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Updated November 2019
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Protein Info
Short Name:
TRPS1
Full Name:
Zinc finger transcription factor Trps1
Alias:
LGCR; Trichorhinophalangeal syndrome I; Tricho-rhino-phalangeal syndrome type I; Zinc finger GC79; Zinc finger transcription factor Trps1: Tricho-rhino-phalangeal syndrome type I protein: Zinc finger protein GC79
Type:
Mass (Da):
141521
Number AA:
1281
UniProt ID:
Q9UHF7
International Prot ID:
IPI00296078
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006607
GO:0001501
GO:0006366
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
P
P
L
R
N
V
A
S
E
G
E
G
Q
I
L
Site 2
T26
Q
I
L
E
P
I
G
T
E
S
K
V
S
G
K
Site 3
S31
I
G
T
E
S
K
V
S
G
K
N
K
E
F
S
Site 4
S38
S
G
K
N
K
E
F
S
A
D
Q
M
S
E
N
Site 5
S43
E
F
S
A
D
Q
M
S
E
N
T
D
Q
S
D
Site 6
S49
M
S
E
N
T
D
Q
S
D
A
A
E
L
N
H
Site 7
S68
S
L
H
V
Q
D
P
S
S
S
S
K
K
D
L
Site 8
S69
L
H
V
Q
D
P
S
S
S
S
K
K
D
L
K
Site 9
S77
S
S
K
K
D
L
K
S
A
V
L
S
E
K
A
Site 10
S81
D
L
K
S
A
V
L
S
E
K
A
G
F
N
Y
Site 11
Y88
S
E
K
A
G
F
N
Y
E
S
P
S
K
G
G
Site 12
S90
K
A
G
F
N
Y
E
S
P
S
K
G
G
N
F
Site 13
S92
G
F
N
Y
E
S
P
S
K
G
G
N
F
P
S
Site 14
S99
S
K
G
G
N
F
P
S
F
P
H
D
E
V
T
Site 15
T106
S
F
P
H
D
E
V
T
D
R
N
M
L
A
F
Site 16
S115
R
N
M
L
A
F
S
S
P
A
A
G
G
V
C
Site 17
S127
G
V
C
E
P
L
K
S
P
Q
R
A
E
A
D
Site 18
T142
D
P
Q
D
M
A
C
T
P
S
G
D
S
L
E
Site 19
S147
A
C
T
P
S
G
D
S
L
E
T
K
E
D
Q
Site 20
S157
T
K
E
D
Q
K
M
S
P
K
A
T
E
E
T
Site 21
T161
Q
K
M
S
P
K
A
T
E
E
T
G
Q
A
Q
Site 22
S178
Q
A
N
C
Q
G
L
S
P
V
S
V
A
S
K
Site 23
S181
C
Q
G
L
S
P
V
S
V
A
S
K
N
P
Q
Site 24
S184
L
S
P
V
S
V
A
S
K
N
P
Q
V
P
S
Site 25
S200
G
G
V
R
L
N
K
S
K
T
D
L
L
V
N
Site 26
T202
V
R
L
N
K
S
K
T
D
L
L
V
N
D
N
Site 27
S216
N
P
D
P
A
P
L
S
P
E
L
Q
D
F
K
Site 28
Y246
L
I
K
H
F
R
K
Y
H
L
G
L
H
N
R
Site 29
S262
R
Q
D
A
E
L
D
S
K
I
L
A
L
H
N
Site 30
S276
N
M
V
Q
F
S
H
S
K
D
F
Q
K
V
N
Site 31
S285
D
F
Q
K
V
N
R
S
V
F
S
G
V
L
Q
Site 32
T323
F
I
G
I
G
R
K
T
P
D
C
Q
G
N
T
Site 33
S365
H
P
N
K
I
K
A
S
L
P
S
S
E
V
A
Site 34
S369
I
K
A
S
L
P
S
S
E
V
A
K
P
S
E
Site 35
S375
S
S
E
V
A
K
P
S
E
K
N
S
N
K
S
Site 36
S379
A
K
P
S
E
K
N
S
N
K
S
I
P
A
L
Site 37
S382
S
E
K
N
S
N
K
S
I
P
A
L
Q
S
S
Site 38
S388
K
S
I
P
A
L
Q
S
S
D
S
G
D
L
G
Site 39
S389
S
I
P
A
L
Q
S
S
D
S
G
D
L
G
K
Site 40
S391
P
A
L
Q
S
S
D
S
G
D
L
G
K
W
Q
Site 41
T402
G
K
W
Q
D
K
I
T
V
K
A
G
D
D
T
Site 42
T409
T
V
K
A
G
D
D
T
P
V
G
Y
S
V
P
Site 43
Y413
G
D
D
T
P
V
G
Y
S
V
P
I
K
P
L
Site 44
S414
D
D
T
P
V
G
Y
S
V
P
I
K
P
L
D
Site 45
S422
V
P
I
K
P
L
D
S
S
R
Q
N
G
T
E
Site 46
S423
P
I
K
P
L
D
S
S
R
Q
N
G
T
E
A
Site 47
T428
D
S
S
R
Q
N
G
T
E
A
T
S
Y
Y
W
Site 48
S442
W
C
K
F
C
S
F
S
C
E
S
S
S
S
L
Site 49
S446
C
S
F
S
C
E
S
S
S
S
L
K
L
L
E
Site 50
S447
S
F
S
C
E
S
S
S
S
L
K
L
L
E
H
Site 51
S448
F
S
C
E
S
S
S
S
L
K
L
L
E
H
Y
Site 52
Y455
S
L
K
L
L
E
H
Y
G
K
Q
H
G
A
V
Site 53
S464
K
Q
H
G
A
V
Q
S
G
G
L
N
P
E
L
Site 54
S476
P
E
L
N
D
K
L
S
R
G
S
V
I
N
Q
Site 55
S479
N
D
K
L
S
R
G
S
V
I
N
Q
N
D
L
Site 56
S489
N
Q
N
D
L
A
K
S
S
E
G
E
T
M
T
Site 57
T494
A
K
S
S
E
G
E
T
M
T
K
T
D
K
S
Site 58
T496
S
S
E
G
E
T
M
T
K
T
D
K
S
S
S
Site 59
T498
E
G
E
T
M
T
K
T
D
K
S
S
S
G
A
Site 60
S501
T
M
T
K
T
D
K
S
S
S
G
A
K
K
K
Site 61
S503
T
K
T
D
K
S
S
S
G
A
K
K
K
D
F
Site 62
S512
A
K
K
K
D
F
S
S
K
G
A
E
D
N
M
Site 63
Y532
C
Q
F
C
D
F
R
Y
S
K
S
H
G
P
D
Site 64
S535
C
D
F
R
Y
S
K
S
H
G
P
D
V
I
V
Site 65
Y550
V
G
P
L
L
R
H
Y
Q
Q
L
H
N
I
H
Site 66
S573
F
C
P
R
G
L
C
S
P
E
K
H
L
G
E
Site 67
Y583
K
H
L
G
E
I
T
Y
P
F
A
C
R
K
S
Site 68
S609
L
S
P
G
A
A
G
S
S
R
V
K
H
Q
C
Site 69
Y633
V
D
V
L
L
F
H
Y
E
S
V
H
E
S
Q
Site 70
S635
V
L
L
F
H
Y
E
S
V
H
E
S
Q
A
S
Site 71
S639
H
Y
E
S
V
H
E
S
Q
A
S
D
V
K
Q
Site 72
S642
S
V
H
E
S
Q
A
S
D
V
K
Q
E
A
N
Site 73
S654
E
A
N
H
L
Q
G
S
D
G
Q
Q
S
V
K
Site 74
S659
Q
G
S
D
G
Q
Q
S
V
K
E
S
K
E
H
Site 75
S663
G
Q
Q
S
V
K
E
S
K
E
H
S
C
T
K
Site 76
S667
V
K
E
S
K
E
H
S
C
T
K
C
D
F
I
Site 77
T675
C
T
K
C
D
F
I
T
Q
V
E
E
E
I
S
Site 78
Y685
E
E
E
I
S
R
H
Y
R
R
A
H
S
C
Y
Site 79
T700
K
C
R
Q
C
S
F
T
A
A
D
T
Q
S
L
Site 80
S706
F
T
A
A
D
T
Q
S
L
L
E
H
F
N
T
Site 81
T713
S
L
L
E
H
F
N
T
V
H
C
Q
E
Q
D
Site 82
T722
H
C
Q
E
Q
D
I
T
T
A
N
G
E
E
D
Site 83
S734
E
E
D
G
H
A
I
S
T
I
K
E
E
P
K
Site 84
Y747
P
K
I
D
F
R
V
Y
N
L
L
T
P
D
S
Site 85
T751
F
R
V
Y
N
L
L
T
P
D
S
K
M
G
E
Site 86
S754
Y
N
L
L
T
P
D
S
K
M
G
E
P
V
S
Site 87
S761
S
K
M
G
E
P
V
S
E
S
V
V
K
R
E
Site 88
S763
M
G
E
P
V
S
E
S
V
V
K
R
E
K
L
Site 89
T782
G
L
K
E
K
V
W
T
E
S
S
S
D
D
L
Site 90
S784
K
E
K
V
W
T
E
S
S
S
D
D
L
R
N
Site 91
S785
E
K
V
W
T
E
S
S
S
D
D
L
R
N
V
Site 92
S786
K
V
W
T
E
S
S
S
D
D
L
R
N
V
T
Site 93
T793
S
D
D
L
R
N
V
T
W
R
G
A
D
I
L
Site 94
S803
G
A
D
I
L
R
G
S
P
S
Y
T
Q
A
S
Site 95
S805
D
I
L
R
G
S
P
S
Y
T
Q
A
S
L
G
Site 96
Y806
I
L
R
G
S
P
S
Y
T
Q
A
S
L
G
L
Site 97
T807
L
R
G
S
P
S
Y
T
Q
A
S
L
G
L
L
Site 98
T815
Q
A
S
L
G
L
L
T
P
V
S
G
T
Q
E
Site 99
S818
L
G
L
L
T
P
V
S
G
T
Q
E
Q
T
K
Site 100
T826
G
T
Q
E
Q
T
K
T
L
R
D
S
P
N
V
Site 101
S830
Q
T
K
T
L
R
D
S
P
N
V
E
A
A
H
Site 102
S863
A
P
A
G
G
E
K
S
G
A
L
P
Q
Q
Y
Site 103
Y870
S
G
A
L
P
Q
Q
Y
P
A
S
G
E
N
K
Site 104
S873
L
P
Q
Q
Y
P
A
S
G
E
N
K
S
K
D
Site 105
S878
P
A
S
G
E
N
K
S
K
D
E
S
Q
S
L
Site 106
S882
E
N
K
S
K
D
E
S
Q
S
L
L
R
R
R
Site 107
S884
K
S
K
D
E
S
Q
S
L
L
R
R
R
R
G
Site 108
S892
L
L
R
R
R
R
G
S
G
V
F
C
A
N
C
Site 109
Y915
R
K
N
A
N
G
G
Y
V
C
N
A
C
G
L
Site 110
Y923
V
C
N
A
C
G
L
Y
Q
K
L
H
S
T
P
Site 111
S928
G
L
Y
Q
K
L
H
S
T
P
R
P
L
N
I
Site 112
T929
L
Y
Q
K
L
H
S
T
P
R
P
L
N
I
I
Site 113
T949
E
Q
I
I
R
R
R
T
R
K
R
L
N
P
E
Site 114
S970
L
N
K
Q
Q
R
G
S
N
E
E
Q
V
N
G
Site 115
S978
N
E
E
Q
V
N
G
S
P
L
E
R
R
S
E
Site 116
S984
G
S
P
L
E
R
R
S
E
D
H
L
T
E
S
Site 117
T989
R
R
S
E
D
H
L
T
E
S
H
Q
R
E
I
Site 118
S991
S
E
D
H
L
T
E
S
H
Q
R
E
I
P
L
Site 119
S1000
Q
R
E
I
P
L
P
S
L
S
K
Y
E
A
Q
Site 120
S1002
E
I
P
L
P
S
L
S
K
Y
E
A
Q
G
S
Site 121
Y1004
P
L
P
S
L
S
K
Y
E
A
Q
G
S
L
T
Site 122
S1009
S
K
Y
E
A
Q
G
S
L
T
K
S
H
S
A
Site 123
T1011
Y
E
A
Q
G
S
L
T
K
S
H
S
A
Q
Q
Site 124
S1013
A
Q
G
S
L
T
K
S
H
S
A
Q
Q
P
V
Site 125
S1015
G
S
L
T
K
S
H
S
A
Q
Q
P
V
L
V
Site 126
S1023
A
Q
Q
P
V
L
V
S
Q
T
L
D
I
H
K
Site 127
S1041
P
L
H
I
Q
I
K
S
P
Q
E
S
T
G
D
Site 128
S1045
Q
I
K
S
P
Q
E
S
T
G
D
P
G
N
S
Site 129
T1046
I
K
S
P
Q
E
S
T
G
D
P
G
N
S
S
Site 130
S1052
S
T
G
D
P
G
N
S
S
S
V
S
E
G
K
Site 131
S1053
T
G
D
P
G
N
S
S
S
V
S
E
G
K
G
Site 132
S1054
G
D
P
G
N
S
S
S
V
S
E
G
K
G
S
Site 133
S1056
P
G
N
S
S
S
V
S
E
G
K
G
S
S
E
Site 134
S1061
S
V
S
E
G
K
G
S
S
E
R
G
S
P
I
Site 135
S1062
V
S
E
G
K
G
S
S
E
R
G
S
P
I
E
Site 136
S1066
K
G
S
S
E
R
G
S
P
I
E
K
Y
M
R
Site 137
Y1071
R
G
S
P
I
E
K
Y
M
R
P
A
K
H
P
Site 138
Y1080
R
P
A
K
H
P
N
Y
S
P
P
G
S
P
I
Site 139
S1081
P
A
K
H
P
N
Y
S
P
P
G
S
P
I
E
Site 140
S1085
P
N
Y
S
P
P
G
S
P
I
E
K
Y
Q
Y
Site 141
Y1090
P
G
S
P
I
E
K
Y
Q
Y
P
L
F
G
L
Site 142
Y1092
S
P
I
E
K
Y
Q
Y
P
L
F
G
L
P
F
Site 143
Y1117
W
L
R
F
W
S
K
Y
K
L
S
V
P
G
N
Site 144
Y1127
S
V
P
G
N
P
H
Y
L
S
H
V
P
G
L
Site 145
S1129
P
G
N
P
H
Y
L
S
H
V
P
G
L
P
N
Site 146
Y1141
L
P
N
P
C
Q
N
Y
V
P
Y
P
T
F
N
Site 147
Y1144
P
C
Q
N
Y
V
P
Y
P
T
F
N
L
P
P
Site 148
T1146
Q
N
Y
V
P
Y
P
T
F
N
L
P
P
H
F
Site 149
S1154
F
N
L
P
P
H
F
S
A
V
G
S
D
N
D
Site 150
S1158
P
H
F
S
A
V
G
S
D
N
D
I
P
L
D
Site 151
S1171
L
D
L
A
I
K
H
S
R
P
G
P
T
A
N
Site 152
T1185
N
G
A
S
K
E
K
T
K
A
P
P
N
V
K
Site 153
T1202
G
P
L
N
V
V
K
T
E
K
V
D
R
S
T
Site 154
S1208
K
T
E
K
V
D
R
S
T
Q
D
E
L
S
T
Site 155
T1209
T
E
K
V
D
R
S
T
Q
D
E
L
S
T
K
Site 156
S1214
R
S
T
Q
D
E
L
S
T
K
C
V
H
C
G
Site 157
T1215
S
T
Q
D
E
L
S
T
K
C
V
H
C
G
I
Site 158
Y1256
Q
H
L
C
T
D
K
Y
D
F
T
T
H
I
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation