
L
R
G
Site 99
Y1034
Q
K
A
A
F
P
Q
Y
Q
P
V
V
M
L
E
Site 100
Y1059
A
P
R
T
T
F
L
Y
L
V
N
F
N
K
N
Site 101
Y1075
W
I
R
V
G
L
C
Y
P
S
N
T
S
F
Q
Site 102
S1077
R
V
G
L
C
Y
P
S
N
T
S
F
Q
V
T
Site 103
T1084
S
N
T
S
F
Q
V
T
F
G
Y
L
Q
R
Q
Site 104
Y1087
S
F
Q
V
T
F
G
Y
L
Q
R
Q
N
G
S
Site 105
S1094
Y
L
Q
R
Q
N
G
S
L
S
K
I
E
E
Y
Site 106
S1096
Q
R
Q
N
G
S
L
S
K
I
E
E
Y
E
P
Site 107
Y1101
S
L
S
K
I
E
E
Y
E
P
V
H
S
L
E
Site 108
S1106
E
E
Y
E
P
V
H
S
L
E
E
L
Q
R
K
Site 109
S1115
E
E
L
Q
R
K
Q
S
E
R
K
F
Y
F
D
Site 110
Y1120
K
Q
S
E
R
K
F
Y
F
D
S
S
T
G
L
Site 111
S1123
E
R
K
F
Y
F
D
S
S
T
G
L
L
F
L
Site 112
T1125
K
F
Y
F
D
S
S
T
G
L
L
F
L
Y
L
Site 113
Y1131
S
T
G
L
L
F
L
Y
L
K
A
K
S
H
R
Site 114
S1142
K
S
H
R
H
G
H
S
Y
C
S
S
Q
G
C
Site 115
Y1143
S
H
R
H
G
H
S
Y
C
S
S
Q
G
C
E
Site 116
S1146
H
G
H
S
Y
C
S
S
Q
G
C
E
R
V
K
Site 117
S1160
K
I
Q
A
A
T
D
S
K
D
I
S
N
C
M
Site 118
Y1171
S
N
C
M
A
K
A
Y
P
Q
Y
Y
R
K
P
Site 119
Y1174
M
A
K
A
Y
P
Q
Y
Y
R
K
P
S
V
V
Site 120
Y1175
A
K
A
Y
P
Q
Y
Y
R
K
P
S
V
V
K
Site 121
S1179
P
Q
Y
Y
R
K
P
S
V
V
K
R
M
P
A
Site 122
T1203
G
T
R
Q
V
V
F
T
S
D
P
H
K
S
Y
Site 123
S1204
T
R
Q
V
V
F
T
S
D
P
H
K
S
Y
L
Site 124
S1209
F
T
S
D
P
H
K
S
Y
L
P
V
Q
F
Q
Site 125
Y1210
T
S
D
P
H
K
S
Y
L
P
V
Q
F
Q
S
Site 126
S1217
Y
L
P
V
Q
F
Q
S
P
D
K
A
E
T
Q
Site 127
T1223
Q
S
P
D
K
A
E
T
Q
R
G
D
P
S
V
Site 128
S1229
E
T
Q
R
G
D
P
S
V
I
S
V
N
G
T
Site 129
S1232
R
G
D
P
S
V
I
S
V
N
G
T
D
F
T
Site 130
Y1276
D
V
S
R
I
E
E
Y
L
K
T
G
I
P
P
Site 131
T1279
R
I
E
E
Y
L
K
T
G
I
P
P
R
S
I
Site 132
S1285
K
T
G
I
P
P
R
S
I
V
L
L
S
T
R
Site 133
S1290
P
R
S
I
V
L
L
S
T
R
G
E
I
K
Q
Site 134
Y1316
L
A
K
P
A
H
L
Y
D
K
G
S
T
I
F
Site 135
S1327
S
T
I
F
L
G
F
S
G
N
F
K
P
S
W
Site 136
S1333
F
S
G
N
F
K
P
S
W
T
K
L
F
T
S
Site 137
S1340
S
W
T
K
L
F
T
S
P
A
G
Q
G
L
G
Site 138
Y1360
I
P
L
Q
L
D
E
Y
G
C
P
R
A
T
T
Site 139
T1366
E
Y
G
C
P
R
A
T
T
V
R
R
R
D
L
Site 140
T1367
Y
G
C
P
R
A
T
T
V
R
R
R
D
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation