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Updated November 2019
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Protein Info
Short Name:
DMBT1
Full Name:
Deleted in malignant brain tumors 1 protein
Alias:
Glycoprotein 340;Hensin;Salivary agglutinin;Surfactant pulmonary-associated D-binding protein
Type:
Mass (Da):
260735
Number AA:
2413
UniProt ID:
Q9UGM3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T27
T
G
G
W
I
P
R
T
T
D
Y
A
S
L
I
Site 2
T28
G
G
W
I
P
R
T
T
D
Y
A
S
L
I
P
Site 3
Y30
W
I
P
R
T
T
D
Y
A
S
L
I
P
S
E
Site 4
S32
P
R
T
T
D
Y
A
S
L
I
P
S
E
V
P
Site 5
S36
D
Y
A
S
L
I
P
S
E
V
P
L
D
P
T
Site 6
T43
S
E
V
P
L
D
P
T
V
A
E
G
S
P
F
Site 7
S48
D
P
T
V
A
E
G
S
P
F
P
S
E
S
T
Site 8
S52
A
E
G
S
P
F
P
S
E
S
T
L
E
S
T
Site 9
S54
G
S
P
F
P
S
E
S
T
L
E
S
T
V
A
Site 10
S58
P
S
E
S
T
L
E
S
T
V
A
E
G
S
P
Site 11
T59
S
E
S
T
L
E
S
T
V
A
E
G
S
P
I
Site 12
S64
E
S
T
V
A
E
G
S
P
I
S
L
E
S
T
Site 13
S67
V
A
E
G
S
P
I
S
L
E
S
T
L
E
S
Site 14
T71
S
P
I
S
L
E
S
T
L
E
S
T
V
A
E
Site 15
S74
S
L
E
S
T
L
E
S
T
V
A
E
G
S
L
Site 16
S80
E
S
T
V
A
E
G
S
L
I
P
S
E
S
T
Site 17
S84
A
E
G
S
L
I
P
S
E
S
T
L
E
S
T
Site 18
S90
P
S
E
S
T
L
E
S
T
V
A
E
G
S
D
Site 19
T91
S
E
S
T
L
E
S
T
V
A
E
G
S
D
S
Site 20
S96
E
S
T
V
A
E
G
S
D
S
G
L
A
L
R
Site 21
Y119
Q
G
R
V
E
I
L
Y
R
G
S
W
G
T
V
Site 22
S172
A
L
D
D
V
R
C
S
G
H
E
S
Y
L
W
Site 23
S208
C
S
A
A
Q
P
Q
S
T
L
R
P
E
S
W
Site 24
T209
S
A
A
Q
P
Q
S
T
L
R
P
E
S
W
P
Site 25
S214
Q
S
T
L
R
P
E
S
W
P
V
R
I
S
P
Site 26
S220
E
S
W
P
V
R
I
S
P
P
V
P
T
E
G
Site 27
T225
R
I
S
P
P
V
P
T
E
G
S
E
S
S
L
Site 28
S228
P
P
V
P
T
E
G
S
E
S
S
L
A
L
R
Site 29
S231
P
T
E
G
S
E
S
S
L
A
L
R
L
V
N
Site 30
S254
V
E
V
L
Y
R
G
S
W
G
T
V
C
D
D
Site 31
S304
V
L
D
D
V
R
C
S
G
H
E
S
Y
L
W
Site 32
S334
E
D
A
G
V
I
C
S
A
P
Q
S
R
P
T
Site 33
S338
V
I
C
S
A
P
Q
S
R
P
T
P
S
P
D
Site 34
T341
S
A
P
Q
S
R
P
T
P
S
P
D
T
W
P
Site 35
S343
P
Q
S
R
P
T
P
S
P
D
T
W
P
T
S
Site 36
T346
R
P
T
P
S
P
D
T
W
P
T
S
H
A
S
Site 37
T349
P
S
P
D
T
W
P
T
S
H
A
S
T
A
G
Site 38
S350
S
P
D
T
W
P
T
S
H
A
S
T
A
G
P
Site 39
S353
T
W
P
T
S
H
A
S
T
A
G
P
E
S
S
Site 40
T354
W
P
T
S
H
A
S
T
A
G
P
E
S
S
L
Site 41
S360
S
T
A
G
P
E
S
S
L
A
L
R
L
V
N
Site 42
T410
Q
L
G
C
G
W
A
T
S
A
P
G
N
A
R
Site 43
S411
L
G
C
G
W
A
T
S
A
P
G
N
A
R
F
Site 44
S422
N
A
R
F
G
Q
G
S
G
P
I
V
L
D
D
Site 45
S433
V
L
D
D
V
R
C
S
G
Y
E
S
Y
L
W
Site 46
Y435
D
D
V
R
C
S
G
Y
E
S
Y
L
W
S
C
Site 47
Y438
R
C
S
G
Y
E
S
Y
L
W
S
C
P
H
N
Site 48
S463
E
D
A
G
V
I
C
S
A
A
H
S
W
S
T
Site 49
S467
V
I
C
S
A
A
H
S
W
S
T
P
S
P
D
Site 50
S469
C
S
A
A
H
S
W
S
T
P
S
P
D
T
L
Site 51
T470
S
A
A
H
S
W
S
T
P
S
P
D
T
L
P
Site 52
S472
A
H
S
W
S
T
P
S
P
D
T
L
P
T
I
Site 53
T475
W
S
T
P
S
P
D
T
L
P
T
I
T
L
P
Site 54
S484
P
T
I
T
L
P
A
S
T
V
G
S
E
S
S
Site 55
S564
V
L
D
D
V
R
C
S
G
N
E
S
Y
L
W
Site 56
Y569
R
C
S
G
N
E
S
Y
L
W
S
C
P
H
N
Site 57
Y677
R
C
S
G
H
E
S
Y
L
W
S
C
P
N
N
Site 58
S702
E
D
A
G
V
I
C
S
A
A
Q
S
R
S
T
Site 59
S706
V
I
C
S
A
A
Q
S
R
S
T
P
R
P
D
Site 60
S708
C
S
A
A
Q
S
R
S
T
P
R
P
D
T
L
Site 61
T709
S
A
A
Q
S
R
S
T
P
R
P
D
T
L
S
Site 62
T714
R
S
T
P
R
P
D
T
L
S
T
I
T
L
P
Site 63
S716
T
P
R
P
D
T
L
S
T
I
T
L
P
P
S
Site 64
T717
P
R
P
D
T
L
S
T
I
T
L
P
P
S
T
Site 65
S723
S
T
I
T
L
P
P
S
T
V
G
S
E
S
S
Site 66
S727
L
P
P
S
T
V
G
S
E
S
S
L
T
L
R
Site 67
S730
S
T
V
G
S
E
S
S
L
T
L
R
L
V
N
Site 68
T732
V
G
S
E
S
S
L
T
L
R
L
V
N
G
S
Site 69
S739
T
L
R
L
V
N
G
S
D
R
C
Q
G
R
V
Site 70
S833
E
D
A
G
V
I
C
S
V
S
Q
S
R
P
T
Site 71
S835
A
G
V
I
C
S
V
S
Q
S
R
P
T
P
S
Site 72
S837
V
I
C
S
V
S
Q
S
R
P
T
P
S
P
D
Site 73
T840
S
V
S
Q
S
R
P
T
P
S
P
D
T
W
P
Site 74
S842
S
Q
S
R
P
T
P
S
P
D
T
W
P
T
S
Site 75
Y1010
Q
G
R
V
E
V
L
Y
Q
G
S
W
G
T
V
Site 76
S1093
E
D
A
G
V
I
C
S
A
S
Q
S
R
P
T
Site 77
S1095
A
G
V
I
C
S
A
S
Q
S
R
P
T
P
S
Site 78
S1097
V
I
C
S
A
S
Q
S
R
P
T
P
S
P
D
Site 79
T1100
S
A
S
Q
S
R
P
T
P
S
P
D
T
W
P
Site 80
S1109
S
P
D
T
W
P
T
S
H
A
S
T
A
G
S
Site 81
S1112
T
W
P
T
S
H
A
S
T
A
G
S
E
S
S
Site 82
T1113
W
P
T
S
H
A
S
T
A
G
S
E
S
S
L
Site 83
S1116
S
H
A
S
T
A
G
S
E
S
S
L
A
L
R
Site 84
S1119
S
T
A
G
S
E
S
S
L
A
L
R
L
V
N
Site 85
S1222
E
D
A
G
V
I
C
S
A
S
Q
S
Q
P
T
Site 86
S1224
A
G
V
I
C
S
A
S
Q
S
Q
P
T
P
S
Site 87
S1226
V
I
C
S
A
S
Q
S
Q
P
T
P
S
P
D
Site 88
T1229
S
A
S
Q
S
Q
P
T
P
S
P
D
T
W
P
Site 89
S1231
S
Q
S
Q
P
T
P
S
P
D
T
W
P
T
S
Site 90
T1234
Q
P
T
P
S
P
D
T
W
P
T
S
H
A
S
Site 91
T1492
Q
P
T
P
S
P
D
T
W
P
T
S
R
A
S
Site 92
T1495
P
S
P
D
T
W
P
T
S
R
A
S
T
A
G
Site 93
S1496
S
P
D
T
W
P
T
S
R
A
S
T
A
G
S
Site 94
S1499
T
W
P
T
S
R
A
S
T
A
G
S
E
S
T
Site 95
T1500
W
P
T
S
R
A
S
T
A
G
S
E
S
T
L
Site 96
S1503
S
R
A
S
T
A
G
S
E
S
T
L
A
L
R
Site 97
Y1526
R
G
R
V
E
V
L
Y
Q
G
S
W
G
T
V
Site 98
S1609
E
D
A
G
V
I
C
S
A
A
Q
S
Q
S
T
Site 99
S1613
V
I
C
S
A
A
Q
S
Q
S
T
P
R
P
D
Site 100
S1615
C
S
A
A
Q
S
Q
S
T
P
R
P
D
T
W
Site 101
T1616
S
A
A
Q
S
Q
S
T
P
R
P
D
T
W
L
Site 102
T1621
Q
S
T
P
R
P
D
T
W
L
T
T
N
L
P
Site 103
T1625
R
P
D
T
W
L
T
T
N
L
P
A
L
T
V
Site 104
Y1715
R
C
S
G
N
E
S
Y
L
W
S
C
P
H
K
Site 105
S1740
E
D
A
G
V
I
C
S
A
T
Q
I
N
S
T
Site 106
T1758
W
W
H
P
T
T
T
T
T
A
R
P
S
S
N
Site 107
T1759
W
H
P
T
T
T
T
T
A
R
P
S
S
N
C
Site 108
S1763
T
T
T
T
A
R
P
S
S
N
C
G
G
F
L
Site 109
S1764
T
T
T
A
R
P
S
S
N
C
G
G
F
L
F
Site 110
S1778
F
Y
A
S
G
T
F
S
S
P
S
Y
P
A
Y
Site 111
S1779
Y
A
S
G
T
F
S
S
P
S
Y
P
A
Y
Y
Site 112
S1781
S
G
T
F
S
S
P
S
Y
P
A
Y
Y
P
N
Site 113
Y1782
G
T
F
S
S
P
S
Y
P
A
Y
Y
P
N
N
Site 114
Y1785
S
S
P
S
Y
P
A
Y
Y
P
N
N
A
K
C
Site 115
Y1786
S
P
S
Y
P
A
Y
Y
P
N
N
A
K
C
V
Site 116
Y1802
E
I
E
V
N
S
G
Y
R
I
N
L
G
F
S
Site 117
Y1823
H
H
N
C
S
F
D
Y
V
E
I
F
D
G
S
Site 118
T1844
L
G
K
I
C
N
D
T
R
Q
I
F
T
S
S
Site 119
Y1852
R
Q
I
F
T
S
S
Y
N
R
M
T
I
H
F
Site 120
T1856
T
S
S
Y
N
R
M
T
I
H
F
R
S
D
I
Site 121
S1861
R
M
T
I
H
F
R
S
D
I
S
F
Q
N
T
Site 122
S1864
I
H
F
R
S
D
I
S
F
Q
N
T
G
F
L
Site 123
Y1874
N
T
G
F
L
A
W
Y
N
S
F
P
S
D
A
Site 124
S1879
A
W
Y
N
S
F
P
S
D
A
T
L
R
L
V
Site 125
T1882
N
S
F
P
S
D
A
T
L
R
L
V
N
L
N
Site 126
Y1902
C
A
G
R
V
E
I
Y
H
G
G
T
W
G
T
Site 127
S1945
N
A
Y
F
G
S
G
S
G
P
I
T
L
D
D
Site 128
T1949
G
S
G
S
G
P
I
T
L
D
D
V
E
C
S
Site 129
S1956
T
L
D
D
V
E
C
S
G
T
E
S
T
L
W
Site 130
T1958
D
D
V
E
C
S
G
T
E
S
T
L
W
Q
C
Site 131
S1986
E
D
A
G
V
I
C
S
G
N
H
L
S
T
P
Site 132
T2004
L
N
I
T
R
P
N
T
D
Y
S
C
G
G
F
Site 133
Y2006
I
T
R
P
N
T
D
Y
S
C
G
G
F
L
S
Site 134
S2007
T
R
P
N
T
D
Y
S
C
G
G
F
L
S
Q
Site 135
S2013
Y
S
C
G
G
F
L
S
Q
P
S
G
D
F
S
Site 136
S2016
G
G
F
L
S
Q
P
S
G
D
F
S
S
P
F
Site 137
S2020
S
Q
P
S
G
D
F
S
S
P
F
Y
P
G
N
Site 138
S2021
Q
P
S
G
D
F
S
S
P
F
Y
P
G
N
Y
Site 139
Y2024
G
D
F
S
S
P
F
Y
P
G
N
Y
P
N
N
Site 140
Y2028
S
P
F
Y
P
G
N
Y
P
N
N
A
K
C
V
Site 141
Y2061
Q
L
E
G
G
C
N
Y
D
Y
I
E
V
F
D
Site 142
Y2063
E
G
G
C
N
Y
D
Y
I
E
V
F
D
G
P
Site 143
S2074
F
D
G
P
Y
R
S
S
P
L
I
A
R
V
C
Site 144
S2087
V
C
D
G
A
R
G
S
F
T
S
S
S
N
F
Site 145
T2089
D
G
A
R
G
S
F
T
S
S
S
N
F
M
S
Site 146
S2090
G
A
R
G
S
F
T
S
S
S
N
F
M
S
I
Site 147
S2091
A
R
G
S
F
T
S
S
S
N
F
M
S
I
R
Site 148
S2092
R
G
S
F
T
S
S
S
N
F
M
S
I
R
F
Site 149
S2096
T
S
S
S
N
F
M
S
I
R
F
I
S
D
H
Site 150
S2101
F
M
S
I
R
F
I
S
D
H
S
I
T
R
R
Site 151
S2104
I
R
F
I
S
D
H
S
I
T
R
R
G
F
R
Site 152
T2106
F
I
S
D
H
S
I
T
R
R
G
F
R
A
E
Site 153
Y2114
R
R
G
F
R
A
E
Y
Y
S
S
P
S
N
D
Site 154
Y2115
R
G
F
R
A
E
Y
Y
S
S
P
S
N
D
S
Site 155
S2116
G
F
R
A
E
Y
Y
S
S
P
S
N
D
S
T
Site 156
S2117
F
R
A
E
Y
Y
S
S
P
S
N
D
S
T
N
Site 157
S2119
A
E
Y
Y
S
S
P
S
N
D
S
T
N
L
L
Site 158
S2122
Y
S
S
P
S
N
D
S
T
N
L
L
C
L
P
Site 159
T2123
S
S
P
S
N
D
S
T
N
L
L
C
L
P
N
Site 160
S2135
L
P
N
H
M
Q
A
S
V
S
R
S
Y
L
Q
Site 161
S2137
N
H
M
Q
A
S
V
S
R
S
Y
L
Q
S
L
Site 162
S2139
M
Q
A
S
V
S
R
S
Y
L
Q
S
L
G
F
Site 163
Y2140
Q
A
S
V
S
R
S
Y
L
Q
S
L
G
F
S
Site 164
S2143
V
S
R
S
Y
L
Q
S
L
G
F
S
A
S
D
Site 165
Y2159
V
I
S
T
W
N
G
Y
Y
E
C
R
P
Q
I
Site 166
Y2160
I
S
T
W
N
G
Y
Y
E
C
R
P
Q
I
T
Site 167
T2182
I
P
Y
S
G
C
G
T
F
K
Q
A
D
N
D
Site 168
T2190
F
K
Q
A
D
N
D
T
I
D
Y
S
N
F
L
Site 169
Y2193
A
D
N
D
T
I
D
Y
S
N
F
L
T
A
A
Site 170
T2210
G
G
I
I
K
R
R
T
D
L
R
I
H
V
S
Site 171
Y2250
I
Q
V
E
E
V
Q
Y
G
N
F
D
V
N
I
Site 172
S2258
G
N
F
D
V
N
I
S
F
Y
T
S
S
S
F
Site 173
T2261
D
V
N
I
S
F
Y
T
S
S
S
F
L
Y
P
Site 174
Y2267
Y
T
S
S
S
F
L
Y
P
V
T
S
R
P
Y
Site 175
T2270
S
S
F
L
Y
P
V
T
S
R
P
Y
Y
V
D
Site 176
S2271
S
F
L
Y
P
V
T
S
R
P
Y
Y
V
D
L
Site 177
Y2274
Y
P
V
T
S
R
P
Y
Y
V
D
L
N
Q
D
Site 178
Y2275
P
V
T
S
R
P
Y
Y
V
D
L
N
Q
D
L
Site 179
S2305
F
V
D
T
C
V
A
S
P
Y
S
N
D
F
T
Site 180
Y2307
D
T
C
V
A
S
P
Y
S
N
D
F
T
S
L
Site 181
S2308
T
C
V
A
S
P
Y
S
N
D
F
T
S
L
T
Site 182
T2312
S
P
Y
S
N
D
F
T
S
L
T
Y
D
L
I
Site 183
S2313
P
Y
S
N
D
F
T
S
L
T
Y
D
L
I
R
Site 184
T2315
S
N
D
F
T
S
L
T
Y
D
L
I
R
S
G
Site 185
S2321
L
T
Y
D
L
I
R
S
G
C
V
R
D
D
T
Site 186
T2328
S
G
C
V
R
D
D
T
Y
G
P
Y
S
S
P
Site 187
Y2329
G
C
V
R
D
D
T
Y
G
P
Y
S
S
P
S
Site 188
Y2332
R
D
D
T
Y
G
P
Y
S
S
P
S
L
R
I
Site 189
S2333
D
D
T
Y
G
P
Y
S
S
P
S
L
R
I
A
Site 190
S2334
D
T
Y
G
P
Y
S
S
P
S
L
R
I
A
R
Site 191
S2336
Y
G
P
Y
S
S
P
S
L
R
I
A
R
F
R
Site 192
Y2368
K
M
V
V
C
R
A
Y
D
P
S
S
R
C
Y
Site 193
Y2375
Y
D
P
S
S
R
C
Y
R
G
C
V
L
R
S
Site 194
S2382
Y
R
G
C
V
L
R
S
K
R
D
V
G
S
Y
Site 195
Y2389
S
K
R
D
V
G
S
Y
Q
E
K
V
D
V
V
Site 196
T2404
L
G
P
I
Q
L
Q
T
P
P
R
R
E
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation