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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBK1
Full Name:
Serine/threonine-protein kinase TBK1
Alias:
EC 2.7.11.1; Kinase TBK1; NAK; NF-KB-activating kinase NAK; TANK binding kinase TBK1; TANK-binding kinase 1
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; IKK family
Mass (Da):
83642
Number AA:
729
UniProt ID:
Q9UHD2
International Prot ID:
IPI00293613
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007249
GO:0045087
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
TANK binding kinase TBK1; Serine/threonine-protein kinase TBK1 S172 phosphosite-specific antibody AB-PK828#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK828#TBK1Subtide - TBK1 protein kinase substrate peptide - Powder PE-01BJO90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BJO90#TANK binding kinase TBK1 / Serine/threonine-protein kinase TBK1 (Q169-G175, human) pS172 phosphopeptide - Powder PE-04ALG90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ALG90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T78
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
Site 2
T79
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
Site 3
T96
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
Site 4
Y105
L
E
E
P
S
N
A
Y
G
L
P
E
S
E
F
Site 5
S151
V
I
G
E
D
G
Q
S
V
Y
K
L
T
D
F
Site 6
Y153
G
E
D
G
Q
S
V
Y
K
L
T
D
F
G
A
Site 7
S172
E
D
D
E
Q
F
V
S
L
Y
G
T
E
E
Y
TANK binding kinase TBK1; Serine/threonine-protein kinase TBK1 S172 phosphosite-specific antibody AB-PK828#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK828#TANK binding kinase TBK1 / Serine/threonine-protein kinase TBK1 (Q169-G175, human) pS172 phosphopeptide - Powder PE-04ALG90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ALG90
Site 8
Y174
D
E
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
Site 9
T176
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
Site 10
Y179
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
Site 11
Y185
E
Y
L
H
P
D
M
Y
E
R
A
V
L
R
K
Site 12
Y198
R
K
D
H
Q
K
K
Y
G
A
T
V
D
L
W
Site 13
Y235
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
P
Site 14
S247
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
Site 15
S266
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Site 16
T343
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
Site 17
S347
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
Site 18
Y354
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
Site 19
T373
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
Site 20
T389
V
S
R
E
P
L
N
T
I
G
L
I
Y
E
K
Site 21
Y406
L
P
K
V
H
P
R
Y
D
L
D
G
D
A
S
Site 22
S413
Y
D
L
D
G
D
A
S
M
A
K
A
I
T
G
Site 23
Y424
A
I
T
G
V
V
C
Y
A
C
R
I
A
S
T
Site 24
Y435
I
A
S
T
L
L
L
Y
Q
E
L
M
R
K
G
Site 25
Y454
I
E
L
I
K
D
D
Y
N
E
T
V
H
K
K
Site 26
T478
C
I
R
N
I
E
K
T
V
K
V
Y
E
K
L
Site 27
T503
G
E
I
S
D
I
H
T
K
L
L
R
L
S
S
Site 28
S509
H
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
Site 29
S510
T
K
L
L
R
L
S
S
S
Q
G
T
I
E
T
Site 30
S511
K
L
L
R
L
S
S
S
Q
G
T
I
E
T
S
Site 31
T514
R
L
S
S
S
Q
G
T
I
E
T
S
L
Q
D
Site 32
S518
S
Q
G
T
I
E
T
S
L
Q
D
I
D
S
R
Site 33
S524
T
S
L
Q
D
I
D
S
R
L
S
P
G
G
S
Site 34
S527
Q
D
I
D
S
R
L
S
P
G
G
S
L
A
D
Site 35
S531
S
R
L
S
P
G
G
S
L
A
D
A
W
A
H
Site 36
Y563
L
N
C
M
T
E
I
Y
Y
Q
F
K
K
D
K
Site 37
Y564
N
C
M
T
E
I
Y
Y
Q
F
K
K
D
K
A
Site 38
Y577
K
A
E
R
R
L
A
Y
N
E
E
Q
I
H
K
Site 39
Y591
K
F
D
K
Q
K
L
Y
Y
H
A
T
K
A
M
Site 40
Y609
T
D
E
C
V
K
K
Y
E
A
F
L
N
K
S
Site 41
S632
H
L
R
K
Q
L
L
S
L
T
N
Q
C
F
D
Site 42
T634
R
K
Q
L
L
S
L
T
N
Q
C
F
D
I
E
Site 43
Y647
I
E
E
E
V
S
K
Y
Q
E
Y
T
N
E
L
Site 44
T657
Y
T
N
E
L
Q
E
T
L
P
Q
K
M
F
T
Site 45
T664
T
L
P
Q
K
M
F
T
A
S
S
G
I
K
H
Site 46
S667
Q
K
M
F
T
A
S
S
G
I
K
H
T
M
T
Site 47
T672
A
S
S
G
I
K
H
T
M
T
P
I
Y
P
S
Site 48
T674
S
G
I
K
H
T
M
T
P
I
Y
P
S
S
N
Site 49
Y677
K
H
T
M
T
P
I
Y
P
S
S
N
T
L
V
Site 50
S680
M
T
P
I
Y
P
S
S
N
T
L
V
E
M
T
Site 51
S716
H
I
L
E
R
F
G
S
L
T
M
D
G
G
L
Site 52
T718
L
E
R
F
G
S
L
T
M
D
G
G
L
R
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation